Breaking News
October 19, 2018 - Nutrition has bigger positive impact on bone mass and strength than exercise
October 19, 2018 - Study finds lack of progress in media representation of nurses over last 20 years
October 19, 2018 - Many people have trouble understanding differences between OCD and OCPD
October 19, 2018 - New family planning app found to be as effective as modern methods
October 19, 2018 - Gastric Banding, Metformin Similar for Improving Glycemia
October 19, 2018 - Physiologist publishes findings on the role of the protein titin in muscle contraction
October 19, 2018 - What digital health companies need to do to succeed
October 19, 2018 - N. Carolina Sees Alarming Spike in Heart Infections Among Opioid Users
October 19, 2018 - Video monitoring of TB therapy works well in urban and rural areas
October 19, 2018 - Determining acid-neutralizing capacity for OTC antacids
October 19, 2018 - Males who spend more time taking care of kids have greater reproductive success
October 18, 2018 - Study to explore bioethics of brain organoids
October 18, 2018 - Environmental conditions may drive development of multiple sclerosis
October 18, 2018 - Genetically modifying zebrafish provides more accurate disease models
October 18, 2018 - Purdue Pharma, Eisai announce positive topline results from Phase 3 study of lemborexant
October 18, 2018 - 5 Strength-Training Mistakes to Avoid
October 18, 2018 - Immune system’s balancing act keeps bowel disease in check
October 18, 2018 - Anti-inflammatory drug effective for treating lymphedema symptoms | News Center
October 18, 2018 - Keeping Your Voice Young
October 18, 2018 - One-time universal screening recommended to tackle increase in hepatitis C
October 18, 2018 - Researchers to develop new stem cell-based strategies for treating vision disorders
October 18, 2018 - Detecting epigenetic signature may help people stay ahead of inflammatory bowel disease
October 18, 2018 - Understanding AFib: Slowing down the dancing heart
October 18, 2018 - Using NMR to Reduce Fraud
October 18, 2018 - New automated model identifies dense breast tissue in mammograms
October 18, 2018 - Mysterious polio-like illness baffles medical experts while frightening parents
October 18, 2018 - Cases of Acute Flaccid Myelitis on the rise across U.S.
October 18, 2018 - Dietary fiber reduces brain inflammation during aging
October 18, 2018 - New tool could help prioritize recovery efforts for the poorest hit by natural disasters
October 18, 2018 - Hundreds of dietary supplements shown to contain unapproved drugs
October 18, 2018 - Active Pharmaceuticals ID’d in >700 Dietary Supplements
October 18, 2018 - Cell death protein also damps inflammation
October 18, 2018 - AI pathology diagnostic tool developed using deep learning technology from Olympus
October 18, 2018 - Health Highlights: Oct. 15, 2018
October 18, 2018 - Largest study of ‘post-treatment controllers’ reveals clues about HIV remission
October 18, 2018 - Bad Blood in Silicon Valley: A conversation with John Carreyrou
October 18, 2018 - ANTRUK’s Annual Lecture sends out message on shortage of funds for antibiotic research
October 18, 2018 - NAM special publication outlines steps to ensure interoperability of health care systems
October 18, 2018 - Novel method uses just a drop of blood to monitor effect of lung cancer therapy
October 18, 2018 - New blood test could spare cancer patients from unnecessary chemotherapy
October 18, 2018 - Training young researchers to work with data volumes arising in the health sector
October 18, 2018 - New Metrohm IC method is reliable and convenient to use for zinc oxide assay
October 18, 2018 - Global AIDS, TB fight needs more money: health fund
October 18, 2018 - Understanding the forces that cause sports concussions
October 18, 2018 - Research points to new target for treating periodontitis
October 18, 2018 - New tool improves assessment of postpartum depression symptoms
October 18, 2018 - From Biopsy to Diagnosis
October 18, 2018 - Sexual harassment and assault linked to worse physical/mental health among midlife women
October 18, 2018 - Stumped by medical school? A Q&A with a learning specialist
October 18, 2018 - Report predicts life expectancy in 2040, Spain comes out on top
October 18, 2018 - Self-lubricating condoms may help raise condom usage
October 18, 2018 - Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation
October 18, 2018 - Study finds changes in antiepileptic drug metabolism during different trimesters of pregnancy
October 18, 2018 - Autonomic nervous system directly controls stem cell proliferation, study shows
October 18, 2018 - FDA Approves Talzenna (talazoparib) for gBRCAm HER2-Negative Locally Advanced or Metastatic Breast Cancer
October 18, 2018 - Sleeping Beauty technique helps identify genes responsible for NAFLD-associated liver cancer
October 18, 2018 - Many U.S. adults confused about primary care, study shows
October 18, 2018 - UC researcher focuses on light-mediated therapies to target breast cancer
October 18, 2018 - With philanthropic gifts, Stanford poised to make major advances in neurosciences | News Center
October 18, 2018 - Mice study shows antibiotics are not always necessary to cure sepsis
October 18, 2018 - Researchers discover why heart contractions are weaker in individuals with HCM
October 18, 2018 - Participation in organized sport during childhood may have long-term skeletal benefits
October 18, 2018 - Probiotic/antibiotic combination could eradicate drug-resistant bacteria
October 17, 2018 - More Socioeconomic Challenges for Hispanic Women With HIV
October 17, 2018 - 49,XXXXY syndrome – Genetics Home Reference
October 17, 2018 - Scientists uncover possible new causes of Tourette syndrome
October 17, 2018 - Girl undergoes unusual heart surgery after compassionate-use exemption | News Center
October 17, 2018 - Health Issues That Are Sometimes Mistaken for Gluten Sensitivity
October 17, 2018 - Elective induction of labor at 39 weeks may be beneficial option for women and their babies
October 17, 2018 - New smart watch algorithms can accurately monitor wearers’ sleep patterns
October 17, 2018 - Researchers demonstrate epigenetic memory transmission via sperm
October 17, 2018 - FDA, DHS announce memorandum of agreement to address cybersecurity in medical devices
October 17, 2018 - Health Tip: Know the Risks of Chicken Pox
October 17, 2018 - Immunotherapy effective against hereditary melanoma
October 17, 2018 - Researchers reveal new mechanism for how animal cells stay intact | News Center
October 17, 2018 - Alzheimer's Goes Under the Cryo-Electron Microscope
October 17, 2018 - Medicare for all? CMS chief warns program has enough problems already
October 17, 2018 - Metrohm Raman introduces Mira P handheld Raman system
October 17, 2018 - Expanding the knowledge about hippocampus to better understand cognitive deficits in MS
October 17, 2018 - Study of Nigerian breast cancer patients reveals prevalence of aggressive molecular features
Innovation Fund Denmark supports research project that aims to fight Clostridium difficile diarrhea

Innovation Fund Denmark supports research project that aims to fight Clostridium difficile diarrhea

image_pdfDownload PDFimage_print

One man’s trash is another man’s treasure, as the saying goes. If things go to plan, feces from registered and thoroughly tested healthy donors will in a few years be the standard treatment for the bacterium Clostridium difficile at Danish hospitals. This is the goal of a research project that is being backed by the Innovation Fund Denmark to the tune of DKK 17 million – USD 2,7 million – in the period 2019-2023.

Medical doctors and researchers have long known that fecal microbiota transplantation (FMT) – as the treatment is called – is so effective against the stubborn bacterium Clostridium difficile that nine out of ten patients are cured by only a single treatment. In essence, the treatment involves transferring feces from a healthy donor to the intestine of a patient. By comparison, only about one third of patients become healthy using antibiotics, and several centres therefore offer FMT as a trial treatment.

However, the problem is that the handling of feces and the use of feces as a treatment places high demands on safety, selection and screening of the feces donors and on pa-tient follow-up. This is where the new research project intends to make a big differ-ence, explains Christian Lodberg Hvas, who is a consultant at Aarhus University Hospital and a clinical associate professor at the Department of Clinical Medicine at Aarhus University. He has been involved in establishing the treatment in Aarhus since 2014 and is one of the researchers who will now administer the investment – among other things, with the establishment of a socalled feces bank and the screening of future fe-ces donors.

“The challenge is systemizing everything so that the treatment can be offered to everyone with Clostridium infection and doing this with the highest possible level of safety and effect. This will be one of the main tasks of the upcoming research project,” says Christian Lodberg Hvas.

“The effect is really quite dramatic. Clostridium difficile typically affects patients who are already weakened or ill for other reasons. Whereas these patients previously could go through one antibiotic treatment after the other over and over again and experience long periods of diarrhoea and general weakness, with a single treatment we can now prevent the bacteria returning, after which the patient becomes healthy again. At the same time, the number of hospitalisation days also falls significantly, which benefits the patients, hospitals and the economy in general,” he says.

Organisationally, the investment by the Innovation Fund Denmark is made to CEFTA (The Centre for Feces Transplantation) at Aarhus University Hospital, which is headed by Christian Lodberg Hvas, and which has treated 200 critically ill patients with FMT since 2014. The coming development, quality assurance and organisation placement in clinical practice will take place in a collaboration between the Department of Hepatolo-gy and Gastroenterology at Aarhus University Hospital, the Blood Bank at Aarhus University Hospital, the Department of Business and Management at Aalborg University and the National Food Institute at the Technical University of Denmark.

“The idea is to use the many years of experience from the blood bank to standardise the selection and screening of feces donors and in this way develop a feces bank that is just as safe as a blood bank. At the same time, the project will contribute to the development of freeze-dried donor feces in the form of capsules that will supplement what we typically do today, which is to provide FMT through an endoscope or probe inserted in the intestines,” explains Christian Lodberg Hvas.

“But having said this, our most important product is the scientific publications. It’s more a case of ensuring an effective treatment at Danish hospitals than about making money. The research project will help us on a general level, and we are grateful to the Innovation Fund Denmark for making a contribution to this,” says Christian Lodberg Hvas.

More about Clostridium difficile:

  • Clostridium difficile is an extremely stubborn bacterium that is able to survive even in sterile hospital environments because it makes spores that can withstand both drying and alcohol.
  • In a weakened patient, Clostridium difficile damages the intestine and causes a se-vere diarrhoea condition that can be life-threatening.
  • For one in four patients, the infection returns even after treatment with antibiotics. If the bacterium returns, it is almost impossible to get rid of, and mortality increases.
  • Clostridium difficile is today regarded as one of the most dangerous bacteria for humans.
Tagged with:

About author

Related Articles