Breaking News
January 19, 2019 - Newly identified subset of immune cells may be key to fighting chronic inflammation
January 19, 2019 - New immune response regulators discovered
January 18, 2019 - Poor blood oxygenation during sleep predicts chance of heart-related death
January 18, 2019 - First international consensus on the diagnosis and management of fibromuscular dysplasia
January 18, 2019 - Rapid resistance gene sequencing technology can hasten identification of antibiotic-resistant bacteria
January 18, 2019 - Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli
January 18, 2019 - Scientists advise caution in immunotherapy research
January 18, 2019 - How children across the world develop language
January 18, 2019 - Columbia Medical Student Receives McDonogh Scholarship
January 18, 2019 - Secretive ‘Rebate Trap’ Keeps Generic Drugs For Diabetes And Other Ills Out Of Reach
January 18, 2019 - Plant based diet could be the best option for the planet says commission
January 18, 2019 - New conservation practice could reduce nitrogen from agricultural drainage, study shows
January 18, 2019 - UIC researchers receive $1.7 million NCI grant to study Southeast Asian fruit
January 18, 2019 - New study determines the fate of DNA derived from genetically modified food
January 18, 2019 - Scientists develop new gene therapy that prevents axon destruction in mice
January 18, 2019 - Study finds critically low HPV vaccination rates among younger adolescents in the U.S.
January 18, 2019 - Brain cells involved in memory play key role in reducing future eating behavior
January 18, 2019 - Risk for Conversion of MS Varies With Different Therapies
January 18, 2019 - Investigational cream may help patients with inflammatory skin disease
January 18, 2019 - Medical school news office receives six writing awards | News Center
January 18, 2019 - County By County, Researchers Link Opioid Deaths To Drugmakers’ Marketing
January 18, 2019 - Research reveals risk for developing more than one mental health disorder
January 18, 2019 - Scientists discover a dramatic pattern of bone growth in female mice
January 18, 2019 - Study finds link between lengthy periods of undisturbed maternal sleep and stillbirths
January 18, 2019 - New nuclear medicine method could improve detection of primary and metastatic melanoma
January 18, 2019 - Combination therapy shows high efficacy in treating people with leishmaniasis and HIV
January 18, 2019 - Health Tip: Don’t Ignore Changes in Skin Color
January 18, 2019 - Dietary Recommendations for Healthy Children
January 18, 2019 - Eliminating the latent reservoir of HIV
January 18, 2019 - Pain From The Government Shutdown Spreads. This Time It’s Food Stamps
January 18, 2019 - Newly discovered regulatory mechanism helps control fat metabolism
January 18, 2019 - New rapid blood tests could speed up TB diagnosis, save the NHS money
January 18, 2019 - Researchers develop intelligent system for ‘tuning’ powered prosthetic knees
January 18, 2019 - Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma
January 18, 2019 - New research detects mosquito known to transmit malaria for the first time in Ethiopia
January 18, 2019 - Lumex Instruments’ RA-915AM monitor installed at Hg treatment plant in Almadén, Spain
January 18, 2019 - ACCC survey finds multiple threats to growth of cancer programs
January 18, 2019 - Meeting the challenge of engaging men in HIV prevention and treatment
January 18, 2019 - Furloughed Feds’ Health Coverage Intact, But Shutdown Still Complicates Things
January 18, 2019 - Experts discuss various aspects on health risks posed by fumigated containers
January 18, 2019 - Researchers use gene-editing tool CRISPR/Cas9 to limit impact of parasitic diseases
January 18, 2019 - Alpha neurofeedback training could be a means of enhancing learning success
January 18, 2019 - Innovative ‘light’ method demonstrates positive results in fight against malignant tumors
January 18, 2019 - The cytoskeleton of neurons found to play role in Alzheimer’s disease
January 18, 2019 - New resource-based approach to improve HIV care in low- and middle-income countries
January 18, 2019 - Bedfont appoints Dr Jafar Jafari as first member of the Gastrolyzer Medical Advisory Board
January 18, 2019 - New study shows link between secondhand smoke and cardiac arrhythmia
January 18, 2019 - DZIF scientists reveal problems with available diagnostics for Zika and chikungunya virus
January 18, 2019 - Breast cancers more likely to metastasize in young women within 10 years of giving birth
January 18, 2019 - Over 5.6 million Americans exposed to high nitrate levels in drinking water
January 18, 2019 - Blood vessels can now be created perfectly in a petri dish
January 18, 2019 - Study identifies prominent socioeconomic and racial disparities in health behavior in Indiana
January 18, 2019 - Young-Onset Type 2 Diabetes Tied to Increased Hospitalization Risk
January 18, 2019 - For-profit nursing schools associated with lower performance on nurse licensure test
January 18, 2019 - Considering the culture of consent in medicine
January 18, 2019 - Researchers identify comprehensive guidelines for managing severe atopic dermatitis
January 18, 2019 - Analyzing proteins in blister fluid may classify burn severity more accurately
January 18, 2019 - Study finds higher suicide rates among youth who were Medicaid enrollees
January 18, 2019 - Opioid drugs often overprescribed to children for pain relief, say CHOP surgeons
January 18, 2019 - New biodegradable wound dressing material accelerates healing
January 18, 2019 - Life in Space May Take Toll on Spinal Muscles
January 18, 2019 - Bulldogs’ screw tails linked to human genetic disease
January 18, 2019 - Immunotherapy target identified for pediatric cancers
January 18, 2019 - Financial stress may increase heart disease risk in African Americans
January 18, 2019 - Scientists solve another piece of Ebola virus puzzle
January 18, 2019 - New project finds how endocrine disruptors interfere with thyroid functions
January 18, 2019 - Research finds decline in ketone body utilization when coronary circulation is reduced
January 18, 2019 - Let’s map our DNA and save billions each year in health costs
January 18, 2019 - AI demonstrates potential to identify irregular heart rhythms as well as humans
January 17, 2019 - Study shows link between air pollution and increased risk of sleep apnea
January 17, 2019 - Neck-strengthening exercises can protect athletes from concussions
January 17, 2019 - Computer model shows how to better control MRSA outbreaks
January 17, 2019 - Pain is unpleasant, and now scientists have identified the set of responsible neurons
January 17, 2019 - CUIMC Celebrates 2018-2019
January 17, 2019 - Study reveals potential pathway for endothelial cells to avoid apoptosis
January 17, 2019 - Hamilton Storage launches LabElite DeCapper SL to expand LabElite product family
January 17, 2019 - Location of epigenetic changes co-locate with genetic signal causing psychartric disorder
January 17, 2019 - Researchers awarded 6.1 million euros to address female fertility problems
January 17, 2019 - Counseling appointments fail to reduce weight gain during pregnancy, shows study
January 17, 2019 - Contraceptive patch that could provide 6 months of contraception within seconds
Researchers uncover new role of TIP60 protein in controlling tumour formation

Researchers uncover new role of TIP60 protein in controlling tumour formation

image_pdfDownload PDFimage_print
Credit: CC0 Public Domain

Scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.

Assistant Professor Sudhakar Jha, Principal Investigator at CSI Singapore, and his team found that TIP60 protein, a known cancer suppressor for breast and colorectal tumours, works with another protein, called BRD4, to suppress the expression of a group of genes called endogenous retroviral elements (ERVs). Also known as “jumping genes” in tissues, ERVs are capable of jumping across the genome during their replication. They can alter the sequences of other genes that encode proteins, and even result in mutations or changes in the genetic sequence. ERVs can also activate tissue inflammation which supports tumour growth.

TIP60 expression has been found to be greatly reduced in different tumour types, including breast, colorectal and human papillomavirus-induced cervical cancer.

“In our study, we found that in tissues with lower TIP60 protein presence, the jumping gene expression is uncontrolled and these tissues can develop an inflammatory response which, in turn, can cause tumours to form.This discovery of TIP60’s association with tissue inflammation is significant because it is known that in certain cancers such as liver and colorectal cancer, inflammation of tissues predisposes individuals to the development of early stage cancer. Thus, TIP60 protein can potentially be used to silence ERV expression and, essentially,stop tumour formation,” explained Asst Prof Jha, who is also from the Department of Biochemistry under the NUS Yong Loo Lin School of Medicine.

New therapeutic opportunities, including possible use of anti-HIV drugs for cancer treatment

When the researchers artificially introduced TIP60 in colorectal cancer cells, a slower growth of cells that have higher TIP60 expression was observed. This is consistent with its function as a tumour suppressorthat slows down or prevents the growth of tumour cells.

“We have also found that tumours where we artificially deplete TIP60 protein are more sensitive to specific drugs that are currently used against human immunodeficiency virus (HIV). This is of huge promise because these drugs have already been tested for their side effects in humans. We can look at cancer patient samples and see if they have low TIP60 levels by correlating with the expression of ERVs and inflammatory genes. In this way, we can potentially identify the cohort of patients that could benefit from this treatment,” said Dr. Deepa Rajagopalan, a Research Fellow at CSI Singapore who had carried out the research when she was a doctoral student at the Department of Biochemistry at NUS Yong Loo Lin School of Medicine. She is also the first author of the paper.

Future research

The research team is currently conducting studies to verify whether this mechanism of TIP60 silencing the jumping genes is true in other cancers such as liver and breast cancers.

They are also in talks with other research groups at CSI Singapore on using an optimised platform to screen drug combinations that are highly efficient in killing cancer cells. They hope to use a variety of different combinations of the anti-HIV drugs to treat colorectal cancer cells first and potentially other tumours such as breast and liver that also have low TIP60 levels.

The team is also looking to investigate the efficacy of drugs that disable the function of BRD4 (the protein that works with TIP60 in tumour formation) in combination with anti-HIV drugs in tumour treatment.

The team’s work and research findings were published on 24 July 2018 in the scientific journal Nucleic Acids Research.


Explore further:
Researchers discover novel mechanism to stop the spread of breast cancer

More information:
Deepa Rajagopalan et al. TIP60 represses activation of endogenous retroviral elements, Nucleic Acids Research (2018). DOI: 10.1093/nar/gky659

Journal reference:
Nucleic Acids Research

Provided by:
National University of Singapore

Tagged with:

About author

Related Articles