Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Study provides new insight into norovirus outbreaks, may help guide efforts to develop vaccines

Study provides new insight into norovirus outbreaks, may help guide efforts to develop vaccines

Outbreaks of norovirus in health care settings and outbreaks caused by a particular genotype of the virus are more likely to make people seriously ill, according to a new study in The Journal of Infectious Diseases. Based on an analysis of nearly 3,800 U.S. outbreaks from 2009 to 2016, the research confirms several factors that can make norovirus outbreaks more severe and may help guide efforts to develop a vaccine to prevent this highly contagious disease.

Each year in the U.S., norovirus causes an estimated 19 to 21 million cases of vomiting and diarrhea, between 56,000 and 71,000 hospitalizations, and 570 to 800 deaths, with much of the disease burden falling on young children and older adults, according to the Centers for Disease Control and Prevention (CDC). The disease spreads through direct contact with an infected person, consuming contaminated food or water, or touching contaminated surfaces.

In the new study, researchers linked, for the first time, data from a national outbreak reporting system and a laboratory surveillance network that collects data about norovirus genotypes associated with confirmed outbreaks. Their analysis, the largest of its kind, included 3,747 norovirus outbreaks affecting more than 100,000 people from 2009 to 2016. Severe outcomes, including hospitalizations and deaths, were more frequent in outbreaks caused by a specific genotype of norovirus, genogroup II type 4 (GII.4), and in outbreaks in health care settings, including hospitals, long-term care facilities, and outpatient facilities.

In a related editorial commentary that appears with the study in The Journal of Infectious Diseases, Geoffrey A. Weinberg, MD, of the University of Rochester School of Medicine and Dentistry in New York, noted that research of this kind helps advance our understanding of norovirus and the outbreaks it can cause. “Their data confirm that the notion of noroviruses simply being ‘a cruise ship virus’ or an occasional foodborne winter vomiting illness is outdated,” Dr. Weinberg wrote in the commentary.

The findings confirm previous research about the severity of GII.4 norovirus outbreaks and suggest that future vaccines against norovirus should include these genotypes, said the lead author of the study, Rachel M. Burke, MPH, PhD, of CDC. The study results also suggest that targeting these vaccines for use in people in health care settings may help reduce hospitalizations and mortality associated with norovirus. Although there is no currently available vaccine that protects against norovirus, several candidate vaccines are in the development pipeline.

“Linking data from these two different sources gives us a really powerful tool, a different way to look at norovirus outbreaks in the U.S., and a better understanding of some of the interactions between what is going on with the virus versus the host versus the environment,” Dr. Burke said.

Fast Facts

  • Norovirus, a highly contagious virus, is the leading cause of vomiting and diarrhea from acute gastroenteritis in the U.S.
  • An analysis of norovirus outbreaks found that severe outcomes, including hospitalizations and deaths, were more frequent in outbreaks caused by a specific genotype of norovirus, genogroup II type 4 (GII.4).
  • Severe outcomes were also more common in outbreaks occurring in health care settings, including hospitals, long-term care facilities, and outpatient facilities.
  • These findings may help guide efforts to develop and use vaccines that effectively protect against norovirus disease.

Source:

https://www.idsociety.org/

Tagged with:

About author

Related Articles