Breaking News
December 11, 2018 - Krystal 2000 microplate design improves fluorescence and luminescence measurement
December 11, 2018 - FDA clears mobile medical app to help increase retention in recovery program for opioid use disorder
December 11, 2018 - Overcoming Challenges in High-Speed Centrifugation Experiments
December 11, 2018 - Study shows link between neighborhoods’ socioeconomic status and dietary choices
December 11, 2018 - Lower BMI before obesity surgery predicts greater post-operative weight loss, study finds
December 11, 2018 - Obesity May Be Driving Rise in Uterine Cancers
December 11, 2018 - Antioxidants may prevent cognitive impairment in diabetes
December 11, 2018 - Oral cancer prognostic signature identified
December 11, 2018 - How Can I Find Out What Caused My Miscarriage?
December 11, 2018 - Novel personalized medicine tool for assessing inherited colorectal cancer syndrome risk developed
December 11, 2018 - Study uncovers 11 new genes associated with epilepsy
December 11, 2018 - Filling research gaps could help develop more disability-inclusive workplaces
December 11, 2018 - Cartilage tissue engineering brings good news for patients with cartilage defects
December 11, 2018 - Novel 3D printing workflow helps predict leaky heart valves
December 11, 2018 - Imagination can help overcome fear and anxiety-related disorders, shows study
December 11, 2018 - Are caries linked to political regime?
December 11, 2018 - Leader in Diabetes Clinical Trials Wins Naomi Berrie Award
December 11, 2018 - Scientists discover cellular mechanism that triggers pneumonia in humans
December 11, 2018 - Increasing mental health problems related to drug use in over 55’s
December 11, 2018 - High-intensity interval exercise could help combat cognitive dysfunction in obese people
December 11, 2018 - Annual flu shot can save lives of heart failure patients
December 11, 2018 - Researchers compare health outcomes for VA and non-VA hospitals
December 11, 2018 - Recommendations Developed for Psoriatic Arthritis Treatment
December 11, 2018 - Genetic analysis links obesity with diabetes, coronary artery disease
December 11, 2018 - Study shows that having genetic information can affect how the body responds
December 11, 2018 - UNAIDS Report: 9 Million Are Likely HIV Positive And Don't Know It
December 11, 2018 - Lund University researchers succeed in obtaining dendritic cells by direct reprogramming
December 11, 2018 - Breast tumors recruit bone marrow cells to boost their growth, study reveals
December 11, 2018 - Updated breast cancer screening guideline highlights importance of shared decision-making
December 11, 2018 - EHR-related stress associated with physician burnout
December 11, 2018 - AHA: 12-Year-Old Heart Defect Survivor Inspires NFL Player’s Foundation
December 11, 2018 - Breast cancer patients who take heart drug with trastuzumab have less heart damage
December 11, 2018 - Providing aid to those humans – and animals – affected by the California fires
December 11, 2018 - Even without proof, CBD is finding a niche as a cure-all
December 11, 2018 - Drawing leads to better memory than writing
December 11, 2018 - Researchers report novel findings on plant hormone
December 10, 2018 - A Tale of Two Labels
December 10, 2018 - Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model
December 10, 2018 - A 14-year-old explains what it’s like to get a new heart
December 10, 2018 - Team Players Honored with 2018 Baton Awards
December 10, 2018 - Global report highlights how the changing world is affecting children’s physical activity levels
December 10, 2018 - Genes play a role in physical activity and sleep
December 10, 2018 - DDT in Alaskan fish shown to increase risk of cancer
December 10, 2018 - Laws to curb use of cell phones have greatly reduced fatalities for motorcyclists
December 10, 2018 - Argenx Provides Detailed Data from Phase 2 Clinical Trial of Efgartigimod in Immune Thrombocytopenia and Phase 1/2 Clinical Trial of Cusatuzumab in Acute Myeloid Leukemia
December 10, 2018 - University of Maryland doctors treat first breast cancer patients with GammaPod radiotherapy
December 10, 2018 - The heartbeat seat: Demoing new well-being technologies in a car
December 10, 2018 - Leading Cancer Researcher to Direct Herbert Irving Comprehensive Cancer Center
December 10, 2018 - Researchers explore how glial cells develop in the brain from neural precursor cells
December 10, 2018 - Study compares pain-related diagnoses in First Nations and non-First Nations children, youth
December 10, 2018 - Experts address sleep disorders following traumatic brain injury
December 10, 2018 - Scientists find answers to how cancer spreads
December 10, 2018 - Study explores why older people read more slowly
December 10, 2018 - Smart life-collar could save lives of young children
December 10, 2018 - Asbestos found in most NHS hospitals finds BBC inquiry
December 10, 2018 - Researchers use new technique to probe hydrogen bonds
December 10, 2018 - Music improves social communication in autistic children
December 10, 2018 - Some Brain Tumors May Respond to Immunotherapy, New Study Suggests
December 10, 2018 - Banning junk food ads to combat childhood obesity
December 10, 2018 - Skin Autofluorescence Predicts T2DM, Heart Disease, Mortality
December 10, 2018 - Largest autism sequencing study to date yields 102 genes associated with ASD
December 10, 2018 - Statins associated with low risk of side effects
December 10, 2018 - Episodic memory tests help in predicting brain atrophy and Alzheimer’s disease
December 10, 2018 - Study explores how schools address adolescent self-harming practices
December 10, 2018 - Pregnancy in adolescence linked to increased risks of complications in young mothers
December 10, 2018 - Risk Analysis publishes special issue on communicating about Zika virus
December 10, 2018 - Botox May Help Prevent Post-Op A-Fib
December 10, 2018 - African-American mothers rate boys higher for ADHD
December 10, 2018 - Graphic warning labels cancel out cigarettes’ appeal to young people
December 10, 2018 - Australian researchers to study gas inhalational anaesthetic and likelihood of cancer return
December 10, 2018 - Individual neurons located within the brain have implications for psychiatric diseases
December 10, 2018 - Researchers improve bariatric surgery scoring system to extend prediction time for diabetic remission
December 10, 2018 - HPV type 16 or 18 associated with cervical cancer risk in young women
December 10, 2018 - Cervical cancer risk is higher in women with positive HPV, but no cellular abnormalities
December 10, 2018 - Combo therapy not needed if low RA disease activity achieved
December 10, 2018 - Novel therapeutic targets based on biology of aging show promise for Alzheimer’s disease
December 10, 2018 - UC San Diego professor receives NCI Outstanding Investigator Award for cancer research
December 10, 2018 - Study evaluates placental mesenchymal stem cell sheets for myocardial repair and regeneration
December 10, 2018 - Blueprint Medicines Announces Updated Results from Ongoing EXPLORER Clinical Trial of Avapritinib Demonstrating Broad Clinical Activity and Significant Symptom Reductions in Patients with Systemic Mastocytosis
December 10, 2018 - Study clarifies ApoE4’s role in dementia
New multi-allergen test works just as well with dried blood

New multi-allergen test works just as well with dried blood

image_pdfDownload PDFimage_print

Using the Allergy Chip co-developed by MedUni Vienna, sensitization to allergens can be detected early on. This normally requires a doctor taking a blood sample for subsequent analysis in a laboratory equipped with the Chip. In Austria, provision is excellent and there are enough laboratories offering this new test. Elsewhere, however, there are only a few per country – blood samples are therefore often protected as well as possible, carefully packed, chilled and air-freighted for analysis. That is a complicated and expensive process. A MedUni Vienna team led by lead investigator Rudolf Valenta from the Institute of Pathophysiology and Allergy Research has now shown that this multi-allergen test works just as well with dried blood. Just a few drops of blood dried on a strip of Whatman paper (the extremely absorbent blotting paper most commonly used throughout the world) are enough.

This discovery by the Viennese researchers was inspired by the experience gained from the new-born screening programme run by MedUni Vienna’s Department of Pediatrics and Adolescent Medicine for more than 50 years. In this program, a small prick of blood is taken from the heel of new-born babies and put onto blotting paper to screen babies for any congenital diseases. “What works well here should also work in the allergy screening developed at MedUni Vienna,” say Valenta and study lead author, Victoria Garib.

Dried blood samples provide just as much information as fresh serum

The main finding is as follows: The dried blood samples taken by a doctor produce the same results as analysing fresh serum. And this is true no matter how long the dried specimen has been in a plastic envelope or in the post or at what temperature it was applied. Says Garib: “We measured it at temperatures of +37°C, -20°C and +4°C. The result was always the same.” The test involves stamping a small piece out of the paper and mixing it with a liquid in a plastic thimble, filtering out the antibodies in a centrifuge and then applying it to the Allergy Chip.

“This means that we are now giving every doctor in the world the ability to obtain an analysis quickly and easily, even if they only have a few patients with suspected allergies and do not have a laboratory nearby, so that they can help patients quickly,” adds Valenta, also clarifying: “Of course, laboratories must not accept dried blood samples sent in by private individuals. A doctor must first establish whether the test is necessary and then take the blood sample properly and send it on.” And this would only cost the same as a standard letter, just a few euros. By way of comparison: sending a chilled, correctly protected and packaged blood sample by airmail costs between €250 and €400. At the same time, say the Vienna researchers, it is possible to use the dried blood samples and antibodies obtained from them to evaluate the efficacy of allergy-related immunotherapy treatments and to monitor treatment.

About the Allergy Chip

The Allergy Chip, which was co-developed at MedUni Vienna by Valenta’s working group, detects potential allergies by means of fluorescent-labeled antibodies. Currently, serum can be tested for more than 100 allergens at once, ranging from apple to pollen, from grasses, food allergens and bee stings right through to various essentially harmless substances in the environment, such as house dust. It is especially important to identify allergies in children at an early stage, to prevent subsequent chronic diseases such as asthma, for example. The Chip has now become established worldwide as the safest method for early detection of allergies.

Source:

https://www.meduniwien.ac.at/

Tagged with:

About author

Related Articles