Breaking News
January 21, 2019 - High Levels of Activity, Motor Ability Linked to Better Cognition
January 21, 2019 - Killer blows? Knockout study of pair of mouse MicroRNA provides cancer insight
January 21, 2019 - Buffalo researchers receive grant to quicken development of generic equivalents of contraceptives
January 21, 2019 - One-third of pregnant women do not believe cannabis is harmful to their fetus
January 21, 2019 - Fiderstat could be used as chemopreventative drug for intestinal cancers caused by APC gene mutations
January 21, 2019 - Modifying healthcare delivery practices may improve discussions between youth and healthcare providers
January 21, 2019 - UNIST researcher named as recipient of Merck’s 2018 Life Science Awards
January 21, 2019 - How Getting a Flu Shot Could Save Your Life
January 21, 2019 - Surgical adhesions can be treated, prevented in mice
January 21, 2019 - Increased physician-targeted marketing associated with higher opioid overdose deaths
January 21, 2019 - Researchers uncover specific microbial signatures of intestinal disease
January 21, 2019 - Study to investigate new targeted oral treatments for severe asthma
January 21, 2019 - Plan Your Plate | NIH News in Health
January 21, 2019 - Fecal occult blood test may improve CRC outcomes in some
January 21, 2019 - Blood test detects Alzheimer’s disease years before symptoms develop
January 21, 2019 - Mount Sinai joins with Paradigm and ReqMed to repurpose drug for treatment of MPS
January 21, 2019 - FDA Advisory Committee Votes on Zynquista (sotagliflozin) as Treatment for Adults with Type 1 Diabetes
January 21, 2019 - The causes and complications of snoring
January 21, 2019 - Placenta adapts and compensates when pregnant mothers have poor diets or low oxygen
January 21, 2019 - New implant could restore the transmission of electrical signals in injured central nervous system
January 21, 2019 - Rapid-acting fentanyl test strips found to be effective at reducing overdose risk
January 21, 2019 - Coronary Artery Calcium May Help Predict CVD in South Asians
January 21, 2019 - The mystery of the super-ager
January 21, 2019 - Scientists develop smart microrobots that can change shape depending on their surroundings
January 21, 2019 - Keep Moving to Keep Brain Sharp in Old Age
January 21, 2019 - Despite progress, gay fathers and their children still structurally stigmatized
January 21, 2019 - New drug for treating liver parasites in vivax malaria
January 21, 2019 - Merck recognized with 2018 Life Science Industry Award for best use of social media
January 21, 2019 - Coeur Wallis equips the canton of Valais with 260 SCHILLER defibrillators
January 21, 2019 - Scientists propose quick and pain-free method for diagnosing kidney cancer
January 21, 2019 - Signs of memory loss could point to hearing issues
January 21, 2019 - HeartFlow Analysis shows highest diagnostic performance for detecting coronary artery disease
January 21, 2019 - How Much Caffeine is Too Much?
January 21, 2019 - Take a timeout before you force your child to apologize
January 21, 2019 - Scientists design two AI algorithms to improve early detection of cognitive impairment
January 21, 2019 - Novel therapy for children with chronic hormone deficiency provides lifeline for parents
January 21, 2019 - Bioethicists call for oversight of poorly regulated, consumer-grade neurotechnology products
January 21, 2019 - Study shows hereditary hemochromatosis behind many cancers and joint diseases
January 21, 2019 - Short bouts of stairclimbing throughout the day can improve cardiovascular health
January 20, 2019 - Liver Transplant Survival May Improve With Race Matching
January 20, 2019 - Study implicates hyperactive immune system in aging brain disorders
January 20, 2019 - Cancer Diagnosis May Quadruple Suicide Risk
January 20, 2019 - Parkinson’s disease experts devise a roadmap
January 20, 2019 - Research brings new hope to treating degenerative brain diseases
January 20, 2019 - Scientists pinpoint a set of molecules that wire the body weight center of the brain
January 20, 2019 - Researchers get close to developing elusive blood test for Alzheimer’s disease
January 20, 2019 - UCLA researchers demonstrate new technique to develop cancer-fighting T cells
January 20, 2019 - Researchers discover how cancer cells avoid genetic meltdown
January 20, 2019 - Exercise makes even the ‘still overweight’ healthier: study
January 20, 2019 - University of Utah to establish first-of-its-kind dark sky studies minor in the US
January 20, 2019 - School-based nutritional programs reduce student obesity
January 20, 2019 - Improved maternity care practices in the southern U.S. reduce racial inequities in breastfeeding
January 20, 2019 - New enzyme biomarker test indicates diseases and bacterial contamination
January 20, 2019 - Republican and Democratic governors have different visions to transform health care, say researchers
January 20, 2019 - Researchers discover that spin flips happen in only half a picosecond in the course of a chemical reaction
January 20, 2019 - Suicide Risk Up More Than Fourfold for Cancer Patients
January 20, 2019 - Doctors find 122 nails in Ethiopian’s stomach
January 20, 2019 - UV disinfection technology eliminates up to 97.7% of pathogens in operating rooms
January 20, 2019 - Researchers discover mechanism which drives leukemia cell growth
January 20, 2019 - AHA: Infection as a Baby Led to Heart Valve Surgery for Teen
January 20, 2019 - Injection improves vision in a form of childhood blindness
January 20, 2019 - Multiple sclerosis therapies delay progression of disability
January 20, 2019 - New study finds infrequent helmet use among bike share riders
January 20, 2019 - Clearing up information about corneal dystrophies
January 20, 2019 - Researchers describe new behavior in energy metabolism that refutes existing evidence
January 20, 2019 - New study takes first step toward treating endometriosis
January 20, 2019 - Researchers find how GREB1 gene promotes resistance to prostate cancer treatments
January 20, 2019 - Replacing Sitting Time With Activity Lowers Mortality Risk
January 20, 2019 - A simple, inexpensive intervention makes birth safer for moms and babies in parts of Africa
January 19, 2019 - New anti-inflammatory compound acts as ‘surge protector’ to reduce cancer growth
January 19, 2019 - Significant flaws found in recently released forensic software
January 19, 2019 - New Leash on Life? Staying Slim Keeps Pooches Happy, Healthy
January 19, 2019 - Men and women remember pain differently
January 19, 2019 - Rising air pollution linked with increased ER visits for breathing problems
January 19, 2019 - Study uses local data to model food consumption patterns among Seattle residents
January 19, 2019 - The brain’s cerebellum plays role in controlling reward and social behaviors, study shows
January 19, 2019 - Relationship between nurse work environment and patient safety
January 19, 2019 - Pioneering surgery restores movement to children paralyzed by acute flaccid myelitis
January 19, 2019 - Genetic variants linked with risk tolerance and risky behaviors
January 19, 2019 - New research provides better understanding of our early human ancestors
Thermo Fisher Scientific and Diamond collaborate to launch new cryo-EM capability for use in life sciences industry

Thermo Fisher Scientific and Diamond collaborate to launch new cryo-EM capability for use in life sciences industry

image_pdfDownload PDFimage_print

Thermo Fisher Scientific and Diamond Light Source are creating a step change for life sciences sector, a one-stop shop for structural biology and one of largest cryo-EM sites in the world.

An agreement to launch a new cryo-EM capability for use in the life sciences industry sector by Thermo Fisher Scientific, one of the world leaders in high-end scientific instrumentation, and Diamond Light Source, the UK’s national synchrotron and one of the most advanced scientific facilities in the world, was announced today (12 September, 2018) at the official opening of the new national electron bio-imaging center (eBIC) at Diamond.

L to R Dr Richard Henderson, Laboratory of Molecular Biology, Cambridge and one of the recipients of the 2017 Nobel Prize for Chemistry winner; Dan Shine, Senior Vice President, Thermo Fisher Scientific; – Professor Andrew Harrison, CEO Diamond Light Source; Professor Dave Stuart, Life Sciences Director at Diamond and MRC Professor of Structural Biology at University of Oxford; and Katie Cunnea, the Electron Bio-Imaging Center’s (eBIC’s) Senior center coordinator;  at the official opening of the new national electron bio-imaging center (eBIC) at Diamond Light Source, the UK’s national synchrotron

This announcement confirms Diamond as one of the major global cryo-EM sites embedded with an abundance of complementary synchrotron-based techniques, and thereby, provides the life sciences sector with an offer not available anywhere else in the world.

Professor Dave Stuart, Life Sciences Director at Diamond and MRC Professor of Structural Biology at the University of Oxford, Department of Clinical Medicine, says:

Access to 21st century scientific tools to push the boundaries of scientific research is essential for both academia and industry, and what we have created here at Diamond is truly unique in the world in terms of size and scale. The new center offers the opportunity for almost real-time physiology, capturing proteins in action at cryo-temperatures by flash-freezing them at various stages. What Diamond has created with eBIC is an integrated facility for structural biology, which will accelerate R&D for both industry and academic users. The additional advanced instruments made available by Thermo Fisher will position the UK as a global leader in providing large-scale industrial access to cryo-EM for drug discovery research. Our new collaboration provides a step change in our offer for industry users and helps ensure that R&D remains in the UK.”

The collaboration with Thermo Fisher will further expand Diamond’s cryo-EM offerings by providing two new dedicated microscopes and professional cryo-EM services designed exclusively for the pharmaceutical industry. New instruments being installed include a Thermo Scientific Glacios Cryo Transmission Electron Microscope (TEM) and a Thermo Scientific Krios Cryo-TEM at eBIC. The two organisations will provide cryo-EM guidance and expertise in sample preparation, cryo-EM sample screening, and high-end data collection to industrial researchers.

“Researchers at leading pharmaceutical companies are already using instruments from Thermo Fisher Scientific to drive impactful research that can help speed the path to understanding and treating viruses and diseases,” says Mike Shafer, President, Materials and Structural Analysis, Thermo Fisher. “The combination of the expert staff members at eBIC and Diamond, alongside these new Thermo Scientific cryo-EM instruments, ensures these researchers are on the cutting edge of discovery.”

The new microscopes will add to Diamond’s four existing high-end microscopes, which are starting operation within eBIC and will continue to support the academic demand.

Recent technology developments in cryo-EM are proving to be powerful for both basic and applied science at Diamond. This is why Diamond, with the wider community led by Birkbeck College and Oxford University, established a center embedded within the synchrotron’s infrastructure through a strategic grant from the Wellcome Trust, Biotechnology and Biological Research Council and Medical Research Council. The center officially opens today by Dr Richard Henderson from the Laboratory of Molecular Biology, Cambridge. Dr Henderson is one of the recipients of the 2017 Nobel Prize for Chemistry for developing the cryo-EM technique.

Dr Henderson says:

Using single particle cryo-EM, researchers can now visualize biomolecules at near atomic resolution. This technology has taken biochemistry into a new era, allowing atomic structure determinations of many protein and other macromolecular building blocks that were previously very difficult or impossible to obtain. The technique also opens up high resolution studies of macromolecules in their cellular context through the use of electron cryotomography. Coupling these techniques with the capabilities at Diamond creates a unique environment that will help keep the UK at the forefront of world-leading science.”

Structural insight into proteins, viruses and other macromolecular complexes helps pharmaceutical companies better understand disease mechanisms, more quickly assess possible drug targets, and accelerates the optimization of these drug targets. Mike Shafer adds:

It’s important for Thermo Fisher to support this effort with both equipment and staffing, allowing researchers to maximize their time spent with the instruments. We are excited Diamond will provide joint staff, expertise in swift and effective data collection and analysis, and support with sample preparation.”

Pharmaceutical company researchers will have easy access to expert knowledge and industry leading cryo-EM equipment, covering the complete workflow for single particle analysis in the first instance. Access to both a Glacios Cryo-TEM and a Krios Cryo-TEM at one location will optimize productivity and time-to-result because of the designed-in connectivity between the two instruments. Scientists will be able to first pre-screen samples on the Glacios Cryo-TEM to find the best quality samples before advancing to the higher resolution imaging on the Krios Cryo-TEM.

The infrastructure on offer at eBIC taps into the expertise of Diamond as a 24-hours per day, six days a week operational model. Typically, eBIC industry users are granted one to three day sessions depending on their requirements. The two new microscopes will have four staff providing support for year-round operation.

Early users of the facility comments include:

Dr John Barker, Senior Vice President and Global Head of Protein Sciences at Evotec says:

The area of single particle cryo-EM is a rapidly developing technology that is delivering a new approach to looking at previously intractable structural questions. It is an area of huge interest to the pharmaceutical industry because we are able to visualize novel atomic structures of new drug targets and, at the same time improve our understanding of challenging current targets.  The decision to expand eBIC, with a focus on industrial users, is an exciting opportunity for UK-based industry to continue to be at the forefront of structural biology in drug discovery.”

Dr Gillian Burgess, Site Head & VP, Research at Vertex Pharmaceuticals Oxford says:

We have collaborated with Diamond Light Source since its inception 10 years ago. The announced investment in cryo-electron microscopy at the Harwell Campus will transform access to this innovative technology for the Life Sciences Industry. We will be able to image large and complex proteins in a way that has previously not been possible with more traditional techniques. At Vertex we are committed to the development of new precision medicines that can treat serious diseases and we believe that cryo-electron microscopy can accelerate the discovery of such medicines.”

Source:

https://www.diamond.ac.uk/

Tagged with:

About author

Related Articles