Breaking News
February 22, 2019 - AbbVie Announces New Drug Application Accepted for Priority Review by FDA for Upadacitinib for Treatment of Moderate to Severe Rheumatoid Arthritis
February 22, 2019 - Nature versus nurture and addiction
February 22, 2019 - New website connects researchers with data experts, resources | News Center
February 22, 2019 - Today’s Concerns About Drug Prices Echo The Past
February 22, 2019 - CT and Doppler equipment have low accuracy in detecting cerebral vasospasm and ischemia
February 22, 2019 - Study finds out similarity in function between healthy retina cell and tumor cell
February 22, 2019 - CWRU awarded NIH grant to identify effective treatments for intimate partner violence
February 22, 2019 - Oncotype DX Not Cost-Effective for Low-Risk Breast Cancer
February 22, 2019 - Scientists discover new type of immune cells that are essential for forming heart valves
February 22, 2019 - Talk About Déjà Vu: Senators Set To Re-Enact Drug Price Hearing Of 60 Years Ago
February 22, 2019 - Genetic defect linked to pediatric liver disease identified
February 22, 2019 - New cellular atlas could provide a deeper insight into blinding diseases
February 22, 2019 - Growing number of cancer survivors, fewer providers point to challenge in meeting care needs
February 22, 2019 - Innovative compound offers a new therapeutic approach to treat multiple sclerosis
February 22, 2019 - $1.5 million grant to develop opioid treatment program for jail detainees
February 22, 2019 - FDA’s new proposed rule would update regulatory requirements for sunscreen products in the U.S
February 22, 2019 - Most Hip, Knee Replacements Last Decades, Study Finds
February 22, 2019 - Wellness problems prevalent among ob-gyn residents
February 22, 2019 - In the Spotlight: “The world is your oyster in geriatrics”
February 22, 2019 - Successful testing of multi-organ “human-on-a-chip” could replace animals as test subjects
February 22, 2019 - Analysis of cervical precancer shows decline in two strains of HPV
February 22, 2019 - Sugary stent eases suturing of blood vessels
February 22, 2019 - From surgery to psychiatry: A medical student reevaluates his motivations
February 22, 2019 - Is New App From Feds Your Answer To Navigating Medicare Coverage? Yes And No
February 22, 2019 - New pacemakers powered by heartbeats could reduce need for surgery
February 22, 2019 - The United States records highest drug overdose death rates
February 22, 2019 - Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy
February 22, 2019 - Vitamin D supplementation less effective in the presence of obesity, shows study
February 22, 2019 - CPRIT awards nearly $20 million to The University of Texas MD Anderson Cancer Center
February 22, 2019 - Sarepta Announces FDA Acceptance of Golodirsen (SRP-4053) New Drug Application for Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
February 22, 2019 - An institutional effort to reduce the amount of opioids prescribed following lumbar surgery
February 22, 2019 - Family-history-based models perform better than non-family-history based models
February 22, 2019 - Failure to take statins leads to higher mortality rates | News Center
February 22, 2019 - New study explains why some patients report phantom sensations after limb amputation
February 22, 2019 - First motor-controlled heart valves implanted by Mainz University Medical Center
February 22, 2019 - Novel preclinical model mimics persistent interneuron loss seen in preterm infants
February 22, 2019 - Global health burden of glaucoma has increased, study reveals
February 22, 2019 - A holistic approach key to minimize treatment complexity in patients with interstitial lung disease
February 22, 2019 - 1 in 10 middle-aged Chinese adults are at high risk for heart disease, finds study
February 22, 2019 - More than half a million breast cancer patient’s lives saved by improvements in treatment
February 22, 2019 - Study finds no evidence that tougher policies prevent teenage cannabis use
February 22, 2019 - New blood test detects genetic disorders in fetuses
February 22, 2019 - Lower Self-Perception Observed in Children With Amblyopia
February 22, 2019 - Up to 15 percent of children have sleep apnea, yet 90 percent go undiagnosed
February 22, 2019 - Rare pulmonary defect prompts parents’ nationwide search for answers | News Center
February 22, 2019 - Lesbian and bisexual women at greater risk of being overweight, study finds
February 22, 2019 - UQ research may explain why vitamin D is essential for brain health
February 22, 2019 - Heart Attacks Rising Among Younger Women
February 22, 2019 - How your smartphone is affecting your relationship
February 22, 2019 - Orthopaedic surgeon receives prestigious award, $10 million grant | News Center
February 22, 2019 - New sepsis test could save thousands of lives
February 22, 2019 - Cervical cancer could be eradicated by 2100
February 21, 2019 - Sustained smoking cessation can lower risk of seropositive RA
February 21, 2019 - Thousands with chronic UTIs are not receiving the treatment they need
February 21, 2019 - Are teens getting high on social media? The surprising study seeking the pot-Instagram link
February 21, 2019 - Stanford expands biobank services | News Center
February 21, 2019 - Scientists identify link between drinking contexts and early onset intoxication among adolescents
February 21, 2019 - Strong social support may reduce cardiovascular disease risk in postmenopausal women
February 21, 2019 - Rapid expansion of interventions could prevent up to 13 million cases of cervical cancer within 50 years
February 21, 2019 - Motif Bio Receives Complete Response Letter From The FDA
February 21, 2019 - Researchers map previously unknown disease in children
February 21, 2019 - A skeptical look at popular diets: Going gluten-free
February 21, 2019 - Podcast: KHN’s ‘What The Health?’ How Safe Are Your Supplements?
February 21, 2019 - Factors associated with increased risk of developing surgical site infections
February 21, 2019 - Anticipatory signals in eye movements can help measure attentive capacity, learning with greater precision
February 21, 2019 - Study explores daily exposure to indoor air pollutants
February 21, 2019 - Evening exercise does not negatively affect sleep, may also reduce hunger
February 21, 2019 - Artificial intelligence technique can be used to identify alcohol misuse in trauma setting
February 21, 2019 - Overweight, obesity in adolescence associated with increased risk of renal cancer later in life
February 21, 2019 - BGU develops new AI platform for monitoring and predicting ALS progression
February 21, 2019 - Researchers discover a new promising target to improve HIV vaccines
February 21, 2019 - Brief Anesthesia in Infancy Does Not Mar Neurodevelopment
February 21, 2019 - Gaming system helps with autism diagnosis
February 21, 2019 - Heart Disease: Six Things Women Should Know
February 21, 2019 - More States Say Doctors Must Offer Overdose Reversal Drug Along With Opioids
February 21, 2019 - Researchers explore case studies focused on industries that kill more people than employed
February 21, 2019 - Only half of GP practice buildings are fit for purpose
February 21, 2019 - Intense exercise, fasting and hormones can enhance waste-protein removal, study shows
February 21, 2019 - Scientists can monitor brain activity to predict epileptic seizures few minutes in advance
February 21, 2019 - Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats
International study increases group of lung cancer patients who may benefit from immunotherapy

International study increases group of lung cancer patients who may benefit from immunotherapy

image_pdfDownload PDFimage_print

The strategy for triggering the patient’s own immune system to attack cancer, immunotherapy, is proving effective for more and more tumor types, although to varying degrees. In lung cancer, immunotherapy had proven to extend survival rates for only some variants of the disease. Now, an international clinical trial led by the oncologist Luis Paz-Ares, head of the Lung Cancer Clinical Research Unit H12O-CNIO at the Spanish National Cancer Research Centre (CNIO), which also encompasses professionals from the University Hospital 12 de Octubre, has substantially increased the group of lung cancer patients who may benefit from immunotherapy.

The clinical trial focuses on squamous cell carcinoma, in advanced stages of the disease presenting metastasis. The results have been published in the prestigious New England Journal of Medicine (NEJM) and show that immunotherapy, when administered alongside conventional chemotherapy, “significantly increases” patient survival. For Paz-Ares, this result “offers new possibilities against a subtype of lung cancer in which, over the past two decades, the possibilities of treatment have barely advanced”.

Lung cancer is the leading cause of cancer deaths worldwide. In Spain, there were over 22,000 deaths from this type of cancer in 2016 (according to data from the Spanish Society of Medical Oncology, SEOM). Squamous cell carcinoma is a type of so-called non-small-cell lung cancer; it represents between 20% and 30% of all cases of lung cancer and has a worse prognosis than other variants. In addition, it is one of the cancers for which the least amount of progress has been made in terms of treatment, because, unlike in other tumors, in this form of carcinoma, molecular targets have not been identified that would be susceptible to therapeutic exploitation -i.e., molecules essential for tumor development and progression that can be blocked with specific drugs.

The results of the new study represent, therefore, a significant step forward. The authors conclude that “in patients with metastatic squamous cell carcinoma, administering the immunotherapy drug pembrolizumab along with chemotherapy (…) significantly prolongs overall and progression-free survival,” compared to when only chemotherapy is administered.

Patients who received chemotherapy and immunotherapy extended their survival by almost 16 months on average, – reducing the risk of death during treatment by 36% – compared to 11.3 months for those who received chemotherapy alone.

These results open the door to investigate the effectiveness of immunotherapy in patients during the early stages of the disease – without metastases- when we can prolong survival much more and even attempt to eradicate the disease, explains Paz-Ares.

One very important aspect is that the combination of immuno- and chemotherapy was effective in all patients, and not only in those who showed very high levels of the protein PD-L1. Pembrolizumab acts on this protein to revitalize the body’s defense systems against the tumor. In general, this type of immunotherapy in lung cancer had only proved effective in cases where PD-L1 protein is expressed.

This study corroborates the results observed in another study conducted in parallel and similar in design, but on patients with advanced non-small-cell carcinoma of non squamous cell carcinoma varieties (for example, adenocarcinoma or large cell carcinoma). In this research, a benefit was also observed when pembrolizumab was administered, which also seemed to encompass all patients, including those affected by tumors without PD-L1 expression.

The challenge now, says Paz-Ares, is to find new biomarkers to help predict in which patients immunotherapy might be more effective, and also to understand why many cancers become resistant to this therapy over time. Finally, “Our intention is to find the right immunotherapy strategy for each tumor and patient, alone or in combination,” says the oncologist.

Source:

https://www.cnio.es/en/news/translational-en/an-international-clinical-trial-extends-the-effectiveness-of-immunotherapy-to-more-lung-cancer-patients/

Tagged with:

About author

Related Articles