Breaking News
February 22, 2019 - Lower Self-Perception Observed in Children With Amblyopia
February 22, 2019 - Up to 15 percent of children have sleep apnea, yet 90 percent go undiagnosed
February 22, 2019 - Rare pulmonary defect prompts parents’ nationwide search for answers | News Center
February 22, 2019 - Lesbian and bisexual women at greater risk of being overweight, study finds
February 22, 2019 - UQ research may explain why vitamin D is essential for brain health
February 22, 2019 - Heart Attacks Rising Among Younger Women
February 22, 2019 - How your smartphone is affecting your relationship
February 22, 2019 - Orthopaedic surgeon receives prestigious award, $10 million grant | News Center
February 22, 2019 - New sepsis test could save thousands of lives
February 22, 2019 - Cervical cancer could be eradicated by 2100
February 21, 2019 - Sustained smoking cessation can lower risk of seropositive RA
February 21, 2019 - Thousands with chronic UTIs are not receiving the treatment they need
February 21, 2019 - Are teens getting high on social media? The surprising study seeking the pot-Instagram link
February 21, 2019 - Stanford expands biobank services | News Center
February 21, 2019 - Scientists identify link between drinking contexts and early onset intoxication among adolescents
February 21, 2019 - Strong social support may reduce cardiovascular disease risk in postmenopausal women
February 21, 2019 - Rapid expansion of interventions could prevent up to 13 million cases of cervical cancer within 50 years
February 21, 2019 - Motif Bio Receives Complete Response Letter From The FDA
February 21, 2019 - Researchers map previously unknown disease in children
February 21, 2019 - A skeptical look at popular diets: Going gluten-free
February 21, 2019 - Podcast: KHN’s ‘What The Health?’ How Safe Are Your Supplements?
February 21, 2019 - Factors associated with increased risk of developing surgical site infections
February 21, 2019 - Anticipatory signals in eye movements can help measure attentive capacity, learning with greater precision
February 21, 2019 - Study explores daily exposure to indoor air pollutants
February 21, 2019 - Evening exercise does not negatively affect sleep, may also reduce hunger
February 21, 2019 - Artificial intelligence technique can be used to identify alcohol misuse in trauma setting
February 21, 2019 - Overweight, obesity in adolescence associated with increased risk of renal cancer later in life
February 21, 2019 - BGU develops new AI platform for monitoring and predicting ALS progression
February 21, 2019 - Researchers discover a new promising target to improve HIV vaccines
February 21, 2019 - Brief Anesthesia in Infancy Does Not Mar Neurodevelopment
February 21, 2019 - Gaming system helps with autism diagnosis
February 21, 2019 - Heart Disease: Six Things Women Should Know
February 21, 2019 - More States Say Doctors Must Offer Overdose Reversal Drug Along With Opioids
February 21, 2019 - Researchers explore case studies focused on industries that kill more people than employed
February 21, 2019 - Only half of GP practice buildings are fit for purpose
February 21, 2019 - Intense exercise, fasting and hormones can enhance waste-protein removal, study shows
February 21, 2019 - Scientists can monitor brain activity to predict epileptic seizures few minutes in advance
February 21, 2019 - Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats
February 21, 2019 - ‘Apple-Shaped’ Body? ‘Pear-Shaped’? Your Genes May Tell
February 21, 2019 - Can we repair the brain? The promise of stem cell technologies for treating Parkinson’s disease
February 21, 2019 - Trump Plan To Beat HIV Hits Rough Road In Rural America
February 21, 2019 - PENTAX Medical introduces new electrosurgical and argon plasma coagulation platforms
February 21, 2019 - Trump plan to beat HIV hits rough road in rural America
February 21, 2019 - Eating blueberries every day could help decrease blood pressure
February 21, 2019 - ‘No Second Chances’ report calls for new measures to combat cardiovascular disease in Australia
February 21, 2019 - Mayo clinic researchers discuss local case studies of leprosy
February 21, 2019 - Scientists demonstrate key role of salt in allergic immune reactions
February 21, 2019 - Experts propose revising the criteria for diagnosis of Parkinson’s disease
February 21, 2019 - The med student and the machine
February 21, 2019 - Hey, Hey! Ho, Ho! Is Striking For School Nurses The Way To Go?
February 21, 2019 - Latest research encourages children to move out and learn through physical activity
February 21, 2019 - Proper oral hygiene and regular visits to dentist can promote heart health
February 21, 2019 - New, versatile technique for remote control of transplanted cells in Parkinson’s
February 21, 2019 - Why melanoma tumors in the brain may be worse?
February 21, 2019 - New project aims to improve lung disease care in Appalachia
February 21, 2019 - Drug increases melanin production in some people with albinism
February 21, 2019 - Over 1 in 3 adults miss the mark on protein, finds study
February 21, 2019 - CymaBay Therapeutics Announces Seladelpar Granted Breakthrough Therapy Designation by the FDA for the Treatment of Primary Biliary Cholangitis
February 21, 2019 - A correlation between obesity and income has only developed in the past 30 years
February 21, 2019 - Baby, then work: An effort to help resident-parents in emergency medicine
February 21, 2019 - Heavy cigarette smoking could damage vision, say researchers
February 21, 2019 - Some drug combinations may be more effective than others for schizophrenic patients
February 21, 2019 - Combination of common antibiotics can eliminate multi-drug resistant E. coli
February 21, 2019 - Number of calls to U.S. Poison Control regarding kratom exposure increased
February 21, 2019 - New computational tool searches for factors that cause specific diseases
February 21, 2019 - New method to assess effectiveness of psychotherapies for social anxiety disorder
February 21, 2019 - New technology measures hormones that influence reproductive health efficiently
February 21, 2019 - Bat influenza viruses could potentially attack the cells of humans and livestock
February 21, 2019 - Immunotherapeutic antibody therapy to kill cancer has now progressed to patient testing
February 21, 2019 - Johns Hopkins scientists find new compound that may prevent reperfusion injury
February 21, 2019 - Researchers develop new way to deliver treatment for cartilage regeneration
February 21, 2019 - Study sheds new light on left ventricular dysfunction in ischemic heart disease
February 21, 2019 - New technique could expedite cancer diagnosis, lead to better patient outcomes
February 21, 2019 - New map of infant brain may aid early diagnosis of autism
February 21, 2019 - Human consciousness depends on the brain’s ability to maintain dynamics of neural activity
February 21, 2019 - Harmony Biosciences Announces File Acceptance Of Its New Drug Application For Pitolisant
February 21, 2019 - Medications could fill treatment gap for adolescents with obesity
February 21, 2019 - New antibiotics are desperately needed: Machine learning could help | News Center
February 21, 2019 - Researchers develop new computer game for dementia carers
February 21, 2019 - University of Dundee partners with Takeda to develop new treatments for tau pathology
Transcatheter mitral-valve repair in patients with heart failure

Transcatheter mitral-valve repair in patients with heart failure

image_pdfDownload PDFimage_print

Heart failure affects nearly two million Americans and millions more worldwide. It can range from mild to severe wherein even the ordinary activities of daily life become difficult.

A new heart device called the MitraClip (from Abbott) has been shown to benefit patients with heart failure and reduce death rates among them significantly.

Image Credit:

Heart is a relentless worker in the body that pumps out blood to the different parts of the body. As the heart muscles fail due to disease or drugs or other pathologies, the pumping action declines. A walk up the stairs and sometimes even across the room may lead to severe breathlessness among sufferers. There are medications that can help control the symptoms of heart failure. However this is a progressive condition with no known cure.

This week however, researchers have come up with a heart device that can help heart failure patients. The team of researchers used the MitraClip in a large clinical trial and found that patients using it had fewer hospitalizations, fewer debilitating symptoms and also a marked improvement in quality of life. The results of the study called COAPT, were published in the latest issue of the New England Journal of Medicine and were also presented at the Transcatheter Cardiovascular Therapeutics (TCT) 2018 meeting in San Diego by lead author Gregg Stone, MD, from Columbia University, New York City.

The mitral valve controls the blood flow between the left atrium and the left ventricle. As the heart fails and the organ becomes flabby and weak, the mitral valve gets pulled and fails to function normally. This leads to stagnation of the blood within the heart that back flows into the lungs causing more severe symptoms of the heart failure. The MitraClip made by Abbott, is used to repair the mitral valve by using a clip to attach the two flaps together in the centre.

Some of the patient recruitments took place at the University of Pennsylvania and its Director of interventional cardiology, Dr. Howard Herrmann, called this study a “huge advance”. “It shows we can treat and improve the outcomes of a disease in a way we never thought we could,” he said. The next step would be seeking approval from the Food and Drug Administration for its use in the treatment of severe heart failure. The researchers hope that insurers like Medicare would cover it soon. This study was funded by the makers Abbott and was reviewed by external experts. Earlier a smaller study in France (Mitra-FR) had failed to find the MitraClip effective in heart failure patients. There were several problems with this study though, say experts.

Once the MitraClip was in place, the valve functions were renewed and blood flow out of the heart normalized. In this new trial 614 patients with severe heart failure from United States and Canada were recruited. The participants were divided into two groups – those on standard care alone and those on the MitraClip along with standard care.

Results showed;

  • Those on medical treatment alone had 151 (68 percent) hospitalizations for heart failure in the duration of the study (2 years)
  • 92 (36 percent) of those on medical treatment and MitraClip were hospitalized for heart failure
  • 70 (23 percent) of those on medical treatment alone died during the first 12 months of the study
  • 57 (19 percent) of those on MitraClip and medical treatment died during the first 12 months of the study
  • Deaths at 24 months during the study were 29 percent among those with the MitraClip and 46 percent among those without the device
  • Only 3.4 percent of those who underwent the MitraClip surgery faced complications
  • The device functioned perfectly as planned in 95 percent participants

Mount Sinai Medical Center also enrolled some patients for the study. Dr. Gilbert Tang, a heart surgeon there, said that this trial was a “powerful message”. NYU Langone Health also recruited a few patients and Dr. Mathew Williams, director of the heart valve program there called this a “game changer”.

Expert cardiologists reviewing the study have called it “impeccably executed”. The device alone is estimated to cost around $30,000.


Tagged with:

About author

Related Articles