Breaking News
December 11, 2018 - New research identifies two genes linked to serious congenital heart condition
December 11, 2018 - NIH Director talks science, STEM careers with preteens
December 11, 2018 - Disabling a Cellular Antivirus System Could Improve Gene Therapy
December 11, 2018 - New tool swiftly provides accurate measure of patients’ cognitive difficulties
December 11, 2018 - Without Obamacare penalty, think it’ll be nice to drop your plan? Better think twice
December 11, 2018 - Researchers capture high-resolution X-ray and NMR image of key immune regulator
December 11, 2018 - Natural flavonoid is effective at treating leishmanisis infections, study shows
December 11, 2018 - Avoidant grievers unconsciously monitor and block mind-wandering contents, study shows
December 11, 2018 - Study identifies how hantaviruses infect lung cells
December 11, 2018 - Improving PTSD care through genetics
December 11, 2018 - Dermatology providers show interest in recommending cannabinoids to patients
December 11, 2018 - Researchers to study effects of electroconvulsive therapy on Alzheimer’s patients with aggression
December 11, 2018 - Four dried fruits have lower glycemic index than starchy foods, study finds
December 11, 2018 - Optimization of drug dose sizes can reduce pharmaceutical wastage
December 11, 2018 - Ultrarestrictive opioid prescribing strategy linked with reduction in number of pills dispensed
December 11, 2018 - PET scans to optimize tuberculosis meningitis treatments and personalize care, study finds
December 11, 2018 - Researchers aim to identify and target high blood pressure indicators
December 11, 2018 - Researchers identify immune cell subset that may drive chronic inflammation
December 11, 2018 - Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows
December 11, 2018 - One implant, two prices. It depends on who’s paying.
December 11, 2018 - Standardizing feeding practices improves growth trends for micro-preemies
December 11, 2018 - COPD Tied to Obesity in Male, Female Never-Smokers
December 11, 2018 - Flossing: Information for Caregivers
December 11, 2018 - Does breastfeeding hormone protect against type 2 diabetes?
December 11, 2018 - Educating future doctors to prescribe physical activity for their patients
December 11, 2018 - Krystal 2000 microplate design improves fluorescence and luminescence measurement
December 11, 2018 - FDA clears mobile medical app to help increase retention in recovery program for opioid use disorder
December 11, 2018 - Overcoming Challenges in High-Speed Centrifugation Experiments
December 11, 2018 - Study shows link between neighborhoods’ socioeconomic status and dietary choices
December 11, 2018 - Lower BMI before obesity surgery predicts greater post-operative weight loss, study finds
December 11, 2018 - Obesity May Be Driving Rise in Uterine Cancers
December 11, 2018 - Antioxidants may prevent cognitive impairment in diabetes
December 11, 2018 - Study discovers link between meditation and how individuals respond to feedback
December 11, 2018 - Researchers identify potential diagnostic tool for Alzheimer’s disease
December 11, 2018 - Oral cancer prognostic signature identified
December 11, 2018 - How Can I Find Out What Caused My Miscarriage?
December 11, 2018 - Novel personalized medicine tool for assessing inherited colorectal cancer syndrome risk developed
December 11, 2018 - Study uncovers 11 new genes associated with epilepsy
December 11, 2018 - Filling research gaps could help develop more disability-inclusive workplaces
December 11, 2018 - Cartilage tissue engineering brings good news for patients with cartilage defects
December 11, 2018 - Novel 3D printing workflow helps predict leaky heart valves
December 11, 2018 - Imagination can help overcome fear and anxiety-related disorders, shows study
December 11, 2018 - Are caries linked to political regime?
December 11, 2018 - Leader in Diabetes Clinical Trials Wins Naomi Berrie Award
December 11, 2018 - Scientists discover cellular mechanism that triggers pneumonia in humans
December 11, 2018 - Increasing mental health problems related to drug use in over 55’s
December 11, 2018 - High-intensity interval exercise could help combat cognitive dysfunction in obese people
December 11, 2018 - Annual flu shot can save lives of heart failure patients
December 11, 2018 - Researchers compare health outcomes for VA and non-VA hospitals
December 11, 2018 - Recommendations Developed for Psoriatic Arthritis Treatment
December 11, 2018 - Genetic analysis links obesity with diabetes, coronary artery disease
December 11, 2018 - Study shows that having genetic information can affect how the body responds
December 11, 2018 - UNAIDS Report: 9 Million Are Likely HIV Positive And Don't Know It
December 11, 2018 - Lund University researchers succeed in obtaining dendritic cells by direct reprogramming
December 11, 2018 - Breast tumors recruit bone marrow cells to boost their growth, study reveals
December 11, 2018 - Updated breast cancer screening guideline highlights importance of shared decision-making
December 11, 2018 - EHR-related stress associated with physician burnout
December 11, 2018 - AHA: 12-Year-Old Heart Defect Survivor Inspires NFL Player’s Foundation
December 11, 2018 - Breast cancer patients who take heart drug with trastuzumab have less heart damage
December 11, 2018 - Providing aid to those humans – and animals – affected by the California fires
December 11, 2018 - Even without proof, CBD is finding a niche as a cure-all
December 11, 2018 - Drawing leads to better memory than writing
December 11, 2018 - Researchers report novel findings on plant hormone
December 10, 2018 - A Tale of Two Labels
December 10, 2018 - Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model
December 10, 2018 - A 14-year-old explains what it’s like to get a new heart
December 10, 2018 - Team Players Honored with 2018 Baton Awards
December 10, 2018 - Global report highlights how the changing world is affecting children’s physical activity levels
December 10, 2018 - Genes play a role in physical activity and sleep
December 10, 2018 - DDT in Alaskan fish shown to increase risk of cancer
December 10, 2018 - Laws to curb use of cell phones have greatly reduced fatalities for motorcyclists
December 10, 2018 - Argenx Provides Detailed Data from Phase 2 Clinical Trial of Efgartigimod in Immune Thrombocytopenia and Phase 1/2 Clinical Trial of Cusatuzumab in Acute Myeloid Leukemia
December 10, 2018 - University of Maryland doctors treat first breast cancer patients with GammaPod radiotherapy
December 10, 2018 - The heartbeat seat: Demoing new well-being technologies in a car
December 10, 2018 - Leading Cancer Researcher to Direct Herbert Irving Comprehensive Cancer Center
December 10, 2018 - Researchers explore how glial cells develop in the brain from neural precursor cells
December 10, 2018 - Study compares pain-related diagnoses in First Nations and non-First Nations children, youth
December 10, 2018 - Experts address sleep disorders following traumatic brain injury
December 10, 2018 - Scientists find answers to how cancer spreads
December 10, 2018 - Study explores why older people read more slowly
New York State approves NYGC’s Whole Genome and Transcriptome Sequencing for oncology

New York State approves NYGC’s Whole Genome and Transcriptome Sequencing for oncology

image_pdfDownload PDFimage_print

The New York Genome Center (NYGC) has received approval from the New York State Department of Health to offer whole genome and RNA transcriptome sequencing in its Clinical Laboratory Evaluation Program (CLEP)-certified laboratory. This is the first approval by New York State for a whole genome sequencing test for oncology, and currently NYGC’s Clinical Lab is the only one to offer it.

Whole Genome and Transcriptome Sequencing (WGTS) for oncology is a complex genetic test developed by NYGC scientists that involves sequencing the genome of the tumor, the matched normal (unaffected) specimen, and the transcriptome of the tumor specimen. Unlike gene panels or whole exome sequencing, this new test includes sequencing the coding and non-coding regions of the genome. WGTS doesn’t rely on enriching the protein-coding part of the genome or make any assumptions about the most relevant genes. It probes the transcriptome of the tumor, revealing an unbiased and more complete depiction of the patient’s cancer from a genomic and molecular perspective. The ultimate advantage of WGTS is that it can lead to more comprehensive disease diagnosis and personalized treatment decisions than tests that sequence only the coding region.

NYGC’s WGTS is a test for all types of cancer that aims to examine the similarities and differences among the genomic and cellular alterations found across diverse tumor types. As such, it is indicated for both solid tumors and hematological malignancies where a mutational profile with multiple types of mutations would assist clinicians in determining disease stratification, prognosis, or treatment options, including targeted therapies and eligibility for clinical trials. The test has been validated for fresh, frozen and FFPE (formalin fixed paraffin embedded) specimens. Significant driver and therapeutic-associated mutations are included as part of the NYGC’s WGTS clinical report. The laboratory also reports secondary findings from the whole genome sequencing of the germline specimen for variants contributing to cancer predisposition and the ACMG-59 gene list when consented. These germline findings could have a significant impact in the clinical management of patients and their families.

Tom Maniatis, PhD, NYGC’s Scientific Director and Chief Executive Officer, noted, “Developing novel approaches to cancer genomics such as WGTS is part of the NYGC’s scientific focus, combining state-of-the-art genomic tools and analysis with whole genome sequencing to help identify more effective cancer treatments and therapies based on the tumor’s genetic profile.”

“Under Governor Cuomo, the biotech sector in New York State has made significant strides, advancing scientific discovery and creating jobs,” said Dr. Jill Taylor, Director of the Wadsworth Center, New York State Department of Health. “NYGC’s work with this next-generation sequencing test could lead to more comprehensive disease diagnosis and personalized treatment decisions, benefiting clinicians and patients in New York and all across the country.”

A recent paper about the WGTS assay developed at the NYGC was published in the Journal of Molecular Diagnostics with Vaidehi Jobanputra, PhD, NYGC’s Director of Molecular Diagnostics and Head of the Clinical Lab, as senior author and Kazimierz Wrzeszczynski, PhD, NYGC’s Assistant Director of Clinical Oncology Informatics, as first author. They and their clinical team describe the unique WGTS assay they developed and validated, and which New York State approved. This test provides more comprehensive genomic profiles of a patient’s tumor than current routine tests. The validation study involved 125 patient-derived tumors (including FFPE specimens) and matched normal specimens for the purpose of interrogating somatic alteration in the patient’s tumor. High confidence variant identification standards were determined and validated for whole genome sequencing detection of single nucleotide variants, insertions and deletions, copy number aberrations, structural variants, and RNA sequencing identified fusions. The study demonstrated that the WGTS assay can provide a variant discovery approach suitable for directed oncologic therapeutic applications.

“Whole genome sequencing provides an unbiased representation of a patient’s somatic tumor profile,” explained Dr. Jobanputra. “When combined with RNA transcriptome sequencing, this comprehensive diagnostic approach can be used to significantly improve diagnosis and potential targeted therapy selection for cancer patients.”

The NYGC’s Clinical Lab also offers a separate clinical whole genome sequencing test for undiagnosed disease and predisposition testing in ostensibly healthy individuals.

Source:

https://www.nygenome.org/news/new-york-genome-center-receives-new-york-state-approval-for-whole-genome-and-transcriptome-sequencing-for-cancer-patients/

Tagged with:

About author

Related Articles