Breaking News
January 18, 2019 - Breast cancers more likely to metastasize in young women within 10 years of giving birth
January 18, 2019 - Blood vessels can now be created perfectly in a petri dish
January 18, 2019 - Young-Onset Type 2 Diabetes Tied to Increased Hospitalization Risk
January 18, 2019 - For-profit nursing schools associated with lower performance on nurse licensure test
January 18, 2019 - Considering the culture of consent in medicine
January 18, 2019 - Researchers identify comprehensive guidelines for managing severe atopic dermatitis
January 18, 2019 - Analyzing proteins in blister fluid may classify burn severity more accurately
January 18, 2019 - Study finds higher suicide rates among youth who were Medicaid enrollees
January 18, 2019 - Opioid drugs often overprescribed to children for pain relief, say CHOP surgeons
January 18, 2019 - New biodegradable wound dressing material accelerates healing
January 18, 2019 - Life in Space May Take Toll on Spinal Muscles
January 18, 2019 - Bulldogs’ screw tails linked to human genetic disease
January 18, 2019 - Immunotherapy target identified for pediatric cancers
January 18, 2019 - Financial stress may increase heart disease risk in African Americans
January 18, 2019 - Scientists solve another piece of Ebola virus puzzle
January 18, 2019 - New project finds how endocrine disruptors interfere with thyroid functions
January 18, 2019 - Research finds decline in ketone body utilization when coronary circulation is reduced
January 18, 2019 - Let’s map our DNA and save billions each year in health costs
January 18, 2019 - AI demonstrates potential to identify irregular heart rhythms as well as humans
January 17, 2019 - Study shows link between air pollution and increased risk of sleep apnea
January 17, 2019 - Neck-strengthening exercises can protect athletes from concussions
January 17, 2019 - Computer model shows how to better control MRSA outbreaks
January 17, 2019 - Pain is unpleasant, and now scientists have identified the set of responsible neurons
January 17, 2019 - CUIMC Celebrates 2018-2019
January 17, 2019 - Study reveals potential pathway for endothelial cells to avoid apoptosis
January 17, 2019 - Hamilton Storage launches LabElite DeCapper SL to expand LabElite product family
January 17, 2019 - Location of epigenetic changes co-locate with genetic signal causing psychartric disorder
January 17, 2019 - Researchers awarded 6.1 million euros to address female fertility problems
January 17, 2019 - Counseling appointments fail to reduce weight gain during pregnancy, shows study
January 17, 2019 - Contraceptive patch that could provide 6 months of contraception within seconds
January 17, 2019 - Yeast model may pave way for development of novel therapies for metabolic disorders
January 17, 2019 - Study determines impact of antibiotic perturbation of the gut microbiome on skeletal health
January 17, 2019 - Cardiometabolic Risk Up With Tourette, Chronic Tic Disorder
January 17, 2019 - Hong Kong scientists claim ‘broad-spectrum’ antiviral breakthrough
January 17, 2019 - Researchers discover the brain cells that make pain unpleasant | News Center
January 17, 2019 - Hepatitis Is Common in New Cancer Patients
January 17, 2019 - Podcast: KHN’s ‘What The Health?’ Drug Prices Are Rising Again. Is Someone Going To Do Something About It?
January 17, 2019 - Smoking significantly increases your biological age, study shows
January 17, 2019 - B-group vitamins may be beneficial for people with first episode psychosis
January 17, 2019 - Researchers demonstrate how manganese produces parkinsonian syndrome
January 17, 2019 - Researchers suggest link between personality type and attitude towards others’ bodies
January 17, 2019 - Mutant mice administered with cocaine failed to exhibit hyperactivity, shows study
January 17, 2019 - Health Tip: Understanding a Heart Murmur
January 17, 2019 - Gut protein mutations shield against spikes in glucose
January 17, 2019 - Engineered immune cells target broad range of pediatric solid tumors in mice | News Center
January 17, 2019 - Study provides comprehensive description of associations between mental disorders
January 17, 2019 - Study finds link between high pesticide exposure and poor sense of smell among farmers
January 17, 2019 - Many cancer patients have undiagnosed hepatitis
January 17, 2019 - New study finds only 13% of outpatient antibiotic prescriptions to be appropriate
January 17, 2019 - Stem cell-based approach to diabetes offers hope for treatment
January 17, 2019 - New project receives €8.65 million from EU and Canada to ease genomic, health data sharing
January 17, 2019 - Improvements in pharmacological study to fight cognitive impairment in schizophrenia
January 17, 2019 - Study looks at trends over time in oral antibiotic prescribing by dermatologists
January 17, 2019 - Most substance use disorder treatment facilities do not offer medication treatment
January 17, 2019 - Multiple sclerosis could benefit from stem cell therapy
January 17, 2019 - Researchers manipulate T cells to improve transplant success
January 17, 2019 - Put away your rulers and reach for your phone
January 17, 2019 - Mindfulness linked with fewer menopausal symptoms
January 17, 2019 - Integrated care to women with PMADs offered at several levels
January 17, 2019 - Researchers identify MANF as a rejuvenating factor in parabiosis
January 17, 2019 - Truncal mutations study suggests new direction in origins of cancer
January 17, 2019 - Beckman Coulter launches new ClearLLab 10C System for clinical flow cytometry lab
January 17, 2019 - Effects of linoleic acid on the body are largely dependent on genes, shows study
January 17, 2019 - Pre-injury exercise reduces damage to both muscles and nerves, study finds
January 17, 2019 - Minimizing Antibody Size to Maximize Research Potential
January 17, 2019 - Research finds large genome in tiny forest defoliator
January 17, 2019 - Technology helps reduce the yearning for unhealthy food
January 17, 2019 - Imec develops prototype cardiovascular device
January 17, 2019 - New Drug Application for Insomnia Disorder Treatment Lemborexant Submitted in the United States
January 17, 2019 - What you should know about teeth whitening
January 17, 2019 - Why Older Adults Should Eat More Protein (And Not Overdo Protein Shakes)
January 17, 2019 - Colorectal cancer mortality rates predicted to increase globally
January 17, 2019 - Scientists discover mutational signatures of tumor hypoxia
January 17, 2019 - New evidence shows how fever alters immune cells
January 17, 2019 - Researchers find new class of blood pressure-regulating peptides in vampire bat venom
January 17, 2019 - Promega to exhibit new Maxwell RSC48 platform at 2019 Festival of Genomics
January 17, 2019 - Study pinpoints immune cells that could be key to tackling hypertension
January 17, 2019 - Couples Intervention May Aid Partners of Diabetes Patients
January 17, 2019 - Your weight history may predict your heart failure risk
January 17, 2019 - Explore a cornucopia of accomplishments in prematurity research

UK set to be global leader in providing large-scale industrial access to Cryo-EM for drug discovery thanks to new collaboration

image_pdfDownload PDFimage_print

An agreement to launch a new cryo-EM capability for use in the life sciences industry sector by Thermo Fisher Scientific, one of the world leaders in high-end scientific instrumentation, and Diamond Light Source, the UK’s national synchrotron and one of the most advanced scientific facilities in the world, was announced on Wednesday (12 September, 2018) at the official opening of the new national electron bio-imaging centre (eBIC) at Diamond.
This announcement confirms Diamond as one of the major global cryo-EM sites embedded with an abundance of complementary synchrotron-based techniques, and thereby, provides the life sciences sector with an offer not available anywhere else in the world.


Professor Dave Stuart, Life Sciences Director at Diamond and MRC Professor of Structural Biology at the University of Oxford, Department of Clinical Medicine, says, “Access to 21st century scientific tools to push the boundaries of scientific research is essential for both academia and industry, and what we have created here at Diamond is truly unique in the world in terms of size and scale. The new centre offers the opportunity for almost real-time physiology, capturing proteins in action at cryo-temperatures by flash-freezing them at various stages. What Diamond has created with eBIC is an integrated facility for structural biology, which will accelerate R&D for both industry and academic users. The additional advanced instruments made available by Thermo Fisher will position the UK as a global leader in providing large-scale industrial access to cryo-EM for drug discovery research. Our new collaboration provides a step change in our offer for industry users and helps ensure that R&D remains in the UK.”


The collaboration with Thermo Fisher will further expand Diamond’s cryo-EM offerings by providing two new dedicated microscopes and professional cryo-EM services designed exclusively for the pharmaceutical industry. New instruments being installed include a Thermo Scientific Glacios Cryo Transmission Electron Microscope (TEM) and a Thermo Scientific Krioswww.fei.com/krios-g3i/ Cryo-TEM at eBIC. The two organisations will provide cryo-EM guidance and expertise in sample preparation, cryo-EM sample screening, and high-end data collection to industrial researchers.


“Researchers at leading pharmaceutical companies are already using instruments from Thermo Fisher Scientific to drive impactful research that can help speed the path to understanding and treating viruses and diseases,” says Mike Shafer, President, Materials and Structural Analysis, Thermo Fisher. “The combination of the expert staff members at eBIC and Diamond, alongside these new Thermo Scientific cryo-EM instruments, ensures these researchers are on the cutting edge of discovery.”


The new microscopes will add to Diamond’s four existing high-end microscopes, which are starting operation within eBIC and will continue to support the academic demand.


Recent technology developments in cryo-EM are proving to be powerful for both basic and applied science at Diamond. This is why Diamond, with the wider community led by Birkbeck College and Oxford University, established a centre embedded within the synchrotron’s infrastructure through a strategic grant from the Wellcome Trust, Biotechnology and Biological Research Council and Medical Research Council. The centre officially opens today by Dr Richard Henderson from the Laboratory of Molecular Biology, Cambridge. Dr Henderson is one of the recipients of the 2017 Nobel Prize for Chemistry for developing the cryo-EM technique.


Dr Henderson says: “Using single particle cryo-EM, researchers can now visualise biomolecules at near atomic resolution. This technology has taken biochemistry into a new era, allowing atomic structure determinations of many protein and other macromolecular building blocks that were previously very difficult or impossible to obtain. The technique also opens up high resolution studies of macromolecules in their cellular context through the use of electron cryotomography. Coupling these techniques with the capabilities at Diamond creates a unique environment that will help keep the UK at the forefront of world-leading science.”


Structural insight into proteins, viruses and other macromolecular complexes helps pharmaceutical companies better understand disease mechanisms, more quickly assess possible drug targets, and accelerates optimisation of these drug targets. Mike Shafer adds: “It’s important for Thermo Fisher to support this effort with both equipment and staffing, allowing researchers to maximize their time spent with the instruments. We are excited Diamond will provide joint staff, expertise in swift and effective data collection and analysis, and support with sample preparation.”


Pharmaceutical company researchers will have easy access to expert knowledge and industry leading cryo-EM equipment, covering the complete workflow for single particle analysis in the first instance. Access to both a Glacios Cryo-TEM and a Krios Cryo-TEM at one location will optimise productivity and time-to-result because of the designed-in connectivity between the two instruments. Scientists will be able to first pre-screen samples on the Glacios Cryo-TEM to find the best quality samples before advancing to the higher resolution imaging on the Krios Cryo-TEM.


The infrastructure on offer at eBIC taps into the expertise of Diamond as a 24-hours per day, six days a week operational model. Typically, eBIC industry users are granted one to three day sessions depending on their requirements. The two new microscopes will have four staff providing support for year-round operation.

Early users of the facility comments include:

Dr John Barker, Senior Vice President and Global Head of Protein Sciences at Evotec says: “The area of single particle cryo-EM is a rapidly developing technology that is delivering a new approach to looking at previously intractable structural questions. It is an area of huge interest to the pharmaceutical industry because we are able to visualise novel atomic structures of new drug targets and, at the same time improve our understanding of challenging current targets. The decision to expand eBIC, with a focus on industrial users, is an exciting opportunity for UK-based industry to continue to be at the forefront of structural biology in drug discovery.”

Dr Gillian Burgess, Site Head & VP, Research at Vertex Pharmaceuticals Oxford says:
“We have collaborated with Diamond Light Source since its inception 10 years ago. The announced investment in cryo-electron microscopy at the Harwell Campus will transform access to this innovative technology for the Life Sciences Industry. We will be able to image large and complex proteins in a way that has previously not been possible with more traditional techniques. At Vertex we are committed to the development of new precision medicines that can treat serious diseases and we believe that cryo-electron microscopy can accelerate the discovery of such medicines.”

 

 

Tagged with:

About author

Related Articles