Breaking News
January 23, 2019 - Scientists reveal new mechanism that could lead to specific treatment of strokes and seizures
January 23, 2019 - Both educational level and occupational orientation predict mother’s smoking during pregnancy
January 23, 2019 - How to (gently) get your child to brush their teeth
January 23, 2019 - Short-term hospital readmissions for gun injuries cost $86 million a year | News Center
January 23, 2019 - New certified reference material for testing residual solvents in cannabis
January 23, 2019 - Gene-edited chickens could prevent future flu pandemic
January 23, 2019 - Cardiovascular disease risk begins even before birth
January 23, 2019 - Younger patients receiving kidney transplant more likely to live longer, shows data
January 23, 2019 - Skin samples hold early signs of prion disease, research suggests
January 23, 2019 - Researchers discover how body initiates repair mechanisms that limits damage to myelin sheath
January 23, 2019 - Fecal transplant from certain donors better than others
January 23, 2019 - Risk for Uninsurance in AMI Patients Reduced With Medicaid Expansion
January 23, 2019 - Readmissions reduction program may be associated with increase in patient-level mortality
January 23, 2019 - Fostering translation and communication in medicine and beyond
January 23, 2019 - To Fight Fatty Liver, Avoid Sugary Foods and Drinks
January 23, 2019 - TPU scientists develop new implants that double the rate of bone lengthening in kids
January 23, 2019 - New sessions at Pittcon 2019
January 23, 2019 - Insilico to present latest findings in AI for Drug Discovery at 3rd Annual SABPA FTD Forum
January 23, 2019 - Opioid overdose patients can be safely discharged an hour after administration of naloxone
January 23, 2019 - Scientists find bacterial extracellular vesicles in human blood
January 23, 2019 - Researchers gain new insights into development of necrotizing enterocolitis in preemies
January 23, 2019 - Medical expert advises people with epilepsy not to stockpile medicines
January 23, 2019 - Study outlines research priorities for improving pediatric patient care and safety
January 23, 2019 - Bedfont to exhibit NObreath FeNO monitor at Arab Health 2019
January 23, 2019 - Nicotinamide riboside supplementation confers significant physiological benefits to mothers and offspring
January 23, 2019 - Increasing temperatures may help preserve crop nutrition
January 23, 2019 - Many Oncologists in the Dark About LGBTQ Health Needs
January 23, 2019 - Epigenetic change causes fruit fly babies to inherit diet-induced heart disease
January 23, 2019 - Erasing memories could reduce relapse rates among drug addicts
January 23, 2019 - African Americans who smoke cigarettes are more likely to develop peripheral artery disease
January 23, 2019 - Unique data combination helps FinnGen researchers to fund links between genetic factors and health
January 23, 2019 - Parents’ mental health problems associated with reactive attachment disorder in children
January 23, 2019 - Graphene Flagship project studies impact of graphene and related materials on our health
January 23, 2019 - The connection between the Pope and contraceptive pills
January 23, 2019 - Prior dengue infection could protect children from symptomatic Zika
January 23, 2019 - Previous dengue virus infection associated with protection from symptomatic Zika
January 23, 2019 - VISTA checkpoint implicated in pancreatic cancer immunotherapy resistance
January 23, 2019 - The Tiny Camera That Could Revolutionize Cardiovascular Surgery
January 23, 2019 - Peptide isolated from soil fungi has antitumor and antibacterial properties
January 23, 2019 - TGen identifies polio-like virus as potential cause of Acute Flaccid Myelitis outbreak
January 23, 2019 - Migrants and refugees do not bring disease and are at greater health risk themselves says WHO
January 23, 2019 - Examing the effects of menopause in workplace
January 23, 2019 - Enemy number 1 – Air pollution and climate change top of WHO agenda
January 23, 2019 - Two Positive Phase III studies of Tafenoquine for the Radical Cure of Plasmodium vivax Malaria Published in The New England Journal of Medicine
January 23, 2019 - World Trade Center responders at increased risk for head and neck cancers
January 23, 2019 - Low-sugar diet leads to significant improvement in nonalcoholic fatty liver disease in boys
January 23, 2019 - Chaos in bodily regulation can optimize our immune system, finds study
January 23, 2019 - Short, text-based exercises can increase happiness for adults recovering from substance use disorders
January 23, 2019 - Body size may have greater influence on women’s lifespan than men
January 23, 2019 - Groundbreaking tool helps visualize neuronal activity with near-infrared light
January 23, 2019 - Prior dengue immunity in children may be protective against symptomatic Zika
January 23, 2019 - Holocaust survivors with PTSD and their offspring exhibit more unhealthy behavior patterns
January 23, 2019 - Scientists discover new genetic mutations causing inherited deaf-blindness
January 23, 2019 - UC team designs new naloxone-dispensing smart device
January 23, 2019 - Torrent Pharmaceuticals Limited Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium and Hydrochlorothiazide Tablets, USP
January 23, 2019 - Brain activity shows development of visual sensitivity in autism
January 23, 2019 - Two hour gap between dinner and sleep is overrated says Japanese research
January 23, 2019 - Fear and embarrassment are causing smear test numbers to plummet
January 23, 2019 - Protein-secreting device implanted in epileptic rats reduces seizures, improves cognition
January 23, 2019 - Reintroduction project recovers current wild population of green turtle in Cayman Islands
January 23, 2019 - Cancer survivors face greater financial burden related to medical bills
January 23, 2019 - PSA screening reduces prostate cancer deaths by 30%
January 23, 2019 - LSTM receives grant to help improve health of people living in informal settlements
January 23, 2019 - Hemochromatosis Mutation Linked to Other Morbidity
January 23, 2019 - Why early diagnosis of autism should lead to early intervention
January 23, 2019 - Aspirin May Lower Stroke Risk in Women with History of Preeclampsia
January 23, 2019 - Exposure to certain chemicals may be linked to decrease in blood pressure during pregnancy
January 23, 2019 - Bowel cancer on the rise among younger Australians
January 23, 2019 - Scientists have reversed memory loss in a mouse model of Alzheimer’s
January 23, 2019 - Defective molecular master switch could lead to age-related macular degeneration
January 23, 2019 - Researchers identify how concussions may contribute to seizures
January 23, 2019 - Short interval between last meal of the day and bedtime may not affect blood glucose levels
January 23, 2019 - Still Too Many Highway Deaths Tied to Speeding
January 23, 2019 - Prenatal valproate exposure linked to increased ADHD risk
January 23, 2019 - Compound identified that may help treat heart failure
January 23, 2019 - Undiagnosed Asthma in Urban Adolescents May Be Common
January 23, 2019 - Study describes metabolism of intestinal microbiota in babies for the first time
January 22, 2019 - Study links concussions to development of epilepsy
January 22, 2019 - Specialist-led hospital bereavement service may help restrain legal action after difficult deaths
January 22, 2019 - Genetic study reveals possible new routes to treating osteoarthritis
New study to evaluate human immune system’s response to influenza

New study to evaluate human immune system’s response to influenza

image_pdfDownload PDFimage_print

The key to lasting protection against influenza may be in your bones. The cells that naturally protect you against illness originate and live in your bone marrow – and that is one spot where scientists will be looking to understand the human immune system’s response to influenza in a groundbreaking new study led by the Human Vaccines Project. The goal is to harness an understanding of the immune system to develop longer lasting protection against the flu.

In the new study, researchers will be conducting a comprehensive evaluation of the human immune system’s response to influenza. “What’s so exciting about clinical research now is that we have more robust tools than ever to ask questions about the immune system and to understand what makes people respond a certain way to vaccination or infection,” says Dr. C. Buddy Creech, a pediatric infectious diseases specialist who directs the Vanderbilt Vaccine Research Program and is leading the clinical study at Vanderbilt University Medical Center.

Subjects for the study are healthy men and women who will receive a standard influenza vaccination, and scientists will then take a sweeping range of measurements to analyze individual responses to the shot. Unlike some studies that focus solely on measuring the antibody response to the flu, this study will also include a look at gene regulation, the influence of the microbiome, and other factors, such as whether gender affects immune response. Importantly, the researchers will also take samples after vaccination from participants’ lymph nodes and bone marrow where key immune cells reside.

“By sampling the blood frequently and getting samples from lymph nodes and the bone marrow, we can provide one of the most comprehensive studies of the immune response to influenza that scientists have ever been able to undertake,” says Wayne Koff, CEO and president of the Human Vaccines Project who presented on this study at the World Vaccine Congress this week in Lisbon, Portugal. “Such work will accelerate the development of more effective influenza vaccines and may lead to the development of a universal influenza vaccine that provides durable protection against influenza even as it changes from year to year. The study will also help elucidate mechanisms of the human immune system that are universal to how people fight disease.”

For some pathogens like hepatitis B, scientists know the exact type of immune response needed to provide durable protection through vaccination. For more complex and constantly changing pathogens like influenza, scientists do not yet fully understand what it will take for someone to be immune to the pathogen for a prolonged period of time. This gap in understanding is one of the primary hurdles to developing universal vaccines the provide lasting protection against different strains.

“From the moment many of us arrive in medical school and start seeing patients, we become very curious about why some individuals do not develop a specific infection, why some are seemingly mildly affected by it, and still others are profoundly devastated by what turns out to be the exact same pathogen,” Creech explains. “We must seek to understand why the body’s response in each case is different.”

To find answers, the nonprofit Human Vaccines Project has established a global consortium of researchers to systematically decode the human immune system in order to create better prevention, diagnostics, and treatments for a range of diseases. Under the collaboration, Seqirus, one of the largest influenza vaccine manufacturers in the world, will be providing the vaccine, while Vanderbilt University Medical Center leads the clinical study, with scientists from the University of British Columbia, Telethon Kids Institute in Australia, University of California, San Diego, J. Craig Venter Institute, the Scripps Research Institute, and La Jolla Institute providing expertise and analysis. This network of field-leading scientists is not merely focused on influenza, but seeks to decipher how the immune system responds across various disease areas.

“This study represents the Human Vaccines Project’s next step in applying comprehensive measures of the human immune system to specific diseases, in an effort to understand the common principles guiding the generation of protective immunity,” says Ian Gust, chairman of the Human Vaccines Project Board of Directors. “Our world-class network is creating a new platform for understanding the human immune system that will allow us to develop a better arsenal for fighting disease.”

Source:

Tagged with:

About author

Related Articles