Breaking News
November 15, 2018 - Mass shootings may trigger unnecessary blood donations
November 15, 2018 - From heart disease to cancer: New study tracks shift of county death rates
November 15, 2018 - Preventing falls with new sensor technology
November 15, 2018 - Promising technology could improve detection, diagnosis of fatal ovarian cancer
November 15, 2018 - AAP updates concussion recommendations for children and teens
November 15, 2018 - Two genomic tests help identify most effective treatment for breast cancer patients
November 15, 2018 - Researchers evaluate efficacy of salivary biomarkers for early detection of oral cancer
November 15, 2018 - NIH awards $3.5 million to continue development of robotic system for treating brain tumors
November 15, 2018 - Researchers succeed in building protein nanotubes from tiny scaffolds
November 15, 2018 - Rectal bleeding
November 15, 2018 - Nasal delivery of weight-loss hormone eases breathing problems in sleeping mice
November 15, 2018 - $9.6 million grant to fund research on vascular risk factors for brain aging, dementia | News Center
November 15, 2018 - Gum disease linked with diabetes
November 15, 2018 - Study identifies unique functional brain networks associated with ASD behaviors in infancy
November 15, 2018 - EU and industry-funded project aims to personalize diabetes treatment
November 15, 2018 - NIH researchers shed light on causes of HBV-associated acute liver failure
November 14, 2018 - FDA Alert: Implanted Pumps: Safety Communication
November 14, 2018 - Weight loss & acute Porphyria
November 14, 2018 - Researchers identify three sub-types of depression
November 14, 2018 - The puzzle of a mutated gene lurking behind many Parkinson’s cases | News Center
November 14, 2018 - The mystery viruses far worse than flu
November 14, 2018 - Research highlights physical changes in the brain of self-injuring teen girls
November 14, 2018 - Speed and error rate of DNA synthesis influenced by DNA structure
November 14, 2018 - Cranberry consumption modifies impact of animal-based diet on gut health
November 14, 2018 - £500,000 grant could pave way for new antibiotic to battle against drug-resistant superbugs
November 14, 2018 - Trump Administration Finalizes Birth Control Coverage Opt-Out
November 14, 2018 - Modern life offers children almost everything they need, except daylight
November 14, 2018 - Getting better: A patient is more than a collection of numbers
November 14, 2018 - 20 Americans Die Each Day Waiting For Organs
November 14, 2018 - First bifacial molecule can invade double-stranded DNA or RNA
November 14, 2018 - Study finds lack of safety data for using flowers in cooking
November 14, 2018 - Statistical methods play key role in predicting efficacy of new drugs
November 14, 2018 - Research explores how exercise may help fight drug addiction
November 14, 2018 - Health Tip: Limit Fat, Sugar and Salt in Your Child’s Diet
November 14, 2018 - CA 19-9 Blood Test (Pancreatic Cancer): MedlinePlus Lab Test Information
November 14, 2018 - Old drug could have new use helping sick premature babies
November 14, 2018 - Surgery, not antibiotics, should remain first-line treatment for appendicitis | News Center
November 14, 2018 - Researchers to develop sports-specific classification system for blind football
November 14, 2018 - Preschool children show awake responses to naptime nonsense words
November 14, 2018 - Researchers develop innovative treatment to repair damaged brain tissues
November 14, 2018 - Survey shows negative effect of vulvovaginal atrophy symptoms on quality of life for women
November 14, 2018 - Study sheds light on mechanisms that prevent autoimmune attack
November 14, 2018 - Sleep quality found to be worse for women who undergo surgical menopause
November 14, 2018 - One-hour cognitive behavioral therapy session reduces insomnia symptoms in prisoners
November 14, 2018 - New study provides deeper insight into chromosome segregation during mitosis
November 14, 2018 - Surgical menopause leads to more disrupted sleep than natural menopause
November 14, 2018 - Inhibition of one protein clears toxic clumps seen in Parkinson’s disease, study finds
November 14, 2018 - Appendix removal is linked to lower risk of Parkinson’s
November 14, 2018 - Lifting weights for less than an hour a week may reduce cardiovascular disease risk
November 14, 2018 - Pulmonary rehabilitation rarely received by hospitalized COPD patients despite health benefits
November 14, 2018 - New anti-HER2 drug shows promising anti-tumor activity in gullet, stomach and bowel cancers
November 14, 2018 - Regular head circumference assessment of preterm babies can help identify long-term IQ problems
November 14, 2018 - Brigham investigators examine opioid use among Massachusetts adolescents, prescription trends
November 14, 2018 - Study defines biomarker in response to treatment of castration-resistant prostate cancer
November 14, 2018 - Study identifies potential therapeutic strategy for patients with clear cell renal cancer
November 14, 2018 - Bausch Health Announces U.S. Launch of Bryhali (halobetasol propionate) Lotion, 0.01%, for Plaque Psoriasis In Adults
November 14, 2018 - Alpha Fetoprotein (AFP) Tumor Marker Test: MedlinePlus Lab Test Information
November 14, 2018 - Researchers evaluate controversial treatment for Parkinson’s disease psychosis
November 14, 2018 - AI could help veterinarians code their notes
November 14, 2018 - Pre-schoolers with autism thrive in mainstream classroom settings
November 14, 2018 - Individual and work-related factors may help promote hospital physician engagement, finds study
November 14, 2018 - Complementary and alternative medicine is widely used by general population in England
November 14, 2018 - Study reveals link between tobacco availability and smoking during pregnancy
November 14, 2018 - Purdue researchers develop translucent base for silicon patches to deliver exact doses of biomolecules
November 14, 2018 - New technology based on moths and magnets could help treat genetic diseases
November 14, 2018 - Concussion-Related Biomarkers Vary Based on Sex, Race
November 14, 2018 - One more year of high school may shape waistlines later in life
November 14, 2018 - Dissecting high drug costs – Scope
November 14, 2018 - Study shows novel strategy to reduce breast cancer bone metastasis
November 14, 2018 - Empowering the NHS through Industry Partnerships
November 14, 2018 - One size does not fit all in obesity treatment, study finds
November 14, 2018 - Seeking ways to prevent ‘secondary cataracts’
November 14, 2018 - Change Within the Eye May Be Early Warning for Macular Degeneration
November 14, 2018 - Study of 500,000 people clarifies the risks of obesity
November 14, 2018 - Ultrasound releases drug to alter activity in targeted brain areas in rats | News Center
November 14, 2018 - Umass Amherst researchers battle against youth suicide in rural Alaska Native communities
November 14, 2018 - Cancer stem cells depend on amino acid metabolism, and it’s proving to be their Achilles’ heel
November 14, 2018 - Epigenetic link found between prenatal exposure to maternal smoking and offspring’s cardio-metabolic health
November 14, 2018 - Meditation, music may change biomarkers of cellular aging and Alzheimer’s disease in older adults
November 14, 2018 - Multidisciplinaryresearch teams selected to study age-related brain disorders
LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative

LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative

image_pdfDownload PDFimage_print

Researchers at La Jolla Institute for Immunology (LJI) and UC San Diego have been awarded $ 4.5 million as part of the National Cancer Institute’s Cancer Moonshot initiative. The funding will support research to develop new and improved immunotherapeutic treatment options for patients with head and neck cancer.

Led by LJI Professor Stephen Schoenberger, Ph.D., a widely recognized authority on personalized cancer vaccines, the collaborative research effort is part of the Immuno-Oncology Translational Network (IOTN), which was established as part of the Cancer Moonshot with the express goal of accelerating translation of basic discoveries into clinical applications to improve immunotherapy outcomes.

The LJI effort brings together the wide-ranging expertise of researchers and clinicians at La Jolla Institute and the UC San Diego Moores Cancer Center to advance current immunotherapeutic options and develop novel precision approaches such as personalized cancer vaccines and cellular therapies for the treatment of head and neck cancer and related malignancies.

“Neoantigens offer an unprecedented opportunity for attacking tumors in a specific and effective manner based on the altered genes they express,” says Schoenberger, “and this funding will accelerate the development of new therapies based on this premise.”

Cancer immunotherapies build on the fact that the immune system can recognize and eliminate tumor cells by targeting molecules only found on the surface of tumor cells. Just like homing beacons, these so called “neo-antigens” guide T cells to their targets where they then unleash their destructive powers.

Tumor associated neo-antigens are the result of tumor-specific genetic alterations or, as is often the case in head and neck cancer, the random integration of human papillomavirus into the genome. Identifying clinically relevant neo-antigens in cancers with moderate levels of mutations, such as head and neck squamous cell carcinoma (HNSCC), has proven challenging since only a tiny fraction of predicted neo-antigens actually generate a T cell response.

“Tumor neo-antigens are highly variable and no two tumors are alike, which represents a challenge but also the opportunity to create highly personalized treatments,” explains LJI Professor Bjoern Peters, Ph.D., a bioinformatician, who has developed a number of tools to predict and analyze which parts of a pathogen, allergen or cancer cell is recognized and targeted by the immune system. “As we learn more about which features trigger a strong immune response, we can fine-tune our predictions.”

Building on their expertise in predicting and verifying neo-antigen T cell responses, Schoenberger’s team will specifically focus on identifying tumor neo-antigens that can fire up tumor-specific immune responses.

The validated neo-antigens will be further analyzed in HNSCC tumor models in collaboration with Professor J. Silvio Gutkind, Ph.D., Associate Director, Basic Science at Moores Cancer Center, who is particularly interested in the molecular basis of oral and head and neck cancers.

As part of the collaboration, LJI Professor Anjana Rao, Ph.D., will explore the role of T cell exhaustion in mouse and human HNSCC. So-called T cell exhaustion is the result of prolonged overactivity of immune cells summoned to a tumor or infection site and effectively shuts down their ability to dispatch tumor cells.

“This effort is so critical because we need to develop better therapies for patients with head and neck cancer. This is a devastatingly deadly disease and all the science points to improving outcomes by activating the immune system through boosting neoantigen specific T cells. This grant will allow us to lay the essential translational foundation to move better treatments to patients,” says Professor Ezra Cohen, M.D., Associate Director, Translational Science, at Moores Cancer Center. “I am very excited to be working with exceptional researchers at LJI and the opportunity to learn how to devise effective immunotherapies that counter exhaustion and re-motivate T cells to eradicate a patient’s tumor.”

Source:

https://www.lji.org/news-events/news/post/la-jolla-institute-receives-4-5-mill-cancer-moonshot-award/

Tagged with:

About author

Related Articles