Breaking News
December 14, 2018 - Lack of peds preventive care ups unplanned hospital admissions
December 14, 2018 - Miscarriage: When Language Deepens Pain
December 14, 2018 - New method helps better understand pathological development of ALS
December 14, 2018 - Intellectually active lifestyle confers protection against neurodegeneration in Huntington’s patients
December 14, 2018 - Mammalian collagen nanofibrils become stronger and tougher with exercise
December 14, 2018 - Considerable Morbidity, Mortality Due to Animal Encounters
December 14, 2018 - Researchers find inhibiting one protein destroys toxic clumps seen in Parkinson’s disease
December 14, 2018 - How early physical therapy can lessen the long-term need for opioids
December 14, 2018 - Depression, suicide rates highest in Mountain West states
December 14, 2018 - New model could cure the potential to underestimate how quickly diseases spread
December 14, 2018 - Exercise-induced hormone activates cells critical for bone remodeling in mice
December 14, 2018 - Researchers discover new mechanism behind spread of malignant pleural mesothelioma
December 14, 2018 - Health Tip: Celebrate a Healthier Holiday
December 14, 2018 - Scalpel-free surgery enhances quality of life for Parkinson’s patients, study finds
December 14, 2018 - Early physical therapy can reduce risk, amount of long-term opioid use | News Center
December 14, 2018 - Genetic marker, predictor of early relapse in common childhood cancer discovered
December 14, 2018 - Study could lead to a potential new way of treating sepsis
December 14, 2018 - New protein complex helps embryonic stem cells to maintain their indefinite potential
December 14, 2018 - Salk professor receives $1.8 million from NOMIS Foundation for research on mechanisms to promote health
December 14, 2018 - New discovery will improve the safety and predictability of CRISPR
December 14, 2018 - Geneticists discover how sex-linked disorders arise
December 14, 2018 - New method to visualize small-molecule interactions inside cells
December 14, 2018 - Study describes mechanism that makes people more vulnerable to hunger-causing stimuli
December 14, 2018 - Chronic opioid therapy associated with increased healthcare spending and hospital stays
December 14, 2018 - Blood Types
December 14, 2018 - Obesity linked to increased risk of early-onset colorectal cancer
December 14, 2018 - Blood test helps identify distinct molecular signatures in children with cystic fibrosis
December 14, 2018 - Scientists use water to track electrical activity of nerve cells
December 14, 2018 - Recurrence of urinary tract infection may depend on bacterial strain, study shows
December 14, 2018 - GBT Announces U.S. FDA Agrees with its Proposal Relating to Accelerated Approval Pathway for Voxelotor for the Treatment of Sickle Cell Disease and GBT Plans to Submit New Drug Application (NDA)
December 14, 2018 - Partial Thromboplastin Time (PTT) Test: MedlinePlus Lab Test Information
December 14, 2018 - Common tactics for health promotion at work may be detrimental to employees with obesity
December 14, 2018 - Myths about migration and health not supported by available evidence
December 14, 2018 - Recent findings on rare genetic disorder may help develop new treatment options
December 14, 2018 - New drug shows promise in treating sarcomas
December 14, 2018 - Scientists perform lung lavage as new approach for tuberculosis diagnosis in rhinoceros
December 14, 2018 - Recent winners of the Nobel Medicine Prize
December 14, 2018 - KHN’s ‘What the Health?’ Insurance enrollment is lagging — and there are lots of reasons why
December 14, 2018 - Study assesses safety and efficacy of new treatment for pancreatic cancer
December 14, 2018 - Weakened metabolism of immune T cells may account for serious complications in elderly
December 14, 2018 - Study finds drug targets for Ebola, Dengue, and Zika viruses
December 14, 2018 - Face masks may offer protection against staph bacteria for hog farm workers and their household members
December 14, 2018 - Shining new light on neuron firing
December 14, 2018 - Study highlights need for personalized approach to treat ICU acquired delirium
December 14, 2018 - Soot particles from road traffic significantly contribute to air pollution
December 14, 2018 - Massage helps relieve pain, improve mobility in patients with knee osteoarthritis
December 14, 2018 - Researchers explore home healthcare nurses’ knowledge attitudes toward infection control
December 14, 2018 - Average outpatient visit in the U.S. costs nearly $500, shows new study
December 14, 2018 - Reference Infliximab, Biosimilar Equivalent for Crohn’s Disease
December 14, 2018 - New contact lens to treat eye injuries
December 14, 2018 - Acne could have a genetic basis find researchers promising new cure
December 14, 2018 - Higher physical activity associated with improved mood
December 14, 2018 - New UGA study points to optimal hypertension treatment for stroke patients
December 14, 2018 - Study highlights factors that can reduce food cravings
December 14, 2018 - Researchers discover Ebola-fighting protein in human cells
December 14, 2018 - Fentanyl surpasses heroin in cause of U.S. drug overdose deaths
December 14, 2018 - When Heart Attack Strikes, Women Often Hesitate to Call for Help
December 14, 2018 - A warning about costume contacts
December 14, 2018 - Study examines link between peripheral artery disease and heart attack
December 14, 2018 - Researchers develop biotechnological tool to produce antifungal proteins in plants
December 14, 2018 - 3D-printed adaptive aids can benefit patients with arthritis
December 14, 2018 - Chronic bullying during adolescence impacts mental health
December 14, 2018 - Integral Molecular and Merus collaborate to develop bispecific antibody therapeutics
December 13, 2018 - Importance of cell cycle and cellular senescence in the placenta discovered
December 13, 2018 - Gold “nanoprisms” open new window into vessels and single cells
December 13, 2018 - Research findings could lead to new targets for cancer-fighting therapeutics
December 13, 2018 - Butantan Institute signs collaboration agreement with MSD to develop dengue vaccines
December 13, 2018 - Study explores how patients want to discuss symptoms with doctors
December 13, 2018 - RUDN medics first to gather scattered data on hepatitis morbidity in Somalia
December 13, 2018 - Age and gender disparities found in use of bed nets to prevent malaria in sub-Saharan Africa
December 13, 2018 - Caffeine therapy benefits developing brains of premature babies
December 13, 2018 - New review focuses on electrospinning techniques used in musculoskeletal tissue engineering
December 13, 2018 - A new division focused on human immune system
December 13, 2018 - Zogenix Announces Positive Phase 3 Trial Results on the Efficacy and Safety of Fintepla (ZX008) in Dravet Syndrome
December 13, 2018 - BCR ABL Genetic Test: MedlinePlus Lab Test Information
December 13, 2018 - Caffeinated beverages during pregnancy linked to lower birth weight babies
December 13, 2018 - Stanford Medicine Health Trends Report examines opportunity to democratize health care
December 13, 2018 - Obsessive-compulsive disorder may protect individuals from obesity
December 13, 2018 - Scientists investigate how a painful event is processed in the brain
December 13, 2018 - Genetic study reveals new insights into underlying causes of moderate-to-severe asthma
Researchers create inexpensive system to test for dangerous levels of lead in water

Researchers create inexpensive system to test for dangerous levels of lead in water

image_pdfDownload PDFimage_print

The discovery of lead in Flint, Michigan’s drinking water drew renewed attention to the health risks posed by the metal. Now researchers at the University of Houston have created an inexpensive system using a smartphone and a lens made with an inkjet printer that can detect lead in tap water at levels commonly accepted as dangerous.

The system builds upon earlier work by Wei-Chuan Shih, associate professor of electrical & computer engineering, and members of his lab, including the discovery of an inexpensive elastomer lens that can convert a basic smartphone into a microscope.

The latest discovery, described in the journal Analytical Chemistry, combines nano-colorimetry with dark-field microscopy, integrated into the smartphone microscope platform to detect levels of lead below the safety threshold set by the Environmental Protection Agency.

“Smartphone nano-colorimetry is rapid, low-cost, and has the potential to enable individual citizens to examine (lead) content in drinking water on-demand in virtually any environmental setting,” the researchers wrote.

Even small amounts of lead can cause serious health problems, with young children especially vulnerable to neurological damage. EPA standards require lead levels in drinking water to be below 15 parts per billion, and Shih said currently available consumer test kits aren’t sensitive enough to accurately detect lead at that level.

By using an inexpensive smartphone equipped with an inkjet-printed lens and using the dark-field imaging mode, researchers were able to produce a system that was both portable and easy to operate, as well as able to detect lead concentrations at 5 parts per billion in tap water. The sensitivity reached 1.37 parts per billion in deionized water.

Shih and his students last year published an open-source dataset in Biomedical Optics Express, explaining how to convert a smartphone equipped with the elastomer lens into a microscope capable of fluorescence microscopy. That paper has been the journal’s most frequently downloaded paper since its publication.

The latest application incorporates color analysis to detect nanoscale lead particles. In addition to Shih, researchers on the project include first author Hoang Nguyen and Yulung Sung, Kelly O’Shaughnessy and Xiaonan Shan, all with the UH Department of Electrical & Computer Engineering. (O’Shaughnessy was a summer intern from the University of Cincinnati under the National Science Foundation’s Research Experiences for Undergraduates program.)

Applying the dataset published in 2017, the researchers built a self-contained smartphone microscope that can operate in both fluorescence and dark-field imaging modes and paired it with an inexpensive Lumina 640 smartphone with an 8-megapixel camera. They spiked tap water with varying amounts of lead, ranging from 1.37 parts per billion to 175 parts per billion. They then added chromate ions, which react with the lead to form lead chromate nanoparticles; the nanoparticles can be detected by combining colorimetric analysis and microscopy.

The analysis measured both the intensity detected from the nanoparticles, correlating that to the lead concentration, and verified that the reaction was spurred by the presence of lead.

The mixture was transferred to a polydimethylsiloxane slab attached to a glass slide; after it dried, deionized water was used to rinse off the chromate compound and the remaining sediment was imaged for analysis.

The microscopy imaging capability proved essential, Shih said, because the quantity of sediment was too small to be imaged with an unassisted smartphone camera, making it impossible to detect relatively low levels of lead.

Building upon the smartphone microscope platform to create a useful consumer product was key, Shih said. “We wanted to be sure we could do something that would be useful from the standpoint of detecting lead at the EPA standard,” he said.

Source:

http://www.uh.edu/news-events/stories/2018/september-2018/09262018shih-smartphone-lead-detection.php

Tagged with:

About author

Related Articles