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January 23, 2019 - Bedfont to exhibit NObreath FeNO monitor at Arab Health 2019
January 23, 2019 - Nicotinamide riboside supplementation confers significant physiological benefits to mothers and offspring
January 23, 2019 - Increasing temperatures may help preserve crop nutrition
January 23, 2019 - Many Oncologists in the Dark About LGBTQ Health Needs
January 23, 2019 - Epigenetic change causes fruit fly babies to inherit diet-induced heart disease
January 23, 2019 - Erasing memories could reduce relapse rates among drug addicts
January 23, 2019 - African Americans who smoke cigarettes are more likely to develop peripheral artery disease
January 23, 2019 - Unique data combination helps FinnGen researchers to fund links between genetic factors and health
January 23, 2019 - Parents’ mental health problems associated with reactive attachment disorder in children
January 23, 2019 - Graphene Flagship project studies impact of graphene and related materials on our health
January 23, 2019 - The connection between the Pope and contraceptive pills
January 23, 2019 - Prior dengue infection could protect children from symptomatic Zika
January 23, 2019 - VISTA checkpoint implicated in pancreatic cancer immunotherapy resistance
January 23, 2019 - The Tiny Camera That Could Revolutionize Cardiovascular Surgery
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January 23, 2019 - Migrants and refugees do not bring disease and are at greater health risk themselves says WHO
January 23, 2019 - Examing the effects of menopause in workplace
January 23, 2019 - Enemy number 1 – Air pollution and climate change top of WHO agenda
January 23, 2019 - Two Positive Phase III studies of Tafenoquine for the Radical Cure of Plasmodium vivax Malaria Published in The New England Journal of Medicine
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January 23, 2019 - Short, text-based exercises can increase happiness for adults recovering from substance use disorders
January 23, 2019 - Body size may have greater influence on women’s lifespan than men
January 23, 2019 - Groundbreaking tool helps visualize neuronal activity with near-infrared light
January 23, 2019 - Prior dengue immunity in children may be protective against symptomatic Zika
January 23, 2019 - Holocaust survivors with PTSD and their offspring exhibit more unhealthy behavior patterns
January 23, 2019 - Scientists discover new genetic mutations causing inherited deaf-blindness
January 23, 2019 - UC team designs new naloxone-dispensing smart device
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January 23, 2019 - Reintroduction project recovers current wild population of green turtle in Cayman Islands
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January 23, 2019 - LSTM receives grant to help improve health of people living in informal settlements
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January 23, 2019 - Why early diagnosis of autism should lead to early intervention
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January 23, 2019 - Bowel cancer on the rise among younger Australians
January 23, 2019 - Scientists have reversed memory loss in a mouse model of Alzheimer’s
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January 23, 2019 - Researchers identify how concussions may contribute to seizures
January 23, 2019 - Short interval between last meal of the day and bedtime may not affect blood glucose levels
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January 23, 2019 - Prenatal valproate exposure linked to increased ADHD risk
January 23, 2019 - Compound identified that may help treat heart failure
January 23, 2019 - Undiagnosed Asthma in Urban Adolescents May Be Common
January 23, 2019 - Study describes metabolism of intestinal microbiota in babies for the first time
January 22, 2019 - Study links concussions to development of epilepsy
January 22, 2019 - Specialist-led hospital bereavement service may help restrain legal action after difficult deaths
January 22, 2019 - Genetic study reveals possible new routes to treating osteoarthritis
January 22, 2019 - Blood test may detect early signs of lung-transplant rejection
January 22, 2019 - Blood marker could aid in early prediction of Alzheimer’s progression
January 22, 2019 - Orthodontic treatment does not guarantee future dental health
January 22, 2019 - Rutgers researchers discover cause of bone loss in people with joint replacements
January 22, 2019 - Diversity among rural Africans extends to their gut microbiomes
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January 22, 2019 - VTv Therapeutics Announces Publication of Comprehensive Data in Science Translational Medicine Detailing the Discovery and Clinical Development of TTP399, including Results of Phase 2 AGATA Study
January 22, 2019 - about one in three adults with prediabetes has arthritis
January 22, 2019 - A look at how data is democratizing health care
January 22, 2019 - Alcohol-Linked Disease Overtakes Hep C As Top Reason For Liver Transplant
January 22, 2019 - Researchers identify new genes linked with age-related macular degeneration
January 22, 2019 - MPFI researchers identify synaptic logic for connections between two brain hemispheres
January 22, 2019 - New approach to reduce toxic protein production in ALS
January 22, 2019 - New study extends our knowledge of the link between miRNAs and cancer
January 22, 2019 - Asthma, eczema are not barriers to active lifestyle in teenagers
January 22, 2019 - Genetic changes may predict likelihood of relapse in breast cancer patients
January 22, 2019 - Antiepileptic drug use by people with Alzheimer’s disease linked to accumulation of hospital days
January 22, 2019 - IUPUI researcher receives $2.85 million grant to find ways to improve bone strength
January 22, 2019 - Precision medicine can help keep astronauts healthy during deep space missions
January 22, 2019 - Detecting signs of neurodegeneration earlier and more accurately
January 22, 2019 - Mouse studies challenge ‘inhibition’ theory of autism
January 22, 2019 - SSB launches BIOSTAT RM TX single-use bioreactor for producing consistent quality cellular products
January 22, 2019 - Experimental drug can positively modify key characteristic behavior in FXS patients
January 22, 2019 - Low-Income Women Lack Menstrual Hygiene Supplies

The Current issue of “The view from here” is concerned with Nanotherapeutic strategies

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I remember being told once, that as technology becomes smaller and smaller and ever decreasing amounts of material required for testing, the larger the room to house them becomes.  I guess this is the pharmaceutical equivalent of Moore’s Law (or should it be eroom’s Law in this case; hard to tell). Well if this trend in technology were to be translated into the delivery of therapeutics, there would be some whose laboratories would need to be the size of small (or perhaps even moderately sized) countries. Over the last few years, I would say that the field of nanotherapeutics has come from virtually nowhere to represent one of the most submitted or suggested article types coming across my desk. I would have to say that they ingenuity in this area seems to hold no bounds and has the potential to revolutionise many aspects of therapy over a wide range of therapeutic applications. The articles in this newsletter are intended in some small way to illustrate some of the technical and practical advances that have become available over the last few years. I hope that you are equally as excited by the potential of some of these approaches as I am.

 

The first article in this month’s offering is entitled: “Design strategies for physical-stimuli- responsive programmable nanotherapeutics”, by Fitsum Feleke Sahle, Muhammad Gulfam and Tao L. Lowe of Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA. In this article, the authors present a systematic approach to design different programmable physicalstimuliresponsive nanotherapeutics intended for controlled and targeted delivery of various therapeutic agents. Such approaches may become ever more useful to control the response of drugs to be controlled both spatially and temporally by external physical stimuli, allowing more precise control over the target site and a significantly improved drug delivery potential.  The ability to facilitate precise site and on demand delivery could offer massive improvements in the treatment of many diseases.

 

Following on from this is the article by Vibhuti Agrahari and Vivek Agrahari entitled: “Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities” from the recent Special Issue on Nanotherapeutic strategies, on which they were guest Editors. The authors point out how understanding of fundamental, characterization, clinical and regulatory aspects of nanomedicines is vital to enhance their translational potential. They go on to discuss the challenges and opportunities related to the commercialization of nanomedicines, essential for the translation of interesting science to valuable medicine.

 

The remaining article in this month’s offering is more of a practical one, related to the nitty gritty of preparation of pharmaceutic nanocrystals. It is from Maria Malamatari, Kevin M.G. Taylor, Stavros Malamataris, Dennis Douroumis and Kyriakos Kachrimanis, entitled: “Pharmaceutical nanocrystals: production by wet milling and applications”. The review outlines the advantages, stabilization, and production of drug nanocrystals with an emphasis on wet milling. Covering their pharmaceutical applications, it reveals why nanocrystals are an industrially-feasible formulation strategy.

 

 

 

Steve Carney was born in Liverpool, England and studied Biochemistry at Liverpool University, obtaining a BSc.(Hons) and then read for a PhD on the Biochemistry and Pathology of Connective Tissue Diseases in Manchester University, in the Departments of Medical Biochemistry and Histopathology. On completion of his PhD he moved to the Kennedy Institute of Rheumatology, London, where he worked with Professor Helen Muir FRS and Professor Tim Hardingham, on the biochemistry of experimental Osteoarthritis. He joined Eli Lilly and Co. and held a number of positions in Biology R&D, initially in the Connective Tissue Department, but latterly in the Neuroscience Department. He left Lilly to take up his present position as Managing Editor, Drug Discovery Today, at Elsevier. Currently, he also holds an honorary lectureship in Drug Discovery at the University of Surrey, UK. He has authored over 50 articles in peer-reviewed journals, written several book chapters and has held a number of patents. On the media front, Dr. Carney has been busy on some hush-hush projects that will be reported on later in the year.

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