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November 12, 2018 - Optibrium and University of Nottingham Collaborate on Innovative Teaching Programme
November 12, 2018 - RNA defects linked to multiple myeloma progression in high risk patients
November 12, 2018 - Science is on trial – and we need doctors to provide the defense
November 12, 2018 - Salk researchers receive $19.2 million to unravel mysteries of age-related cognitive decline
November 12, 2018 - KE Eye Centers offer new solution for patients with myopia and astigmatism
November 12, 2018 - Trumpeted new Medicare Advantage benefits will be hard for seniors to find
November 12, 2018 - Biogen and Eisai Announce Presentation of Detailed Analyses from the Phase 1b Long-Term Extension Study of Aducanumab at Clinical Trials on Alzheimer’s Disease (CTAD)
November 12, 2018 - Scientists reveal new cystic fibrosis treatments work best in inflamed airways
November 12, 2018 - Testing coronary calcium levels can better predict patient’s risk for coronary heart disease
November 12, 2018 - FDA conducts mass seizure of food and medical products held under insanitary conditions
November 12, 2018 - FDA Approves Invokana (canagliflozin) to Reduce the Risk of Heart Attack, Stroke or Cardiovascular Death in Adults with Type 2 Diabetes and Established Cardiovascular Disease
November 12, 2018 - Hormone helps reverse brain damage caused by obesity
November 12, 2018 - Grants aim to provide better cancer clinical trial access for military veterans
November 12, 2018 - Mitochondrial DNA may have strong influence on cellular metabolism and disease susceptibility
November 12, 2018 - High stakes, entrenched interests and the Trump rollback of environmental regs
November 12, 2018 - Stem cells transplanted for treatment of Parkinson’s disease
November 12, 2018 - Sandoz Inc. Issues Voluntary Nationwide Recall of One Lot of Losartan Potassium and Hydrochlorothiazide Due to the Detection of Trace Amounts of NDEA (N-Nitrosodiethylamine) Impurity Found in the Active Pharmaceutical Ingredient (API)
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November 12, 2018 - Allied BioScience receives approved label from EPA for new bacteriostatic surface coating
November 12, 2018 - MR Solutions displays elegant bench top CT scanner with clip-on PET and SPECT at EANM congress
November 12, 2018 - FDA announces emergency use authorization of Ebola fingerstick test with portable reader
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November 12, 2018 - Exercise routines affect mental health in Japanese expatriates
November 12, 2018 - Fish oil and vitamin D pills no guard against cancer or serious heart trouble
November 12, 2018 - Excess Gestational Weight Gain Not Better for Child Bone Health
November 12, 2018 - Immune receptor provides protective immunity against Group A Streptococcus
November 12, 2018 - Scientists develop new method to produce irradiated nanomaterials for medical applications
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November 12, 2018 - Researchers find how natural killer cells regulate protective HIV antibodies
November 12, 2018 - Rutgers receives $4.2 million federal grant to improve mental health services
November 12, 2018 - Sussex scientists develop a piece of hardware to show how brains function
November 12, 2018 - Study shows pivotal role of parents in efforts to change sexual orientation of LGBT teens
November 12, 2018 - Neck scan detects dementia way before symptoms appear
November 12, 2018 - Risk-profiling can benefit HIV prevention
November 12, 2018 - New thrombolytic based on magnetite nanoparticles successfully tested on animals
November 12, 2018 - Smoking rates go down in the US, lowest since 1965
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November 12, 2018 - Moderate exercise before conception resulted in lower body weight, increased insulin sensitivity of offspring
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November 11, 2018 - More adults and children are using yoga and meditation
November 11, 2018 - Female smokers at greater risk of heart attacks, finds study
November 11, 2018 - Happy Childhood Memories Associated With Better Health
November 11, 2018 - X-linked infantile spinal muscular atrophy – Genetics Home Reference
November 11, 2018 - RNA thought to spread cancer shows ability to suppress breast cancer metastasis
November 11, 2018 - Study finds that thymus plays key role during normal pregnancy
November 11, 2018 - Exploring why some athletes ice their muscles after exercise
November 11, 2018 - Female Genital Mutilation Decreasing in African Nations
November 11, 2018 - Are humans immune to the CRISPR-Cas9 gene editing scissors?
November 11, 2018 - Breastmilk and saliva mixtures regulate oral microbiome of newborn babies
November 11, 2018 - Learning familiar faces through social interactions reduces variability in face recognition
November 11, 2018 - New open source decision support tool could help clinicians chose chemotherapy drugs
November 11, 2018 - New weapons drawn in global TB fight
November 11, 2018 - UCB and Biogen Announce Topline Results from a Phase 2b Study of Dapirolizumab Pegol in Systemic Lupus Erythematosus
November 11, 2018 - Surgery restores boy’s ability to walk post-acute flaccid myelitis
November 11, 2018 - Comorbidity negatively impacts quality of life in people with dementia
November 11, 2018 - Neuroscientists receive $16.75 million from BRAIN Initiative to decipher the brain’s visual system
November 11, 2018 - Purdue researchers invent new smart drainage device to help glaucoma patients
November 11, 2018 - New initiative may benefit entrepreneurs working to transform patient care
November 11, 2018 - Sage Therapeutics Announces FDA Advisory Committee Votes 17-1 in Support of Benefit-Risk Profile of Zulresso (brexanolone) Injection for Treatment of Postpartum Depression
November 11, 2018 - Exercise could delay progression of type 1 diabetes when first diagnosed
November 11, 2018 - Study of gaze fixation in monkeys reveals role of dopamine neurons in response inhibition
November 11, 2018 - Bilingual therapy is vital to improve language disorders in dual-language children, finds study
November 11, 2018 - More Frequent Surveillance No Benefit After NSCLC Resection
November 11, 2018 - Phenylketonuria (PKU) Screening: MedlinePlus Lab Test Information
November 11, 2018 - Researchers discovered a new mechanism of action in a first-line drug for diabetes
November 11, 2018 - Study explains how dermal fibroblasts age
November 11, 2018 - New multi-allergen test works just as well with dried blood
November 11, 2018 - CWRH/UH researcher receives grant to study role of KLF2 factor in vascular-related disorders
November 11, 2018 - New infrared detector may transform smartphones into pocket-sized portable labs
November 11, 2018 - AHA: Young Golfer Returns to Sport He Loves After Stroke
November 11, 2018 - Yuan-Harel-Lupski syndrome – Genetics Home Reference
November 11, 2018 - Effective diagnosis of persistent facial pain will benefit patients and save money
November 11, 2018 - Loyola tests new catheter ablation system that can reach deeper into heart muscle
November 11, 2018 - Pilates exercise program offers many benefits for people with musculoskeletal conditions

The Current issue of “The view from here” is concerned with Nanotherapeutic strategies

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I remember being told once, that as technology becomes smaller and smaller and ever decreasing amounts of material required for testing, the larger the room to house them becomes.  I guess this is the pharmaceutical equivalent of Moore’s Law (or should it be eroom’s Law in this case; hard to tell). Well if this trend in technology were to be translated into the delivery of therapeutics, there would be some whose laboratories would need to be the size of small (or perhaps even moderately sized) countries. Over the last few years, I would say that the field of nanotherapeutics has come from virtually nowhere to represent one of the most submitted or suggested article types coming across my desk. I would have to say that they ingenuity in this area seems to hold no bounds and has the potential to revolutionise many aspects of therapy over a wide range of therapeutic applications. The articles in this newsletter are intended in some small way to illustrate some of the technical and practical advances that have become available over the last few years. I hope that you are equally as excited by the potential of some of these approaches as I am.

 

The first article in this month’s offering is entitled: “Design strategies for physical-stimuli- responsive programmable nanotherapeutics”, by Fitsum Feleke Sahle, Muhammad Gulfam and Tao L. Lowe of Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA. In this article, the authors present a systematic approach to design different programmable physicalstimuliresponsive nanotherapeutics intended for controlled and targeted delivery of various therapeutic agents. Such approaches may become ever more useful to control the response of drugs to be controlled both spatially and temporally by external physical stimuli, allowing more precise control over the target site and a significantly improved drug delivery potential.  The ability to facilitate precise site and on demand delivery could offer massive improvements in the treatment of many diseases.

 

Following on from this is the article by Vibhuti Agrahari and Vivek Agrahari entitled: “Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities” from the recent Special Issue on Nanotherapeutic strategies, on which they were guest Editors. The authors point out how understanding of fundamental, characterization, clinical and regulatory aspects of nanomedicines is vital to enhance their translational potential. They go on to discuss the challenges and opportunities related to the commercialization of nanomedicines, essential for the translation of interesting science to valuable medicine.

 

The remaining article in this month’s offering is more of a practical one, related to the nitty gritty of preparation of pharmaceutic nanocrystals. It is from Maria Malamatari, Kevin M.G. Taylor, Stavros Malamataris, Dennis Douroumis and Kyriakos Kachrimanis, entitled: “Pharmaceutical nanocrystals: production by wet milling and applications”. The review outlines the advantages, stabilization, and production of drug nanocrystals with an emphasis on wet milling. Covering their pharmaceutical applications, it reveals why nanocrystals are an industrially-feasible formulation strategy.

 

 

 

Steve Carney was born in Liverpool, England and studied Biochemistry at Liverpool University, obtaining a BSc.(Hons) and then read for a PhD on the Biochemistry and Pathology of Connective Tissue Diseases in Manchester University, in the Departments of Medical Biochemistry and Histopathology. On completion of his PhD he moved to the Kennedy Institute of Rheumatology, London, where he worked with Professor Helen Muir FRS and Professor Tim Hardingham, on the biochemistry of experimental Osteoarthritis. He joined Eli Lilly and Co. and held a number of positions in Biology R&D, initially in the Connective Tissue Department, but latterly in the Neuroscience Department. He left Lilly to take up his present position as Managing Editor, Drug Discovery Today, at Elsevier. Currently, he also holds an honorary lectureship in Drug Discovery at the University of Surrey, UK. He has authored over 50 articles in peer-reviewed journals, written several book chapters and has held a number of patents. On the media front, Dr. Carney has been busy on some hush-hush projects that will be reported on later in the year.

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