Breaking News
February 24, 2019 - Novel MRI sensor can peer deep into the brain to detect intracellular calcium activity
February 24, 2019 - AHA News: Diabetes Remains Dangerous Despite Modern Medicine
February 24, 2019 - Dup15q syndrome – Genetics Home Reference
February 24, 2019 - Could ‘Cardio-obstetrics’ curb rise in pregnancy-related deaths?
February 24, 2019 - Using computer model to visualize brain’s internal valuation system
February 24, 2019 - Study reveals insights into how the brain learns new locomotor patterns
February 24, 2019 - Depression Screening: MedlinePlus Lab Test Information
February 24, 2019 - Researchers discover a weakness in a rare cancer that could be exploited with drugs
February 23, 2019 - U.S.-based patient advocacy organizations received majority of pharma donations, finds study
February 23, 2019 - UCL and AIIMS collaborates to increase academic and student exchange
February 23, 2019 - Mechanism behind how diabetes causes muscle loss revealed
February 23, 2019 - Hepatocellular carcinoma diagnosis, prognosis and treatment may improve by identifying a protein
February 23, 2019 - The American Heart Association issues new reference toolkit for healthcare providers
February 23, 2019 - Studies explore physiological dangers that climate change will have on animal life
February 23, 2019 - Penn study reveals increase in health-related internet searches before ER visits
February 23, 2019 - Intensive therapy during early stages of MS leads to better long-term outcomes
February 23, 2019 - Prenatal Fluconazole Exposure Increases Neonatal Risks
February 23, 2019 - Mental Health Screening: MedlinePlus Lab Test Information
February 23, 2019 - Study suggests birth mechanics are part of the process that leads to autism
February 23, 2019 - Unhealthy diet linked to poor mental health
February 23, 2019 - Study gives a snapshot of crocodile evolution
February 23, 2019 - Research finds steep rise in self-poisonings among young people
February 23, 2019 - American Gastroenterological Association announces “AGA Future Leaders Program”
February 23, 2019 - Scientists uncover new mechanisms regulating neural stem cells
February 23, 2019 - Combinations of certain insecticides turn out to be lethal for honeybees
February 23, 2019 - AHA News: Why Are Black Women at Higher Risk of Dying From Pregnancy Complications?
February 23, 2019 - NIMH » Anxiety Disorders
February 23, 2019 - Autistic people urgently need access to tailored mental health support
February 23, 2019 - Newly designed molecule could benefit people with Friedrich’s Ataxia
February 23, 2019 - Chinese CRISPR twins may have better cognition and memory
February 23, 2019 - Study finds new genetic clues associated with asthma in African ancestry populations
February 23, 2019 - Fetal signaling pathways may offer future opportunities to treat lung damage
February 23, 2019 - Early-stage osteoarthritis drug wins prestigious innovation award
February 23, 2019 - Researchers report positive findings with dasotraline for ADHD in children ages 6-12
February 23, 2019 - News study reanalyzes the effects of noncaloric sweeteners on gut microbiota
February 23, 2019 - New device allows scientists to reproduce blow effects on the heart in lab
February 23, 2019 - Paying more attention to antibiotic dosing could improve clinical outcomes for CF patients
February 23, 2019 - Big-data analysis finds new link between popular arthritis drug and heart valve calcification
February 23, 2019 - Holy herb identified as a potential treatment for Alzheimer’s disease
February 23, 2019 - New technology platform digitally counts growth factors in single cells
February 23, 2019 - Physicians still remain at higher risk for burnout compared to other professionals
February 23, 2019 - Surgery and other treatments offer viable options for adult scoliosis
February 23, 2019 - Reduced antibody adaptability may make the elderly more vulnerable to influenza
February 23, 2019 - Researchers find increased rates of CRC screening in Kentucky after Medicaid expansion
February 23, 2019 - Neighborhood income, education associated with risk of disability progression in MS patients
February 23, 2019 - Endocrine Society opposes new rule that restricts access to Title X Family Planning Program
February 23, 2019 - 2019 guidelines for management of patients with atrial fibrillation
February 23, 2019 - Surprise rheumatoid arthritis discovery points to new treatment for joint inflammation
February 23, 2019 - A just-right fix for a tiny heart
February 23, 2019 - UMass Amherst scientist explores role of citrus peel in decreasing gut inflammation
February 23, 2019 - Owlstone Medical and Shanghai Renji Hospital collaborate to initiate breath biopsy lung cancer trial
February 23, 2019 - AMSBIO’s comprehensive portfolio of knock-out cell lines and lysates
February 23, 2019 - New app reliably determines physicians’ skills in forming accurate, efficient diagnoses
February 23, 2019 - Peripheral nerve injury can trigger the onset and spread of ALS, shows study
February 23, 2019 - Researchers uncover mechanisms that prevent tooth replacement in mice
February 23, 2019 - Once-a-day capsule offers new way to reduce symptoms of chronic breathlessness
February 23, 2019 - FDA Adds Boxed Warning for Increased Risk of Death with Gout Medicine Uloric (febuxostat)
February 23, 2019 - Phone-based intervention aids rheumatoid arthritis care
February 23, 2019 - Opioid epidemic makes eastern inroads and targets African-Americans
February 23, 2019 - New identified biomarker predicts patients who might benefit from HER2-targeted agents
February 23, 2019 - Study offers new insights into mechanisms of changes in erythrocytes under stress
February 23, 2019 - Antipsychotic polypharmacy may be beneficial for schizophrenia patients
February 23, 2019 - Researchers investigate how marijuana and tobacco co-use affects quit attempts by smokers
February 23, 2019 - Patients with diabetes mellitus have high risk of stable ischemic heart disease
February 23, 2019 - Transparency on healthcare prices played key role in Arizona health system’s turnaround
February 23, 2019 - A comprehensive, multinational review of peppers around the world
February 23, 2019 - Study finds modest decrease in burnout among physicians
February 23, 2019 - A simple change can drastically reduce unnecessary tests for urinary tract infections
February 23, 2019 - Deep Learning-Enhanced Device Detects Diabetic Retinopathy
February 23, 2019 - Researchers discover new binding partner for amyloid precursor protein
February 23, 2019 - Modest decrease seen in burnout among physicians, researchers say | News Center
February 23, 2019 - Transplanting bone marrow of young mice into old mice prevents cognitive decline
February 23, 2019 - Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding
February 23, 2019 - Johns Hopkins study describes cells that may help speed bone repair
February 23, 2019 - Scientists demonstrate influence of food odors on proteostasis
February 23, 2019 - Researchers unlock the secret behind reproduction of fish called ‘Mary’
February 23, 2019 - Acupuncture Could Help Ease Menopausal Symptoms
February 23, 2019 - Researchers use AI to detect early signs of Alzheimer’s
February 23, 2019 - On recovery, vulnerability and ritual: An exhibit in white | News Center
February 23, 2019 - Memory Stored in Unexpected Region of the Brain
Novel system can pinpoint ingestible implants inside the body using wireless signals

Novel system can pinpoint ingestible implants inside the body using wireless signals

image_pdfDownload PDFimage_print

Medical processes like imaging often require cutting someone open or making them swallow huge tubes with cameras on them. But what if could get the same results with methods that are less expensive, invasive and time-consuming?

Researchers from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) led by professor Dina Katabi are working on exactly that with ReMix, a system that they describe as an “in-body GPS.” ReMix can pinpoint the location of ingestible implants inside the body using low-power wireless signals. In animal tests the team demonstrated that they can track implants with centimeter-level accuracy, and said that one day similar implants could be used to deliver drugs to specific regions in the body.

To test ReMix, Katabi’s group first implanted a small marker in animal tissues. To track its movement, they used a wireless device that reflects radio signals at the patient, and a special algorithm to pinpoint the exact location of the marker. The team used a wireless technology that they’ve previously demonstrated to detect heart rate, breathing and movement.

Interestingly, the marker inside the body does not need to transmit any wireless signal. It simply reflects the signal transmitted by a device outside the body, without needing a battery or any other external source of energy.

A key challenge in using wireless signals in this way is the many competing reflections that bounce off a person’s body. In fact, the signals that reflect off a person’s skin are actually 100 million times more powerful than the signals of the metal marker itself.

To overcome this, the team designed an approach that essentially separates the interfering skin signals from the ones they’re trying to measure. They did this using a small semiconductor device called a “diode” that can mix signals together so that the team can then filter out the skin-related signals. For example, if the skin reflects at frequencies of F1 and F2, the diode creates new combinations of those frequencies such as F1-F2 and F1+F2. When all of the signals reflect back to the system, the system only picks up the combined frequencies , thereby filtering out the original frequencies that came from the patient’s skin.

“The ability to continuously sense inside the human body has largely been a distant dream,” says Romit Roy Choudhury, a professor of electrical engineering and computer science at the University of Illinois, who was not involved in the research. “One of the roadblocks has been wireless communication to a device and its continuous localization. ReMix makes a leap in this direction by showing that the wireless component of implantable devices may no longer be the bottleneck.”

One potential application for ReMix is in proton therapy, a type of cancer treatment that involves bombarding tumors with beams of magnet-controlled protons. The approach allows doctors to prescribe higher doses of radiation, but requires a very high degree of precision, which means that it’s usually limited to only certain cancers.

Its success hinges on something that’s actually quite unreliable: a tumor staying exactly where it is during the radiation process. If a tumor moves, then healthy areas could be exposed to the radiation. But with a small marker like ReMix’s, doctors could better determine the location of a tumor in real-time, and be able to either pause the treatment or steer the beam into the right position to deal with the movement. (To be clear, ReMix is not yet accurate enough to be used in clinical settings – Katabi says a margin of error closer to a couple of millimeters would be necessary for actual implementation.)

Looking ahead

There are still many challenges ahead for improving ReMix. The team next hopes to combine the wireless data with medical information like MRI scans to further improve the system’s accuracy. In addition, the team will continue to reassess the algorithm and the various trade-offs needed to account for the complexity of different peoples’ bodies.

“We want a model that’s technically feasible, while still complex enough to accurately represent the human body,” says PhD student Deepak Vasisht, lead author on the new paper. “If we want to use this technology on actual cancer patients one day, it will have to come from better modeling a person’s physical structure.”

ReMix was developed in collaboration with researchers from Massachusetts General Hospital (MGH). The team says that such systems could help enable more widespread adoption of proton therapy centers, of which there are only about 100 globally.

“One reason that [proton therapy] is so expensive is because of the cost of installing the hardware,” says Vasisht. “If these systems can encourage more applications of the technology, there will be more demand, which will mean more therapy centers and lower prices for patients.”

Source:

http://news.mit.edu/2018/gps-inside-your-body-0820

Tagged with:

About author

Related Articles