Breaking News
November 13, 2018 - Janssen Reports Positive Topline Results for FLAIR Phase 3 Study of a Novel, Long Acting Injectable Two-Drug Regimen for the treatment of HIV-1
November 13, 2018 - Experimental compound reduces Gulf War illness-like behavior in mice
November 13, 2018 - Study shows how pneumococci challenge the immune system
November 13, 2018 - Simple cysts can be safely ignored, study finds
November 13, 2018 - First fully personalized tissue implant engineered from patient’s own materials and cells
November 13, 2018 - FDA Approves Keytruda (pembrolizumab) in Combination with Carboplatin and Either Paclitaxel or Nab-Paclitaxel for the First-Line Treatment of Patients with Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
November 13, 2018 - Scientists take big step toward finding non-addictive painkiller
November 13, 2018 - Diabetes medication reduces risk of heart failure hospitalization
November 13, 2018 - Achieving high follow-up rates for violently injured patient population is feasible
November 13, 2018 - Shortage of specific gene ‘silencing’ molecules linked with pediatric low-grade gliomas
November 13, 2018 - Abx-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI
November 13, 2018 - US approves first new type of flu drug in 2 decades
November 13, 2018 - Is zinc the link to how we think? Some evidence, and a word of warning
November 13, 2018 - Dispelling taboos, Michelle Obama talks IVF and miscarriage
November 13, 2018 - Medical experts discuss future challenges of healthcare at HSMA’s inaugural conference
November 13, 2018 - Growth and spread of deadly eye tumor suppressed in cells, animals
November 12, 2018 - Study finds huge shortfall in use of home-based medical care by frail seniors
November 12, 2018 - Cocaine Cut With Anti-Worming Drug, Levamisole, May Cause Brain Damage
November 12, 2018 - Obese mice lose a third of their fat using a natural protein
November 12, 2018 - Behind many a Parkinson’s case lurks a mutation in a gene called LRRK2 — why?
November 12, 2018 - Drug with fish oil cuts risk of heart attack, stroke, study finds
November 12, 2018 - Mild exposure to single blast can induce meaningful pathogenic effects, study shows
November 12, 2018 - Miniature pacemakers aim to make heart procedures for infants less invasive, more efficient
November 12, 2018 - Treating pre-cancerous stem cells at early stage could be key to preventing bowel cancer
November 12, 2018 - Kawasaki disease triggered by a combination of factors
November 12, 2018 - Optibrium and University of Nottingham Collaborate on Innovative Teaching Programme
November 12, 2018 - RNA defects linked to multiple myeloma progression in high risk patients
November 12, 2018 - Science is on trial – and we need doctors to provide the defense
November 12, 2018 - Salk researchers receive $19.2 million to unravel mysteries of age-related cognitive decline
November 12, 2018 - KE Eye Centers offer new solution for patients with myopia and astigmatism
November 12, 2018 - Trumpeted new Medicare Advantage benefits will be hard for seniors to find
November 12, 2018 - Biogen and Eisai Announce Presentation of Detailed Analyses from the Phase 1b Long-Term Extension Study of Aducanumab at Clinical Trials on Alzheimer’s Disease (CTAD)
November 12, 2018 - Scientists reveal new cystic fibrosis treatments work best in inflamed airways
November 12, 2018 - Hands-Only CPR training kiosks can teach life-saving skills in just minutes
November 12, 2018 - Inexpensive and effective drug does not reduce major adverse cardiovascular event rates
November 12, 2018 - Testing coronary calcium levels can better predict patient’s risk for coronary heart disease
November 12, 2018 - FDA conducts mass seizure of food and medical products held under insanitary conditions
November 12, 2018 - FDA Approves Invokana (canagliflozin) to Reduce the Risk of Heart Attack, Stroke or Cardiovascular Death in Adults with Type 2 Diabetes and Established Cardiovascular Disease
November 12, 2018 - Hormone helps reverse brain damage caused by obesity
November 12, 2018 - Grants aim to provide better cancer clinical trial access for military veterans
November 12, 2018 - Mitochondrial DNA may have strong influence on cellular metabolism and disease susceptibility
November 12, 2018 - High stakes, entrenched interests and the Trump rollback of environmental regs
November 12, 2018 - Stem cells transplanted for treatment of Parkinson’s disease
November 12, 2018 - Sandoz Inc. Issues Voluntary Nationwide Recall of One Lot of Losartan Potassium and Hydrochlorothiazide Due to the Detection of Trace Amounts of NDEA (N-Nitrosodiethylamine) Impurity Found in the Active Pharmaceutical Ingredient (API)
November 12, 2018 - Protein found in patients with severe asthma can help identify who would benefit from targeted drugs
November 12, 2018 - Experts develop a list of competencies in antimicrobial prescribing and stewardship
November 12, 2018 - Allied BioScience receives approved label from EPA for new bacteriostatic surface coating
November 12, 2018 - MR Solutions displays elegant bench top CT scanner with clip-on PET and SPECT at EANM congress
November 12, 2018 - FDA announces emergency use authorization of Ebola fingerstick test with portable reader
November 12, 2018 - Grieving spouses with sleep problems have increased risk of chronic immune activation
November 12, 2018 - Exercise routines affect mental health in Japanese expatriates
November 12, 2018 - Fish oil and vitamin D pills no guard against cancer or serious heart trouble
November 12, 2018 - Excess Gestational Weight Gain Not Better for Child Bone Health
November 12, 2018 - Immune receptor provides protective immunity against Group A Streptococcus
November 12, 2018 - Scientists develop new method to produce irradiated nanomaterials for medical applications
November 12, 2018 - Blue light exposure decreases blood pressure
November 12, 2018 - Researchers discover two proteins essential for development of skeletal muscle
November 12, 2018 - Yelp reviews help understand strengths, weaknesses of emergency departments and urgent care centers
November 12, 2018 - Adolescent obesity linked with increased risk of pancreatic cancer later in life
November 12, 2018 - AHA: Poor Teeth-Brushing Habits Tied to Higher Heart Risk
November 12, 2018 - Researchers find how natural killer cells regulate protective HIV antibodies
November 12, 2018 - Rutgers receives $4.2 million federal grant to improve mental health services
November 12, 2018 - Sussex scientists develop a piece of hardware to show how brains function
November 12, 2018 - Study shows pivotal role of parents in efforts to change sexual orientation of LGBT teens
November 12, 2018 - Neck scan detects dementia way before symptoms appear
November 12, 2018 - Risk-profiling can benefit HIV prevention
November 12, 2018 - New thrombolytic based on magnetite nanoparticles successfully tested on animals
November 12, 2018 - Smoking rates go down in the US, lowest since 1965
November 12, 2018 - Phase III Trial of Darolutamide in Patients with Non-metastatic Castration-resistant Prostate Cancer Meets Primary Endpoint
November 12, 2018 - Moderate exercise before conception resulted in lower body weight, increased insulin sensitivity of offspring
November 11, 2018 - Community choirs for older adults reduce loneliness and increase interest in life
November 11, 2018 - Trevena Receives Complete Response Letter for Oliceridine from FDA
November 11, 2018 - More adults and children are using yoga and meditation
November 11, 2018 - Female smokers at greater risk of heart attacks, finds study
November 11, 2018 - Happy Childhood Memories Associated With Better Health
November 11, 2018 - X-linked infantile spinal muscular atrophy – Genetics Home Reference
November 11, 2018 - RNA thought to spread cancer shows ability to suppress breast cancer metastasis
November 11, 2018 - Study finds that thymus plays key role during normal pregnancy
November 11, 2018 - Exploring why some athletes ice their muscles after exercise
November 11, 2018 - Female Genital Mutilation Decreasing in African Nations
October 2018 Briefing – Nephrology

October 2018 Briefing – Nephrology

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Here are what the editors at HealthDay consider to be the most important developments in Nephrology for October 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Link Between Statins, Non-CVD Outcomes Lacks Evidence

WEDNESDAY, Oct. 31, 2018 — There is a lack of convincing evidence for an association between statin use and non-cardiovascular disease (CVD) outcomes, according to a review published in the Oct. 16 issue of the Annals of Internal Medicine.

Abstract/Full Text (subscription or payment may be required)

AMA Announces Initiative to Reinvent Physician Training

TUESDAY, Oct. 30, 2018 — The American Medical Association (AMA) today announced a new $15 million competitive grant initiative, the “Reimagining Residency” initiative, aimed at improving residency training.

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Many Hospitals Noncompliant With Record Request Regulations

MONDAY, Oct. 29, 2018 — Among top-ranked U.S. hospitals, data reveal discrepancies in information provided to patients regarding medical records release processes as well as noncompliance with state and federal regulations, according to a study published online Oct. 5 in JAMA Network Open.

Abstract/Full Text

ASN: Home Dialysis Associated With Improved Survival

MONDAY, Oct. 29, 2018 — Home hemodialysis (HHD) is associated with better survival than in-center hemodialysis (IHD) among incident dialysis patients, according to a study presented at the American Society of Nephrology’s Kidney Week, held Oct. 23 to 28 in San Diego.

Abstract
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In Complicated UTI, Cefiderocol Noninferior to Imipenem-Cilastin

MONDAY, Oct. 29, 2018 — For complicated urinary tract infections caused by multidrug-resistant Gram-negative uropathogens, the siderophore cephalosporin cefiderocol is non-inferior to imipenem-cilastatin, according to a study published online Oct. 25 in The Lancet Infectious Diseases.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Trump Administration Announces Plan to Cut Drug Prices

FRIDAY, Oct. 26, 2018 — In an effort to cut high drug costs, the prices paid by Medicare for certain prescription drugs would be based on those in other advanced industrial nations, according to a proposal announced Oct. 25 by the Trump administration.

HHS Study
New York Times Article

Pace of Change Has Accelerated in Alternative Payment Models

THURSDAY, Oct. 25, 2018 — The impact of alternative payment models (APMs) on physician practices has been described in a study published by the RAND Corp. and the American Medical Association.

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Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

THURSDAY, Oct. 25, 2018 — For patients with gout, allopurinol is associated with a reduced risk for developing chronic kidney disease stage ≥3, according to a study published online Oct. 8 in JAMA Internal Medicine.

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Editorial (subscription or payment may be required)

Most Supplements Contain Prohibited Stimulants

WEDNESDAY, Oct. 24, 2018 — Many supplements contain one or more stimulants that have been the subject of U.S. Food and Drug Administration-issued public notices, according to a research letter published online Oct. 22 in JAMA Internal Medicine.

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Editor’s Note (subscription or payment may be required)

High-Dose Flu Vaccine May Cut Hospitalization in Dialysis Patients

WEDNESDAY, Oct. 23, 2018 — Receipt of the high-dose influenza vaccine in 2016 to 2017 was associated with lower rates of hospitalization among dialysis patients, according to a study published online Oct. 23 in the Clinical Journal of the American Society of Nephrology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

White House Unveils New Insurance Option for Small Firms

TUESDAY, Oct. 23, 2018 — A plan to allow small businesses to use tax-free accounts to provide health coverage for employees was announced today by the Trump administration.

AP News Article
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Intensive SBP Tx Cuts Kidney Damage Biomarkers in Incident CKD

TUESDAY, Oct. 23, 2018 — Patients with incident chronic kidney disease (CKD) in the setting of intensive systolic blood pressure (SBP) treatment have decreases rather than increases in kidney damage biomarkers, according to a study published online Oct. 23 in the Annals of Internal Medicine.

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Poor Experience With PCP Linked to Hospitalization in CKD

FRIDAY, Oct. 19, 2018 — For Hispanic patients with chronic kidney disease (CKD), lower perceived quality of the patient experience with their primary care physician is associated with increased risk of hospitalization, according to a study published online Oct. 18 in the Clinical Journal of the American Society of Nephrology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Sharp Drop in U.S. Life Expectancy Rankings by 2040

THURSDAY, Oct. 18, 2018 — The United States will have the largest drop in life expectancy rankings of all high-income countries by 2040, a new study says.

CNN Article
Abstract/Full Text
Editorial

Procurement Requirements Drive Interoperability in Health Care IT

THURSDAY, Oct. 18, 2018 — Interoperability of health care information technology (IT) must be improved to facilitate creation of a fully integrated health care system that can improve health and health care at lower cost, according to a report published by the National Academy of Medicine.

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Well-Being of Young Adults on Kidney Replacement Tx Studied

WEDNESDAY, Oct. 17, 2018 — For young adults receiving kidney replacement therapy (KRT), well-being and medication adherence are associated with psychological morbidity, according to a study published online Oct. 16 in the Clinical Journal of the American Society of Nephrology.

Abstract/Full Text
Editorial 1
Editorial 2

Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM

TUESDAY, Oct. 15, 2018 — For patients with severe obesity and type 2 diabetes, bariatric surgery is associated with a lower risk for macrovascular outcomes compared with not undergoing surgery, according to a study published in the Oct. 16 issue of the Journal of the American Medical Association.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Job Market for Nephrologists Continuing to Improve

TUESDAY, Oct. 16, 2018 — The job market for new nephrologists is continuing to improve, and most fellows would recommend nephrology to medical students or residents, according to a report published online Oct. 15 by the American Society of Nephrology.

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Without Medicaid Expansion, Poor Patients Forgo Medical Care

MONDAY, Oct. 15, 2018 — Doing without medical care is much more common among low-income residents of states that have not expanded Medicaid than among low-income people in other states, according to a Government Accountability Office report.

AP News Article

Active Pharmaceuticals ID’d in >700 Dietary Supplements

MONDAY, Oct. 15, 2018 — Dietary supplements often include active pharmaceuticals, even after warnings from the U.S. Food and Drug Administration, according to a study published online Oct. 12 in JAMA Network Open.

Abstract/Full Text
Editorial

Ultrasound Can Predict Success of AV Fistula for Hemodialysis

FRIDAY, Oct. 12, 2018 — Detection of arteriovenous fistula (AVF) blood flow, diameter, and depth on ultrasound can predict AVF clinical maturation, according to a study published online Oct. 11 in the Journal of the American Society of Nephrology.

Abstract/Full Text
Editorial (subscription or payment may be required)

Aetna-CVS Merger Approved

WEDNESDAY, Oct. 10, 2018 — A $69 billion merger between health insurer Aetna and pharmacy manager CVS Health has been approved, according to the U.S. Justice Department.

The New York Times Article

Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis

WEDNESDAY, Oct. 10, 2018 — For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus a delayed strategy, according to a study published in the Oct. 11 issue of the New England Journal of Medicine.

Abstract/Full Text (subscription or payment may be required)

ADA, EASD Issue New Recommendations for T2DM

WEDNESDAY, Oct. 10, 2018 — Recommendations for the management of type 2 diabetes have been updated, according to a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) published online Oct. 5 in Diabetes Care.

Abstract/Full Text

Less Pre-Kidney Transplant Dialysis With Preemptive Waitlist

TUESDAY, Oct. 9, 2018 — Kidney transplant patients who are preemptively wait-listed have substantially fewer years of pretransplant dialysis than transplant recipients listed after dialysis onset, according to a study published online Aug. 21 in Clinical Transplantation.

Abstract/Full Text (subscription or payment may be required)

Minority Residents Experience Burdens Linked to Race/Ethnicity

TUESDAY, Oct. 9 2018 — Minority residents describe burdens associated with race/ethnicity, including microaggressions and bias on a daily basis, according to a study published online Sept. 28 in JAMA Network Open.

Abstract/Full Text
Editorial

Industry-Funded Trials Often Involve Employees in Studies

FRIDAY, Oct. 5, 2018 — Industry employees are often involved in the design, conduct, and reporting of industry-funded trials in high-impact journals, according to a study published online Oct. 3 in The BMJ.

Abstract/Full Text
Editorial

Inflammatory Marker Tied to Decline in Kidney Function

THURSDAY, Oct. 4, 2018 — High circulating levels of an inflammatory marker, soluble tumor necrosis factor receptor-1 (sTNFR-1), are linked to long-term decline of kidney function, according to a study published online Oct. 4 in the Journal of the American Society of Nephrology.

Abstract/Full Text (subscription or payment may be required)

Three-Quarters of Health Care Workers Got Flu Shot Last Year

THURSDAY, Oct. 4, 2018 — Just over three-quarters of health care personnel received a flu vaccine last season, according to research published in the Sept. 28 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Abstract/Full Text

Price Hikes Noted in Small Subset of Generic Drugs

THURSDAY, Oct. 4, 2018 — A small but growing subset of generic drugs experienced sudden large price increases from 2007 to 2013, according to a study published in the October issue of Health Affairs.

Abstract/Full Text (subscription or payment may be required)

Tips Provided for Budgeting in Medical Residency

THURSDAY, Oct. 4, 2018 — Medical residents should start budgeting and save for the future, according to an article published in the American Medical Association AMA Wire.

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Cancer Risk Varies for Hispanics, Including in Puerto Rico

THURSDAY, Oct. 4, 2018 — Hispanics have lower incidence and mortality than non-Hispanic whites for all cancers combined, although there is considerable variability in cancer risk within the U.S. Hispanic population, according to a report published online Oct. 4 in CA: A Cancer Journal for Clinicians.

Abstract/Full Text

Uninsured Rate at 8.8 Percent in First Quarter of 2018

WEDNESDAY, Oct. 3, 2018 — In the first quarter of 2018, the uninsured rate was 8.8 percent, not significantly different from a year earlier, according to a report released Aug. 29 by the National Center for Health Statistics (NCHS).

Abstract/Full Text

For Employer-Based Plans, Spending Across Services Steady

TUESDAY, Oct. 2, 2018 — Despite large health policy changes, the distribution of spending across service areas has remained fairly consistent over the past 10 years for those enrolled in employer-sponsored insurance, according to a study published in the October issue of Health Affairs.

Abstract/Full Text (subscription or payment may be required)

Number of Health-Related Data Breaches Increasing

TUESDAY, Oct. 2, 2018 — The number of health data breaches has steadily increased since 2010, according to a research letter published in the Sept. 25 issue of the Journal of the American Medical Association.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Interviews Can Help Ensure Physician Candidates Fit Culture

TUESDAY, Oct. 2, 2018 — In preparing to interview to hire a new physician, practices must understand their own cultures, according to an article published in Medical Economics.

Abstract/Full Text

Readmission, Death Risk Higher in COPD With Comorbidities

MONDAY, Oct. 1, 2018 — Patients with chronic obstructive pulmonary disease (COPD) who have comorbidities are more likely to experience readmission or mortality and less likely to receive beneficial treatments, according to a study published in the September issue of the Annals of the American Thoracic Society.

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Risk of Venous Thromboembolism Recurrence High

MONDAY, Oct. 1, 2018 — The risk of recurrence after incident venous thromboembolism is high, particularly among patients with cancer-related venous thromboembolism, according to a study published in the September issue of The American Journal of Medicine.

Abstract/Full Text

More Non-Elderly Americans Uninsured in 2017 Versus 2016

MONDAY, Oct. 1, 2018 — From 2016 to 2017, there was an increase in the number of uninsured non-elderly Americans, according to a report published by the Robert Wood Johnson Foundation.

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Posted: November 2018

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