Breaking News
November 15, 2018 - Mass shootings may trigger unnecessary blood donations
November 15, 2018 - From heart disease to cancer: New study tracks shift of county death rates
November 15, 2018 - Preventing falls with new sensor technology
November 15, 2018 - Promising technology could improve detection, diagnosis of fatal ovarian cancer
November 15, 2018 - AAP updates concussion recommendations for children and teens
November 15, 2018 - Two genomic tests help identify most effective treatment for breast cancer patients
November 15, 2018 - Researchers evaluate efficacy of salivary biomarkers for early detection of oral cancer
November 15, 2018 - NIH awards $3.5 million to continue development of robotic system for treating brain tumors
November 15, 2018 - Researchers succeed in building protein nanotubes from tiny scaffolds
November 15, 2018 - Rectal bleeding
November 15, 2018 - Nasal delivery of weight-loss hormone eases breathing problems in sleeping mice
November 15, 2018 - $9.6 million grant to fund research on vascular risk factors for brain aging, dementia | News Center
November 15, 2018 - Gum disease linked with diabetes
November 15, 2018 - Study identifies unique functional brain networks associated with ASD behaviors in infancy
November 15, 2018 - EU and industry-funded project aims to personalize diabetes treatment
November 15, 2018 - NIH researchers shed light on causes of HBV-associated acute liver failure
November 14, 2018 - FDA Alert: Implanted Pumps: Safety Communication
November 14, 2018 - Weight loss & acute Porphyria
November 14, 2018 - Researchers identify three sub-types of depression
November 14, 2018 - The puzzle of a mutated gene lurking behind many Parkinson’s cases | News Center
November 14, 2018 - The mystery viruses far worse than flu
November 14, 2018 - Research highlights physical changes in the brain of self-injuring teen girls
November 14, 2018 - Speed and error rate of DNA synthesis influenced by DNA structure
November 14, 2018 - Cranberry consumption modifies impact of animal-based diet on gut health
November 14, 2018 - £500,000 grant could pave way for new antibiotic to battle against drug-resistant superbugs
November 14, 2018 - Trump Administration Finalizes Birth Control Coverage Opt-Out
November 14, 2018 - Modern life offers children almost everything they need, except daylight
November 14, 2018 - Getting better: A patient is more than a collection of numbers
November 14, 2018 - 20 Americans Die Each Day Waiting For Organs
November 14, 2018 - First bifacial molecule can invade double-stranded DNA or RNA
November 14, 2018 - Study finds lack of safety data for using flowers in cooking
November 14, 2018 - Statistical methods play key role in predicting efficacy of new drugs
November 14, 2018 - Research explores how exercise may help fight drug addiction
November 14, 2018 - Health Tip: Limit Fat, Sugar and Salt in Your Child’s Diet
November 14, 2018 - CA 19-9 Blood Test (Pancreatic Cancer): MedlinePlus Lab Test Information
November 14, 2018 - Old drug could have new use helping sick premature babies
November 14, 2018 - Surgery, not antibiotics, should remain first-line treatment for appendicitis | News Center
November 14, 2018 - Researchers to develop sports-specific classification system for blind football
November 14, 2018 - Preschool children show awake responses to naptime nonsense words
November 14, 2018 - Researchers develop innovative treatment to repair damaged brain tissues
November 14, 2018 - Survey shows negative effect of vulvovaginal atrophy symptoms on quality of life for women
November 14, 2018 - Study sheds light on mechanisms that prevent autoimmune attack
November 14, 2018 - Sleep quality found to be worse for women who undergo surgical menopause
November 14, 2018 - One-hour cognitive behavioral therapy session reduces insomnia symptoms in prisoners
November 14, 2018 - New study provides deeper insight into chromosome segregation during mitosis
November 14, 2018 - Surgical menopause leads to more disrupted sleep than natural menopause
November 14, 2018 - Inhibition of one protein clears toxic clumps seen in Parkinson’s disease, study finds
November 14, 2018 - Appendix removal is linked to lower risk of Parkinson’s
November 14, 2018 - Lifting weights for less than an hour a week may reduce cardiovascular disease risk
November 14, 2018 - Pulmonary rehabilitation rarely received by hospitalized COPD patients despite health benefits
November 14, 2018 - New anti-HER2 drug shows promising anti-tumor activity in gullet, stomach and bowel cancers
November 14, 2018 - Regular head circumference assessment of preterm babies can help identify long-term IQ problems
November 14, 2018 - Brigham investigators examine opioid use among Massachusetts adolescents, prescription trends
November 14, 2018 - Study defines biomarker in response to treatment of castration-resistant prostate cancer
November 14, 2018 - Study identifies potential therapeutic strategy for patients with clear cell renal cancer
November 14, 2018 - Bausch Health Announces U.S. Launch of Bryhali (halobetasol propionate) Lotion, 0.01%, for Plaque Psoriasis In Adults
November 14, 2018 - Alpha Fetoprotein (AFP) Tumor Marker Test: MedlinePlus Lab Test Information
November 14, 2018 - Researchers evaluate controversial treatment for Parkinson’s disease psychosis
November 14, 2018 - AI could help veterinarians code their notes
November 14, 2018 - Pre-schoolers with autism thrive in mainstream classroom settings
November 14, 2018 - Individual and work-related factors may help promote hospital physician engagement, finds study
November 14, 2018 - Complementary and alternative medicine is widely used by general population in England
November 14, 2018 - Study reveals link between tobacco availability and smoking during pregnancy
November 14, 2018 - Purdue researchers develop translucent base for silicon patches to deliver exact doses of biomolecules
November 14, 2018 - New technology based on moths and magnets could help treat genetic diseases
November 14, 2018 - Concussion-Related Biomarkers Vary Based on Sex, Race
November 14, 2018 - One more year of high school may shape waistlines later in life
November 14, 2018 - Dissecting high drug costs – Scope
November 14, 2018 - Study shows novel strategy to reduce breast cancer bone metastasis
November 14, 2018 - Empowering the NHS through Industry Partnerships
November 14, 2018 - One size does not fit all in obesity treatment, study finds
November 14, 2018 - Seeking ways to prevent ‘secondary cataracts’
November 14, 2018 - Change Within the Eye May Be Early Warning for Macular Degeneration
November 14, 2018 - Study of 500,000 people clarifies the risks of obesity
November 14, 2018 - Ultrasound releases drug to alter activity in targeted brain areas in rats | News Center
November 14, 2018 - Umass Amherst researchers battle against youth suicide in rural Alaska Native communities
November 14, 2018 - Cancer stem cells depend on amino acid metabolism, and it’s proving to be their Achilles’ heel
November 14, 2018 - Epigenetic link found between prenatal exposure to maternal smoking and offspring’s cardio-metabolic health
November 14, 2018 - Meditation, music may change biomarkers of cellular aging and Alzheimer’s disease in older adults
November 14, 2018 - Multidisciplinaryresearch teams selected to study age-related brain disorders
Knowledge of sex differences in lower urinary tract may help stimulate breakthroughs in diagnosis, management

Knowledge of sex differences in lower urinary tract may help stimulate breakthroughs in diagnosis, management

image_pdfDownload PDFimage_print

The biological differences between women and men go beyond basic anatomy. Researchers must consider sex differences down to the cellular level in order to discover crucial information about the varied development, function, and biology between women and men.

A new report written by the Society for Women’s Health Research’s Interdisciplinary Network on Urological Health in Women and published today in the Biology of Sex Differences journal highlights how improving our knowledge about sex differences in cell biology in the female and male lower urinary tract may help stimulate breakthroughs in the diagnosis and management of urinary dysfunction for both women and men.

For example, while anatomical differences between the sexes have long been thought to be the reason women experience significantly more urinary tract infections (UTIs) than men, more recent evidence supports the existence of other, non-anatomical contributors to women’s increased vulnerability.

The location of the female external urethra and the shorter length of that urethra are typically cited as why women get UTIs up to 30 times more often than men do, with more than half of all women experiencing at least one UTI during their lifetime. However, recent research investigating the role of the reticuloendothelial system, which provides immunity against microbes, suggests that differential expression of immune cells in the bladder may amplify the rate of UTIs in women.

“In addition to our basic anatomy, women and men exhibit sex differences at the cellular level that influence both the form and function of the lower urinary tract,” said senior author Margot S. Damaser, PhD, staff and professor at the Cleveland Clinic and senior research scientist at the Cleveland VA Medical Center. “These differences need to be taken into account when treating urinary dysfunction in order to provide optimal treatment for both women and men.”

The authors note that the review paper should serve as an overview of the current knowledge regarding sex differences in the lower urinary tract, as well as a catalyst for investigators seeking to contribute to the field.

Further investigation of sex differences in lower urinary tract cell types is necessary to better develop our understanding of normal and abnormal function, and specifically, the paper states that more research is needed regarding:

  • How sex differences in urinary microbiome impact susceptibility to UTIs
  • Whether sex differences in native reticuloendothelial system cell populations mediate variations in susceptibility to UTIs
  • The role of sex hormones on lower urinary tract development, physiology and susceptibility to malignancies like cancer

Source:

https://swhr.org/more-than-just-anatomy-sex-differences-in-the-lower-urinary-tract/

Tagged with:

About author

Related Articles