Breaking News
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
October 19, 2018 - Better assessments for early age-related macular degeneration
October 19, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum | News Center
October 19, 2018 - Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics
October 19, 2018 - Beckman Coulter Life Sciences announces new research-focused website
October 19, 2018 - Study finds link between refined soluble fibers, gut microbiota and liver cancer
October 19, 2018 - Social media reduces risk of depression among seniors with pain
October 19, 2018 - Newly developed synthetic DNA molecule may one day be used as ‘vaccine’ for prostate cancer
October 19, 2018 - Preoperative weight loss may not provide health benefits after surgery
October 19, 2018 - U.S. Birth Rates Continue to Drop as Age of New Moms Rises
October 19, 2018 - New technology can keep an eye on babies’ movements in the womb
October 19, 2018 - Juul e-cigarettes pose addiction risk for young users | News Center
October 19, 2018 - Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei
October 19, 2018 - New DNA vaccine strategy protects mice against lethal challenge by multiple H3N2 viruses
October 19, 2018 - Study shows close link between cytokine interleukin-1ß and obesity-promoted colon cancer
October 19, 2018 - Muscle mass plays a critical role in health, shows research
October 19, 2018 - Study finds undiagnosed prediabetes in many infertile men
October 19, 2018 - The Current issue of “The view from here” is concerned with Nanotherapeutic strategies
October 19, 2018 - Delay in replacing the Pap smear with HPV screening is costing lives
October 19, 2018 - Physicians battle pediatric diseases of ear, nose, throat in Zimbabwe | News Center
October 19, 2018 - Researchers investigate why some cancers affect only young women
October 19, 2018 - Drugmakers funnel millions to lawmakers; a few dozen get $100,000-plus
October 19, 2018 - Unselfish people tend to have more children and receive higher salaries
October 19, 2018 - New findings reveal potential cellular players in tumor microenvironment
October 19, 2018 - Study reveals impact of Juul use on teenagers and young adults
October 19, 2018 - Green leafy vegetables could help reduce macular degeneration risk
October 19, 2018 - Some countries take more time for reimbursement decisions on new cancer drugs
October 19, 2018 - Human brain cell transplant offers insights into neurological conditions
October 19, 2018 - Parental education associated with increased family health care spending
October 19, 2018 - New statistical method estimates long- and short-term risk of recurrence of breast cancer in US women
October 19, 2018 - Father’s exposure to nicotine may cause cognitive deficits in descendants
October 19, 2018 - Could we prevent Alzheimer’s disease by treating herpes?
October 19, 2018 - Nurse-led care can be more successful in managing gout
October 19, 2018 - Trump administration, pharma exchange verbal volleys on drug-price transparency
October 19, 2018 - Duke researchers find way to detect blood doping in athletes
Zika virus could become a weapon against brain cancer

Zika virus could become a weapon against brain cancer

image_pdfDownload PDFimage_print

Zika virus infection is a dreaded one that can lead to severe brain damage in the unborn babies of mothers who get it.

In a new research now, scientists from the University of Texas Medical Branch in collaboration with others have found that a modified version of the Zika virus could kill some of the stem cells that let the brain tumour cells live. This was proved to be true in mice and human trials are on the cards say the researchers.

Zika virus is spread by infected mosquito bites and has been causing mental retardation microcephaly (small brain), blindness and other deformities among babies since the 1940s when it was first discovered. It was predominantly seen in Asia, Africa and parts of South and Central America. The last outbreak of this viral flu like illness was noted in 2015 in the Americas. While adults came down with the mild flu like illness, the virus spelled danger to pregnant women, damaging the unborn babies.

Zika virus, a virus which causes Zika fever. Image Credit: Kateryna Kon / Shutterstock

Zika virus, a virus which causes Zika fever. Image Credit: Kateryna Kon / Shutterstock

This new study was led by geneticist Pei-Yong Shi of the University of Texas Medical Branch. This team was looking at Zika virus and its genetically similar cousins to understand the effects of the virus on the brains of unborn babies. They noted that despite being similar to the West Nile virus, Zika infected only a specific fetal brain cell called the neural progenitor cell. This hampers the normal growth of the neurons in the brain and alters the brain development of the baby.

This unique property of Zika virus to target the neuro progenitor cells only was a finding wherein researchers wondered if this could help patients with glioblastoma multiforme (GBM). GBM is a form of incurable brain cancer that has less than 5 percent survival among those affected. These tumours are typically resistant to chemotherapy and radiation and tend to return even after they are eradicated. Researchers noted that this tenacity of the tumours to keep returning is dependent on a special type of stem cell that produces the brain cells called the glioma cells. These glioma cells are similar to the neural progenitor cells that the Zika virus prefers. Shi and his team thus hypothesized that the Zika virus could be modified to kill the glioma cells and thus stop the cancer from returning.

The team then started to work with weakened versions of the Zika virus to see if it could affect the cancer and kill the GBM form of brain tumours in the mice. In other words they developed a vaccine strain of the Zika virus which is much weakened. The mice they tested upon had weakened immune system and the vaccine strain of the Zika virus did not cause any harm. In some of the mice, the GBM was grafted. The vaccine Zika strain seemed to kill of these GBM tumours. As obvious, says Shi, this is the first step and much more work is necessary before the virus strain can be used in patients with GBM. “Nothing is guaranteed, but so far the data is very promising, and we would like to move step-by-step to moving into clinics as soon as possible,” he said.

The results of the study were published in the latest issue of the journal mBio.

Source:

https://mbio.asm.org/content/9/5/e01683-18

Posted in: Medical Research News | Medical Condition News

Tags: Baby, Blindness, Brain, Brain Cancer, Brain Cell, Cancer, Cell, Chemotherapy, Fever, Flu, Glioblastoma, Glioblastoma Multiforme, Glioma, Immune System, Mental Retardation, microcephaly, Mosquito, Neurons, Research, Stem Cell, Vaccine, Virus, West Nile Virus, Zika Virus

Tagged with:

About author

Related Articles