Breaking News
December 19, 2018 - Researchers uncover genes that play a key role in the inactivation of X chromosomes
December 19, 2018 - The case for the federal minister of health to recall them
December 19, 2018 - Regular theatre and cinema visits keeps depression away in seniors finds study
December 19, 2018 - Personalization techniques give a new lease of life to anticancer vaccines
December 19, 2018 - Research opens door to development of drug or vaccine for late-onset Alzheimer’s
December 19, 2018 - Single workout can boost metabolism for days
December 19, 2018 - UI study leads to better understanding of signaling capacity between neurons
December 19, 2018 - Gut microbiome plays role in immune system regulation, study finds
December 19, 2018 - How MAPK translocation leads to drug resistance in melanoma
December 19, 2018 - Increasing prevalence of antibiotic resistance in the U.S. linked with occasional use
December 19, 2018 - Mind-body exercises may improve cognition in older adults
December 19, 2018 - Hepatitis C drug can eliminate chikungunya, yellow fever virus
December 19, 2018 - Separating male and female mice changes the way they smell, shows study
December 19, 2018 - FDA Approves Genentech’s Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of Metastatic Non-Squamous Non-Small Cell Lung Cancer
December 19, 2018 - Mediterranean Diet for Osteoarthritis | About OA
December 19, 2018 - Successful bladder repair using silk fibroid scaffolds
December 19, 2018 - Quidel receives CE mark to use Sofia 2 Lyme+ Fluorescent Immunoassay with Sofia 2 analyzer
December 19, 2018 - Horizon Discovery partners with C4XD to validate novel synthetic lethal oncology targets
December 19, 2018 - Research suggests a promising therapeutic target to treat or prevent metabolic disorders
December 19, 2018 - Split liver transplants could save children on wait list finds study
December 19, 2018 - Michigan-based food manufacturer ordered to discontinue operations after recurrent food safety violations
December 19, 2018 - HPV discovery could lead to new treatments for cervical cancer
December 19, 2018 - Real-time neurofeedback controls Parkinson’s brainwaves
December 19, 2018 - Incorrect prescribing warnings in electronic prescribing systems
December 19, 2018 - New $1.6 million NIH grant supports study on a gene vital to circadian rhythms
December 19, 2018 - Racial Disparities Seen Among Teens Undergoing Flu Vaccination
December 19, 2018 - To resolve inflammation, location matters
December 19, 2018 - Dancing could help older women to perform their daily tasks
December 19, 2018 - Research identifies new therapeutic target for cancer treatment and tissue regeneration
December 19, 2018 - Energy costs, social isolation contribute to health risk of older adults in extreme weather
December 19, 2018 - Potential combination therapy against rare disease of the bone marrow could improve treatment
December 19, 2018 - Researchers aim to improve cognition, reverse weight gain in schizophrenia
December 19, 2018 - UC San Diego Health offers new DRG stimulation device for phantom limb pain
December 19, 2018 - Study examines relationship between growth restriction and risk of childhood mortality
December 19, 2018 - New study provides insights on increased risk of suicide in young patients visiting ED
December 19, 2018 - AHA: Thyroid Problems Linked to Worsening Heart Failure
December 19, 2018 - World-first coeliac disease vaccine enters Phase 2 trials
December 19, 2018 - RNA sequencing offers novel insights into the microbiome
December 19, 2018 - A promising, effective vaccine for common respiratory disease
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - ‘Little Foot’ endocast reveals a small brain combining ape-like and human-like features
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
Fibre can strengthen the intestinal barrier

Fibre can strengthen the intestinal barrier

image_pdfDownload PDFimage_print
Credit: CC0 Public Domain

Similar to patients with Crohn’s disease, elderly people with stomach problems have a intestinal barrier that is not functioning optimally. However, fibre can strengthen the intestinal barrier and thus, counteract gastrointestinal problems. This is shown in John-Peter Ganda Mall’s thesis in biomedicine at Örebro University.

The function of the intestinal barrier can be compared to a filter. It protects against harmful substances and bacteria, while also absorbing nutrients from the diet.

“A large proportion of the elderly suffer from stomach problems such as constipation and diarrhoea, the underlying mechanisms of which are not fully understood. Our findings show that elderly people with stomach problems have an increased permeability in the intestine and, consequently, a deteriorating barrier function,” says John-Peter Ganda Mall.

Fibre has positive effects on the intestinal barrier

In a substudy, John-Peter Ganda Mall has studied large intestine biopsies in people over 65 with stomach problems and compared these with biopsies taken from healthy control subjects. A variety of fibre was added together with a chemical agent aimed at increasing intestinal permeability.

“We could see that the fibres being studied had a protective effect in the biopsies. In some cases, permeability decreased by 50 per cent, and in some cases, the fibre completely offset the effect of the chemical on the barrier’s permeability,” explains John-Peter Ganda Mall.

Findings also show that the effect of different fibre varies in different age groups.

“We saw, for example, that a fibre from a yeast fungus had positive effects in the elderly, but not in the younger control group. On the other hand, a wheat fiber proved to bemore effective in the young population and marginally effective in the elderly.”

More clinical studies

John-Peter Ganda Mall has also followed some fifty elderly persons with stomach problems who supplemented their diet with two different types of fibre for six weeks. He then examined how the fibre affected the barrier function in the intestine. However, in this clinical study, there was no protective effect of fibre, as the one found in the lab environment.

“This may suggest that fibre in itself has a direct effect on the intestine in the lab environment, but perhaps needs to be taken in higher doses or for a longer period to have an effect in the body. More research is needed,”he explains.

At the moment, John-Peter Ganda Mall is working on analysing the results of a clinical study in which he studied the gastrointestinal barrier in the elderly with stomach problems. They consumed fibre from a yeast fungus– the same fibre that in his previous studies was shown to have positive effects in both the elderly with stomach problems and patients with Crohn’s disease, but in the lab environment.

“Older people generally consume less fibre than recommended and our results can be the basis for future dietary advice that could strengthen the health in the elderly and save healthcare costs.”


Explore further:
Gut reaction: Smart pill smells out the body’s fiber factor

More information:
Non-digestible Polysaccharides and Intestinal Barrier Function: specific focus on its efficacy in elderly and patients with Crohn’s disease. www.diva-portal.org/smash/reco … fRows=50&dswid=-1565

Provided by:
Örebro Universitet

Tagged with:

About author

Related Articles