Breaking News
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
December 18, 2018 - Russian scientists identify molecular ‘switch’ that could be target for treatment of allergic asthma
December 18, 2018 - Surgeons make more mistakes in the operating room during stressful moments, shows study
December 18, 2018 - Immune cells explode themselves to inform about the danger of invading bacteria
December 18, 2018 - Malnutrition in children with Crohn’s disease linked with increased risk of surgical complications
December 18, 2018 - FDA Approves Motegrity (prucalopride) for Adults with Chronic Idiopathic Constipation (CIC)
December 18, 2018 - The long and short of CDK12
December 18, 2018 - Hologic’s Cynosure division introduces TempSure Surgical RF technology in North America
December 18, 2018 - CMR Surgical partners with Nicholson Center to launch U.S.-based training program for Versius
December 18, 2018 - Findings reinforce guidelines for cautious use of antipsychotics in younger populations
December 18, 2018 - Study finds new strains of hepatitis C virus in sub-Saharan Africa
December 18, 2018 - New battery-free, implantable device aids weight loss
December 18, 2018 - Parental alcohol use disorder associated with offspring marital outcomes
December 18, 2018 - Novel Breast Imaging Technique Might Cut Unnecessary Biopsies
December 18, 2018 - What can a snowflake teach us about how cancer spreads in the body?
December 18, 2018 - Management of nausea and vomiting in pregnancy costs the NHS more than previously thought
December 18, 2018 - Green leafy vegetables may reduce risk of developing liver steatosis
December 18, 2018 - Veganism linked to nutrient deficiencies and malnutrition if not planned correctly
December 18, 2018 - Coming Soon: A Tiny Robot You Swallow to Help You Stay Healthy
December 18, 2018 - Modified malaria drug proven effective at inhibiting Ebola
December 18, 2018 - Study finds epigenetic differences in the brains of individuals with schizophrenia
December 18, 2018 - Fitness instructors’ motivational comments influence women’s body satisfaction
December 18, 2018 - Study focuses on modification of lipid nanoparticles for successful brain cell targeting
December 18, 2018 - New gut bacteria may be effective against obesity, metabolic and mental disorders
December 18, 2018 - New two-in-one powder aerosol to upgrade fight against deadly superbugs in lungs
December 18, 2018 - Biofilms feed with swirling flows
December 17, 2018 - Study identifies specific neurological changes related to traumatic brain injury
December 17, 2018 - New study confirms geographic bias in lung allocation for transplant
December 17, 2018 - Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate
December 17, 2018 - Carpal tunnel syndrome – Genetics Home Reference
December 17, 2018 - A novel insulin accelerant
December 17, 2018 - Tips for caring for patients with disabilities, from a mother and physician
December 17, 2018 - Menopause-related sexual, urinary problems tied to worse quality of life
December 17, 2018 - In-school nutrition programs among students limit increases in BMI, finds study
December 17, 2018 - Risk for Hospitalization for Heart Failure Greater With Diabetes
December 17, 2018 - Food assistance may help older adults adhere to diabetes meds
December 17, 2018 - Supporting a family’s goals during a difficult pregnancy
December 17, 2018 - Neurons with Good Housekeeping Are Protected from Alzheimer’s
December 17, 2018 - New approach to tumor analysis could improve prognosis for bowel cancer patients
December 17, 2018 - New ‘epigenetics-based’ cervical cancer test outperforms Pap smear and HPV tests
December 17, 2018 - Ten year follow-up after negative colonoscopy related to reduced risk of colorectal cancer
December 17, 2018 - CTF along with NTAP and Sage announce first-ever open data portal for neurofibromatosis
December 17, 2018 - Intimacy: The Elusive Fountain of Youth?
December 17, 2018 - Will saliva translate to a real diagnostic tool?
December 17, 2018 - DFG establishes nine new Research Units and one new Clinical Research Unit
December 17, 2018 - Assisted living’s breakneck growth leaves patient safety behind
December 17, 2018 - America’s teens report dramatic increase in their use of vaping devices in just one year
December 17, 2018 - Enlarged heart linked to a higher risk of dementia
December 17, 2018 - Prostate cancer detection using MRI now first-line investigation tool
December 17, 2018 - Loughborough academics part of new project investigating effectiveness of personalized breast cancer screening
Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

image_pdfDownload PDFimage_print

In certain forms of cancer, connective tissue forms around and within the tumor. One previously unproven theory is that there are several different types of connective tissue cells with different functions, which affect the development of the tumor in different ways. Now, a research team at Lund University in Sweden has identified three different types of connective tissue cells. In studies of breast cancer patients, the team found that two of these are linked to a worse prognosis.

Cancer arises as a result of mutations and other genetic changes that shut down the control systems for growth that are normally present in our cells. New studies, however, emphasize the importance of the cancer cells’ communication with various cell types in the surrounding tissue, such as connective tissue, blood vessels and immune cells, in allowing the tumor to form, spread and resist treatment.

During the development of certain types of cancer, e.g. in the breast, liver and pancreas, the formation of connective tissue around and in the tumor is stimulated. However, researchers have not understood how the connective tissue affects tumor growth. Previous studies support the theory that it either drives the spread of the tumor by stimulating the formation of blood vessels, or that it weakens the immune system. However, inhibiting effects have also been studied, which could mean that the connective tissue encapsulates the tumor, thereby preventing it from spreading.

“We have investigated the pattern of gene expression in the connective tissue cells – known as fibroblasts – with a sensitive technique that enables the analysis of one cell at a time. By seeing which genes are active in 768 individual connective tissue cells from a mouse model of breast cancer, we were able to identify three different subgroups of fibroblasts which differ in function and origin”, says Kristian Pietras, research team leader at Lund University.

The largest group of connective tissue cells identified by the researchers controls the development of blood vessels; these cells are known as vascular fibroblasts. A second group of connective tissue cells has the task of producing connective tissue proteins that make the tumor stable and facilitate the migration of cells. These cells are called matrix fibroblasts and have been “kidnaped” by the tumor from the normal breast tissue as the tumor grows over them and converts them into helping. Finally, the researchers found a third group of cells, that are actually tumor cells that have disguised themselves as connective tissue cells.

“It is a well-known fact that tumor cells must undergo a transformation to acquire more connective tissue-like properties in order to be able to spread in the body – a process known as epithelial-mesenchymal transition. We were able to follow how, step by step, the malignant cells start to invade surrounding tissue. However, more detailed studies are needed to follow their journey all the way to a metastatic tumor in another organ”, says Michael Bartoschek, who is the principal author of the study.

Through precise tissue analyses, the researchers were able to confirm that the three types of fibroblasts are separate cell types which co-exist within different kinds of tumors. When they investigated the significance of the various subgroups of connective tissue cells for breast cancer prognosis, using tissue samples, they found that patients with large numbers of vascular fibroblasts or matrix fibroblasts in their tumors had a worse prognosis, as both these cell types affect the development of metastases.

Successful attempts to impede tumor cell communication with surrounding tissue through drugs already exist, but more research is required to find better treatment strategies targeting tumor cell communication, according to the researchers behind the study. The study confirms the old hypothesis that tumors have several different types of connective tissue cells, with different origins. The current findings open up the possibility of developing drugs that shut down specific functions in subgroups of connective tissue cells in order to achieve better therapeutic results with fewer side effects in breast cancer patients.

“We are convinced that more knowledge of the cellular structure of tumors and the function of communication between different cell types will enable us to find new ways to treat tumor diseases. In addition, measurements of the number of different connective tissue cells within a tumor can be developed to assess the risk of cancer recurrence in patients”, concludes Kristian Pietras.

Source:

https://www.lunduniversity.lu.se/article/the-wrong-connective-tissue-cells-signal-worse-prognosis-for-breast-cancer-patients

Tagged with:

About author

Related Articles