Breaking News
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
December 18, 2018 - Russian scientists identify molecular ‘switch’ that could be target for treatment of allergic asthma
December 18, 2018 - Surgeons make more mistakes in the operating room during stressful moments, shows study
December 18, 2018 - Immune cells explode themselves to inform about the danger of invading bacteria
December 18, 2018 - Malnutrition in children with Crohn’s disease linked with increased risk of surgical complications
December 18, 2018 - FDA Approves Motegrity (prucalopride) for Adults with Chronic Idiopathic Constipation (CIC)
December 18, 2018 - The long and short of CDK12
December 18, 2018 - Hologic’s Cynosure division introduces TempSure Surgical RF technology in North America
December 18, 2018 - CMR Surgical partners with Nicholson Center to launch U.S.-based training program for Versius
December 18, 2018 - Findings reinforce guidelines for cautious use of antipsychotics in younger populations
December 18, 2018 - Study finds new strains of hepatitis C virus in sub-Saharan Africa
December 18, 2018 - New battery-free, implantable device aids weight loss
December 18, 2018 - Parental alcohol use disorder associated with offspring marital outcomes
December 18, 2018 - Novel Breast Imaging Technique Might Cut Unnecessary Biopsies
December 18, 2018 - What can a snowflake teach us about how cancer spreads in the body?
December 18, 2018 - Management of nausea and vomiting in pregnancy costs the NHS more than previously thought
December 18, 2018 - Green leafy vegetables may reduce risk of developing liver steatosis
December 18, 2018 - Veganism linked to nutrient deficiencies and malnutrition if not planned correctly
December 18, 2018 - Coming Soon: A Tiny Robot You Swallow to Help You Stay Healthy
December 18, 2018 - Modified malaria drug proven effective at inhibiting Ebola
December 18, 2018 - Study finds epigenetic differences in the brains of individuals with schizophrenia
December 18, 2018 - Fitness instructors’ motivational comments influence women’s body satisfaction
December 18, 2018 - Study focuses on modification of lipid nanoparticles for successful brain cell targeting
December 18, 2018 - New gut bacteria may be effective against obesity, metabolic and mental disorders
December 18, 2018 - New two-in-one powder aerosol to upgrade fight against deadly superbugs in lungs
December 18, 2018 - Biofilms feed with swirling flows
December 17, 2018 - Study identifies specific neurological changes related to traumatic brain injury
December 17, 2018 - New study confirms geographic bias in lung allocation for transplant
December 17, 2018 - Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate
December 17, 2018 - Carpal tunnel syndrome – Genetics Home Reference
December 17, 2018 - A novel insulin accelerant
December 17, 2018 - Tips for caring for patients with disabilities, from a mother and physician
December 17, 2018 - Menopause-related sexual, urinary problems tied to worse quality of life
December 17, 2018 - In-school nutrition programs among students limit increases in BMI, finds study
December 17, 2018 - Risk for Hospitalization for Heart Failure Greater With Diabetes
December 17, 2018 - Food assistance may help older adults adhere to diabetes meds
New insights into application of drug-eluting stents during percutaneous coronary intervention

New insights into application of drug-eluting stents during percutaneous coronary intervention

image_pdfDownload PDFimage_print

Researchers at the Thorax Centrum Twente of Medisch Spectrum Twente (MST) and the University of Twente have recently completed their fourth major study into the application of drug-eluting stents during percutaneous coronary intervention. In what was known as the BIONYX study, two stents of the latest generation were used in order to gain understanding of the application and continued refinement of stents.

The results were presented by Professor Clemens von Birgelen at the Transcatheter Cardiovascular Therapeutics conference (TCT) in San Diego, the largest conference for interventional cardiologists in the US. The results were simultaneously published in the medical journal ‘The Lancet’. Remarkably, this is the third successive Twente-based stent study to have been published in this renowned academic journal.

Application of stents during heart attacks and in narrowed blood vessels
Every year, millions of patients receive minimally invasive treatment from specialist cardiologists following a heart attack or for serious narrowings of their coronary arteries. This involves the insertion, via a minuscule entry point in the blood vessels of the wrist or groin, of stents into the coronary arteries. The stents are made of very thin metal wire mesh, covered by an even thinner layer that elutes a drug. Stents are developed to keep previously narrowed blood vessels open after the percutaneous coronary intervention.

In recent years, more and more new stents have been developed that have gradually improved the results of this intervention. Professor von Birgelen, who is associated with the MST in his capacity as a cardiologist and is the holder of the Chair of Interventional Cardiology in the department of Health Technology and Services Research at the University of Twente, explained: “Over the years we have made great progress regarding both the technological development of the stents that are available on the market and the way in which they are applied in clinical settings. We have now reached the point where the number of complications has been reduced to a minimum. Within twelve months after their treatment, 97 percent of all patients required no further intervention in the coronary arteries into which stents had been implanted.”

Large-scale research
Almost 2500 patients in the Netherlands, Belgium, and Israel took part in the research, which was only recently completed. About one third of these patients were treated in the MST. During their treatment, one of the two different modern drug-eluting stents was inserted. The results of both stents were very encouraging, with very little difference between them: “It is essential that the results from the new stents are studied very carefully. This type of very large-scale research project is quite unique. With the information from such large-scale studies, there is more we can do than simply compare the results of the two stents. For years now, researchers in our group have been examining heart disease in women and in patients with previously undiagnosed diabetes,” says Von Birgelen.

The willingness on the part of patients to take part in these studies is very important, believes the cardiologist. “At the end of the publication in The Lancet, we wrote a word of thanks to the patients who took part – thanks for their trust and for their willingness to be part of the research and to help science progress. The oldest patient who participated in BIONYX was 96 years old. In practice, we often help older patients, but there are not many studies that allow older and very old patients to participate.”

The cardiologists in Enschede regard scientific research as extremely important: “It is thanks to such randomized studies, where independent researchers observe and verify the outcomes (in the most recent study, the experts were from Amsterdam and Zwolle), that we gain important insights into the benefits of new and promising technology, and that enables us to optimize how it is applied. In recent years, researchers have succeeded in reducing to a minimum the discomfort for patients caused by the intervention, in increasing the chances of successful outcomes, and even in lowering the costs of treatment. And the meticulous registration of treatment and of the results keeps everyone on their toes, and ultimately every patient benefits from this.”

Long tradition
The research team has a long tradition of applying and assessing new stents. Under the leadership of Professor von Birgelen, four stent studies have been launched in the past ten years – these have become known in cardiology circles as the ‘TWENTE studies’. The studies involved more than 9000 patients. Last week in the MST, the latest study – the COASTLINE study – saw the inclusion of its first patient.

Von Birgelen says, “We always make carefully considered choices when initiating a new study. As a result, we have been able to get stents of exceptional quality and achieve outstanding outcomes. Indeed, studies of this kind have to meet the highest quality requirements. That in turn requires excellent and close collaboration with epidemiologists and other experts from the University of Twente, who help with statistical analyses and with the interpretation of the results.”

Source:

https://www.utwente.nl/en/news/!/2018/9/144663/new-steps-in-the-application-of-stents-during-percutaneous-coronary-interventions

Tagged with:

About author

Related Articles