Breaking News
January 17, 2019 - Better understanding of aggressive brain tumour
January 17, 2019 - Why is life expectancy in the U.S. going down? A Q&A
January 17, 2019 - The Electronics Industry Sees Money In Your Health
January 17, 2019 - Hypertension drug may improve effectiveness of ovarian cancer treatment
January 17, 2019 - Scientists reveal key mechanism in worms that controls cell’s response to stress
January 17, 2019 - How Patch Clamp Technology Can Benefit Ion Channel Research
January 16, 2019 - Researchers cultivate organoids that perfectly mimic blood vessels
January 16, 2019 - Sound Pharmaceuticals Advances Phase 2 Hearing Loss Clinical Trial in Cystic Fibrosis
January 16, 2019 - Unraveling the genetic causes of skin cancer
January 16, 2019 - Higher percentages of saturated fat in low-carb diets may not harm cholesterol levels, new analysis suggests
January 16, 2019 - Using bottled or tap water impacts health benefits of green tea
January 16, 2019 - Best trained alert dogs have potential to improve Type 1 diabetes patients’ quality of life
January 16, 2019 - States with lower incidence of melanoma have higher mortality rates
January 16, 2019 - Pollution on the London Underground found to be dangerously high
January 16, 2019 - Breast cancer cells in mice coaxed to turn into harmless fat cells
January 16, 2019 - Study connects the genetic background of autistic spectrum disorders with stem cell dysfunction
January 16, 2019 - When activated, ‘social’ brain circuits inhibit feeding behavior in mice | News Center
January 16, 2019 - How Exercise May Help Keep Our Memory Sharp
January 16, 2019 - Researchers identify a key regulator that stops excessive inflammation
January 16, 2019 - TGF-beta signaling pathway in uterine cells protects against cancer
January 16, 2019 - MD Anderson Cancer Center collaborates with Dragonfly for new immunotherapy drug clinical trials
January 16, 2019 - Drug Repurposing May Provide More Psychiatric Tx Options
January 16, 2019 - A new brain imaging study challenges the dominant theoretical model of autism spectrum disorders
January 16, 2019 - GoFundMe CEO: ‘Gigantic Gaps’ In Health System Showing Up In Crowdfunding
January 16, 2019 - Induced neuronal cells derived from fibroblasts are similar to neurons in the brain
January 16, 2019 - New study finds link between childhood abuse and suicide in later life
January 16, 2019 - Lifestyle and health factors that are good for the heart can also prevent diabetes
January 16, 2019 - Scientists take another step in understanding bacteria that cause Salmonella epidemic
January 16, 2019 - Look to Your Aunts, Uncles and Parents for Clues to Your Longevity
January 16, 2019 - Study finds ADHD drugs are unlikely to cause cardiac damage in children who take them
January 16, 2019 - Call The Midwife! (If The Doctor Doesn’t Object)
January 16, 2019 - Changes in hippocampal structural connectivity differentiate responders of electroconvulsive therapy
January 16, 2019 - Study sheds light on the deadly venom of Mojave rattlesnakes
January 16, 2019 - University of Nebraska to develop new drugs that prevent and counteract effects of radiation exposure
January 16, 2019 - Sugar-based stent makes precarious sewing process easier
January 16, 2019 - FDA-approved drug hampers cancer metastasis in animal model, shows study
January 16, 2019 - Low-level cannabis use can change the adolescent brain
January 16, 2019 - MTC in Rouen acquires Robocath’s R-One robot for future healthcare practitioner training
January 16, 2019 - OSSIO granted FDA 510(k) market clearance for OSSIOfiber Bone Pin Family
January 16, 2019 - Childhood body composition may play a role in future respiratory health
January 16, 2019 - Outdated commissioning methods are failing mental health services in the UK, reveals report
January 16, 2019 - Unconventional immune cells trigger disturbed cytokine production in human spondyloarthritis
January 16, 2019 - Patients Turn To GoFundMe When Money And Hope Run Out
January 16, 2019 - Researchers develop novel viral identification method
January 16, 2019 - Study proposes improvements in pharmacological study of cognitive function enhancers in schizophrenia
January 16, 2019 - Study points to potential new biomarker and drug target for amyotrophic lateral sclerosis
January 16, 2019 - Differences in geographic origin of genes may affect mitochondrial function
January 16, 2019 - Study analyzes vaccine-preventable infections in children who receive solid organ transplants
January 16, 2019 - MiRagen Announces New Clinical Data in Patients With Three Different Types of Blood Cancers Treated With Cobomarsen
January 16, 2019 - Scientists uncover why knee joint injury leads to osteoarthritis
January 16, 2019 - Salk team uses new model to study health effects of AMP-activated protein kinase
January 16, 2019 - Research reveals novel approach to suppressing chemotherapy-induced tumor growth
January 16, 2019 - Researchers reveal how fasting leads to better overall health
January 16, 2019 - Deprivation and neglect in early childhood have impact on cognitive functioning in adolescence, shows study
January 16, 2019 - Training Students to use Imaging Techniques: NMR and EPR
January 16, 2019 - Nerve transfer surgery restores arm movement in children with acute flaccid myelitis
January 16, 2019 - Exelixis Announces U.S. FDA Approval of Cabometyx (cabozantinib) Tablets for Previously Treated Hepatocellular Carcinoma
January 16, 2019 - DNA vaccine reduces both toxic proteins linked to Alzheimer’s
January 16, 2019 - Even in the U.S., poor women often can't afford tampons, pads
January 16, 2019 - One time use of Marijuana could affect teen brains finds study
January 16, 2019 - Persistent Opioid Use High in Head, Neck Cancer Patients
January 16, 2019 - Questions to ask your doctor about post pregnancy care: MedlinePlus Medical Encyclopedia
January 16, 2019 - Neurons with good housekeeping are protected from Alzheimer’s
January 16, 2019 - Is mindfulness worthy of all the hype?
January 16, 2019 - Physical Activity, Any Type or Amount, Cuts Health Risk from Sitting
January 16, 2019 - New understanding in the evolution of human feet
January 15, 2019 - AHA: New Cholesterol Guidelines Put Ethnicity in the Spotlight
January 15, 2019 - Different brain areas linked to smoking and drinking
January 15, 2019 - Henry Marsh shares insights into neurosurgery and more at Dean’s Lecture Series
January 15, 2019 - Want to Live Longer? For Just 30 Minutes a Day, Do Anything Else But Sit
January 15, 2019 - The Current issue of “The view from here” is concerned with Targets
January 15, 2019 - Plain packaging sparked tobacco price rises, new study finds
January 15, 2019 - Sedentary lifestyles can be unhealthy, physical activity can lower risk
January 15, 2019 - Gut microbiome may help prevent development of cow’s milk allergy
January 15, 2019 - Lesbian, gay and bisexual individuals more likely to suffer severe substance use disorders
January 15, 2019 - New England Journal of Medicine Publishes Positive Results of the Pivotal Trial of Cablivi (caplacizumab) for Rare Blood Clotting Disorder
January 15, 2019 - Levels of inflammatory marker (CRP) linked to housing type and tenure
January 15, 2019 - Three gifts I’m glad I gave myself in 2018
January 15, 2019 - Columbia’s Pediatrics Department Names New Vice Chairs, Expands Leadership
January 15, 2019 - US FDA Accepts Regulatory Submissions for Review of Tafamidis to Treat Transthyretin Amyloid Cardiomyopathy
Length of breathing disruption in OSA may be better predictor of mortality risk

Length of breathing disruption in OSA may be better predictor of mortality risk

image_pdfDownload PDFimage_print
In OSA, the duration of apnea and hypopnea events during sleep is linked to mortality risk. Credit: ATS

How long a person with obstructive sleep apnea (OSA) stops breathing may be a better predictor of mortality risk from OSA than the number of times they stop breathing, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

In “Apnea-hypopnea Event Duration Predicts Mortality in Men and Women in the Sleep Heart Health Study,” lead study author Matthew P. Butler, Ph.D., and colleagues report that participants who had short apneas and hypopneas (stopped breaths and shallow breaths, respectively) were at greater risk of dying over a decade of follow up.

“This result seems counter-intuitive because you might expect longer periods of not breathing to be more severe,” said Dr. Butler, assistant professor in the Oregon Institute of Occupational Health Sciences at Oregon Health & Science University. “On the other hand, shorter periods of disturbed breathing indicate a low arousal threshold, which would associate with sleep fragmentation, elevated sympathetic tone and greater risk for hypertension.”

Previous studies have shown that the apnea-hypopnea index (AHI), the most widely used measure of sleep apnea severity, is linked to mortality and heart disease. However, according Dr. Butler, AHI remains a coarse measure of sleep apnea severity and is not a good risk predictor for women.

The current study found that the duration of abnormal breathing events may be a better predictor of mortality risk in both women and men. The duration of these events, the authors wrote, is easily determined from the same polysomnography studies that patients now undergo to measure AHI.

The researchers analyzed the records of 5,712 adults (average age 63) who participated in the National Heart, Lung, and Blood Institute (NHLBI)’s Sleep Heart Health Study made available through the Institute’s National Sleep Research Resource.

This community-based study enrolled an approximately equal number of men and women and followed them for up to 11 years.

The study found:

  • Participants with the shortest duration of breathing events were 31 percent more likely to die.
  • This association was strongest in participants with moderate sleep apnea as measured by AHI. In this group, participants with the shortest duration of breathing events had a 59 percent increased risk of dying.

“This study shows the power of ‘big data’ analysis to identify novel predictors of disease outcomes,” said senior study author Susan Redline, MD, senior physician, Division of Sleep and Circadian Disorders at Brigham and Women’s Hospital in Massachusetts. “The findings indicate that there may be several mechanisms by which sleep apnea leads to increased mortality and a need to measure several features associated with apnea occurrence. In particular, apneas of different types and event durations may result in adverse health outcomes.”

According to the researchers, these findings suggest a phenotype of OSA that may be genetically encoded. They add that other studies have shown that the duration of breathing events is highly heritable and that shorter abnormal breathing events are more common in women and in African Americans.

The study has an important limitation. Because it was not a randomized controlled trial, the study could not determine causality between shorter events and death. Shorter events, the authors explained, may be a marker for underlying problems that result in increased deaths, rather than the cause itself.

“This study shows that a readily available trait that is usually not analyzed—the duration of respiratory disturbances—predicts mortality over and beyond that predicted by AHI in both women and men,” Dr. Butler said. “Further research is needed to determine how OSA and a low arousal threshold interact as a health risk.”

Michael Twery, Ph.D., director of the National Center on Sleep Disorders Research at NHLBI, part of the National Institutes of Health, said, “Discovering new ways to measure the connection between abnormal breathing during sleep and risks to health is a great example of how NIH-supported research sets the stage for future medical advances.”


Explore further:
Sleep apnea found to be prevalent, undiagnosed in African-American community

More information:
www.thoracic.org/about/newsroo … ration-mortality.pdf

Matthew P Butler et al, Apnea-Hypopnea Event Duration Predicts Mortality in Men and Women in the Sleep Heart Health Study, American Journal of Respiratory and Critical Care Medicine (2018). DOI: 10.1164/rccm.201804-0758OC

Journal reference:
American Journal of Respiratory and Critical Care Medicine

Provided by:
American Thoracic Society

Tagged with:

About author

Related Articles