Breaking News
January 20, 2019 - New study takes first step toward treating endometriosis
January 20, 2019 - Researchers find how GREB1 gene promotes resistance to prostate cancer treatments
January 20, 2019 - Replacing Sitting Time With Activity Lowers Mortality Risk
January 20, 2019 - A simple, inexpensive intervention makes birth safer for moms and babies in parts of Africa
January 19, 2019 - New anti-inflammatory compound acts as ‘surge protector’ to reduce cancer growth
January 19, 2019 - Significant flaws found in recently released forensic software
January 19, 2019 - New Leash on Life? Staying Slim Keeps Pooches Happy, Healthy
January 19, 2019 - Men and women remember pain differently
January 19, 2019 - Rising air pollution linked with increased ER visits for breathing problems
January 19, 2019 - Study uses local data to model food consumption patterns among Seattle residents
January 19, 2019 - The brain’s cerebellum plays role in controlling reward and social behaviors, study shows
January 19, 2019 - Relationship between nurse work environment and patient safety
January 19, 2019 - Pioneering surgery restores movement to children paralyzed by acute flaccid myelitis
January 19, 2019 - Genetic variants linked with risk tolerance and risky behaviors
January 19, 2019 - New research provides better understanding of our early human ancestors
January 19, 2019 - First-ever tailored reporting guidance to improve patient care and outcomes
January 19, 2019 - 4.6 percent of Massachusetts residents have opioid use disorder
January 19, 2019 - New study suggests vital exhaustion as risk factor for dementia
January 19, 2019 - New antibiotic discovery heralds breakthrough in the fight against drug-resistant bacteria
January 19, 2019 - Ural Federal University scientists synthesize a group of multi-purpose fluorophores
January 19, 2019 - Researchers identify new therapeutic target in the fight against chronic liver diseases
January 19, 2019 - Preparation, characterization of Soyasapogenol B loaded onto functionalized MWCNTs
January 19, 2019 - FDA Approves Ontruzant (trastuzumab-dttb), a Biosimilar to Herceptin
January 19, 2019 - Tobacco use linked with higher use of opioids and sedatives
January 19, 2019 - Study delves deeper into developmental dyslexia
January 19, 2019 - Anti-vaccination movement one of the top health threats in 2019 says WHO
January 19, 2019 - Newly developed risk score more effective at identifying type 1 diabetes
January 19, 2019 - Highly effective protocol to prepare cannabis samples for THC/CBD analysis
January 19, 2019 - Prinston Pharmaceutical Inc. Issues Voluntary Nationwide Recall of Irbesartan and Irbesartan HCTZ Tablets Due to Detection of a Trace Amount of Unexpected Impurity, N-Nitrosodiethylamine (NDEA) in the Products
January 19, 2019 - How does solid stress from brain tumors cause neuronal loss, neurologic dysfunction?
January 19, 2019 - $14.7 million partnership to supercharge vaccine development
January 19, 2019 - Ian Fotheringham receives Charles Tennant Memorial Lecture award
January 19, 2019 - Brain vital signs detect neurophysiological impairments in players with concussions
January 19, 2019 - Lack of job and poor housing conditions increased likelihood of people attending A&E
January 19, 2019 - Novel targeted drug delivery system improves conventional cancer treatments
January 19, 2019 - Rutgers study finds gene responsible for spread of prostate cancer
January 19, 2019 - Complications Higher Than Expected for Invasive Lung Tests
January 19, 2019 - 3-D printed implant promotes nerve cell growth to treat spinal cord injury
January 19, 2019 - Automated texts lead to improved outcomes after total knee or hip replacement surgery
January 19, 2019 - Poor cardiorespiratory fitness could increase risk of future heart attack, finds new study
January 19, 2019 - Drinking soft drinks while exercising in hot weather may increase risk of kidney disease
January 19, 2019 - Formlabs 3D prints anatomical models
January 19, 2019 - Heart-Healthy Living Also Wards Off Type 2 Diabetes
January 19, 2019 - Teaching Kids to Be Smart About Social Media (for Parents)
January 19, 2019 - Metabolite produced by gut microbiota from pomegranates reduces inflammatory bowel disease
January 19, 2019 - Researchers examine how spray from showers and toilets expose us to disease causing bacteria
January 19, 2019 - Behavioral experiments confirm that additional neurons improve brain function
January 19, 2019 - New study compares performance of real-time infectious disease forecasting models
January 19, 2019 - Obesity can be risk factor for developing renal cell carcinoma, confirms study
January 19, 2019 - New regulation designs on cigarette packs direct smokers’ attention to health warnings
January 19, 2019 - QIAGEN receives first companion diagnostic approval in Japan
January 19, 2019 - Study explores role of Dunning-Kruger effect in anti-vaccine attitudes
January 19, 2019 - Newly identified subset of immune cells may be key to fighting chronic inflammation
January 19, 2019 - New immune response regulators discovered
January 18, 2019 - Poor blood oxygenation during sleep predicts chance of heart-related death
January 18, 2019 - First international consensus on the diagnosis and management of fibromuscular dysplasia
January 18, 2019 - Rapid resistance gene sequencing technology can hasten identification of antibiotic-resistant bacteria
January 18, 2019 - Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli
January 18, 2019 - Scientists advise caution in immunotherapy research
January 18, 2019 - How children across the world develop language
January 18, 2019 - Columbia Medical Student Receives McDonogh Scholarship
January 18, 2019 - Secretive ‘Rebate Trap’ Keeps Generic Drugs For Diabetes And Other Ills Out Of Reach
January 18, 2019 - Plant based diet could be the best option for the planet says commission
January 18, 2019 - New conservation practice could reduce nitrogen from agricultural drainage, study shows
January 18, 2019 - UIC researchers receive $1.7 million NCI grant to study Southeast Asian fruit
January 18, 2019 - New study determines the fate of DNA derived from genetically modified food
January 18, 2019 - Scientists develop new gene therapy that prevents axon destruction in mice
January 18, 2019 - Study finds critically low HPV vaccination rates among younger adolescents in the U.S.
January 18, 2019 - Brain cells involved in memory play key role in reducing future eating behavior
January 18, 2019 - Risk for Conversion of MS Varies With Different Therapies
January 18, 2019 - Investigational cream may help patients with inflammatory skin disease
January 18, 2019 - Medical school news office receives six writing awards | News Center
January 18, 2019 - County By County, Researchers Link Opioid Deaths To Drugmakers’ Marketing
January 18, 2019 - Research reveals risk for developing more than one mental health disorder
January 18, 2019 - Scientists discover a dramatic pattern of bone growth in female mice
January 18, 2019 - Study finds link between lengthy periods of undisturbed maternal sleep and stillbirths
January 18, 2019 - New nuclear medicine method could improve detection of primary and metastatic melanoma
January 18, 2019 - Combination therapy shows high efficacy in treating people with leishmaniasis and HIV
January 18, 2019 - Health Tip: Don’t Ignore Changes in Skin Color
January 18, 2019 - Dietary Recommendations for Healthy Children
Alzheimer’s Association’s Part the Cloud program funds innovative research on brain cells

Alzheimer’s Association’s Part the Cloud program funds innovative research on brain cells

image_pdfDownload PDFimage_print

Innovative research aimed to possibly rejuvenate brain cells will be explored by six international researchers with the goal of discovering effective drugs for people with early stage Alzheimer’s disease and other dementias. All of the research is being funded by the Alzheimer’s Association’s Part the Cloud to RESCUE (REverse, reStore, Cease and UndErstand) Brain Cell Degeneration in Alzheimer’s disease program.

Each of the awardees will receive $1 million over two years to support their research. Since 2012, Part the Cloud has raised more than $29 million to invest in the Alzheimer’s Association research grants. These are “high risk” science projects that need seed funding as the researchers test their ideas and build initial supportive data. The supportive data will allow scientists to seek broader funding from the National Institutes of Health or other sources for larger clinical trials to more definitively test safety and effectiveness.

The grants are funded through the Alzheimer’s Association’s Part the Cloud program. The primary focus is to advance pioneering ideas for early phase human trials – Phase I or Phase 2a proof of concept – targeting brain cell health in Alzheimer’s. The destruction of the brain’s nerve cells causes memory failure, personality changes, problems carrying out daily activities and other symptoms of Alzheimer’s disease dementia.

“Currently, there are no truly effective treatments or preventions for Alzheimer’s disease,” said Maria C. Carrillo, Ph.D., Alzheimer’s Association chief science officer. “With the aging of the global population, the urgency has never been greater to change that situation and the sooner the better.”

“These Part the Cloud to RESCUE grants encourage discovery and development of a wide range of interventions that might someday be viable treatments for people with or at risk for Alzheimer’s. We are expanding the Alzheimer’s drug pipeline at the front end – Phase 1 and 2 clinical trials – where it is most desperately needed,” Carrillo said. “The research funded by these grants will not only advance possible treatments, but also accelerate our understanding of processes associated with Alzheimer’s and related dementias, as well as other diseases that impact the brain.”

The new grants are awarded to:

Roberta Diaz Brinton, Ph.D., University of Arizona (Tucson, AZ)

This phase 2a study will test whether allopregnanolone, an important hormone in brain function, is able to restore brain cell function in people with Alzheimer’s.

Rafael de la Torre, Pharm.D., Ph.D., Hospital del Mar Medical Research Institute (Barcelona, Spain)

A phase 1 study to test the ability of high dose epigallocatechin gallate (EGCG), an organic compound found in green tea with antioxidant and anti-inflammatory properties known to regulate insulin signals in cells, to reverse cognitive changes in people with early stage Alzheimer’s. The study also includes a lifestyle intervention of diet, exercise and cognitive training that will be tested with the EGCG in a low income, low education community.

Xue Hua, Ph.D., M3 Biotechnology, Inc (Seattle, WA)

This phase 2 proof-of-concept study will evaluate NDX-1017 to determine its potential to treat Alzheimer’s disease and dementia. NDX-1017 is a novel compound focused on regeneration, with a potential to slow, halt or reverse the effects of Alzheimer’s disease, rather than only alleviating symptoms.

Paul A. Newhouse, M.D., Vanderbilt University (Nashville, TN)

A phase 2a study of a new drug, M1-PAM VU319, to improve brain cell communications that could boost memory and attention in people with mild cognitive impairment (MCI). This phase 2a clinical trial will test the drug for the first time in people with MCI.

Stephen M. Strittmatter, M.D., Ph.D., Yale University (New Haven, CT)

Targeting a relatively new approach, this phase 1b study will test a compound, mGluR5 SAM, to target brain cell communication systems for improved brain cell health.

Intent-to-Fund: Raymond Tesi, M.D., INmune Bio (La Jolla, CA)

This phase 1 study will evaluate a new compound, XPRO1595, which aims to reduce inflammation and reverse brain cell death.

Part the Cloud was founded by philanthropist Michaela “Mikey” Hoag after losing her father to younger-onset Alzheimer’s. In partnership with the Alzheimer’s Association, the Part the Cloud movement addresses the critical need to support promising early phase clinical trials to help accelerate the transition of findings from the laboratory into possible therapies.

Part the Cloud is a research funding effort from the Alzheimer’s Association, the world’s leading nonprofit funder of Alzheimer’s and dementia research. The Association is currently investing over $160 million in more than 450 projects in 25 countries. Since 1982, the Association has invested over $435 million to more than 2,900 scientific investigations.

About author

Related Articles