Breaking News
December 11, 2018 - AHA: 12-Year-Old Heart Defect Survivor Inspires NFL Player’s Foundation
December 11, 2018 - Breast cancer patients who take heart drug with trastuzumab have less heart damage
December 11, 2018 - Providing aid to those humans – and animals – affected by the California fires
December 11, 2018 - Even without proof, CBD is finding a niche as a cure-all
December 11, 2018 - Drawing leads to better memory than writing
December 11, 2018 - Researchers report novel findings on plant hormone
December 10, 2018 - A Tale of Two Labels
December 10, 2018 - Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model
December 10, 2018 - A 14-year-old explains what it’s like to get a new heart
December 10, 2018 - Team Players Honored with 2018 Baton Awards
December 10, 2018 - Global report highlights how the changing world is affecting children’s physical activity levels
December 10, 2018 - Genes play a role in physical activity and sleep
December 10, 2018 - DDT in Alaskan fish shown to increase risk of cancer
December 10, 2018 - Laws to curb use of cell phones have greatly reduced fatalities for motorcyclists
December 10, 2018 - Argenx Provides Detailed Data from Phase 2 Clinical Trial of Efgartigimod in Immune Thrombocytopenia and Phase 1/2 Clinical Trial of Cusatuzumab in Acute Myeloid Leukemia
December 10, 2018 - University of Maryland doctors treat first breast cancer patients with GammaPod radiotherapy
December 10, 2018 - The heartbeat seat: Demoing new well-being technologies in a car
December 10, 2018 - Leading Cancer Researcher to Direct Herbert Irving Comprehensive Cancer Center
December 10, 2018 - Study compares pain-related diagnoses in First Nations and non-First Nations children, youth
December 10, 2018 - Experts address sleep disorders following traumatic brain injury
December 10, 2018 - Scientists find answers to how cancer spreads
December 10, 2018 - Study explores why older people read more slowly
December 10, 2018 - Smart life-collar could save lives of young children
December 10, 2018 - Asbestos found in most NHS hospitals finds BBC inquiry
December 10, 2018 - Researchers use new technique to probe hydrogen bonds
December 10, 2018 - Music improves social communication in autistic children
December 10, 2018 - Some Brain Tumors May Respond to Immunotherapy, New Study Suggests
December 10, 2018 - Banning junk food ads to combat childhood obesity
December 10, 2018 - Skin Autofluorescence Predicts T2DM, Heart Disease, Mortality
December 10, 2018 - Largest autism sequencing study to date yields 102 genes associated with ASD
December 10, 2018 - Statins associated with low risk of side effects
December 10, 2018 - Episodic memory tests help in predicting brain atrophy and Alzheimer’s disease
December 10, 2018 - Study explores how schools address adolescent self-harming practices
December 10, 2018 - Pregnancy in adolescence linked to increased risks of complications in young mothers
December 10, 2018 - Risk Analysis publishes special issue on communicating about Zika virus
December 10, 2018 - Botox May Help Prevent Post-Op A-Fib
December 10, 2018 - African-American mothers rate boys higher for ADHD
December 10, 2018 - Graphic warning labels cancel out cigarettes’ appeal to young people
December 10, 2018 - Australian researchers to study gas inhalational anaesthetic and likelihood of cancer return
December 10, 2018 - Individual neurons located within the brain have implications for psychiatric diseases
December 10, 2018 - Researchers improve bariatric surgery scoring system to extend prediction time for diabetic remission
December 10, 2018 - HPV type 16 or 18 associated with cervical cancer risk in young women
December 10, 2018 - Cervical cancer risk is higher in women with positive HPV, but no cellular abnormalities
December 10, 2018 - Combo therapy not needed if low RA disease activity achieved
December 10, 2018 - Novel therapeutic targets based on biology of aging show promise for Alzheimer’s disease
December 10, 2018 - UC San Diego professor receives NCI Outstanding Investigator Award for cancer research
December 10, 2018 - Study evaluates placental mesenchymal stem cell sheets for myocardial repair and regeneration
December 10, 2018 - Blueprint Medicines Announces Updated Results from Ongoing EXPLORER Clinical Trial of Avapritinib Demonstrating Broad Clinical Activity and Significant Symptom Reductions in Patients with Systemic Mastocytosis
December 10, 2018 - Study clarifies ApoE4’s role in dementia
December 10, 2018 - Eating disorders now a top priority with Australian Government
December 10, 2018 - Neuronal activity in the brain allows prediction of risky or safe decisions
December 10, 2018 - FDA Alerts Health Care Professionals and Patients Not to Use Drug Products Intended to be Sterile from Promise Pharmacy
December 10, 2018 - Improving dementia care and treatment saves thousands of pounds in care homes
December 10, 2018 - Heroin-assisted treatment can offer benefits, reduce harms
December 10, 2018 - People covered by Michigan’s expanded Medicaid program report improvements in health, finds study
December 10, 2018 - Hazelnuts improve micronutrient levels in older adults
December 9, 2018 - History of Partner Violence Tied to Menopause Symptoms
December 9, 2018 - Clean Up Safely After a Disaster|Natural Disasters and Severe Weather
December 9, 2018 - Drug wholesalers drove fentanyl’s deadly rise, report concludes
December 9, 2018 - Deprescribing could help manage polypharmacy in older adults
December 9, 2018 - Retraction of article “Joy of cooking too much” from journal
December 9, 2018 - FDA Warns of Rare Stroke Risk With MS Drug Lemtrada (Alemtuzumab)
December 9, 2018 - Feds say heroin, fentanyl remain biggest drug threat to US
December 9, 2018 - Eliminating microglia can reverse some aspects of stress sensitization, study shows
December 9, 2018 - New genetic insight could help treat rare debilitating heart and lung condition
December 9, 2018 - MiRagen Therapeutics Announces Final Safety, Biodistribution and Clinical Efficacy Data From Phase 1 Cobomarsen Clinical Trial in Patients With Mycosis Fungoides
December 9, 2018 - Work with your doctor to weigh pros, cons of treatment options for hyperthyroidism
December 9, 2018 - CWRU researcher secures $14.6 million funding for genetic study into Alzheimer’s disease
December 9, 2018 - High intensity statin treatment and adherence could save more lives
December 9, 2018 - Surgery patients use only 1/4 of prescribed opioids, and prescription size matters
December 9, 2018 - AXT offers Phi Optics upgrade to QPI systems for inverted light microscopes
December 9, 2018 - New booklet could help improve conditions of young pupils with albinism
December 9, 2018 - Few Physicians Work in Practices That Use Telemedicine
December 9, 2018 - Older Adults and Oral Health
December 9, 2018 - Health utility values improve after septorhinoplasty
December 9, 2018 - New EU-funded project provides insight into how the brain develops
December 9, 2018 - Expanded use of tele-emergency services can help strengthen rural hospitals
December 9, 2018 - Infections in the Young May Be Tied to Risk for Mental Illness: Study
December 9, 2018 - Profile: Native Hawaiians and Pacific Islanders
December 9, 2018 - Snoring poses greater cardiac risk to women
Brown researchers awarded $12 million NIH grant renewal to explore fundamentals of brain function

Brown researchers awarded $12 million NIH grant renewal to explore fundamentals of brain function

image_pdfDownload PDFimage_print

Brown University’s Center for Central Nervous System Function, part of the Carney Institute for Brain Science, has been awarded a $12 million grant renewal from the National Institutes of Health’s Centers of Biomedical Research Excellence (COBRE) program. The funding will support the research center for the next five years.

With a focus on the genetic and neural basis for attention, decision-making and action, the expansion of research in the Center for Central Nervous System Function will complement Brown’s broader scientific discovery at the Carney Institute in the areas of cognitive neuroscience, computational neuroscience, neurobiology of brain circuits and brain imaging, recording and stimulation.

“Our goal is to develop fundamental knowledge about higher-order nervous system function,” said Jerome Sanes, a Brown professor of neuroscience who leads the center. “With this support, we will work on understanding fundamental properties in the brain from decision-making to sensory perception. The five new projects funded through this grant are models of a wide range of neural processes — from making decisions to detecting objects in the world around you to going through sequential tasks in your daily life.”

COBRE is a National Institute for General Medical Sciences program that aims to bolster research and mentorship of promising junior faculty members. Researchers at eligible institutions can apply for up to three five-year phases of COBRE support. Brown’s central nervous system program is in its second phase, with an $11 million award in 2013 launching the center.

The new $12 million federal grant follows on the heels of a $100 million gift to the Carney Institute to advance work on how the brain functions as well as finding cures for some of the world’s most devastating diseases, from ALS to Alzheimer’s.

Sanes said that phase one COBRE funding focused on developing institutional research infrastructure and helping junior investigators establish research projects so they could successfully compete for other grants. The junior researchers from phase one published almost 60 papers and received approximately $20 million in additional funding from the National Institutes of Health (NIH), the National Science Foundation and private foundations, according to Sanes.

Research infrastructure work in phase one centered around establishing a design and analysis research core. This core, a nexus of experts and the technology needed for their research, is focused on developing methods and procedures for experimental design and data analysis across the COBRE projects, the Carney Instituteand Brown-affiliated hospitals, Sanes said. It will continue in the next phase.

While continuing to support junior faculty, the phase two grant adds a focus on developing and optimizing neuroimaging analysis tools to better understand the neural basis of behavior through a behavior and neuroimaging core. With techniques like magnetic resonance imaging (MRI) and electroencephalography (EEG), the analysis tools will be a benefit to the broader Brown brain science community, Sanes said.

Phase three, if granted in the years to come, would provide support for the research cores and small, pilot projects.

“To have a successful phase three application in 2023, in addition to the project leaders publishing good papers, getting external funding and giving presentations, we need to demonstrate that the research cores are relevant and useful for the University,” Sanes said.

Eight projects were supported during phase one, with a general focus on normal and abnormal attention and decision-making. They included, among others:

Dima Amso, an associate professor of cognitive, linguistic and psychological sciences, studied context-dependent attention and learning in infant development. She found that both 6-month-old and 10-month-old healthy babies learned where to expect friendly faces from context — a pattern of repeated shapes.

Dr. Wael Asaad, an associate professor of neurosurgery and neuroscience at the Warren Alpert Medical School, focused on the dorsolateral prefrontal cortex and how it integrates sensory information. He found this specific brain region played a key role in assigning cause and effect, which is critical for learning.

Dr. Eric Morrow, an associate professor of molecular biology, cell biology and biochemistry and psychiatry and human behavior, studied a rare autism-like disorder called Christianson syndrome using a combination of genetics, neuroimaging and behavioral observations. He complied the first diagnostic criteria for Christianson syndrome, including a signature genetic mutation and common behavioral and clinical symptoms.

Joo-Hyun Song, an associate professor of cognitive, linguistic and psychological sciences, studied how multiple neural systems in the brain work together to weed out distraction when someone is reaching for objects of different colors. She found that objects that were slightly different, pink compared to red, were more distracting than objects that were blatantly different, such as blue objects.

Michael Worden, an assistant professor of neuroscience (research), studied visual processing in humans by examining cases in which the brain must adapt to conflicting visual stimuli such as arrows pointing in opposite directions that seem to call for incompatible responses.

Karla Kaun, an assistant professor of neuroscience, began her project in the third year of phase one. She studied the molecular basis of cravings and addiction and found in fruit flies that alcohol hijacks a conserved memory pathway in the brain and changes which versions of genes are made.

Phase two projects include:

Theresa Desrochers, an assistant professor of neuroscience and psychiatry and human behavior, will continue work she started in phase one on the role of the frontal cortex in monitoring complex sequences, such as making a cup of coffee.

Amitai Shenhav, an assistant professor of cognitive, linguistic and psychological sciences, is investigating the neural foundation of normal and abnormal decision-making presented with many options, using EEG and MRI. Shenhav’s work is also a continuation of phase one support.

Oriel FeldmanHall, an assistant professor of cognitive, linguistic and psychological sciences, will examine the neural mechanisms of social decision-making. She studies individuals both with and without anxiety disorders make decisions about trusting other people.

Ani Eloyan, an assistant professor of biostatistics, will focus on how brain networks form, change and convey information. She is developing a computational method to estimate the functional connectivity of different areas of the brain using data from MRI signals.

Stephanie Jones, an associate professor of neuroscience, will study how humans perceive sensation, specifically the strength and number of brief events in the beta frequency (as measured by EEG) that are needed to produce a detectible sensation.

Source:

https://news.brown.edu/articles/2018/12/cobre

Tagged with:

About author

Related Articles