Breaking News
March 22, 2019 - Researchers develop new tool for imaging large groups of neurons in living animals
March 22, 2019 - Certain bacteria and immune factors in vagina may cause or protect against preterm birth
March 22, 2019 - Novel breath test could pave new way to non-invasively measure gut health
March 22, 2019 - Pharmaceutical and personal care products may result in new contaminants in waterways
March 22, 2019 - ACC: Catheter Ablation Does Not Cut Mortality, Stroke in A-Fib
March 22, 2019 - Wiedemann-Rautenstrauch syndrome – Genetics Home Reference
March 22, 2019 - Health insurance is not assurance of healthcare
March 22, 2019 - Supporting “curiosity-driven research” at the Discovery Innovation Awards
March 22, 2019 - Must-Reads Of The Week (Some Flying Below The Radar)
March 22, 2019 - Newly engineered nanoscale protein micelles can be tracked by MRI
March 22, 2019 - Pitt engineers win $550,000 NSF CAREER award to develop new intervention for people with ASD
March 22, 2019 - Early discharge does not increase readmission risk for patients after lung surgery
March 22, 2019 - Creating diverse pool of trained scientists to address Alzheimer’s research needs
March 22, 2019 - Study shows ACA’s positive impact on healthcare affordability and access for women
March 22, 2019 - New combination treatment shows promise for common brain tumor in children
March 22, 2019 - Virginia Tech Helmet Lab releases first youth-specific football helmet ratings
March 22, 2019 - New algae-based treatment could reduce need for limb amputation
March 22, 2019 - Stroke risk reduces in both black and white older Medicare beneficiaries, study reports
March 22, 2019 - City of Hope exhibits current studies and data on cancer therapies at AACR
March 22, 2019 - New study identifies CD40 molecule as key entry point for dangerous bacteria
March 22, 2019 - Health Tip: Six Steps to a Healthier Life
March 22, 2019 - even a little activity helps you live longer
March 22, 2019 - Many individuals recovering from addiction continue to suffer from chronic physical disease
March 22, 2019 - New drugs on PBS for Parkinson’s, MND and Cutaneous T cell lymphoma
March 22, 2019 - Saving energy also saves lives, UW-Madison study says
March 22, 2019 - Former inmates who receive social support have better mental health, study finds
March 22, 2019 - Nanofibrous membrane could enhance periodontal tissue regeneration
March 22, 2019 - Anti-vaxxer Italian leader down with chickenpox
March 22, 2019 - Servier collaborates with Harvard researchers to fight metabolic diseases
March 22, 2019 - National Eating Disorders Association
March 22, 2019 - Pumping up red blood cell production
March 22, 2019 - Excessive phosphate fertilizer may hurt plants by altering microbial composition in soil
March 22, 2019 - Medical marijuana laws could be improving older Americans’ health, study suggests
March 22, 2019 - Study indicates the benefits of stopping aspirin in heart attack patients
March 22, 2019 - Deep brain stimulation offers significant relief for patients with treatment-resistant depression
March 22, 2019 - Mental health problems in young adults on the rise
March 22, 2019 - Innovative membrane offers a viable solution for periodontitis
March 22, 2019 - The FDA Grants Rare Pediatric Disease Designation to Odiparcil for the Treatment of MPS VI
March 22, 2019 - insulin therapy: MedlinePlus Medical Encyclopedia
March 22, 2019 - Guidelines on the use of genetic testing in psychiatry
March 22, 2019 - Aspiring Doctors Seek Advanced Training In Addiction Medicine
March 22, 2019 - A change in focus could enable the development of new treatments for Alzheimer’s disease
March 22, 2019 - A new way to visualize the immune cell “landscape” of bowel cancer tumors
March 22, 2019 - Understanding maintenance of quiescent stem cells in chronic myelogenous leukemia
March 22, 2019 - Ludwig scientists to share advances in cancer research at AACR Annual Meeting 2019
March 22, 2019 - Less invasive valve replacement can be safe and effective alternative for healthier patients
March 22, 2019 - Aphasia research reveals new, complex interactions between thought and language
March 22, 2019 - Artificial neural networks can predict how different areas in the brain respond to words
March 22, 2019 - Age-related changes to gut microbiome have adverse impact on vascular health, study shows
March 22, 2019 - Study provides new insight into blood cell and immune cell production
March 22, 2019 - Isolated seniors chat online to prevent cognitive decline
March 22, 2019 - Repurposing drugs to outsmart cancers
March 22, 2019 - Naltrexone implant more effective in reducing relapses in HIV patients with opioid addiction
March 22, 2019 - The Brain Institute wins $7.04 million grant to investigate ‘neurophilosphy of free will’
March 22, 2019 - Karyopharm Announces FDA Extension of Review Period for Selinexor New Drug Application
March 22, 2019 - Eruptive xanthomatosis
March 22, 2019 - Cause of vascular disease in kidney failure reversed in animal model
March 22, 2019 - Researchers discover possible new therapeutic strategy for pancreatic cancer
March 22, 2019 - Ebola spreads to second largest city in DRC
March 22, 2019 - Perivascular spaces contribute to worse cognitive health in older adults
March 22, 2019 - Adolescent daily users more likely to obtain electronic cigarettes from commercial sources
March 22, 2019 - FDA Approves Genentech’s Tecentriq in Combination With Chemotherapy for the Initial Treatment of Adults With Extensive-Stage Small Cell Lung Cancer
March 22, 2019 - Diabetes myths and facts: MedlinePlus Medical Encyclopedia
March 22, 2019 - TGen and ABL pursue global rollout of advanced TB test
March 22, 2019 - Traffic light labels influence people to choose healthier and more sustainable meals
March 22, 2019 - Alzheimer’s patients using antiepileptic drugs have twice the risk of pneumonia, study shows
March 22, 2019 - Skin diseases may be more prevalent than previously thought
March 22, 2019 - Overall rates of death from breast cancer are falling across the EU
March 22, 2019 - Novel plasmid could hold key to control of mosquito-borne illness
March 22, 2019 - Female Emergency Physicians Paid Less Than Males
March 22, 2019 - Estimated average glucose (eAG): MedlinePlus Medical Encyclopedia
March 22, 2019 - Experimental drug could be new option for type 2 diabetes
March 22, 2019 - Five Things To Know About The Electronic Health Records Mess
March 22, 2019 - TMJ disorders could be treated with tissue-engineered implants after successful animal study
March 22, 2019 - Team-based approach is key to successful care of pregnant women with heart failure
March 22, 2019 - Study identifies gene variant associated with accelerated cellular aging
March 21, 2019 - Salk scientists show how background noise from neurons can interrupt focused attention
March 21, 2019 - New class of drugs could help treat patients diagnosed with ovarian cancer
March 21, 2019 - Tecentriq Approved for Small Cell Lung Cancer
March 21, 2019 - Adipocyte glucocorticoid receptors play a role in developing steroid diabetes
Multi-national database can help researchers address questions about bipolar disorder throughout adult lifespan

Multi-national database can help researchers address questions about bipolar disorder throughout adult lifespan

image_pdfDownload PDFimage_print

Not much is known about how bipolar disorder (BD) affects people throughout their lives. Do women and men differ in the severity of their symptoms? Does a person’s age when a bipolar diagnosis is made have any bearing on how severe the symptoms are? How do other medical conditions affect symptoms of BD across the life-span?

These questions and others like them are the focus of an international team of researchers, joined by Martha Sajatovic, MD, professor of psychiatry and of neurology at Case Western Reserve University School of Medicine, who has received a three-year, $600,000 grant from the International Society for Bipolar Disorders. She and her colleagues will develop the first-of-its-kind multi-national database that can be used to help researchers address questions about BD throughout the adult lifespan.

“Bipolar disorder affects millions of people at all ages,” said Sajatovic. “The need for this work reflects the demographic tsunami of people living longer lives both in this country and worldwide. It is crucial to understand how bipolar disease evolves as people with the condition age. This will help us anticipate their needs better and develop appropriate treatment plans for different stages of life. In particular, this applies to older age, since by 2030, more than fifty percent of bipolar patients will be 60 and above.”

Under the grant, Sajatovic and her colleagues, aided by a steering committee of other bipolar experts, will aggregate and standardize data from more than 1,000 bipolar patients worldwide who have been previously studied. But most findings from these studies are based on research samples of no more than 50 participants from a relatively narrow geographic and age representation. By creating a single comprehensive data set, the scientific team aims to overcome these shortfalls and increase knowledge about BD, its symptoms, and changes in behavior at different stages of life.

For example, some of these studies suggest a progressive worsening of symptoms, with more depression in older age and fewer psychotic symptoms. (Many people with BD experience at least one symptom of psychosis, such as delusions and hallucinations, during their lives.) But is this the case more generally? Or is there something about the relatively small populations that were studied that rules out generalizing the findings to more people? “Having access to sufficiently large data samples will enable researchers to determine if these and other trends are valid for the population as a whole,” said Sajatovic. “It will also help uncover other patterns of and predictors for bipolar disease that we may only currently have no or little knowledge about.”

Other areas that the integrated database will allow investigators to examine include mood-symptom changes over time, common medical problems found in people with BD, long-term effects of medications on general health, and the evolution of cognitive function over time.

Sajatovic, who is the lead investigator of a team of authorities in BD and data science that will carry out the work of the grant, is also Willard Brown Chair in Neurological Outcomes Research and director of the Neurological and Behavioral Outcomes Research Center at University Hospitals Cleveland Medical Center. In addition to Sajatovic, the study leaders include Lisa Eyler, PhD, from the University of California; Annemiek Dols, MD, PhD, from the Dutch Association of Mental Health and Addiction Care in Amsterdam, the Netherlands; and. Soham Rej, MD, from McGill University in Montreal.

Also known as manic depression, BD is a mental health condition that causes unusually large shifts in mood, ranging from extreme emotional highs (mania) to debilitating lows (depression). Directly affecting more than five million people, an estimated 4.4 percent of U.S. adults experience the condition at some time in their lives, with nearly three percent having had BD episodes in the past year. The effects of the disease extend to millions more family members, co-workers, and friends.

Tagged with:

About author

Related Articles