Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Could Diabetes Drugs Help Curb Alzheimer’s?

Could Diabetes Drugs Help Curb Alzheimer’s?

THURSDAY, Nov. 1, 2018 — Alzheimer’s patients taking diabetes drugs may have fewer signs of dementia in their brains than similar patients not taking the drugs, new research finds.

Specifically, the post-mortem study found that people who’d taken diabetes meds had fewer abnormalities in tiny blood vessels in their brains, and less abnormal gene activity.

“The results of this study are important because they give us new insights for the treatment of Alzheimer’s disease,” said study senior author Vahram Haroutunian, a professor of psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai in New York City.

Earlier studies on brain tissue showed that the brains of people who had Alzheimer’s and diabetes had fewer Alzheimer’s lesions than brains of people with Alzheimer’s with no diabetes.

One Alzheimer’s expert said the study highlights the relationship between cardiovascular and brain health.

The findings “remind us of how important it is to keep vascular risk factors under control as we age,” said Dr. Luca Giliberto. He’s assistant professor at the Litwin-Zucker Center for Alzheimer’s Disease and Memory Disorders at The Feinstein Institute for Medical Research in Manhasset, N.Y.

In the new study, conducted on autopsied brains, Haroutunian and his colleagues developed a way to separate the tiny blood vessels (capillaries) in the brain from adjacent brain tissue.

They first used this method on the brains of 34 people who had been diagnosed with Alzheimer’s and type 2 diabetes treated with standard diabetes drugs.

The researchers then compared those findings to an examination of 30 brains from people with Alzheimer’s who did not have diabetes, and 19 brains of people who had experienced neither disease.

The study focused on changes in certain genetic “markers” tied closely to proper brain signaling.

According to the researchers, levels of about half of these markers were lower in the vessels and brain tissue of patients who had both Alzheimer’s and diabetes. And the majority of the unhealthy genetic changes that are usually seen in Alzheimer’s were missing in patients who had taken diabetes drugs.

This all suggests that diabetes medications have a protective effect on the brains of Alzheimer’s patients, the researchers said, which in turn might boost the search for effective therapies.

“Most modern Alzheimer’s treatments target amyloid plaques and haven’t succeeded in effectively treating the disease,” Haroutunian said in a Mount Sinai news release.

But the new study focused on “insulin and diabetes medications such as metformin, [which are] FDA-approved and safely administered to millions of people,” he said.

The new study suggests these drugs may “have a beneficial effect on people with Alzheimer’s,” Haroutunian said. “This opens opportunities to conduct research trials on people using similar drugs or on drugs that have similar effects on the brains’ biological pathways and cell types identified in this study.”

For his part, Giliberto said the results “are not surprising,” since experts have long noted links between diabetes’ effects on blood sugar and blood vessel health, and brain health.

But he added that the study doesn’t prove that these issues cause Alzheimer’s, or whether diabetes medications could curb or stop the brain-wasting disease once it had begun.

However, “treating chronic hyperglycemia will result in a reduction of further brain insult,” Giliberto reasoned. For people with Alzheimer’s disease, that “might result in better cognitive performance and quality of life,” he said.

Dr. Satjit Bhusri is a cardiologist at Lenox Hill Hospital in New York City. Reviewing the study, he said it “establishes a relationship between the blood vessels of the brain and Alzheimer’s disease.”

The findings could “open the door to a new pathway that may be of therapeutic use in patients with Alzheimer’s disease,” Bhusri said.

The report was published online Nov. 1 in the journal PLOS One.

More information

The Alzheimer’s Association offers more on Alzheimer’s disease.

© 2018 HealthDay. All rights reserved.

Posted: November 2018

Tagged with:

About author

Related Articles