Breaking News
November 19, 2018 - FDA Grants Orphan Drug Designation To RGX-181 Gene Therapy For The Treatment Of CLN2 Form Of Batten Disease
November 19, 2018 - Systemic mastocytosis – Genetics Home Reference
November 19, 2018 - Eye trauma secondary to falls in older adults increasing
November 19, 2018 - Empowering women in India to improve their health: A Q&A
November 19, 2018 - Researchers have trained a computer to analyze breast cancer images and classify tumors
November 19, 2018 - New glucose binding molecule could be key to better metabolic control for diabetics
November 19, 2018 - Biologists uncover novel genetic control of lipid maintenance and its potential connection to lifespan
November 19, 2018 - Warmer winters may set scene for higher rates of violent crimes
November 19, 2018 - Acacia Pharma Resubmits Barhemsys New Drug Application
November 19, 2018 - PDL1 (Immunotherapy) Tests: MedlinePlus Lab Test Information
November 19, 2018 - Transforming pregnancy research with a smartphone app
November 19, 2018 - Stanford Medicine magazine explores how digital technology is changing health care
November 19, 2018 - Marijuana prevention programs should focus on promoting mental wellbeing of youth
November 19, 2018 - New report calls for greater awareness and emphasis on scale and impact of atrial fibrillation
November 19, 2018 - In throes of turkey salmonella outbreak, don’t invite illness to your table
November 19, 2018 - UK health policies should be redesigned to become more accessible for men
November 19, 2018 - Short Interpregnancy Intervals Tied to Adverse Outcome Risk
November 19, 2018 - New mothers’ breastfeeding pain can affect infant health
November 19, 2018 - Stanford Medicine magazine reports on ways digital technology is transforming health care | News Center
November 19, 2018 - Human drugs alter cricket personality
November 19, 2018 - Insilico Medicine to introduce ‘Cure a disease in a year’ program at Biodata World Congress 2018
November 19, 2018 - Experts debate over whether gut or brain is more important in regulating appetite
November 19, 2018 - Playing on fear and fun, hospitals follow pharma in direct-to-consumer advertising
November 19, 2018 - 2PG Company receives grant to develop sensitive, low-cost molecular diagnostic tests for tuberculosis
November 19, 2018 - Low-Carb Diets May Work By Boosting Calorie Burn
November 19, 2018 - Key molecule responsible for learning and memory discovered
November 19, 2018 - New blood test developed for early diagnosis of ovarian cancer
November 19, 2018 - Researchers identify molecule to fight myotubular myopathy
November 19, 2018 - New solution to stop spread of brain cancer
November 19, 2018 - Immune cells trigger OCD-like behaviour in multiple sclerosis, study finds
November 19, 2018 - Scientists equip new virus that kills carcinoma cells with protein
November 19, 2018 - Novel approach could provide painless, efficient alternative for treating eye diseases
November 19, 2018 - Protein in cell membranes of sperm plays key role in finding their way to eggs
November 19, 2018 - Parents who decline flu vaccination for their child may be exposed to limited information
November 19, 2018 - Mirati Presents Data From Ongoing Phase 2 Clinical Trial Of Mocetinostat In Combination With Durvalumab At The SITC 33rd Annual Meeting
November 19, 2018 - FDA warns of common diabetes meds’ link to dangerous genital infection
November 19, 2018 - New methods for preserving shoulder function, quality of life in breast cancer patients
November 19, 2018 - Surprising discovery about BH4 may rekindle interest in once-promising pathway
November 19, 2018 - Nabriva Therapeutics Completes Submission of New Drug Application to U.S. Food and Drug Administration for Intravenous Contepo to Treat Complicated Urinary Tract Infections
November 19, 2018 - Beating breast cancer only to die of opioid use – a sad Appalachian story
November 19, 2018 - Workplace bullying or violence linked to higher risk of cardiovascular problems
November 19, 2018 - Changes in Risk Indicators of MetS Severity Tied to T2DM Risk
November 19, 2018 - ‘Game-changing’ skin sensor could improve life for a million hydrocephalus patients
November 19, 2018 - Alcohol ads on social media sites with pro-drinking comments increase desire to drink
November 19, 2018 - Neural networks could replace marker genes in RNA sequencing
November 19, 2018 - Obese adolescents feel less food enjoyment than those with normal weight, study reveals
November 18, 2018 - Goodbye ‘Gluten-Free’? Celiac Disease Vaccine May Make It Possible
November 18, 2018 - Skin ages when the main cells in the dermis lose their identity and function
November 18, 2018 - Rainforest vine compound makes pancreatic cancer cells susceptible to nutrient starvation
November 18, 2018 - A new mechanism in the control of inflammation
November 18, 2018 - Age-related decline in abstract reasoning ability predicts depressive symptoms over time
November 18, 2018 - Scientists succeed in increasing stability, biocompatibility of light-transducing nanoparticles
November 18, 2018 - Sugar, a ‘sweet’ tool to understand brain injuries
November 18, 2018 - Pharmacist-Led Effort Cuts Inappropriate Rx in Older Adults
November 18, 2018 - Novel discovery could lead to new cancer, autoimmune disease therapy
November 18, 2018 - AHA and ADA launch new initiative to help people with type 2 diabetes reduce heart disease risk
November 18, 2018 - Balanced production of pro and anti-inflammatory cytokines at two years of age protects against malaria
November 18, 2018 - New pharmacological agent shows promise for prevention of heart rhythm disorders
November 18, 2018 - All That Social Media May Boost Loneliness, Not Banish It
November 18, 2018 - Scientists shine new light on link between obesity and cancer
November 18, 2018 - Risk factors for cardiovascular disease closely track with changes in diet patterns
November 18, 2018 - Biogen Scoops Sixth Prix Galien Award with UK Win for Life-Changing Rare Disease Medicine
November 18, 2018 - Detectable HIV-1 in treated human liver cells found to be inert
November 18, 2018 - Using light to control crucial step in embryonic development
November 18, 2018 - Unusual case of father-to-son HIV transmission reported
November 18, 2018 - FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
November 18, 2018 - Poverty blamed on widening north-south gap in young adult deaths in England
November 18, 2018 - Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
November 18, 2018 - Consensus Statement Issued on Management of Foot, Ankle Gout
November 18, 2018 - Fine particle air pollution is a public health emergency hiding in plain sight
November 18, 2018 - In-hospital mortality higher among patients with drug-resistant infections
November 17, 2018 - Research shines new, explanatory light on link between obesity and cancer
November 17, 2018 - FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
November 17, 2018 - Tracking Preemies’ Head Size May Yield IQ Clues
November 17, 2018 - Scientists call for unified standards in 3-D genome and epigenetic data
November 17, 2018 - Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
November 17, 2018 - New strategy to hinder emergence of antimicrobial-resistant pathogens
November 17, 2018 - Sexuality education before age 18 may reduce risk of sexual assault in college
November 17, 2018 - Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure
November 17, 2018 - New model of FSHD could be useful to study effectiveness of experimental therapeutics
5 Questions with Jordan Orange, Chair of Pediatrics

5 Questions with Jordan Orange, Chair of Pediatrics

image_pdfDownload PDFimage_print

Jordan Orange is the new chair of pediatrics at Columbia University Vagelos College of Physicians and SurgeonsMost people are healthy, at least most of the time. Why that is has always captivated Jordan Orange, MD, PhD, the new chair of pediatrics at Columbia University Vagelos College of Physicians and Surgeons.

“I do not come from a family of physicians and scientists, and I thought the best way to answer the question was to be a physician who investigates the human condition–and I was at least partly correct,” Orange says.

Throughout his career, Orange has blended a commitment to pediatric clinical care with a focus on basic and translational research. He is an international leader in pediatric primary immunodeficiency and has defined a new class of diseases known as natural-killer-cell deficiencies.

“Natural killer cells are there–always ready–to protect us against danger,” Orange says. When the cells are broken in some way, the immune system cannot fight pathogens or cancer. “One of the things we’re focused on now is how to use natural killer cells therapeutically as treatment for diseases.”

Before joining Columbia this summer, Orange was professor of pediatrics, vice chair for research, and chief of immunology, allergy, and rheumatology at Baylor College of Medicine.

 

Q: Tell us a little about yourself. How did you choose pediatrics?

During my clinical years in medical school, I was really just taken by the discipline of pediatrics. Children are experiencing their environment for the first time, and there are so many twists and turns that an individual goes through that allows them to either emerge as healthy or not. Then also, just from a very humanistic perspective, any day that we could do something to help a child really felt like a good day. I was trained to be a healer and that’s very important to me.

 

Q: How do you see pediatric clinical care evolving at Columbia in the next few years?

The leaders of both NYP and Columbia are talking about a new future for child health in New York City, what I refer to as “For New York, In New York.” Columbia has the largest pediatrics faculty in the city; we have the largest footprint and we really have to be there for New York’s children. This means getting out into our communities, bringing new clinical programs and excellence to the communities, that’s a priority.

Columbia has the largest pediatrics faculty in the city, and we really have to be there for New York’s children.

We also need to be clinically super potent–with broad excellence across all clinical areas of child health so that we can be a comprehensive and superb children’s hospital of the highest level. When a patient comes here with a complex problem, we have to be able to offer the very best of available services.

We currently have a full range of specialties here and we can treat any child that walks into this hospital today. In some places, we will be increasing critical mass to improve accessibility.

 

Q: Does the mix of patients who come to Columbia make that a challenge?

We have what’s referred to as a high case mix index; that is, we have some of the sickest patients in the United States. The complexity of patients at this children’s hospital is actually the second highest in the country.

I think that requires specialties to really work together to treat the patient comprehensively and holistically. That does happen here, and we’ll be creating avenues and programs for it to happen more fluidly and more effectively.

The complexity of patients at this children’s hospital is actually the second highest in the country. That requires specialties to really work together.

Some of our complex patients are drawn here for our areas of distinction in which we have especially good outcomes, for example, complex congenital heart defects. We have phenomenal surgeons, phenomenal cardiologists, phenomenal interventionalists, phenomenal nurses, and phenomenal cardiorespiratory therapists. A full range of services allows for these patients to converge here and for the outcomes to be exceptional.

 

Q: One of your goals for the department is to strengthen research in the department. Why is it important for pediatricians in academic medical centers to conduct research?

Research is of the essence in pediatrics. Pediatrician-scientists are people who speak both the language of child health and of research. They are, I believe, better positioned to innovate on behalf of children and better able to apply new research advances to the needs and gaps in pediatrics.

We’re at Columbia, which is a top national research institution, and our department is filled with high-quality faculty, really brilliant individuals advancing an important clinical mission and meaningful research. There is every reason that we should be one of the top research departments of pediatrics. With regards to NIH funding for departments of pediatrics, we just jumped in the rankings to number 14, but we should really be able to do what other Columbia departments do, and that’s outpace the NIH and other institutes in research and funding.

How do we do that? We’re not a free-standing children’s research institute, but I think that that’s a strength. We exist within the free-flowing environment of Columbia and we really need to work hard to bring other Columbia researchers and programs to pediatrics. I would love to see recruitments that can connect spheres of excellence at Columbia with child health.

 

Q: In running a pediatrics department, do you have any guiding principles?

Something that’s very important to me personally is what I call DRG: Dignity, Respect, and Gentility. It’s an important way of describing how we need to interact with each other, how we need to interact with the people our work touches, how we need to interact with our patients and families.

We have a great existing culture around these concepts and I just want to be sure that we crystallize that and build upon it.

 

Jordan Orange, MD, PhD, became the Reuben S. Carpentier Professor and Chair of the Department of Pediatrics at Columbia University Vagelos College of Physicians and Surgeons on July 1, 2018, succeeding Lawrence R. Stanberry, MD, PhD. Orange also is pediatrician-in-chief at NewYork-Presbyterian/Morgan Stanley Children’s Hospital.

Tagged with:

About author

Related Articles