Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
New insights into application of drug-eluting stents during percutaneous coronary intervention

New insights into application of drug-eluting stents during percutaneous coronary intervention

Researchers at the Thorax Centrum Twente of Medisch Spectrum Twente (MST) and the University of Twente have recently completed their fourth major study into the application of drug-eluting stents during percutaneous coronary intervention. In what was known as the BIONYX study, two stents of the latest generation were used in order to gain understanding of the application and continued refinement of stents.

The results were presented by Professor Clemens von Birgelen at the Transcatheter Cardiovascular Therapeutics conference (TCT) in San Diego, the largest conference for interventional cardiologists in the US. The results were simultaneously published in the medical journal ‘The Lancet’. Remarkably, this is the third successive Twente-based stent study to have been published in this renowned academic journal.

Application of stents during heart attacks and in narrowed blood vessels
Every year, millions of patients receive minimally invasive treatment from specialist cardiologists following a heart attack or for serious narrowings of their coronary arteries. This involves the insertion, via a minuscule entry point in the blood vessels of the wrist or groin, of stents into the coronary arteries. The stents are made of very thin metal wire mesh, covered by an even thinner layer that elutes a drug. Stents are developed to keep previously narrowed blood vessels open after the percutaneous coronary intervention.

In recent years, more and more new stents have been developed that have gradually improved the results of this intervention. Professor von Birgelen, who is associated with the MST in his capacity as a cardiologist and is the holder of the Chair of Interventional Cardiology in the department of Health Technology and Services Research at the University of Twente, explained: “Over the years we have made great progress regarding both the technological development of the stents that are available on the market and the way in which they are applied in clinical settings. We have now reached the point where the number of complications has been reduced to a minimum. Within twelve months after their treatment, 97 percent of all patients required no further intervention in the coronary arteries into which stents had been implanted.”

Large-scale research
Almost 2500 patients in the Netherlands, Belgium, and Israel took part in the research, which was only recently completed. About one third of these patients were treated in the MST. During their treatment, one of the two different modern drug-eluting stents was inserted. The results of both stents were very encouraging, with very little difference between them: “It is essential that the results from the new stents are studied very carefully. This type of very large-scale research project is quite unique. With the information from such large-scale studies, there is more we can do than simply compare the results of the two stents. For years now, researchers in our group have been examining heart disease in women and in patients with previously undiagnosed diabetes,” says Von Birgelen.

The willingness on the part of patients to take part in these studies is very important, believes the cardiologist. “At the end of the publication in The Lancet, we wrote a word of thanks to the patients who took part – thanks for their trust and for their willingness to be part of the research and to help science progress. The oldest patient who participated in BIONYX was 96 years old. In practice, we often help older patients, but there are not many studies that allow older and very old patients to participate.”

The cardiologists in Enschede regard scientific research as extremely important: “It is thanks to such randomized studies, where independent researchers observe and verify the outcomes (in the most recent study, the experts were from Amsterdam and Zwolle), that we gain important insights into the benefits of new and promising technology, and that enables us to optimize how it is applied. In recent years, researchers have succeeded in reducing to a minimum the discomfort for patients caused by the intervention, in increasing the chances of successful outcomes, and even in lowering the costs of treatment. And the meticulous registration of treatment and of the results keeps everyone on their toes, and ultimately every patient benefits from this.”

Long tradition
The research team has a long tradition of applying and assessing new stents. Under the leadership of Professor von Birgelen, four stent studies have been launched in the past ten years – these have become known in cardiology circles as the ‘TWENTE studies’. The studies involved more than 9000 patients. Last week in the MST, the latest study – the COASTLINE study – saw the inclusion of its first patient.

Von Birgelen says, “We always make carefully considered choices when initiating a new study. As a result, we have been able to get stents of exceptional quality and achieve outstanding outcomes. Indeed, studies of this kind have to meet the highest quality requirements. That in turn requires excellent and close collaboration with epidemiologists and other experts from the University of Twente, who help with statistical analyses and with the interpretation of the results.”

Source:

https://www.utwente.nl/en/news/!/2018/9/144663/new-steps-in-the-application-of-stents-during-percutaneous-coronary-interventions

Tagged with:

About author

Related Articles