Breaking News
December 12, 2018 - Sprayable gel could help prevent recurrences of cancer after surgery
December 12, 2018 - How do patients want to discuss symptoms with clinicians?
December 12, 2018 - Zinc chelation may be able to deliver drug to insulin-producing cells
December 12, 2018 - Brigham researchers develop automated, low-cost tool to predict a woman’s ovulation
December 12, 2018 - Some people with Type 2 diabetes may be testing their blood sugar more often than needed
December 12, 2018 - Slow-growing type of glioma may be vulnerable to immunotherapy, suggests study
December 12, 2018 - Study provides new information regarding microRNA function in cellular homeostasis of zebrafish
December 12, 2018 - Study provides new understanding of mysterious ‘hereditary swelling’
December 12, 2018 - Researchers shed new light on how to combat Shiga and ricin toxins
December 12, 2018 - Pregnant Women Commonly Refuse Vaccines
December 12, 2018 - Drug treatment could offer new hope for some patients with brain bleeding
December 12, 2018 - Health care financial burden of animal-related injuries is growing, study says
December 12, 2018 - Macrophage cells could help repair the heart following a heart attack, study finds
December 12, 2018 - Researchers develop new system for efficiently producing human norovirus
December 12, 2018 - New artificial intelligence-based system to differentiate between different types of cancer cells
December 11, 2018 - Brazilian professors propose guidelines for therapeutic use of melatonin
December 11, 2018 - Healthy Lifestyle Lowers Odds of Breast Cancer’s Return
December 11, 2018 - New research identifies two genes linked to serious congenital heart condition
December 11, 2018 - NIH Director talks science, STEM careers with preteens
December 11, 2018 - Disabling a Cellular Antivirus System Could Improve Gene Therapy
December 11, 2018 - New tool swiftly provides accurate measure of patients’ cognitive difficulties
December 11, 2018 - NICE releases new guidelines for diagnosis and management of COPD
December 11, 2018 - Without Obamacare penalty, think it’ll be nice to drop your plan? Better think twice
December 11, 2018 - Researchers capture high-resolution X-ray and NMR image of key immune regulator
December 11, 2018 - Natural flavonoid is effective at treating leishmanisis infections, study shows
December 11, 2018 - Avoidant grievers unconsciously monitor and block mind-wandering contents, study shows
December 11, 2018 - Study identifies how hantaviruses infect lung cells
December 11, 2018 - Improving PTSD care through genetics
December 11, 2018 - Dermatology providers show interest in recommending cannabinoids to patients
December 11, 2018 - Researchers to study effects of electroconvulsive therapy on Alzheimer’s patients with aggression
December 11, 2018 - Four dried fruits have lower glycemic index than starchy foods, study finds
December 11, 2018 - Optimization of drug dose sizes can reduce pharmaceutical wastage
December 11, 2018 - Ultrarestrictive opioid prescribing strategy linked with reduction in number of pills dispensed
December 11, 2018 - PET scans to optimize tuberculosis meningitis treatments and personalize care, study finds
December 11, 2018 - Researchers aim to identify and target high blood pressure indicators
December 11, 2018 - Researchers identify immune cell subset that may drive chronic inflammation
December 11, 2018 - Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows
December 11, 2018 - One implant, two prices. It depends on who’s paying.
December 11, 2018 - Standardizing feeding practices improves growth trends for micro-preemies
December 11, 2018 - COPD Tied to Obesity in Male, Female Never-Smokers
December 11, 2018 - Flossing: Information for Caregivers
December 11, 2018 - Does breastfeeding hormone protect against type 2 diabetes?
December 11, 2018 - Educating future doctors to prescribe physical activity for their patients
December 11, 2018 - Krystal 2000 microplate design improves fluorescence and luminescence measurement
December 11, 2018 - FDA clears mobile medical app to help increase retention in recovery program for opioid use disorder
December 11, 2018 - Overcoming Challenges in High-Speed Centrifugation Experiments
December 11, 2018 - Study shows link between neighborhoods’ socioeconomic status and dietary choices
December 11, 2018 - Lower BMI before obesity surgery predicts greater post-operative weight loss, study finds
December 11, 2018 - Obesity May Be Driving Rise in Uterine Cancers
December 11, 2018 - Antioxidants may prevent cognitive impairment in diabetes
December 11, 2018 - Study discovers link between meditation and how individuals respond to feedback
December 11, 2018 - Researchers identify potential diagnostic tool for Alzheimer’s disease
December 11, 2018 - Oral cancer prognostic signature identified
December 11, 2018 - How Can I Find Out What Caused My Miscarriage?
December 11, 2018 - Novel personalized medicine tool for assessing inherited colorectal cancer syndrome risk developed
December 11, 2018 - Study uncovers 11 new genes associated with epilepsy
December 11, 2018 - Filling research gaps could help develop more disability-inclusive workplaces
December 11, 2018 - Cartilage tissue engineering brings good news for patients with cartilage defects
December 11, 2018 - Novel 3D printing workflow helps predict leaky heart valves
December 11, 2018 - Imagination can help overcome fear and anxiety-related disorders, shows study
December 11, 2018 - Are caries linked to political regime?
December 11, 2018 - Leader in Diabetes Clinical Trials Wins Naomi Berrie Award
December 11, 2018 - Scientists discover cellular mechanism that triggers pneumonia in humans
December 11, 2018 - Increasing mental health problems related to drug use in over 55’s
December 11, 2018 - High-intensity interval exercise could help combat cognitive dysfunction in obese people
December 11, 2018 - Annual flu shot can save lives of heart failure patients
December 11, 2018 - Researchers compare health outcomes for VA and non-VA hospitals
December 11, 2018 - Recommendations Developed for Psoriatic Arthritis Treatment
December 11, 2018 - Genetic analysis links obesity with diabetes, coronary artery disease
December 11, 2018 - Study shows that having genetic information can affect how the body responds
December 11, 2018 - UNAIDS Report: 9 Million Are Likely HIV Positive And Don't Know It
December 11, 2018 - Lund University researchers succeed in obtaining dendritic cells by direct reprogramming
December 11, 2018 - Breast tumors recruit bone marrow cells to boost their growth, study reveals
December 11, 2018 - Updated breast cancer screening guideline highlights importance of shared decision-making
December 11, 2018 - EHR-related stress associated with physician burnout
December 11, 2018 - AHA: 12-Year-Old Heart Defect Survivor Inspires NFL Player’s Foundation
December 11, 2018 - Breast cancer patients who take heart drug with trastuzumab have less heart damage
December 11, 2018 - Providing aid to those humans – and animals – affected by the California fires
December 11, 2018 - Even without proof, CBD is finding a niche as a cure-all
December 11, 2018 - Drawing leads to better memory than writing
New project launched to map out lung cancer immunology

New project launched to map out lung cancer immunology

image_pdfDownload PDFimage_print

A ‘rule book’ to guide precision combination immunotherapies and to speed up the development of new lung cancer treatments will be created as part of a collaboration between Cancer Research UK, the Francis Crick Institute and Bristol-Myers Squibb, announced today (Friday).

The new £2.4 million research project called RUBICON – a rule book and immune atlas for combination therapy – will map out the immunology of lung cancer in detail.

The study will be led by Cancer Research UK’s chief clinician and Francis Crick Institute group leader, Professor Charles Swanton. He said: “Biological therapies, including immunotherapies are set to transform the way we treat patients and the RUBICON study will bring us a step closer to this vision.

“When we see patients with hard-to-treat cancers like lung, we struggle to keep up with the speed at which tumours evolve, become aggressive and resistant to treatment. Our research so far has uncovered many of cancer’s evolutionary secrets, opening opportunities for us to develop new and targeted biological therapies, and understand how they can be combined to maximum effect.

“By learning more about immune suppressive cell types – the molecules they express and how stable they are during disease evolution – we hope researchers can start to develop molecularly targeted immunotherapy combination strategies.”

The innovative project builds on Cancer Research UK’s strategic investment in lung cancer, enhancing our understanding of cancer evolution through tumour samples and data prospectively gathered and analysed as part of the TRACERx* and PEACE** studies, led by Professor Swanton and his team at the Cancer Research UK-Lung Cancer Centre of Excellence at UCL.

Multidisciplinary researchers at the Francis Crick Institute will use state of the art technologies, including deep learning and artificial intelligence tools, to analyse tumour samples and data from TRACERx and PEACE. This will allow them to map an atlas of immune cell activity across distinct tumour regions, and to understand how the incredibly complex tumour immune microenvironment evolves and develops over time.

Veronique Birault, head of translation at the Francis Crick Institute, said: “This project is a fantastic example of the industry and charity sectors working together to support world-class discovery science for the benefit of patients. The project wouldn’t be possible without Cancer Research UK’s significant investment in research, amplified by the complementary expertise of three different cancer labs collaborating at the Crick. This new funding will allow our scientists to map out the immune landscape around lung tumours to develop better combination therapies for patients.”

Dr Iain Foulkes, Cancer Research UK’s executive director of research and innovation, said: “We’re pleased to bring together these partners of industry and academia to advance this ambitious study. As we delve ever deeper into the tumour microenvironment, we can equip ourselves with the necessary knowledge to take the next steps toward truly personalised cancer treatments.

“Lung cancer is a disease for which there has been very little improvement in patient survival over the last 40 years. We look forward to seeing how new treatment combinations that arise from this study could make a real difference for these patients.”

Bristol-Myers Squibb will provide £2.4 million in funding for the RUBICON project.

“Bristol-Myers Squibb is proud to be part of this innovative research initiative. We look for first-class science everywhere and we know that continued progress in cancer can only happen through strong collaboration with scientists, academic researchers, clinicians and patients who participated in clinical trials,” said Tom Lynch, M.D., Executive Vice President and Chief Scientific Officer, Bristol-Myers Squibb.

“The UK has a strong heritage in cutting edge research and, through this RUBICON project, we believe further progress will be made for lung cancer patients across the world.”

Source:

https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2018-11-30-cancer-research-uk-the-francis-crick-institute-and-bristol-myers-squibb-join-forces-to-map-out-lung

Tagged with:

About author

Related Articles