Breaking News
February 17, 2019 - Exercise gives a better brain boost to older men than women
February 17, 2019 - New research disproves previous assumptions of how looks influence personality
February 17, 2019 - Cannabis use as a teenager linked to depression later in life
February 17, 2019 - Sinks by Toilets in ICU Patient Rooms Harbor Harmful Bacteria
February 17, 2019 - Cancer cells’ plasticity makes them harder to stop
February 17, 2019 - Young cannabis users have increased risk of depression and suicidal behavior
February 17, 2019 - Tasmanian Devils Likely to Survive Cancer Scourge
February 17, 2019 - Neoadjuvant PD-1 blockade seems effective in glioblastoma
February 17, 2019 - Personal, social factors play role in enabling sustainable return to work after ill health
February 17, 2019 - Mouse studies show ‘inhibition’ theory of autism wrong
February 17, 2019 - Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins
February 17, 2019 - Use of liver grafts from older donors decreased despite better outcomes in recipients
February 17, 2019 - MUSC researchers discover new mechanism for a class of anti-cancer drugs
February 17, 2019 - HPV misconceptions are causing women to miss smear tests
February 17, 2019 - Sanofi and Regeneron Offer Praluent (alirocumab) at a New Reduced U.S. List Price
February 17, 2019 - Researchers say auditory testing can identify children for autism screening
February 17, 2019 - New method analyzes how single biological cells react to stressful situations
February 17, 2019 - WVU gynecologic oncologist investigates novel treatment for cervical and vaginal cancers
February 17, 2019 - ADHD diagnoses poorly documented
February 17, 2019 - Majority of gender minority youth do not identify with traditional sexual identity labels
February 17, 2019 - AbbVie, Teneobio enter into strategic transaction to develop potential treatment for multiple myeloma
February 17, 2019 - Lower Birth Weight May Up Risk for Psychiatric Disorders
February 17, 2019 - Scientists identify reversible molecular defect underlying rheumatoid arthritis
February 17, 2019 - Moffitt researchers shed light on how CAR T cells function mechanistically
February 16, 2019 - Female Anatomy May Play Big Role in Sperm’s Success
February 16, 2019 - BMI may mediate inverse link between fiber intake, knee OA
February 16, 2019 - Movement impairments in autism can be reversed through behavioral training
February 16, 2019 - Studies address racial disparities in postpartum period and cardiovascular health
February 16, 2019 - Scientists implicate hidden genes in the severity of autism symptoms
February 16, 2019 - Decreased deep sleep linked to early signs of Alzheimer’s disease
February 16, 2019 - Neuroscientists show how the brain responds to texture
February 16, 2019 - Gilead Announces Topline Data From Phase 3 STELLAR-4 Study of Selonsertib in Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
February 16, 2019 - What Can I Do About Sweating? (for Teens)
February 16, 2019 - Companies navigate dementia conversations with older workers
February 16, 2019 - Newly developed stem cell technologies show promise for treating PD patients
February 16, 2019 - Collaborative material research could advance self-assembling nanomaterials
February 16, 2019 - Researchers take major step in creating technology that mimics the human brain
February 16, 2019 - Erasing memories associated with cocaine use reduces drug seeking behavior
February 16, 2019 - Artificial intelligence can accurately predict prognosis of ovarian cancer patients
February 16, 2019 - Racial disparities in cancer deaths on the decline for America
February 16, 2019 - FDA authorizes new interoperable insulin pump for children, adults with diabetes
February 16, 2019 - Coexisting Medical Conditions, Smoking Explain PTSD-CVD Link
February 16, 2019 - Skin Cancer Screening: MedlinePlus Lab Test Information
February 16, 2019 - ‘Happiness’ exercises can boost mood in those recovering from substance use disorder
February 16, 2019 - Cell manipulation could soon halt or reverse aging
February 16, 2019 - Pumped Breast Milk Falls Short of Breastfed Version
February 16, 2019 - Men’s porn habits could fuel partners’ eating disorders, study suggests
February 16, 2019 - Rapid progression of age-related diseases may result from formation of vicious cycles
February 16, 2019 - Immune checkpoint molecule protects against future development of cancer
February 16, 2019 - New method produces hydrogels that have properties similar to cells’ environment
February 16, 2019 - $4.1 million funding for heart research on Valentine’s Day
February 16, 2019 - General anesthesia in early infancy unlikely to have lasting effects on developing brains
February 16, 2019 - New breakthroughs for muscular dystrophy research
February 16, 2019 - First Opinion: Embryo editing for higher IQ is a fantasy. Embryo profiling for it is almost here
February 16, 2019 - Vapers develop cancer-related gene deregulation as cigarette smokers
February 16, 2019 - Bringing Antimicrobial Susceptibility Testing (AST) to the Community
February 16, 2019 - Decolonization protocol after hospital discharge can prevent dangerous infections
February 16, 2019 - Children with ASD more likely to face maltreatment, study finds
February 16, 2019 - Study finds genetic vulnerability to use of menthol cigarettes
February 16, 2019 - Promising drug developed to rejuvenate muscle cells
February 16, 2019 - H-RT should be the standard of care for men with low risk prostate cancer, study shows
February 16, 2019 - New technique using patients’ own modified cells could help treat Crohn’s disease
February 16, 2019 - Therapeutic endoscopy has an expanding role in the treatment of IBD
February 16, 2019 - Blood clot discovery could lead to development of better treatments for blood diseases
February 16, 2019 - Intervention can increase exclusive breastfeeding rates
February 16, 2019 - New project explores how gaming technologies can help cancer patients communicate better
February 16, 2019 - Catalyst Biosciences Presents Updated Data from Its Phase 2/3 Trial of Subcutaneous Marzeptacog Alfa (Activated) in Individuals with Hemophilia A or B with Inhibitors at the 12th Annual EAHAD Congress
February 16, 2019 - Rerouting nerves during amputation reduces phantom limb pain before it starts
February 16, 2019 - A Hormone Produced When We Exercise Might Help Fight Alzheimer’s
February 16, 2019 - Millions of British people breathe toxic air travelling to GPs
February 16, 2019 - Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft
February 16, 2019 - Researchers use optogenetic tool to control, visualize receptor signals in neural cells
February 16, 2019 - New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis
February 16, 2019 - Testosterone is not the only hormone needed for penis development
February 16, 2019 - FDA Advisory Committee Recommends Approval of Spravato (esketamine) Nasal Spray for Adults with Treatment-Resistant Depression
February 15, 2019 - Heart surgery technology developed at Baptist Health debuts after years of secrecy
February 15, 2019 - Prescription Opioids Double Risk of Triggering Fatal Car Crash
February 15, 2019 - New study helps doctors better understand high blood pressure in pregnant women
February 15, 2019 - Beta wave control in Parkinson’s diseased brain could be a potential therapy
February 15, 2019 - Media representations of love may justify gender-based violence in young people
CAR-T cell therapy appears to be promising option for treating large B-cell lymphoma

CAR-T cell therapy appears to be promising option for treating large B-cell lymphoma

image_pdfDownload PDFimage_print

So-called CAR-T cell therapy is a promising option for treating around a fifth of patients with diffuse large B-cell lymphoma. That is the main finding of the multi-center JULIET study, in which researchers from the Comprehensive Cancer Centre (CCC) of MedUni Vienna/Vienna General Hospital participated. In CAR-T cell therapy, previously modified T-cells recognize a specific protein on the surface of the tumor. This, in turn, triggers destruction of the tumor cells. This introduces a new option for treating such patients, besides the conventional standard treatment (chemotherapy). Because: the two-year survival rate following standard treatment is only 20%, whereas, with CAR-T cell therapy, overall survival was doubled to 40%. The results of this study have now been published in the prestigious “New England Journal of Medicine”.

With 480 new cases a year, diffuse large cell B-cell lymphoma is the commonest type of lymphoma (cancer of the lymph cells) in Austria. Moreover, it is a very aggressive disease, which is normally treated with a combination of chemotherapy and immunotherapy. Around 50% of cases are permanently cured with this regime, the other half suffering a relapse, for which there has hitherto been no satisfactory treatment.

Immune system permanently modified

A potential new treatment could now help these people: CAR-T cell therapy. This is a targeted therapy directed against the protein CD19. CD19 is found on the surface of tumor cells in 90% of relapsed patients.

In CAR-T cell therapy, the T-cells are removed by blood dialysis and genetically modified in a special device, in that a receptor capable of docking onto CD19 is attached to their surface. In the third stage of the therapy, the modified T-cells are multiplied and returned to the patient by infusion. The modified T-cells are now able to recognize the tumor cells and so destroy them. Since the T-cells remain in the body and continue to multiply, they are permanently available to recognize and destroy newly occurring cancer cells with the surface characteristic CD19.

Says Ulrich Jäger, Head of the Division of Hematology and Hemastasology at the Department of Medicine I of MedUni Vienna/Vienna General Hospital, member of the CCC and principal investigator of the JULIET study in Austria:

Our study shows that CAR-T cell therapy is a ground-breaking treatment option that enables us to permanently cure the disease, even in previously hopeless cases.”

Special know-how required

Since CAR-T cell therapy provokes a strong immune response, the treatment is administered on an in-patient basis, so that patients can be closely monitored.

Says Jäger:

The procedure is very complex and can only be implemented in an interdisciplinary context. MedUni Vienna is one of the few centers in Europe capable of performing this treatment. We are therefore maintaining an active scientific exchange with other centers. These include, for example, St. Anna Children’s Cancer Research in the field of CAR-T cell therapy for childhood leukemia.”

The next steps

The next goal for the researchers led by Ulrich Jäger is to find out why 40% of patients respond to CAR-T cell therapy, and are cured, while the remaining 60% do not; and, of course, how this situation can be rectified. It is planned to conduct a study into this, building on the JULIET study.

Says Jäger:

We are expecting that the procedure can also be used for many other indications. With this major field of study, MedUni Vienna is positioning itself as a center for cell therapy, where even complex treatments and procedures can be carried out.”

Source:

https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2018/news-im-dezember-2018/b-cell-lymphoma-new-treatment-option-doubles-survival-time-compared-to-chemotherapy/

Tagged with:

About author

Related Articles