Breaking News
April 19, 2019 - Key research takeaways from ECCMID 2019
April 19, 2019 - AI Can Identify Model of Cardiac Rhythm Device From Chest X-Ray
April 19, 2019 - New way to combat childhood anxiety: treat the parents
April 19, 2019 - Women getting C-sections best judge of own pain medication needs | News Center
April 19, 2019 - Immune responses that prevent fungal infections may eliminate Trichinella spiralis
April 19, 2019 - Exercising in the morning, rather than at night, may yield better results, shows study
April 19, 2019 - Why eating ‘right’ could cause you to stray from your diet
April 19, 2019 - Health Tip: Antidepressant Precautions – Drugs.com MedNews
April 19, 2019 - Bigger portions lead to preschoolers eating more over time
April 19, 2019 - Specific strains of Staphylococcus aureus linked to wounds that do not heal
April 19, 2019 - Revolutionary discovery paves new way for treatment of necrotizing enterocolitis
April 19, 2019 - Drug that treats high blood pressure shows promise against neurodegenerative diseases
April 19, 2019 - More care is needed for patients after kidney transplantations, reports research
April 19, 2019 - Virtual reality offers benefits for Parkinson’s disease patients
April 19, 2019 - Liver Illness Strikes Latino Children Like A ‘Silent Tsunami’
April 19, 2019 - Disruptive behaviors in autistic children linked to reduced brain connectivity
April 19, 2019 - New insights into how vitamin D affects immune system
April 19, 2019 - Pfizer Announces Presentation of Data from a Phase 2 Study of its 20-Valent Pneumococcal Conjugate Vaccine Candidate Being Investigated for the Prevention of Invasive Disease and Pneumonia in Adults Aged 18 Years and Older
April 19, 2019 - Exercise can improve non-motor symptoms of Parkinson’s disease
April 19, 2019 - KZFPs play a key role in the regulation of human genome
April 19, 2019 - Extracts of ginkgo seeds show antibacterial activity on pathogens that cause skin infections
April 19, 2019 - Groundbreaking experiment in pigs challenges the notion about brain damage
April 19, 2019 - Improving the quality of digital pathology imaging
April 19, 2019 - Scientists get closer to injecting artificial lymph nodes into people to fight disease
April 19, 2019 - Exercises and swimming goggles may reduce adverse effects on eye during long spaceflights
April 19, 2019 - Review suggests a reciprocal relationship between obesity and self-control
April 19, 2019 - Study identifies how enterococci bacteria cause antibiotic-resistant bloodstream infections
April 19, 2019 - Triple negative breast cancer develop resistance to chemotherapy by turning on molecular pathway
April 19, 2019 - Researchers identify key clues to brain and pancreas development
April 19, 2019 - Metformin May Cut Risk for Prematurity, Miscarriage in PCOS
April 19, 2019 - Obese mouse mothers trigger heart problems in offspring
April 19, 2019 - Research sheds light on how leukemia cells become resistant to drugs
April 19, 2019 - Health Tip: Stopping Nosebleeds – Drugs.com MedNews
April 19, 2019 - Pediatric endocrinologist gives iconic ‘Mona Lisa’ a second medical opinion
April 19, 2019 - Tapping patients’ wisdom for C-section pain management
April 18, 2019 - Why have autism rates ‘exploded’ in New Jersey?
April 18, 2019 - Microbiome science may help doctors to improve treatment for children with IBS
April 18, 2019 - New gene therapy cures babies with fatal ‘Bubble Boy’ disease
April 18, 2019 - No female mice? Scientists may still approve NIH grant
April 18, 2019 - What needs to be said about mental health in medicine
April 18, 2019 - Hickenlooper Expanded Medicaid, Created State-Run Marketplace To Insure Nearly All Coloradans
April 18, 2019 - Cancer cells grown in tumor-mimicking environment can help predict the effect of experimental drugs
April 18, 2019 - Albireo Announces FDA Clearance of IND to Commence Phase 2 Trial of Elobixibat for the Treatment of NAFLD/NASH
April 18, 2019 - Adhesive gel bonds to eye surface, could repair injuries without surgery
April 18, 2019 - The future of genomics: A podcast featuring Stanford geneticists
April 18, 2019 - As Syphilis Invades Rural America, A Fraying Health Safety Net Is Failing To Stop It
April 18, 2019 - APOE gene impacts sleep depending on gender and severity of Alzheimer’s
April 18, 2019 - PCORI’s newly approved awards focus on cancer pain and opioid use disorders
April 18, 2019 - New tool provides a standard way to measure effects of caring for survivors of TBI
April 18, 2019 - Smartphone use risks eye examination misdiagnosis
April 18, 2019 - How drug-resistant bugs grow in CF patients’ lungs
April 18, 2019 - Gordana Vunjak-Novakovic Elected to American Academy of Arts & Sciences
April 18, 2019 - Podcast: KHN’s ‘What The Health?’ You Have Questions, We Have Answers
April 18, 2019 - Diabetic drug shows potential to be repurposed as heart disease treatment for non-diabetic patients
April 18, 2019 - New estimation method assesses natural variations in sex ratio at birth
April 18, 2019 - UTA scientist receives $1.17 million grant for cancer research
April 18, 2019 - Coagulation factor VIIa prevents bleeds in hemophilia animal models
April 18, 2019 - Researchers identify risk factors for severe infection after knee replacement
April 18, 2019 - Mass drug administration can offer community-level protection against malaria
April 18, 2019 - FDA’s added sugar label could have substantial health and cost-saving benefits
April 18, 2019 - Researchers identify cause of inherited metabolic disorder
April 18, 2019 - Single strip of white paint not sufficient to protect people who ride bikes
April 18, 2019 - Partner status influences link between sexual problems and self-efficacy in breast cancer survivors
April 18, 2019 - Colorectal Neoplasia Risk Up for Hodgkin Lymphoma Survivors
April 18, 2019 - Rigid spine muscular dystrophy – Genetics Home Reference
April 18, 2019 - Simple bile acid blood test could tell risk of stillbirth
April 18, 2019 - Center for Experimental Therapeutics aims to enable all steps of drug development | News Center
April 18, 2019 - Falling for telephone scams could be an early sign of dementia
April 18, 2019 - Researchers annotate key neuronal proteins in lamprey genome
April 18, 2019 - Study uncovers new biomarker for personalized cancer treatments
April 18, 2019 - Scientists enter research collaboration to find a cure for cancer
April 18, 2019 - Study to compare benefits of tai chi and mindfulness meditation on MS symptoms
April 18, 2019 - Gestational diabetes during pregnancy may increase risk of type 1 diabetes in children
April 18, 2019 - Maternal age has no effect on IVF success, conclude researchers
April 18, 2019 - Is a New Remedy for Body Odor on the Horizon?
April 18, 2019 - Orthostatic hypotension – Genetics Home Reference
April 18, 2019 - Healing the heartbreak of stillbirth and newborn death
April 18, 2019 - New study calls healthiness of eggs into question
April 18, 2019 - Conference to highlight advances in human immune monitoring, bioinformatics | News Center
April 18, 2019 - Bacteria use viruses for self-recognition, study reveals
Groundbreaking Khíron chip enables fast, accurate intra-tissue measurement

Groundbreaking Khíron chip enables fast, accurate intra-tissue measurement

image_pdfDownload PDFimage_print

A new gold standard for electrical measurement in the emerging in vitro world of three dimensional models. That’s what Swiss medtech 3Brain has established by partnering with CSEM. Its Khíron chip enables fast, accurate intra-tissue measurement and continuous nutrient and oxygen supply through all tissue layers for the first time. And it is set to unlock the potential of next-generation cell culture models in disease modeling and preclinical studies.

Khíron embedded in its substrate, ready to be used with cells.

Modeling systems have become a highly promising tool for understanding the mysteries of the brain, one of the biggest scientific challenges of the century. Over the last decade, three dimensional in vitro biological models such as spheroids and brain organoids have emerged, proving to reliably mimic the microenvironment of living tissues and bridge the gap with in vivo animal models. As the spatial distribution of cells in tissue affects gene expression, signal transduction and several biological functions, this 3D approach enables far better disease modeling and preclinical pharmacokinetic studies than its 2D predecessor. Increasing use of this revolutionary technique has, however, revealed the limitations of existing methods for measuring the activity of neurons packed in a 3D environment.

Revolutionizing recording from complex 3D neuronal assemblies

The ‘z-dimension’ poses serious limits on optical measurements as well as on conventional planar micro electrode arrays (MEAs). Standard cell culture model measuring techniques can only monitor events on the surface of biological samples, thus missing the neuronal processing taking place in the three dimensions. 3Brain, the first company in the world to design and realize high resolution MEAs, has developed a solution that overcomes all these complex technological challenges.

With our new technology we aimed to get inside the tissue and replicate the right environment with continuous cell perfusion so that measurements are much more predictive of what will actually happen in clinical trials,”

Mauro Gandolfo, CEO of 3Brain

3Brain, a CSEM spin-off, developed its new MEA chip in partnership with CSEM within an Innosuisse project. Together, the partners have introduced several innovations. “These include microelectronic circuit design to interface a large neuronal network, post-CMOS MEMS processing to fabricate 3D electrodes and a packaging solution compatible with the culture of biological in vitro models,” explains Michel Despont, Vice-President and Head of CSEM’s microsystems program, whose team also carried out biological validation with relevant neuronal models. “CSEM’s ability to bring together this wide variety of competencies, combined with its long successful relationship with 3Brain, were instrumental in getting the chip for 3D brain tissue modeling to market.”

Improving disease understanding and drug development success

Named Khíron, the new application-specific integrated circuit (ASIC) provides a high density MEA specifically targeting intra-tissue measurement of a 3D structure in vitro models by integrating a micro-needle for each electrode for in vitro penetration of brain tissue. It also includes a microfluidic structure at the base of the chip for fluidic exchange even from the bottom layers, unlike most conventional MEA devices.

“The Khíron chip gives neuroscientists the tool they have been waiting for to solve their problems and acquire the information they want from 3D in vitro models” says Dr Gandolfo. “I think it will have a big impact in disease modeling for Alzheimer’s and Parkinson’s and also in the study of conditions like epilepsy and autism.”

3Brain will present Khíron at the SfN Society for Neuroscience annual meeting 2018 (3-7 Nov). The company will introduce its innovation to the market in 2019, initially targeting laboratories and universities interested in undertaking validation studies. It will then be integrated into the next generation of its products for the pharmaceutical and biotechnology sectors. 3Brain expects its new technology to double sales in two years.

Source:

https://www.csem.ch/page.aspx?pid=51660

Tagged with:

About author

Related Articles