Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Novel finger-prick test can help prevent toxoplasmosis

Novel finger-prick test can help prevent toxoplasmosis

A recent study, performed in Chicago and Rabat, Morocco, found that a novel finger-prick test for infection with the parasite Toxoplasma gondii during pregnancy -; and many other potential applications -; is 100 percent sensitive and 100 percent specific for detecting the presence of this life-damaging microorganism.

A positive result from the Toxoplasma ICT IgG-IgM point-of-care test, performed with a drop of a pregnant woman’s blood, can rapidly inform an obstetrician about the need for prompt treatment of toxoplasmosis. Timely intervention before birth can prevent the disease, which can cause death, severe brain damage and loss of sight in an infected fetus.

The test, developed by LDBIO Diagnostic of Lyon, France, “meets the World Health Organization’s criteria for an optimal point-of-care test,” said toxoplasmosis specialist Rima McLeod, MD, a professor of ophthalmology and visual science and pediatrics at the University of Chicago Medicine.

“It is sensitive and specific, quick and easy to perform, equipment-free, and easily utilized,” she said. “Results are available in half an hour while the patient is seeing the doctor. A positive result can be confirmed quickly, so health care providers can immediately begin treatment.”

The test is also inexpensive. It costs $4 to $5 per test. Pregnant women at risk should be tested eight to 10 times -; once a month during pregnancy, beginning in the 12th week, then once more four to six weeks after delivery. Total cost for repeated tests is about $40 to $50. Hospitals and clinics in developed countries charge substantially more.

“This well-studied, inexpensive test opens the door to life, sight and cognition-saving treatments for children exposed to the parasite in utero,” said McLeod. By spotting the infection early with monthly testing and alerting physicians to the need for urgent treatment, “it markedly improves outcomes for infants infected in utero,” she said. “This test leads to prevention of the severe consequences of Toxoplasma gondii infection and saves lives.”

“A paper cut,” she added, “is more painful than the finger prick for this test.”

Toxoplasma gondii gains access to human hosts when they eat undercooked contaminated meat or are exposed to material contaminated by feces from an acutely infected cat, which usually goes unrecognized. Current methods of detecting the infection include serum tests, which require blood samples to be processed using technologies that are often cost prohibitive in developing areas and “may be considered too costly even in developed countries,” McLeod said.

In the August 16, 2018 issue of PLOS Neglected Tropical Diseases, a study by researchers based at the University of Chicago Medicine shows that the new test “performed with high sensitivity and specificity. It obviates the need for venipuncture and sample processing.” The test is accurate whether the patients were recently exposed or infected long before testing.

The LDBIO test relies on an immuno-chromatographic lateral-flow assay. This is a paper-based system designed to detect the presence (or absence) of a specific target -; in this case the IgG and IgM antibodies -; by slowly flowing the liquid sample through a paper matrix and over a substance that binds to the antibodies and causes the appearance of a colored band.

The researchers, including colleagues in the United States, France and Morocco, collected and tested 244 samples from 205 individuals. Overall, 101 of the samples indicated that the patients had developed antibodies against T. gondii. The other 143 samples did not have T. gondii antibodies.

Blood from these volunteer donors was examined in multiple ways. The researchers compared reference tests and standard-of-care serum tests against the finger-stick test. The new test’s results with whole blood exactly matched those from established but more cumbersome methods, even for women with low levels of anti-T. gondii antibodies.

Although the test does not distinguish between acute and chronic infections, it provides valuable information that can guide decisions in outpatient settings at very low cost, enabling rapid diagnosis and treatment for infections acquired just before or during pregnancy.

“Adoption of this type of high functioning point-of-care test would reduce costs substantially and require significantly less infrastructure than conventional testing,” the researchers conclude. “Value also arises from bringing pregnant women into care, leading to screening for other preventable and treatable conditions.”

“Testing of pregnant women for this infection has already changed how this parasite affects babies in France, Austria, Germany and Colombia,” McLeod said. “This test should facilitate similar improvements in patient care and well-being in the U.S. and many other developed and developing countries.”

The makers are submitting the point-of-care test for approval by the U.S. Food and Drug Administration based on recent U.S studies, but it has not yet been approved.

Source:

http://www.uchospitals.edu/

Tagged with:

About author

Related Articles