Breaking News
November 13, 2018 - Entasis Therapeutics Announces Zoliflodacin Phase 2 Results Published in The New England Journal of Medicine
November 13, 2018 - Gene changes driving myopia reveal new focus for drug development
November 13, 2018 - $6 million grant to support study of preeclampsia, atherosclerosis links | News Center
November 13, 2018 - Beneficial gut microbes metabolize high-fiber diet to improve heart health in mouse model
November 13, 2018 - Excessive use of social media through visual postings linked to increase in narcissistic traits
November 13, 2018 - Study finds why obesity both fuels cancer growth and helps immunotherapy to kill tumors
November 13, 2018 - Women prefer and invest more in daughters, while men favor sons
November 13, 2018 - With hospitalization losing favor, judges order outpatient mental health treatment
November 13, 2018 - Transgenic rat model may provide new insights into cerebral amyloid angiopathy
November 13, 2018 - Study identifies factors tied to greater risk of advanced liver disease in cystic fibrosis patients
November 13, 2018 - Risk of blindness among premature babies with low levels of blood platelets
November 13, 2018 - A new strategy for combatting antibiotic-resistant infections
November 13, 2018 - Study aims to find which outreach method is more effective at improving cancer screening rates
November 13, 2018 - Insufficient sleep duration linked with unhealthy lifestyle profile among children
November 13, 2018 - IIASA researchers introduce new, simple measure for human wellbeing
November 13, 2018 - Scientists examine FCMs containing silver nanoparticles
November 13, 2018 - Failed DNA repair triggers chromosomal chaos
November 13, 2018 - Food insecurity during pregnancy linked to severity of neonatal abstinence syndrome
November 13, 2018 - Majority of Americans are concerned about health threat posed by antibiotic resistance
November 13, 2018 - Addition of Elotuzumab Ups PFS in Refractory Multiple Myeloma
November 13, 2018 - Study finds women with pregnancy-related nausea, vomiting use marijuana more
November 13, 2018 - Lethal heart rhythm more likely to be found in patients with common heart failure
November 13, 2018 - Study provides new clues to origin and development of multiple sclerosis
November 13, 2018 - Climate change could pose threat to male fertility
November 13, 2018 - Researchers discover how mitochondria deploy a powerful punch against disease-causing bacteria
November 13, 2018 - AHA: Traumatic Childhood Could Increase Heart Disease Risk in Adulthood
November 13, 2018 - Feeling the Burn? | NIH News in Health
November 13, 2018 - Women’s birth canals in Kenya, Korea, Kansas not the same: study
November 13, 2018 - Fecal microbiota transplantation effective against ICI-associated colitis
November 13, 2018 - New physical activity guidelines released that urge people to “move more”
November 13, 2018 - Angiotensin receptor blockers improve sodium excretion in blacks
November 13, 2018 - New project seeks to address alarming injury rate in youth footballers
November 13, 2018 - Fish oil or omega 3 fatty acid supplements can prevent heart attacks finds study
November 13, 2018 - The Human Heart-in-a-Jar That Could One Day Replace Animal Testing
November 13, 2018 - Treat patients’ partners without a doctor visit
November 13, 2018 - Belgian beer landscape mapped using scientific insights
November 13, 2018 - ‘Master key’ gene has links to both ASD and schizophrenia
November 13, 2018 - Gladstone scientists gain new insights into the aging brain
November 13, 2018 - Drug therapy can improve outcomes for acutely ill heart patients
November 13, 2018 - Three landmark studies provide better understanding of sudden cardiac arrest
November 13, 2018 - Cholesterol control revised in the latest AHA/ACC guidelines
November 13, 2018 - Vulnerable young teenagers urgently need better sex education, say researchers
November 13, 2018 - Breakthrough research reveals how deadly pneumococcus avoids immune defenses
November 13, 2018 - Researchers discover possible path forward in preventing cancers tied to two viruses
November 13, 2018 - Wishes can help pediatric patients to get better over time
November 13, 2018 - Janssen Reports Positive Topline Results for FLAIR Phase 3 Study of a Novel, Long Acting Injectable Two-Drug Regimen for the treatment of HIV-1
November 13, 2018 - Experimental compound reduces Gulf War illness-like behavior in mice
November 13, 2018 - Small-stature in rainforest populations may be linked to cardiac adaptations
November 13, 2018 - Study shows how pneumococci challenge the immune system
November 13, 2018 - Simple cysts can be safely ignored, study finds
November 13, 2018 - First fully personalized tissue implant engineered from patient’s own materials and cells
November 13, 2018 - FDA Approves Keytruda (pembrolizumab) in Combination with Carboplatin and Either Paclitaxel or Nab-Paclitaxel for the First-Line Treatment of Patients with Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
November 13, 2018 - Scientists take big step toward finding non-addictive painkiller
November 13, 2018 - Diabetes medication reduces risk of heart failure hospitalization
November 13, 2018 - Achieving high follow-up rates for violently injured patient population is feasible
November 13, 2018 - Shortage of specific gene ‘silencing’ molecules linked with pediatric low-grade gliomas
November 13, 2018 - Abx-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI
November 13, 2018 - US approves first new type of flu drug in 2 decades
November 13, 2018 - Is zinc the link to how we think? Some evidence, and a word of warning
November 13, 2018 - Dispelling taboos, Michelle Obama talks IVF and miscarriage
November 13, 2018 - Medical experts discuss future challenges of healthcare at HSMA’s inaugural conference
November 13, 2018 - Growth and spread of deadly eye tumor suppressed in cells, animals
November 12, 2018 - Study finds huge shortfall in use of home-based medical care by frail seniors
November 12, 2018 - Cocaine Cut With Anti-Worming Drug, Levamisole, May Cause Brain Damage
November 12, 2018 - Obese mice lose a third of their fat using a natural protein
November 12, 2018 - Behind many a Parkinson’s case lurks a mutation in a gene called LRRK2 — why?
November 12, 2018 - Drug with fish oil cuts risk of heart attack, stroke, study finds
November 12, 2018 - Mild exposure to single blast can induce meaningful pathogenic effects, study shows
November 12, 2018 - Miniature pacemakers aim to make heart procedures for infants less invasive, more efficient
November 12, 2018 - Treating pre-cancerous stem cells at early stage could be key to preventing bowel cancer
November 12, 2018 - Kawasaki disease triggered by a combination of factors
November 12, 2018 - Optibrium and University of Nottingham Collaborate on Innovative Teaching Programme
November 12, 2018 - RNA defects linked to multiple myeloma progression in high risk patients
November 12, 2018 - Science is on trial – and we need doctors to provide the defense
November 12, 2018 - Salk researchers receive $19.2 million to unravel mysteries of age-related cognitive decline
November 12, 2018 - KE Eye Centers offer new solution for patients with myopia and astigmatism
November 12, 2018 - Trumpeted new Medicare Advantage benefits will be hard for seniors to find
November 12, 2018 - Biogen and Eisai Announce Presentation of Detailed Analyses from the Phase 1b Long-Term Extension Study of Aducanumab at Clinical Trials on Alzheimer’s Disease (CTAD)
November 12, 2018 - Scientists reveal new cystic fibrosis treatments work best in inflamed airways
November 12, 2018 - Hands-Only CPR training kiosks can teach life-saving skills in just minutes
Alzheimer’s Association’s Part the Cloud program funds innovative research on brain cells

Alzheimer’s Association’s Part the Cloud program funds innovative research on brain cells

image_pdfDownload PDFimage_print

Innovative research aimed to possibly rejuvenate brain cells will be explored by six international researchers with the goal of discovering effective drugs for people with early stage Alzheimer’s disease and other dementias. All of the research is being funded by the Alzheimer’s Association’s Part the Cloud to RESCUE (REverse, reStore, Cease and UndErstand) Brain Cell Degeneration in Alzheimer’s disease program.

Each of the awardees will receive $1 million over two years to support their research. Since 2012, Part the Cloud has raised more than $29 million to invest in the Alzheimer’s Association research grants. These are “high risk” science projects that need seed funding as the researchers test their ideas and build initial supportive data. The supportive data will allow scientists to seek broader funding from the National Institutes of Health or other sources for larger clinical trials to more definitively test safety and effectiveness.

The grants are funded through the Alzheimer’s Association’s Part the Cloud program. The primary focus is to advance pioneering ideas for early phase human trials – Phase I or Phase 2a proof of concept – targeting brain cell health in Alzheimer’s. The destruction of the brain’s nerve cells causes memory failure, personality changes, problems carrying out daily activities and other symptoms of Alzheimer’s disease dementia.

“Currently, there are no truly effective treatments or preventions for Alzheimer’s disease,” said Maria C. Carrillo, Ph.D., Alzheimer’s Association chief science officer. “With the aging of the global population, the urgency has never been greater to change that situation and the sooner the better.”

“These Part the Cloud to RESCUE grants encourage discovery and development of a wide range of interventions that might someday be viable treatments for people with or at risk for Alzheimer’s. We are expanding the Alzheimer’s drug pipeline at the front end – Phase 1 and 2 clinical trials – where it is most desperately needed,” Carrillo said. “The research funded by these grants will not only advance possible treatments, but also accelerate our understanding of processes associated with Alzheimer’s and related dementias, as well as other diseases that impact the brain.”

The new grants are awarded to:

Roberta Diaz Brinton, Ph.D., University of Arizona (Tucson, AZ)

This phase 2a study will test whether allopregnanolone, an important hormone in brain function, is able to restore brain cell function in people with Alzheimer’s.

Rafael de la Torre, Pharm.D., Ph.D., Hospital del Mar Medical Research Institute (Barcelona, Spain)

A phase 1 study to test the ability of high dose epigallocatechin gallate (EGCG), an organic compound found in green tea with antioxidant and anti-inflammatory properties known to regulate insulin signals in cells, to reverse cognitive changes in people with early stage Alzheimer’s. The study also includes a lifestyle intervention of diet, exercise and cognitive training that will be tested with the EGCG in a low income, low education community.

Xue Hua, Ph.D., M3 Biotechnology, Inc (Seattle, WA)

This phase 2 proof-of-concept study will evaluate NDX-1017 to determine its potential to treat Alzheimer’s disease and dementia. NDX-1017 is a novel compound focused on regeneration, with a potential to slow, halt or reverse the effects of Alzheimer’s disease, rather than only alleviating symptoms.

Paul A. Newhouse, M.D., Vanderbilt University (Nashville, TN)

A phase 2a study of a new drug, M1-PAM VU319, to improve brain cell communications that could boost memory and attention in people with mild cognitive impairment (MCI). This phase 2a clinical trial will test the drug for the first time in people with MCI.

Stephen M. Strittmatter, M.D., Ph.D., Yale University (New Haven, CT)

Targeting a relatively new approach, this phase 1b study will test a compound, mGluR5 SAM, to target brain cell communication systems for improved brain cell health.

Intent-to-Fund: Raymond Tesi, M.D., INmune Bio (La Jolla, CA)

This phase 1 study will evaluate a new compound, XPRO1595, which aims to reduce inflammation and reverse brain cell death.

Part the Cloud was founded by philanthropist Michaela “Mikey” Hoag after losing her father to younger-onset Alzheimer’s. In partnership with the Alzheimer’s Association, the Part the Cloud movement addresses the critical need to support promising early phase clinical trials to help accelerate the transition of findings from the laboratory into possible therapies.

Part the Cloud is a research funding effort from the Alzheimer’s Association, the world’s leading nonprofit funder of Alzheimer’s and dementia research. The Association is currently investing over $160 million in more than 450 projects in 25 countries. Since 1982, the Association has invested over $435 million to more than 2,900 scientific investigations.

About author

Related Articles