Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
New analytic model can accurately predict patients at risk of developing PTSD

New analytic model can accurately predict patients at risk of developing PTSD

New findings from an international research team led by psychiatrists at NYU School of Medicine show that a newly-developed analytic model can predict soon after a shocking or scary event – and with significant accuracy — the likelihood of someone developing Post-Traumatic Stress Disorder (PTSD).

Patients in the study — who had experienced trauma ranging from traffic and workplace accidents to assaults and terrorist attacks — were initially evaluated using the Clinician-Administered PTSD Scale for DSM-IV (CAPS), considered the “gold standard” for assessing PTSD. All study participants had a CAPS interview within 60 days of their traumatic event and a follow-up interview four to 15 months later.

The researchers took these CAPS scores and then further analyzed them using the Brier Score, a measurement developed in the 1950s, as well as other validation methods to estimate of each individual’s risk of developing PTSD nine to 15 months later. They found that this approach could, indeed, predict chronic PTSD with high confidence and compute, with similar accuracy, additional risk associated with other factors such as sex, lower education or a lifetime experience of interpersonal trauma.

Specifically, the researchers found that PTSD prevalence after follow-up was on average 11.8 percent in those exposed to a traumatic event — 9.2 percent in men and 16.4 percent in women. They also found that the results in women with less than a secondary education and prior exposure to interpersonal trauma, such as child abuse or sexual assault, indicated a much higher risk of chronic PTSD. Other previously known risk factors such as age, marital status and type of trauma did not increase individuals’ the risk of developing PTSD.

Chronic PTSD is difficult to treat. Knowing soon after trauma exposure how likely a survivor will develop it may help those at significant risk. The findings, recently reported in the journal World Psychiatry, could assist health professionals identify and intercede more quickly with interventions for PTSD — such as cognitive behavioral therapy — that have been shown to be effective in treating the disorder, especially in the emergency room setting — where most victims of trauma are often first seen.

The published study includes an online tool allowing a clinician an immediate access to the risk estimate model.

“We are moving from the near impossible task of trying to predict who will develop PTSD to more accurately identifying a risk score for each individual who was exposed to a traumatic event,” says Arieh Y. Shalev, MD, the Barbara Wilson Professor of Psychiatry at NYU School of Medicine and lead author of the report. “Knowing that a person has an increased risk for PTSD will help mitigate it more rapidly, and with fewer residual consequences.”

Shalev adds: “Early symptoms, previously known to globally predict the risk of PTSD among trauma survivors (e.g., 11% in road traffic accidents or 38% following terror in our previous work) were unable to tell us who, within a group, was at particularly high risk. We now can precisely predict each individual’s risk, thus moving PTSD evaluation to a more personalized and individualized risk estimate.”

For example, Shalev points out, the new analysis model can help determine that a specific patient will likely (e.g., > 40%; 50%) remain with chronic PTSD unless treated, whereas another from the same study group may only have 2% risk. “It is a more immediate call for action that the previous group estimates could not provide,” he says.

A Comparable Tool to Those Used in Heart Disease and Cancer Diagnosis

Shalev and his colleagues, who are members of the International Consortium to Predict PTSD, analyzed medical records of nearly 2,500 patients in 10 longitudinal studies of civilian trauma survivors treated in emergency departments in the United States, Australia, Japan, the Netherlands, Switzerland and Israel. They were able to assign odds of likelihood of developing PTSD based on initial CAPS scores. The international source of their sample, and the relatively small differences between sources of data, increased the researchers’ confidence that the model can be generalized for a world-wide use.

The researchers add that the new PTSD evaluation model joins a large family of online tools used in other clinical areas, such as heart disease and cancer, to assign a likelihood of developing a disease or a recurrence based on current information (e.g., cholesterol, weight and smoking history in heart attacks). In the case of PTSD, patients with higher initial CAPS scores could require earlier intervention, while lower scores might justify a “watchful waiting” approach with additional follow-up assessments.

In the United States, 70 percent of adults have experienced some type of trauma, and over 10 percent will go on to develop PTSD.

“Early symptom severity has shown to be a major predictor of PTSD risk, so enhanced evaluation provides a valid warning and a call for action,” Shalev says. “We hope that that quantifying individuals’ PTSD risk will be a first step toward systematic prevention of the disorder.”

Tagged with:

About author

Related Articles