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November 2018 Briefing – Neurology

November 2018 Briefing – Neurology

Here are what the editors at HealthDay consider to be the most important developments in Neurology for November 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Case Description Can Reliably Define Acute Flaccid Myelitis

FRIDAY, Nov. 30, 2018 — A case description can reliably define patients with acute flaccid myelitis (AFM), according to a study published online Nov. 30 in JAMA Pediatrics.

Abstract/Full Text
Editorial 1
Editorial 2

Results of Pediatric Genomic Epilepsy Tests Often Reclassified

FRIDAY, Nov. 30, 2018 — The interpretation of genomic epilepsy tests has evolved rapidly in the last five years, and genetic variants identified in pediatric patients are often reclassified, according to research published online Nov. 5 in JAMA Pediatrics.

Abstract/Full Text (subscription or payment may be required)

Burnout, Satisfaction Vary With Age, Sex Among Neurologists

FRIDAY, Nov. 30, 2018 — Burnout, career satisfaction, and well-being vary by age and sex among neurologists, according to a study published online Nov. 15 in Neurology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

FDA Approves Firdapse for Rare Autoimmune Disorder

THURSDAY, Nov. 29, 2018 — Firdapse (amifampridine) tablets have been approved by the U.S. Food and Drug Administration for adults with Lambert-Eaton myasthenic syndrome (LEMS).

More Information

Dementia Often Misclassified With Brief Cognitive Assessments

THURSDAY, Nov. 29, 2018 — When using brief cognitive assessments, dementia is often misclassified, according to a study published online Nov. 28 in Neurology Clinical Practice.

Abstract/Full Text (subscription or payment may be required)

Monitoring Movement Reflects Efficacy of Mandibular Splint

THURSDAY, Nov. 29, 2018 — For individuals with obstructive sleep apnea (OSA) treated with an optimally titrated mandibular advancement splint, normalization of the respiratory effort index derived from vertical mandibular movements (MM-REI) reflects the efficacy of the appliance, according to a study published online Nov. 6 in CHEST.

Abstract/Full Text (subscription or payment may be required)

Liquid Biopsy Can Assess Tx Response of Peds Brain Tumors

THURSDAY, Nov. 29, 2018 — A liquid biopsy using blood or cerebrospinal fluid (CSF) can effectively quantify changes in mutation levels among pediatric patients being treated for diffuse midline gliomas (DMGs), according to a study recently published in Clinical Cancer Research.

Abstract/Full Text (subscription or payment may be required)

ADHD Diagnosis, Treatment Up for August-Born Children

WEDNESDAY, Nov. 28, 2018 — In states with a Sept. 1 cutoff for kindergarten entry, the rates of attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment are higher for children born in August than those born in September, according to a study published in the Nov. 29 issue of the New England Journal of Medicine.

Abstract/Full Text (subscription or payment may be required)

Gene Therapy Forms New Polysynaptic Pathways in Parkinson’s

WEDNESDAY, Nov. 28, 2018 — For patients with Parkinson’s disease (PD) undergoing gene therapy, new polysynaptic functional pathways develop in the brain, according to a study published in the Nov. 28 issue of Science Translational Medicine.

Abstract/Full Text (subscription or payment may be required)

Feature Tagging of Home Videos Promising in Autism Diagnosis

WEDNESDAY, Nov. 28, 2018 — Feature tagging of home videos for machine learning classification of autism spectrum disorder (ASD) with the use of a mobile device produces accurate results in short time frames, according to a study published online Nov. 27 in PLOS Medicine.

Abstract/Full Text

Fruits, Veggies, Orange Juice May Protect Men’s Memory

WEDNESDAY, Nov. 28, 2018 — Higher consumption of vegetables and fruits is associated with lower odds of future memory loss in men, according to a study published online Nov. 21 in Neurology.

Abstract/Full Text (subscription or payment may be required)

FDA to Update Medical Device Approvals Process

TUESDAY, Nov. 27, 2018 — A major update of the United States’ system for approving medical devices was announced yesterday by the Food and Drug Administration.

CBS/AP News Article
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Four Principles Underlie Patient and Family Partnership in Care

TUESDAY, Nov. 27, 2018 — Patient and family partnership in care should include treatment of patients and families with dignity and respect, their active engagement in all aspects of care, and their contribution to the improvement of health care systems and education of health care professionals, according to a position paper published online Nov. 27 in the Annals of Internal Medicine.

Position Paper
Editorial (subscription or payment may be required)

Risks of Trazodone Similar to Those of Atypical Antipsychotics

TUESDAY, Nov. 27, 2018 — For older adults with dementia, trazodone is associated with a comparable risk for falls and fractures as that of atypical antipsychotics, according to a study published online Nov. 26 in CMAJ, the Journal of the Canadian Medical Association.

Abstract/Full Text
Editorial (subscription or payment may be required)

Estimated 2.5 Percent of U.S. Children Diagnosed With Autism

MONDAY, Nov. 26, 2018 — The prevalence of parent-reported autism spectrum disorder (ASD) is estimated at 2.5 percent among U.S. children aged 3 to 17 years, according to a study published online Nov. 26 in Pediatrics.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

ACA Coverage Substantial, but Did Not Impact Labor Markets

MONDAY, Nov. 26, 2018 — Millions of workers gained insurance coverage under the Affordable Care Act (ACA) without adverse effects on labor markets, according to a report published by the Robert Wood Johnson Foundation and the Urban Institute.

Report: How Have Workers Fared Under the ACA?

Ocrelizumab May Help Preserve Hand, Arm Function in PPMS

MONDAY, Nov. 26, 2018 — For patients with primary progressive multiple sclerosis (PPMS), ocrelizumab reduces progression of upper-extremity (UE) impairment, according to an exploratory analysis published online Nov. 12 in the Multiple Sclerosis Journal.

Abstract/Full Text

CDC: U.S. Prevalence of ALS Was 5.2 Per 100,000 in 2015

MONDAY, Nov. 26, 2018 — In 2015, the prevalence of amyotrophic lateral sclerosis (ALS) in the United States was 5.2 per 100,000 population, with 16,583 cases identified, according to research published in the Nov. 23 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Abstract/Full Text

FDA Approves Drug to Treat Rare Immune Disease

WEDNESDAY, Nov. 21, 2018 — The U.S. Food and Drug Administration on Monday approved Gamifant (emapalumab-lzsg) for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in pediatric (as young as newborn) and adult patients who have refractory, recurrent, or progressive disease or intolerance with conventional HLH treatment.

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ED Utilization Up for Pediatric mTBI After TBI Legislation

WEDNESDAY, Nov. 21, 2018 — Implementation of state youth traumatic brain injury (TBI) legislation correlated with an increase in pediatric emergency department utilization for youth sports- and recreation-related mild TBI (mTBI) evaluation, according to a study published in the November/December issue of the Journal of Head Trauma Rehabilitation.

Abstract/Full Text (subscription or payment may be required)

Arterial Stiffness May Predict Dementia Risk

WEDNESDAY, Nov. 21, 2018 — Arterial stiffness may predict dementia risk, independent of subclinical brain damage, according to a study recently published in the Journal of Alzheimer’s Disease.

Abstract/Full Text (subscription or payment may be required)

CDC Announces Acute Flaccid Myelitis Task Force

TUESDAY, Nov. 20, 2018 — A task force to investigate a rising number of cases of a rare polio-like disease among children in the United States has been created by the U.S. Centers for Disease Control and Prevention.

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Dementia Tied to Mortality in Older Adults With Down Syndrome

TUESDAY, Nov. 20, 2018 — Dementia is associated with mortality in most older adults with Down syndrome, according to a study published online Nov. 19 in JAMA Neurology.

Abstract/Full Text
Editorial

Prenatal Nitric Oxide Exposure Linked to Higher Risk for Autism

TUESDAY, Nov. 20, 2018 — Prenatal exposure to nitric oxide (NO) is associated with an increased risk for autism spectrum disorder (ASD), according to a study published online Nov. 19 in JAMA Pediatrics.

Abstract/Full Text (subscription or payment may be required)

MS Relapse Drops During Pregnancy but Rises After

MONDAY, Nov. 19, 2018 — Rates of multiple sclerosis (MS) relapse decrease during pregnancy but increase postpartum, according to a study published online Oct. 23 in Neurology.

Abstract/Full Text
Editorial (subscription or payment may be required)

AAP Updates Management of Sport-Related Concussion

FRIDAY, Nov. 14, 2018 — Recommendations have been developed for the diagnosis and management of pediatric sport-related concussion (SRC), according to a clinical report published online Nov. 12 in Pediatrics.

Abstract/Full Text

CDC: 8.8 Percent Uninsured in U.S. in First Half of 2018

FRIDAY, Nov. 16, 2018 — In the first six months of 2018, 8.8 percent of U.S. individuals of all ages were uninsured, which was not significantly different from 2017, according to a report published Nov. 15 by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.

Abstract/Full Text

Name-Brand Medications Driving Spike in U.S. Drug Spending

THURSDAY, Nov. 15, 2018 — Rising drug spending in the United States is being fueled by expensive name-brand prescription medicines, a new study shows.

NBC News Article
Blue Cross Blue Shield Report

Many Patients Do Not Engage Health Care Provider During MS Relapse

THURSDAY, Nov. 15, 2018 — The rate and frequency of relapse vary for patients with multiple sclerosis (MS), and many report not visiting a health care provider during relapse, according to a study published in the November issue of Multiple Sclerosis and Related Disorders.

Abstract/Full Text

Patient Experiences Shed Light on Diagnostic Errors

THURSDAY, Nov. 15, 2018 — Data from patient- and family-reported error narratives indicate that problems related to patient-physician interactions are major contributors to diagnostic errors, according to a study published in the November issue of Health Affairs.

Abstract/Full Text (subscription or payment may be required)

AMA to Collect Data on Suicide Among Doctors-in-Training

WEDNESDAY, Nov. 14, 2018 — By collecting data on suicides by medical students, residents, and fellows, the American Medical Association hopes to identify ways to reduce suicides among doctors-in-training. The data collection policy was approved at a meeting yesterday.

More Information

CDC Probe Continues as Cases of Acute Flaccid Myelitis Rise

WEDNESDAY, Nov. 14, 2018 — Cases of a mysterious polio-like illness continue to mount in the United States, and health officials are scrambling to figure out the cause.

HealthDay Article
Abstract/Full Text

No Efficacy Signal for Fluoxetine in EV-D68 Acute Flaccid Myelitis

TUESDAY, Nov. 13, 2018 — The antiviral agent fluoxetine is well tolerated but is not effective for patients with proven or presumptive enterovirus D68-associated acute flaccid myelitis (AFM), according to a study published online Nov. 9 in Neurology.

Abstract/Full Text (subscription or payment may be required)

Repetitive Hits May Predispose Athletes to Concussion

TUESDAY, Nov. 13, 2018 — Repetitive head impact exposure appears to be a predisposing factor for the onset of concussion, according to a study published online Oct. 22 in the Annals of Biomedical Engineering.

Abstract/Full Text

18F-FDG PET Algorithm Allows Early Prediction of Alzheimer’s

TUESDAY, Nov. 13, 2018 — Fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) of the brain can be used to develop a deep learning algorithm for early prediction of Alzheimer’s disease (AD) that has high specificity and sensitivity, according to a study published online Nov. 6 in Radiology.

Abstract/Full Text

In-Hospital Infection May Up Readmission After Stroke

THURSDAY, Nov. 8, 2018 — For patients with ischemic stroke, infection during stroke hospitalization is associated with increased odds of 30-day readmission, according to a study published online Nov. 1 in Stroke.

Abstract/Full Text (subscription or payment may be required)

Quitting Cannabis Tied to Improved Memory

THURSDAY, Nov. 8, 2018 — Abstaining from cannabis is associated with improvements in memory and verbal learning in adolescents and young adults, according to a study published online Oct. 30 in the Journal of Clinical Psychiatry.

Abstract/Full Text (subscription or payment may be required)

Use of Polyetheretherketone Devices May Up Pseudarthrosis

THURSDAY, Nov. 8, 2018 — For one-level anterior cervical discectomy and fusion (ACDF), use of polyetheretherketone (PEEK) devices is associated with significantly higher rates of radiographically demonstrated pseudarthrosis and need for revision surgery compared with allografts, according to a study published online Oct. 30 in the Journal of Neurosurgery: Spine.

Abstract/Full Text

Concussion-Related Biomarkers Vary Based on Sex, Race

THURSDAY, Nov. 8, 2018 — Concussion-related serum biomarkers vary by sex and race, which may complicate their interpretation, according to three studies published online Nov. 7 in Neurology.

Abstract/Full Text 1 (subscription or payment may be required)
Abstract/Full Text 2 (subscription or payment may be required)
Abstract/Full Text 3 (subscription or payment may be required)
Editorial (subscription or payment may be required)

Medicaid Expansion Approved in Three Republican-Leaning States

WEDNESDAY, Nov. 7, 2018 — Hundreds of thousands more low-income Americans could get health insurance after voters in three Republican-leaning states approved Medicaid expansion in the midterm elections.

CNBC Article

Short Questionnaire IDs GI Disorders in Children With Autism

WEDNESDAY, Nov. 7, 2018 — A short parent questionnaire may be able to identify gastrointestinal disorders in children with autism spectrum disorder (ASD), according to a study published online Oct. 22 in the Journal of Autism and Developmental Disorders.

Abstract/Full Text (subscription or payment may be required)

CDC: Cases of Polio-Like Illness Still Increasing in the U.S.

TUESDAY, Nov. 6, 2018 — Cases of a polio-like condition that mainly affects children continue to rise this year in the United States, health officials say.

More Information: CDC

Reduced Survival for Patients With Idiopathic Parkinsonism

TUESDAY, Nov. 6, 2018 — Patients with idiopathic parkinsonism have reduced survival, although survival is dependent on the type and characteristics of the parkinsonian disorder, according to a study published online Oct. 31 in Neurology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Surgery Restores Boy’s Ability to Walk Post-Acute Flaccid Myelitis

MONDAY, Nov. 5, 2018 — A first-of-its-kind surgery has restored the ability to walk in a boy paralyzed by acute flaccid myelitis (AFM).

CBS News Article
More Information: CDC

Most Meds Affecting Neurotransmitters Not Linked to Autism Risk

MONDAY, Nov. 5, 2018 — Prenatal exposure to most medications affecting neurotransmitter systems is not associated with estimates of autism spectrum disorder (ASD) risk, according to a study published online Oct. 31 in JAMA Psychiatry.

Abstract/Full Text
Editorial (subscription or payment may be required)

Older Paternal Age Linked to Adverse Perinatal Outcomes

MONDAY, Nov. 5, 2018 — Advanced paternal age is associated with adverse infant and maternal outcomes, according to a study published online Oct. 31 in The BMJ.

Abstract/Full Text
Editorial

Removing Appendix May Lower Risk for Parkinson’s Disease

MONDAY, Nov. 5, 2018 — The normal human appendix seems to contain pathogenic forms of α-synuclein, which may impact the risk for developing Parkinson’s disease (PD), according to a study published online Oct. 31 in Science Translational Medicine.

Abstract/Full Text

Abnormalities in Genes Linked to IRSP in Alzheimer’s Disease

MONDAY, Nov. 5, 2018 — Individuals with Alzheimer’s disease (AD) have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway (IRSP), according to a study published online Nov. 1 in PLOS ONE.

Abstract/Full Text

Sign-Up Season Begins on HealthCare.gov

FRIDAY, Nov. 2, 2018 — The federal government website where Americans can sign up for health insurance under the Affordable Care Act is up and running, officials said yesterday.

AP News Article
HealthCare.gov

Higher Serum Cortisol Level Linked to Lower Brain Volumes

FRIDAY, Nov. 2, 2018 — Higher serum cortisol level is associated with lower brain volumes and impaired memory in asymptomatic younger to middle-aged adults, according to a study published online Oct. 24 in Neurology.

Abstract/Full Text (subscription or payment may be required)

Social Stigma Worsens Mental Health With Autism

FRIDAY, Nov. 2, 2018 — Stress related to social stigma may contribute to why people with autism experience more mental health problems than the general population, according to a study published online Oct. 12 in Society and Mental Health.

Abstract/Full Text (subscription or payment may be required)

First FDA-Approved Cannabis Drug Now Available in U.S.

THURSDAY, Nov. 1, 2018 — The first cannabis-based medication approved by the U.S. Food and Drug Administration is now available by prescription nationwide.

CNN Article
HealthDay Article
FDA June Approval

Financial Conflicts of Interest Prevalent Among CPG Authors

THURSDAY, Nov. 1, 2018 — There is a high prevalence of financial conflicts of interest among authors of clinical practice guidelines (CPGs) related to high-revenue medications and in gastroenterology, according to two research letters published online Oct. 29 in JAMA Internal Medicine.

Abstract/Full Text – Khan (subscription or payment may be required)
Abstract/Full Text – Combs (subscription or payment may be required)
Editorial (subscription or payment may be required)

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Posted: December 2018

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