Breaking News
November 17, 2018 - Warmer winter temperatures related to higher crime rates
November 17, 2018 - MCO places increasing emphasis on helping people find and access healthy food
November 17, 2018 - Group of students aim to improve malaria diagnosis using old smartphones
November 17, 2018 - Transplantation of feces may protect preterm children from deadly bowel disease
November 17, 2018 - Researchers explore whether low-gluten diets can be recommended for people without allergies
November 17, 2018 - New and better marker for assessing patients after cardiac arrest
November 17, 2018 - For 7-year-old with failing bone marrow, a life-saving transplant | News Center
November 17, 2018 - New first-line treatment for peripheral T-cell lymphoma approved by FDA
November 17, 2018 - Artificial intelligence could be valuable tool to help young victims disclose traumatic testimony
November 17, 2018 - Breakthrough in the treatment of Restless Legs Syndrome
November 16, 2018 - FDA Approves Keytruda (pembrolizumab) for the Treatment of Patients with Hepatocellular Carcinoma (HCC) Who Have Been Previously Treated with Sorafenib
November 16, 2018 - Eagle Books | Native Diabetes Wellness Program
November 16, 2018 - Patients with common heart failure more likely to have lethal heart rhythms
November 16, 2018 - How AI could help veterinarians code their notes | News Center
November 16, 2018 - Bias-based bullying does more harm to students than generalized bullying
November 16, 2018 - Researchers find first direct evidence that cerebellum plays role in cognitive functions
November 16, 2018 - Non-coding genetic variant plays key role in endothelial function and disease incidence
November 16, 2018 - EMA recommends first all-oral treatment to tackle deadly sleeping sickness
November 16, 2018 - Drug used to treat dizziness may slow down growth of triple-negative breast cancer
November 16, 2018 - AHA: Icosapent Ethyl Cuts CV Risk From Elevated Triglycerides
November 16, 2018 - ‘Orphan’ RNAs make cancer deadlier, but potentially easier to diagnose
November 16, 2018 - Air Cube touches down at hospital | News Center
November 16, 2018 - CRISPR-based tool shown to enhance cell-based immunotherapy
November 16, 2018 - Mechanisms that govern HIV latency differ in the gut and blood, finds study
November 16, 2018 - Researchers unravel mystery of NPM1 protein in acute myeloid leukemia
November 16, 2018 - High school students less likely to select milk, fruit for lunch when fruit juice is available
November 16, 2018 - Football coaches with great emotional competence are more successful
November 16, 2018 - Researchers awarded $10 million grant to address root causes of asthma in Puerto Rico
November 16, 2018 - Health Tip: Manage Morning Sickness
November 16, 2018 - Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study
November 16, 2018 - ACC Latin America Conference brings experts to discuss latest cardiovascular science
November 16, 2018 - Pooled analysis of Intersect ENT’s steroid releasing implants in patients after frontal sinus surgery to be published
November 16, 2018 - Expectations about pain intensity can become self-fulfilling prophecies
November 16, 2018 - NIH awards $3.4 million to UC researchers to study gastrointestinal lymphatic system
November 16, 2018 - Highlighting Advances in Bioengineering and Analytical Technologies with eBooks
November 16, 2018 - Scientist Dr David Taylor of MR Solutions is a finalist in the BMW i UK Tech Founder Awards
November 16, 2018 - Earlier treatment could help reverse autistic-like behavior in tuberous sclerosis
November 16, 2018 - Sucking your baby’s pacifier could improve their health
November 16, 2018 - Vegetables and salad may include bacteria that are resistant to antibiotics
November 16, 2018 - Autism linked to prolonged connection between brain regions
November 16, 2018 - Endocrine Society chooses four Diabetes Caucus leaders as winners of Diabetes Champion Award
November 16, 2018 - Brain and muscle cells found within kidney organoids
November 16, 2018 - Person’s sex hormones may play key role in trauma survival, finds study
November 16, 2018 - PTEN Genetic Test: MedlinePlus Lab Test Information
November 16, 2018 - Toxic metal pollution linked with development of autism spectrum disorder
November 16, 2018 - Calcified nodules in the retina increase risk for progression to late stages of AMD
November 16, 2018 - ZEISS teams up with arivis AG to offer complete 3D imaging solutions
November 16, 2018 - Georgia State professor receives $1.2 million grant to study how the brain controls eating behavior
November 16, 2018 - Specific bacterial toxins reduce number of cells suppressing immune response
November 16, 2018 - Review by ID physician improves outcomes for outpatient parenteral antimicrobial therapy
November 16, 2018 - Conditions that produce signs similar to arthritis
November 16, 2018 - New artificial intelligence-based method predicts treatment effectiveness
November 16, 2018 - AHA: Dapagliflozin Noninferior to Placebo for MACE in T2DM
November 16, 2018 - Surgery remains best treatment for appendicitis, Stanford study finds
November 16, 2018 - Non-surgical fistula creation system Ellipsys becomes key focus of attention at CiDA
November 16, 2018 - Researchers find no link between ‘allergy friendly’ dogs and lower risk of asthma
November 16, 2018 - Researchers elucidate new rules of connectivity of neurons in the neocortex
November 16, 2018 - Treating children with ‘bubble baby disease’
November 16, 2018 - Nexus announces availability of Arsenic Trioxide Injection in the US
November 16, 2018 - Researchers find metabolite shuttle between cells in the liver that may combat tissue fibrosis
November 16, 2018 - AHA: PTSD Common Among Those Who Suffer Tear in the Aorta’s Wall
November 16, 2018 - Many RA patients’ pain related to central nervous system
November 16, 2018 - Changes in Himalayan gut microbiomes linked to diet
November 16, 2018 - Inhibition of prostaglandin E2 enhances ability to combat infectious colitis
November 16, 2018 - Chronic dry eye can slow reading rate and disrupt day to day tasks
November 16, 2018 - Researchers develop new drug molecule that inhibits inflammation
November 16, 2018 - Dementia symptoms peak in winter and spring, study finds
November 16, 2018 - Stanford tobacco researcher weighs in on JUUL
November 16, 2018 - Increasing omega-3 fatty acid intake during pregnancy reduces risk of premature birth, review finds
November 16, 2018 - Researchers find no link between infants waking up at night and later developmental problems
November 16, 2018 - Both parents and children agree about confidential medical services
November 16, 2018 - FDA warns against use of unapproved pain medications with implanted pumps
November 16, 2018 - Precision medicine-based approach to slow or reverse biologic drivers of Alzheimer’s disease
November 16, 2018 - Study provides new insight into norovirus outbreaks, may help guide efforts to develop vaccines
November 16, 2018 - Inexpensive, portable air purifier could help protect the heart from pollution
November 16, 2018 - New 15-minute scan could help diagnose brain damage in babies up to two years old
November 16, 2018 - Deep brain stimulation not effective for treating early Alzheimer’s
November 16, 2018 - Traditional chemotherapy superior to new alternative for oropharyngeal cancers | News Center
November 16, 2018 - What This Pond Protist Does With Its Genome Will Astound You
November 15, 2018 - Researchers develop tool that speeds up analysis and publication of biomedical data
Targeted drug and hormone therapy combination extends breast cancer survival

Targeted drug and hormone therapy combination extends breast cancer survival

image_pdfDownload PDFimage_print

Combining a targeted drug with hormone therapy substantially extends survival for women with advanced breast cancer, a major clinical trial has found.

Women taking palbociclib together with hormone therapy lived seven months longer than those on hormone treatment alone – adding to previous data showing the combination could delay the disease’s progression.

The drug’s benefit was stronger in women who had previously responded to hormone therapy – who lived 10 months longer with the combination treatment.

The international PALOMA-3 clinical trial was led by researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, and involved 144 research centers in 17 countries.

The study was funded by the drug’s manufacturer, Pfizer. It is published in the New England Journal of Medicine today (Saturday), and is being presented simultaneously at the European Society of Medical Oncology congress in Munich, Germany.

The clinical trial tested the benefit of adding palbociclib to the hormone therapy fulvestrant in 521 women with advanced, hormone-sensitive breast cancer whose tumors did not have a protein called HER2.

When women with advanced breast cancer stop responding to other treatments, the only option available is chemotherapy, which can have debilitating side-effects.

The trial examined what effect palbociclib had on women’s overall survival and whether it could delay their having to receive chemotherapy.

In the new analysis, the researchers found that women who received the combination treatment survived for an average of 34.9 months – 6.9 months longer than those who received fulvestrant and a dummy pill.

Three years after they were enrolled in the study, 49.6 per cent of women who received both palbociclib and fulvestrant were still alive, compared with 40.8 per cent of women who were treated with fulvestrant alone.

In women whose tumors had previously been sensitive to hormone therapy, the benefit of palbociclib was even clearer – with the combination treatment extending survival by 10 months.

In these women, those who were given the combination treatment survived for an average of 39.7 months, compared with 29.7 months in women who received fulvestrant alone.

The group of women given the combination treatment also saw a longer delay until the start of chemotherapy.

For these women, the average time between enrollment in the trial and the start of chemotherapy increased to 17.6 months compared with 8.8 months in women who received fulvestrant alone.

The trial was led by Professor Nicholas Turner, who works within the Breast Cancer Research Division and Breast Cancer Now Research Centre at The Institute of Cancer Research (ICR), and is a Consultant Medical Oncologist at The Royal Marsden.

Researchers at the ICR – a research institute and charity – believe the findings strengthen the case for making palbociclib available to women whose cancer has progressed on prior hormone therapy. It was approved by NICE for women with previously untreated advanced breast cancer in November last year.

Professor Nicholas Turner, Professor of Molecular Oncology at The Institute of Cancer Research, London, and Consultant Medical Oncologist at The Royal Marsden NHS Foundation Trust, said:

“The development of palbociclib is one of the biggest advances in treatment for women with advanced breast cancer in the last two decades.

“It’s incredibly rewarding that the benefits we had previously seen for palbociclib are now translating into such significant extensions in survival. This drug can offer women more precious time with their loved ones and because it is a targeted treatment it is much kinder than chemotherapy, and enables many women to carry on with their lives normally.

“I’m keen to see it available on the NHS for women with breast cancer who have been treated previously with hormone therapy, as well as those with newly diagnosed advanced disease, as soon as possible.”

Professor Paul Workman, Chief Executive of The Institute of Cancer Research, London, said:

“Palbociclib is an innovative new drug that targets specific weaknesses in cancer cells, treating breast cancer in a smarter, kinder way than anything that had been available for these women before.

“This important trial provides further evidence that precision therapies for cancer, based on our scientific understanding of tumors, can offer real survival benefits over traditional treatments. It is an illustration too of the way that targeted drugs can be given together in innovative combinations, as a way of tackling cancer’s ability to adapt and evolve, and slowing down development of resistance to treatment.”

Christine O’Connell, 45, from London, who is being treated with palbociclib and hormone therapy for advanced breast cancer, said:

“My treatment with palbociclib and hormone therapy has been much more manageable than the chemotherapy I received when I was first diagnosed with breast cancer in 2012, with all the unpleasant side-effects.

“Without palbociclib, my breast cancer would probably progress sooner. At some point I might need to move on to chemotherapy, but for the moment, palbociclib is doing the job.

“Palbociclib has allowed me to lead a relatively normal life. I’m able to work part-time, and I can keep up my cycling, which I could never have done had I been on conventional therapy.”

Source:

https://www.icr.ac.uk/news-archive/esmo-2018-major-trial-shows-targeted-drug-palbociclib-extends-breast-cancer-survival

Tagged with:

About author

Related Articles