Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Geroscience takes center stage in Journal of the American Medical Association

Geroscience takes center stage in Journal of the American Medical Association

Geroscience–the burgeoning research field that focuses on the genetic, molecular, and cellular mechanisms that make aging a major risk factor for most chronic diseases as we age–takes center stage in the Journal of the American Medical Association (JAMA), the world’s most widely circulated medical journal.

“The fact that JAMA, long one of the most highly influential and respected voices for the medical community, invited five AFAR experts to contribute articles on different aspects of geroscience vividly illustrates how this important and potentially transformative area of research continues to gain momentum,” AFAR Executive Director Stephanie Lederman said.

Highlighting how geroscience paves the way for therapeutic interventions and extending healthspan at large, the three articles co-authored by five AFAR experts are available online, and will appear in the October 2, 2018 print edition of JAMA. They are:

  • “Aging as a Biological Target for Prevention and Therapy,” by Nir Barzilai, MD, AFAR’s Deputy Scientific Director, Ana Maria Cuervo, MD, PhD, a former AFAR grantee, and Steven Austad, PhD, AFAR’s Scientific Director. The co-authors outline the substantial progress that has been made in targeting the underlying biological processes of aging in experimental animal models, and the potential to “prevent, or at a minimum delay, the onset and progression of multiple chronic diseases and debilities that are typically observed in older adults.” They wrote: “The discovery of cellular and molecular pathways that modulate healthy aging in diverse species across great evolutionary distances offers an unprecedented opportunity for intervention.”
  • “Aging, Cell Senescence, and Chronic Disease: Emerging Therapeutic Strategies,” by AFAR President-elect and 2012 AFAR grantee James L. Kirkland, MD, PhD, who heads Mayo Clinic’s Kogood Center on Aging. The article recounts the development of senolytic drugs, which target senescent cells that secrete inflammatory substances that exacerbate major chronic diseases. The first senolytics were identified by Kirkland’s team at Mayo in 2015, and are now entering clinical trials. “If senolytics are shown to be safe and effective in humans, they could transform care of older adults and patients with multiple chronic diseases that now can only be managed and have not been amenable to disease-modifying interventions. This speculation merits intensive and rapid investigation.”
  • “From Lifespan to Healthspan,” by AFAR board member S. Jay Olshansky, PhD. The article celebrates the 30-year increase in expected lifespan achieved in the past century, while arguing that “life extension should no longer be the primary goal of medicine when applied to people over age 65.” Instead, Olshansky wrote, “the principal outcome and most important metric of success should be the extension of healthspan”–the time we live independently in good health as we age.

JAMA’s recognition of geroscience builds on momentum led by AFAR experts in collaboration with major media and research partners.

  • All five of the AFAR experts published in JAMA were among the 14 AFAR experts featured in the recent PBS documentary, Incredible Aging: Adding Life to Your Years, which examined the latest research on healthy aging. The program was hosted by 14-time Emmy Award-winning host, executive producer, and anchor Meredith Vieira.
  • This fall, on November 17, at the Annual Meeting of the Gerontological Society of America, AFAR is organizing a panel on “The TAME Trial: A Prototype for Geroscience-Guided Therapeutics.” The session will explore how the Targeting Aging with Metformin (TAME) Trial applies geroscience-based research concepts that can be translated into clinically relevant interventions.
  • In fall 2019, the National Institute on Aging will host its third geroscience summit to expand awareness and engage the research community to fully embrace new funding opportunities unlocked by addressing multiple age-related diseases at once instead of focusing on individual chronic diseases. AFAR has been a sponsoring partner in the first two geroscience summits, which focused on disease drivers of aging, and how aging drives disease, in 2013 and 2016.

“By improving our understanding of the molecular mechanisms underlying the biological processes of aging, geroscience opens the door to exciting and innovative new pathways to address the major chronic diseases that affect older adults,” AFAR Medical Officer Richard W. Besdine, MD, said. “We will need a determined effort, involving not only the medical and biological research communities, but public and private partners as well, to make the translational discoveries needed to help people live healthier, longer as they age.”

Tagged with:

About author

Related Articles