Breaking News
November 18, 2018 - Pharmacist-Led Effort Cuts Inappropriate Rx in Older Adults
November 18, 2018 - Novel discovery could lead to new cancer, autoimmune disease therapy
November 18, 2018 - AHA and ADA launch new initiative to help people with type 2 diabetes reduce heart disease risk
November 18, 2018 - Balanced production of pro and anti-inflammatory cytokines at two years of age protects against malaria
November 18, 2018 - New pharmacological agent shows promise for prevention of heart rhythm disorders
November 18, 2018 - All That Social Media May Boost Loneliness, Not Banish It
November 18, 2018 - Scientists shine new light on link between obesity and cancer
November 18, 2018 - Risk factors for cardiovascular disease closely track with changes in diet patterns
November 18, 2018 - Biogen Scoops Sixth Prix Galien Award with UK Win for Life-Changing Rare Disease Medicine
November 18, 2018 - Detectable HIV-1 in treated human liver cells found to be inert
November 18, 2018 - Using light to control crucial step in embryonic development
November 18, 2018 - Unusual case of father-to-son HIV transmission reported
November 18, 2018 - FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
November 18, 2018 - Poverty blamed on widening north-south gap in young adult deaths in England
November 18, 2018 - Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
November 18, 2018 - Consensus Statement Issued on Management of Foot, Ankle Gout
November 18, 2018 - Fine particle air pollution is a public health emergency hiding in plain sight
November 18, 2018 - In-hospital mortality higher among patients with drug-resistant infections
November 17, 2018 - Research shines new, explanatory light on link between obesity and cancer
November 17, 2018 - FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
November 17, 2018 - Tracking Preemies’ Head Size May Yield IQ Clues
November 17, 2018 - Scientists call for unified standards in 3-D genome and epigenetic data
November 17, 2018 - Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
November 17, 2018 - New strategy to hinder emergence of antimicrobial-resistant pathogens
November 17, 2018 - Sexuality education before age 18 may reduce risk of sexual assault in college
November 17, 2018 - Reducing cellular proliferation could help deplete HIV reservoir and lead to a functional cure
November 17, 2018 - New model of FSHD could be useful to study effectiveness of experimental therapeutics
November 17, 2018 - FDA approves antibacterial drug to treat travelers’ diarrhea
November 17, 2018 - Lab Innovations 2018 confirmed as a major hit with visitors, exhibitors and speakers
November 17, 2018 - Largest parasitic worm genetic study hatches novel treatment possibilities
November 17, 2018 - UCLA biologists uncover how head injuries can lead to serious brain disorders
November 17, 2018 - Static and dynamic physical activities offer varying protection against heart disease
November 17, 2018 - Obesity significantly increases risk of Type 2 diabetes and coronary artery disease
November 17, 2018 - Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission
November 17, 2018 - People with rare cancers can benefit from genomic profiling, shows research
November 17, 2018 - NIH awards over $1.8 million to husband-and-wife doctors to test new breast cancer approach
November 17, 2018 - Four-in-one antibody used to fight flu shows promise in mice
November 17, 2018 - New approach allows pathogens to be starved by blocking important enzymes
November 17, 2018 - Higher body mass index could cause depression even without health problems
November 17, 2018 - Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension
November 17, 2018 - FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated Systemic Anaplastic Large Cell Lymphoma or Other CD30-Expressing Peripheral T-Cell Lymphomas
November 17, 2018 - ID specialist input improves outcomes for outpatient parenteral antimicrobial therapy
November 17, 2018 - UT Southwestern scientists selected to receive 2019 Edith and Peter O’Donnell Awards
November 17, 2018 - New clinical algorithm to help individuals manage type 2 diabetes when fasting during Ramadan
November 17, 2018 - Researchers identify LZTR1 as evolutionarily conserved component of RAS pathway
November 17, 2018 - Heart Disease Leading Cause of Death in Low-Income Counties
November 17, 2018 - Estrogen Levels Test: MedlinePlus Lab Test Information
November 17, 2018 - Research reveals link between immunity, diabetes
November 17, 2018 - Research shows how to achieve improved smoking cessation outcomes within California’s Medicaid population
November 17, 2018 - New study finds less understanding and implementation of patient engagement
November 17, 2018 - New shoe insole technology could help diabetic ulcers heal better while walking
November 17, 2018 - New method to extend cell division and immortalization of avian-derived cells
November 17, 2018 - Australian Academy of Science urges parents to vaccinate children against meningococcal disease
November 17, 2018 - Hot water treatment may help improve inflammation and metabolism in sedentary people
November 17, 2018 - Researchers produce 3D chemical maps of small biological samples
November 17, 2018 - Must Blood Pressure Rise Wth Age? Remote Tribes Hold Clues
November 17, 2018 - Noonan Syndrome
November 17, 2018 - Interventions to delay and prevent type 2 diabetes are underused, researchers say
November 17, 2018 - Hackathon prize winner seeks to remotely monitor patient skin conditions
November 17, 2018 - Research team identifies Ashkenazi Jewish founder mutation for Leigh syndrome
November 17, 2018 - Gene editing could be used to halt kidney disease in patients with Joubert syndrome
November 17, 2018 - Study uncovers link between gut disruption and aging
November 17, 2018 - Teens more likely to pick up smoking after exposure from friends and family
November 17, 2018 - Nicoya designate the Institute for Stem Cell Biology and Regenerative Medicine as the OpenSPR Centre of Excellence
November 17, 2018 - new horizon in dental, oral and craniofacial research
November 17, 2018 - How does poor air quality affect your health?
November 17, 2018 - New device can regulate children’s blood glucose more like natural pancreas
November 17, 2018 - Game-Changers in Western Blotting and Protein Analysis
November 17, 2018 - FDA announces new actions to limit sale of e-cigarettes to youth
November 17, 2018 - Warmer winter temperatures related to higher crime rates
November 17, 2018 - MCO places increasing emphasis on helping people find and access healthy food
November 17, 2018 - Group of students aim to improve malaria diagnosis using old smartphones
November 17, 2018 - Transplantation of feces may protect preterm children from deadly bowel disease
November 17, 2018 - Researchers explore whether low-gluten diets can be recommended for people without allergies
November 17, 2018 - New and better marker for assessing patients after cardiac arrest
November 17, 2018 - For 7-year-old with failing bone marrow, a life-saving transplant | News Center
November 17, 2018 - New first-line treatment for peripheral T-cell lymphoma approved by FDA
November 17, 2018 - Artificial intelligence could be valuable tool to help young victims disclose traumatic testimony
November 17, 2018 - Breakthrough in the treatment of Restless Legs Syndrome
November 16, 2018 - FDA Approves Keytruda (pembrolizumab) for the Treatment of Patients with Hepatocellular Carcinoma (HCC) Who Have Been Previously Treated with Sorafenib
Samara scholars assessed a new way of skin cancer early diagnostics

Samara scholars assessed a new way of skin cancer early diagnostics

image_pdfDownload PDFimage_print

A team of scholars of Samara National Research University and Samara State Medical University as well as clinic specialists of Samara Regional Oncology Centre (SROC) tested a new way of skin cancer early diagnostics with the help of original complex of three devices.

The efficiency of oncology treatment is directly connected with the timeliness of their detection. For instance, for melanoma – the most aggressive form of skin tumor detected at the first stage – five-year survival rate after the treatment makes 98% and does not exceed 15% with diagnostics at the fourth stage.

Methods created by the team of Samara scholars allowed enhancing the efficiency of active and early skin neoplasm diagnostics up to 97% when the exactness of usual standard clinical research does not exceed 50-60%.

The research results are given in the article “Combined Raman and autofluorescence ex vivo diagnostics of skin cancer in NIR and visible regions” which was published in one of the most authoritative journals devoted to the use of modern optical technology for research in Medicine and Biology – Journal of Biomedical Optics.

In the basis of methodology developed by Samara scholars at the Department of Laser and Biotechnical Systems of Samara University (headed by professor Valeriy Zakharov) is a system of spectral measurement of problem skin areas with the further medical interpretation of the received data offered by the Department of Oncology of SSMU (headed by professor Sergey Kozlov).

As professor Zakharov explained the developed system of spectral measurement allows registering parameters of a patient’s skin in many spectral ranges simultaneously and this gives opportunity to spot pathological changes on cell level as ill cells in their range are different from the healthy ones.

This means is the most suitable for screening programmes: not only it allows diagnosing pathology rather precisely and quickly, but it also does not require any use of additional consumable materials and chemical agents and permits to do without the use of invasive method of diagnosis confirmation. “For example, in case of suspicion in skin melanoma incorrect biopsy of a tumour increases the risk of metastasis”, – Alexander Moryatov, the curator of the project, associate professor of the department of Oncology of SSMU added. – In any case after examination of a patient and surgical treatment we finally confirm the diagnosis morphologically”.

The scholars use three devices for diagnostics.

The first one is an experimental setting for measurement of Raman scattering, it studies spectral characteristics of neoplasms, first of all, skin melanoma. According to Sergey Kozlov this device is suitable for precise diagnostics of a malignant tumor nature allowing to diagnose and differentiate between melanoma and other forms of skin tumor quickly and safely. “This setting can be set in an ordinary regional hospital”, – the professor specified.

The second device – dermatoscope – gives a visual picture of tumor with the maximum approach to its surface and allows seeing and fixing characteristic signs of this disease in real time. According to Sergey Kozlov this device can be compared favorably with the similar ones in respect of a user-friendly interface, the ability to conduct analysis in the mode of polarized light, as well as with the help of special highlight to study peculiarities of melanin, hemoglobin, structure of capillary network in the studied skin area.

The third – hyperspectral camera – allows in a short period of time to make several tens of shots in different ranges (for different skin neoplasms are characteristic different optical characteristics) with high definition.

All three devices represent a joint development of Samara University scholars, SSMU and SROC and are directed at comparative research of optical characteristics of healthy and pathologically changed tissues in which analysis of different types of neoplasms is built on the basis of joint interpretation of their ranges got with the application of completely safe technologies and laser light sources of different wavelengths.

It is said about two types of spectral analysis the character of which depends on biochemical composition of tissues under investigation – Raman spectrum (RS) and autofluorescence spectrum (AS). “Thus “double” spectroscopy allows, as our experiments show, getting information about tissue structure on the basis of which different types of skin tumor can be identified rather precisely”, – Ivan Bratchenko, associate professor of Department of Laser and Biotechnical Systems of Samara University, asserts.

All three devices work at the department of Oncology of SSMU, clinical site of Samara Regional Clinical Ontology Dispensary and have already been used for several months when oncologists examine patients. With the help of this equipment more than 400 people have already been examined. “The received results give hope that we approach precise diagnostics comparable with morphological research”, – Alexander Moryatov mentioned.

According to Sergey Kozlov diagnostic devices showed high resolution and with time can emerge in the market of medical equipment: “We have few rivalries in Russia and abroad and here we have received better results”.

Samara scholars connect perspectives of their research in diagnostics of skin neoplasm with the increase of its resolution due to the complication of mathematical analysis of spectrum data. Their further plans are to integrate a complex of three devices with fiber-optics to use them for diagnosis of inner located tumors (gastrointestinal tract, lungs, etc.) preserving with this safe for a human being research principle – spectral analysis of tumors.

Tagged with:

About author

Related Articles