Breaking News
December 11, 2018 - Lund University researchers succeed in obtaining dendritic cells by direct reprogramming
December 11, 2018 - Breast tumors recruit bone marrow cells to boost their growth, study reveals
December 11, 2018 - Updated breast cancer screening guideline highlights importance of shared decision-making
December 11, 2018 - EHR-related stress associated with physician burnout
December 11, 2018 - AHA: 12-Year-Old Heart Defect Survivor Inspires NFL Player’s Foundation
December 11, 2018 - Breast cancer patients who take heart drug with trastuzumab have less heart damage
December 11, 2018 - Providing aid to those humans – and animals – affected by the California fires
December 11, 2018 - Even without proof, CBD is finding a niche as a cure-all
December 11, 2018 - Drawing leads to better memory than writing
December 11, 2018 - Researchers report novel findings on plant hormone
December 10, 2018 - A Tale of Two Labels
December 10, 2018 - Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model
December 10, 2018 - A 14-year-old explains what it’s like to get a new heart
December 10, 2018 - Team Players Honored with 2018 Baton Awards
December 10, 2018 - Global report highlights how the changing world is affecting children’s physical activity levels
December 10, 2018 - Genes play a role in physical activity and sleep
December 10, 2018 - DDT in Alaskan fish shown to increase risk of cancer
December 10, 2018 - Laws to curb use of cell phones have greatly reduced fatalities for motorcyclists
December 10, 2018 - Argenx Provides Detailed Data from Phase 2 Clinical Trial of Efgartigimod in Immune Thrombocytopenia and Phase 1/2 Clinical Trial of Cusatuzumab in Acute Myeloid Leukemia
December 10, 2018 - University of Maryland doctors treat first breast cancer patients with GammaPod radiotherapy
December 10, 2018 - The heartbeat seat: Demoing new well-being technologies in a car
December 10, 2018 - Leading Cancer Researcher to Direct Herbert Irving Comprehensive Cancer Center
December 10, 2018 - Study compares pain-related diagnoses in First Nations and non-First Nations children, youth
December 10, 2018 - Experts address sleep disorders following traumatic brain injury
December 10, 2018 - Scientists find answers to how cancer spreads
December 10, 2018 - Study explores why older people read more slowly
December 10, 2018 - Smart life-collar could save lives of young children
December 10, 2018 - Asbestos found in most NHS hospitals finds BBC inquiry
December 10, 2018 - Researchers use new technique to probe hydrogen bonds
December 10, 2018 - Music improves social communication in autistic children
December 10, 2018 - Some Brain Tumors May Respond to Immunotherapy, New Study Suggests
December 10, 2018 - Banning junk food ads to combat childhood obesity
December 10, 2018 - Skin Autofluorescence Predicts T2DM, Heart Disease, Mortality
December 10, 2018 - Largest autism sequencing study to date yields 102 genes associated with ASD
December 10, 2018 - Statins associated with low risk of side effects
December 10, 2018 - Episodic memory tests help in predicting brain atrophy and Alzheimer’s disease
December 10, 2018 - Study explores how schools address adolescent self-harming practices
December 10, 2018 - Pregnancy in adolescence linked to increased risks of complications in young mothers
December 10, 2018 - Risk Analysis publishes special issue on communicating about Zika virus
December 10, 2018 - Botox May Help Prevent Post-Op A-Fib
December 10, 2018 - African-American mothers rate boys higher for ADHD
December 10, 2018 - Graphic warning labels cancel out cigarettes’ appeal to young people
December 10, 2018 - Australian researchers to study gas inhalational anaesthetic and likelihood of cancer return
December 10, 2018 - Individual neurons located within the brain have implications for psychiatric diseases
December 10, 2018 - Researchers improve bariatric surgery scoring system to extend prediction time for diabetic remission
December 10, 2018 - HPV type 16 or 18 associated with cervical cancer risk in young women
December 10, 2018 - Cervical cancer risk is higher in women with positive HPV, but no cellular abnormalities
December 10, 2018 - Combo therapy not needed if low RA disease activity achieved
December 10, 2018 - Novel therapeutic targets based on biology of aging show promise for Alzheimer’s disease
December 10, 2018 - UC San Diego professor receives NCI Outstanding Investigator Award for cancer research
December 10, 2018 - Study evaluates placental mesenchymal stem cell sheets for myocardial repair and regeneration
December 10, 2018 - Blueprint Medicines Announces Updated Results from Ongoing EXPLORER Clinical Trial of Avapritinib Demonstrating Broad Clinical Activity and Significant Symptom Reductions in Patients with Systemic Mastocytosis
December 10, 2018 - Study clarifies ApoE4’s role in dementia
December 10, 2018 - Eating disorders now a top priority with Australian Government
December 10, 2018 - Neuronal activity in the brain allows prediction of risky or safe decisions
December 10, 2018 - FDA Alerts Health Care Professionals and Patients Not to Use Drug Products Intended to be Sterile from Promise Pharmacy
December 10, 2018 - Improving dementia care and treatment saves thousands of pounds in care homes
December 10, 2018 - Heroin-assisted treatment can offer benefits, reduce harms
December 10, 2018 - People covered by Michigan’s expanded Medicaid program report improvements in health, finds study
December 10, 2018 - Hazelnuts improve micronutrient levels in older adults
December 9, 2018 - History of Partner Violence Tied to Menopause Symptoms
December 9, 2018 - Clean Up Safely After a Disaster|Natural Disasters and Severe Weather
December 9, 2018 - Drug wholesalers drove fentanyl’s deadly rise, report concludes
December 9, 2018 - Deprescribing could help manage polypharmacy in older adults
December 9, 2018 - Retraction of article “Joy of cooking too much” from journal
December 9, 2018 - FDA Warns of Rare Stroke Risk With MS Drug Lemtrada (Alemtuzumab)
December 9, 2018 - Feds say heroin, fentanyl remain biggest drug threat to US
December 9, 2018 - Eliminating microglia can reverse some aspects of stress sensitization, study shows
December 9, 2018 - New genetic insight could help treat rare debilitating heart and lung condition
December 9, 2018 - MiRagen Therapeutics Announces Final Safety, Biodistribution and Clinical Efficacy Data From Phase 1 Cobomarsen Clinical Trial in Patients With Mycosis Fungoides
December 9, 2018 - Work with your doctor to weigh pros, cons of treatment options for hyperthyroidism
December 9, 2018 - CWRU researcher secures $14.6 million funding for genetic study into Alzheimer’s disease
December 9, 2018 - High intensity statin treatment and adherence could save more lives
December 9, 2018 - Surgery patients use only 1/4 of prescribed opioids, and prescription size matters
December 9, 2018 - AXT offers Phi Optics upgrade to QPI systems for inverted light microscopes
December 9, 2018 - New booklet could help improve conditions of young pupils with albinism
December 9, 2018 - Few Physicians Work in Practices That Use Telemedicine
December 9, 2018 - Older Adults and Oral Health
December 9, 2018 - Health utility values improve after septorhinoplasty
December 9, 2018 - New EU-funded project provides insight into how the brain develops
Geroscience takes center stage in Journal of the American Medical Association

Geroscience takes center stage in Journal of the American Medical Association

image_pdfDownload PDFimage_print

Geroscience–the burgeoning research field that focuses on the genetic, molecular, and cellular mechanisms that make aging a major risk factor for most chronic diseases as we age–takes center stage in the Journal of the American Medical Association (JAMA), the world’s most widely circulated medical journal.

“The fact that JAMA, long one of the most highly influential and respected voices for the medical community, invited five AFAR experts to contribute articles on different aspects of geroscience vividly illustrates how this important and potentially transformative area of research continues to gain momentum,” AFAR Executive Director Stephanie Lederman said.

Highlighting how geroscience paves the way for therapeutic interventions and extending healthspan at large, the three articles co-authored by five AFAR experts are available online, and will appear in the October 2, 2018 print edition of JAMA. They are:

  • “Aging as a Biological Target for Prevention and Therapy,” by Nir Barzilai, MD, AFAR’s Deputy Scientific Director, Ana Maria Cuervo, MD, PhD, a former AFAR grantee, and Steven Austad, PhD, AFAR’s Scientific Director. The co-authors outline the substantial progress that has been made in targeting the underlying biological processes of aging in experimental animal models, and the potential to “prevent, or at a minimum delay, the onset and progression of multiple chronic diseases and debilities that are typically observed in older adults.” They wrote: “The discovery of cellular and molecular pathways that modulate healthy aging in diverse species across great evolutionary distances offers an unprecedented opportunity for intervention.”
  • “Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies,” by AFAR President-elect and 2012 AFAR grantee James L. Kirkland, MD, PhD, who heads Mayo Clinic’s Kogood Center on Aging. The article recounts the development of senolytic drugs, which target senescent cells that secrete inflammatory substances that exacerbate major chronic diseases. The first senolytics were identified by Kirkland’s team at Mayo in 2015, and are now entering clinical trials. “If senolytics are shown to be safe and effective in humans, they could transform care of older adults and patients with multiple chronic diseases that now can only be managed and have not been amenable to disease-modifying interventions. This speculation merits intensive and rapid investigation.”
  • “From Lifespan to Healthspan,” by AFAR board member S. Jay Olshansky, PhD. The article celebrates the 30-year increase in expected lifespan achieved in the past century, while arguing that “life extension should no longer be the primary goal of medicine when applied to people over age 65.” Instead, Olshansky wrote, “the principal outcome and most important metric of success should be the extension of healthspan”–the time we live independently in good health as we age.

JAMA’s recognition of geroscience builds on momentum led by AFAR experts in collaboration with major media and research partners.

  • All five of the AFAR experts published in JAMA were among the 14 AFAR experts featured in the recent PBS documentary, Incredible Aging: Adding Life to Your Years, which examined the latest research on healthy aging. The program was hosted by 14-time Emmy Award-winning host, executive producer, and anchor Meredith Vieira.
  • This fall, on November 17, at the Annual Meeting of the Gerontological Society of America, AFAR is organizing a panel on “The TAME Trial: A Prototype for Geroscience-Guided Therapeutics.” The session will explore how the Targeting Aging with Metformin (TAME) Trial applies geroscience-based research concepts that can be translated into clinically relevant interventions.
  • In fall 2019, the National Institute on Aging will host its third geroscience summit to expand awareness and engage the research community to fully embrace new funding opportunities unlocked by addressing multiple age-related diseases at once instead of focusing on individual chronic diseases. AFAR has been a sponsoring partner in the first two geroscience summits, which focused on disease drivers of aging, and how aging drives disease, in 2013 and 2016.

“By improving our understanding of the molecular mechanisms underlying the biological processes of aging, geroscience opens the door to exciting and innovative new pathways to address the major chronic diseases that affect older adults,” AFAR Medical Officer Richard W. Besdine, MD, said. “We will need a determined effort, involving not only the medical and biological research communities, but public and private partners as well, to make the translational discoveries needed to help people live healthier, longer as they age.”

Tagged with:

About author

Related Articles