Breaking News
October 16, 2018 - Health Highlights: Oct. 12, 2018
October 16, 2018 - Study holds promise for new pediatric brain tumor treatment
October 16, 2018 - Patient advocate uses MRI scans to create art and spark conversations about life with illness
October 16, 2018 - Fish oil based diets may suppress growth and spread of breast cancer cells
October 16, 2018 - Number of VHA facilities offering acupuncture has increased rapidly
October 16, 2018 - Influential Leapfrog Group jumps in to rate 5,600 surgery centers
October 16, 2018 - HIV-infected infants more likely to acquire congenital cytomegalovirus infection
October 16, 2018 - Study pinpoints new marker that can predict Crohn’s disease subtype
October 16, 2018 - Simple procedure could be efficacious intervention for failed back surgery
October 16, 2018 - New research identifies modifiable dementia risk factor in elderly people
October 16, 2018 - Zebrafish study uncovers molecular ‘brake’ that helps control eye lens development
October 16, 2018 - Overlapping copy number variations underlie autism and schizophrenia in Japanese patients
October 16, 2018 - Majority of Americans’ ancestry can be traced through existing DNA databases
October 16, 2018 - Patients coerced into mental health care less likely to perceive treatment as effective
October 16, 2018 - Interactive robot helps older people exercise and detects underlying health problems
October 16, 2018 - What you need to know about autism spectrum disorder
October 16, 2018 - Antidepressants can be used to treat Alzheimer’s disease
October 16, 2018 - Study uncovers important role of PRMT1 in dilated cardiomyopathy
October 16, 2018 - Nutritional quality of breakfast linked to cardiovascular and metabolic risk factors in children
October 16, 2018 - Study uses novel approach to investigate genetic origins of mental illnesses
October 16, 2018 - Scientists develop dual anthrax-plague vaccine
October 16, 2018 - Poor Outcomes for Hispanic Infants With Congenital Heart Dz
October 16, 2018 - Global study finds youngest in class more likely to be diagnosed with ADHD
October 16, 2018 - Researchers sequence two selfish genes in the fungus Neurospora intermedia
October 16, 2018 - Survey results highlight the need for better communication between patients and HCPs about bacterial vaginosis
October 16, 2018 - Researchers develop fibrin-targeting immunotherapy to protect against neurodegeneration
October 16, 2018 - Researchers create open access database on healthy immunity
October 16, 2018 - Rice University chemist wins big award to study small surfaces
October 16, 2018 - Study finds 43% drop in stroke rate
October 16, 2018 - Researchers identify basic relationships of cell cycle and cellular senescence in the placenta
October 16, 2018 - UA professor receives NSF grant to develop antifouling materials for medical implants
October 16, 2018 - Obesity Doubles Odds for Colon Cancer in Younger Women
October 16, 2018 - Adults with ADHD not constrained in creativity
October 16, 2018 - Raising visibility for people and students with chronic illness and disability
October 16, 2018 - Allele awarded NIH grant to develop nanoantibody therapies for treatment of sepsis
October 16, 2018 - Only 59% of young adults undergoing surgery are fluid responsive
October 16, 2018 - Research points to potential new treatment for hearing loss
October 16, 2018 - MDI Biological Laboratory receives $1.2 million SEPA grant to promote data literacy
October 16, 2018 - Vast majority of dementia cases may arise from spontaneous genetic errors
October 16, 2018 - New project aims to deliver fast, effective treatment for autoimmune rheumatic diseases
October 16, 2018 - Study identifies molecular switch that controls fate of milk-producing breast cells
October 16, 2018 - Research shows diet has little influence on precursor to gout
October 16, 2018 - “Without Dr. Shumway doing his miracle work, three generations would not be here”: A Stanford heart transplant patient’s story
October 16, 2018 - Non-invasive brain stimulation sheds light on neurobiology underlying implicit bias
October 16, 2018 - Researchers demonstrate integrated technique to control production of cell therapeutics
October 16, 2018 - Breast tomosynthesis detects 34% more tumors than traditional mammography
October 16, 2018 - Rhode Island Hospital, Brown receive $800,000 grant to keep up fight against opioid epidemic
October 16, 2018 - UVA partners with health systems in AVIA network’s Medicaid Transformation Project
October 16, 2018 - Trevena Announces Oliceridine FDA Advisory Committee Meeting Outcome
October 16, 2018 - Study reveals early warning signs of heart problems in patients with newly diagnosed lupus
October 16, 2018 - Connecting the dots of Alzheimer’s disease
October 16, 2018 - New publication offers evidence-based content for global breast imaging medical community
October 16, 2018 - ‘EinsteinVision’ that improves hand-eye coordination of surgeons introduced at Harefield Hospital
October 16, 2018 - WRAIR clinical study evaluates safety and immunogenicity of Marburg vaccine
October 16, 2018 - Ketamine can be considered as alternative to opioids for short-term pain control in ED
October 16, 2018 - Endurance exercise training beneficially alters gut microbiota composition
October 15, 2018 - FDA Approves Yutiq (fluocinolone acetonide intravitreal implant) for Chronic Non-Infectious Posterior Segment Uveitis
October 15, 2018 - Birthing Options for Full-Term Pregnancy
October 15, 2018 - Stressed, toxic, zombie cells seen for first time in Alzheimer’s
October 15, 2018 - Concussion researchers study head motion in high school football hits | News Center
October 15, 2018 - Neuropsychiatric symptoms related to earliest stages of Alzheimer’s brain pathology
October 15, 2018 - Neck collar device may help protect the brain of female high school soccer players
October 15, 2018 - Research reveals how the inner ear processes speech
October 15, 2018 - Many parents still skeptical about safety and effectiveness of flu shot, survey finds
October 15, 2018 - Payer Policies May Discourage Non-Pharma Tx for Low Back Pain
October 15, 2018 - Exercise may delay cognitive decline in people with rare Alzheimer’s disease
October 15, 2018 - Researchers modify CRISPR to reorganize genome | News Center
October 15, 2018 - Innovative brain tumor operation set to tailor to patients’ needs
October 15, 2018 - Findings offer new insight into early changes that occur during AD pathology
October 15, 2018 - Neurons regulating reproductive hormone release have different activity in epileptic mice
October 15, 2018 - More parents are concerned about taking babies swimming in public pools
October 15, 2018 - Health Tip: Know the Risk Factors for Lower Back Pain
October 15, 2018 - Study shows cigarillo flavors enhanced by high-intensity sweeteners
October 15, 2018 - Study traces hospital-acquired bloodstream infections to patients’ own bodies | News Center
October 15, 2018 - Abnormal vision in childhood can affect development of brain areas responsible for attention
October 15, 2018 - Study highlights need for increased support for alcohol-related liver disease patients
October 15, 2018 - Color-changing contact lens could help doctors to monitor eye disease medications
October 15, 2018 - Tobacco heating products cause less staining to teeth than conventional cigarettes
October 15, 2018 - Young adults who are obese can expect to lose up to 10 years in life expectancy
October 15, 2018 - Scientists uncover how proteins meet on the cell membrane
Geroscience takes center stage in Journal of the American Medical Association

Geroscience takes center stage in Journal of the American Medical Association

image_pdfDownload PDFimage_print

Geroscience–the burgeoning research field that focuses on the genetic, molecular, and cellular mechanisms that make aging a major risk factor for most chronic diseases as we age–takes center stage in the Journal of the American Medical Association (JAMA), the world’s most widely circulated medical journal.

“The fact that JAMA, long one of the most highly influential and respected voices for the medical community, invited five AFAR experts to contribute articles on different aspects of geroscience vividly illustrates how this important and potentially transformative area of research continues to gain momentum,” AFAR Executive Director Stephanie Lederman said.

Highlighting how geroscience paves the way for therapeutic interventions and extending healthspan at large, the three articles co-authored by five AFAR experts are available online, and will appear in the October 2, 2018 print edition of JAMA. They are:

  • “Aging as a Biological Target for Prevention and Therapy,” by Nir Barzilai, MD, AFAR’s Deputy Scientific Director, Ana Maria Cuervo, MD, PhD, a former AFAR grantee, and Steven Austad, PhD, AFAR’s Scientific Director. The co-authors outline the substantial progress that has been made in targeting the underlying biological processes of aging in experimental animal models, and the potential to “prevent, or at a minimum delay, the onset and progression of multiple chronic diseases and debilities that are typically observed in older adults.” They wrote: “The discovery of cellular and molecular pathways that modulate healthy aging in diverse species across great evolutionary distances offers an unprecedented opportunity for intervention.”
  • “Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies,” by AFAR President-elect and 2012 AFAR grantee James L. Kirkland, MD, PhD, who heads Mayo Clinic’s Kogood Center on Aging. The article recounts the development of senolytic drugs, which target senescent cells that secrete inflammatory substances that exacerbate major chronic diseases. The first senolytics were identified by Kirkland’s team at Mayo in 2015, and are now entering clinical trials. “If senolytics are shown to be safe and effective in humans, they could transform care of older adults and patients with multiple chronic diseases that now can only be managed and have not been amenable to disease-modifying interventions. This speculation merits intensive and rapid investigation.”
  • “From Lifespan to Healthspan,” by AFAR board member S. Jay Olshansky, PhD. The article celebrates the 30-year increase in expected lifespan achieved in the past century, while arguing that “life extension should no longer be the primary goal of medicine when applied to people over age 65.” Instead, Olshansky wrote, “the principal outcome and most important metric of success should be the extension of healthspan”–the time we live independently in good health as we age.

JAMA’s recognition of geroscience builds on momentum led by AFAR experts in collaboration with major media and research partners.

  • All five of the AFAR experts published in JAMA were among the 14 AFAR experts featured in the recent PBS documentary, Incredible Aging: Adding Life to Your Years, which examined the latest research on healthy aging. The program was hosted by 14-time Emmy Award-winning host, executive producer, and anchor Meredith Vieira.
  • This fall, on November 17, at the Annual Meeting of the Gerontological Society of America, AFAR is organizing a panel on “The TAME Trial: A Prototype for Geroscience-Guided Therapeutics.” The session will explore how the Targeting Aging with Metformin (TAME) Trial applies geroscience-based research concepts that can be translated into clinically relevant interventions.
  • In fall 2019, the National Institute on Aging will host its third geroscience summit to expand awareness and engage the research community to fully embrace new funding opportunities unlocked by addressing multiple age-related diseases at once instead of focusing on individual chronic diseases. AFAR has been a sponsoring partner in the first two geroscience summits, which focused on disease drivers of aging, and how aging drives disease, in 2013 and 2016.

“By improving our understanding of the molecular mechanisms underlying the biological processes of aging, geroscience opens the door to exciting and innovative new pathways to address the major chronic diseases that affect older adults,” AFAR Medical Officer Richard W. Besdine, MD, said. “We will need a determined effort, involving not only the medical and biological research communities, but public and private partners as well, to make the translational discoveries needed to help people live healthier, longer as they age.”

Tagged with:

About author

Related Articles