Breaking News
April 19, 2019 - Cytosurge’s first FluidFM User Conference
April 19, 2019 - New study finds that previously described differences among endoscopists are not true
April 19, 2019 - Study compares effectiveness and cost of gene therapy and HSCT in major beta-thalassemia
April 19, 2019 - Scientific breakthrough provides new hope for people living with multiple sclerosis
April 19, 2019 - New Virtual Reality Therapy game could offer relief for patients with chronic pain, mobility issues
April 19, 2019 - Emergency medicine doctors find better way to treat severe epileptic seizures in children
April 19, 2019 - MedlinePlus: Cholesterol Good and Bad
April 19, 2019 - For busy medical students, two-hour meditation study may be as beneficial as longer course
April 19, 2019 - Music therapy helps young patients feel better
April 19, 2019 - Molecular target UNC45A is essential for cancer cell proliferation and tumor growth
April 19, 2019 - Crackling and wheezing could be the sounds of a progressing lung disease
April 19, 2019 - Key research takeaways from ECCMID 2019
April 19, 2019 - AI Can Identify Model of Cardiac Rhythm Device From Chest X-Ray
April 19, 2019 - New way to combat childhood anxiety: treat the parents
April 19, 2019 - Women getting C-sections best judge of own pain medication needs | News Center
April 19, 2019 - Immune responses that prevent fungal infections may eliminate Trichinella spiralis
April 19, 2019 - Exercising in the morning, rather than at night, may yield better results, shows study
April 19, 2019 - Why eating ‘right’ could cause you to stray from your diet
April 19, 2019 - Health Tip: Antidepressant Precautions – Drugs.com MedNews
April 19, 2019 - Bigger portions lead to preschoolers eating more over time
April 19, 2019 - Specific strains of Staphylococcus aureus linked to wounds that do not heal
April 19, 2019 - Revolutionary discovery paves new way for treatment of necrotizing enterocolitis
April 19, 2019 - Drug that treats high blood pressure shows promise against neurodegenerative diseases
April 19, 2019 - More care is needed for patients after kidney transplantations, reports research
April 19, 2019 - Virtual reality offers benefits for Parkinson’s disease patients
April 19, 2019 - Liver Illness Strikes Latino Children Like A ‘Silent Tsunami’
April 19, 2019 - Disruptive behaviors in autistic children linked to reduced brain connectivity
April 19, 2019 - New insights into how vitamin D affects immune system
April 19, 2019 - Pfizer Announces Presentation of Data from a Phase 2 Study of its 20-Valent Pneumococcal Conjugate Vaccine Candidate Being Investigated for the Prevention of Invasive Disease and Pneumonia in Adults Aged 18 Years and Older
April 19, 2019 - Exercise can improve non-motor symptoms of Parkinson’s disease
April 19, 2019 - KZFPs play a key role in the regulation of human genome
April 19, 2019 - Bedfont wins 2nd accolade at the South East FSB Awards 2019
April 19, 2019 - Extracts of ginkgo seeds show antibacterial activity on pathogens that cause skin infections
April 19, 2019 - Groundbreaking experiment in pigs challenges the notion about brain damage
April 19, 2019 - Improving the quality of digital pathology imaging
April 19, 2019 - Scientists get closer to injecting artificial lymph nodes into people to fight disease
April 19, 2019 - Exercises and swimming goggles may reduce adverse effects on eye during long spaceflights
April 19, 2019 - Review suggests a reciprocal relationship between obesity and self-control
April 19, 2019 - Study identifies how enterococci bacteria cause antibiotic-resistant bloodstream infections
April 19, 2019 - Triple negative breast cancer develop resistance to chemotherapy by turning on molecular pathway
April 19, 2019 - Researchers identify key clues to brain and pancreas development
April 19, 2019 - Metformin May Cut Risk for Prematurity, Miscarriage in PCOS
April 19, 2019 - Obese mouse mothers trigger heart problems in offspring
April 19, 2019 - Research sheds light on how leukemia cells become resistant to drugs
April 19, 2019 - Health Tip: Stopping Nosebleeds – Drugs.com MedNews
April 19, 2019 - Pediatric endocrinologist gives iconic ‘Mona Lisa’ a second medical opinion
April 19, 2019 - Tapping patients’ wisdom for C-section pain management
April 18, 2019 - Why have autism rates ‘exploded’ in New Jersey?
April 18, 2019 - Microbiome science may help doctors to improve treatment for children with IBS
April 18, 2019 - New gene therapy cures babies with fatal ‘Bubble Boy’ disease
April 18, 2019 - No female mice? Scientists may still approve NIH grant
April 18, 2019 - What needs to be said about mental health in medicine
April 18, 2019 - Hickenlooper Expanded Medicaid, Created State-Run Marketplace To Insure Nearly All Coloradans
April 18, 2019 - Cancer cells grown in tumor-mimicking environment can help predict the effect of experimental drugs
April 18, 2019 - Albireo Announces FDA Clearance of IND to Commence Phase 2 Trial of Elobixibat for the Treatment of NAFLD/NASH
April 18, 2019 - Adhesive gel bonds to eye surface, could repair injuries without surgery
April 18, 2019 - The future of genomics: A podcast featuring Stanford geneticists
April 18, 2019 - As Syphilis Invades Rural America, A Fraying Health Safety Net Is Failing To Stop It
April 18, 2019 - APOE gene impacts sleep depending on gender and severity of Alzheimer’s
April 18, 2019 - PCORI’s newly approved awards focus on cancer pain and opioid use disorders
April 18, 2019 - New tool provides a standard way to measure effects of caring for survivors of TBI
April 18, 2019 - Smartphone use risks eye examination misdiagnosis
April 18, 2019 - How drug-resistant bugs grow in CF patients’ lungs
April 18, 2019 - Gordana Vunjak-Novakovic Elected to American Academy of Arts & Sciences
April 18, 2019 - Podcast: KHN’s ‘What The Health?’ You Have Questions, We Have Answers
April 18, 2019 - Diabetic drug shows potential to be repurposed as heart disease treatment for non-diabetic patients
April 18, 2019 - New estimation method assesses natural variations in sex ratio at birth
April 18, 2019 - UTA scientist receives $1.17 million grant for cancer research
April 18, 2019 - Coagulation factor VIIa prevents bleeds in hemophilia animal models
April 18, 2019 - Researchers identify risk factors for severe infection after knee replacement
April 18, 2019 - Mass drug administration can offer community-level protection against malaria
April 18, 2019 - FDA’s added sugar label could have substantial health and cost-saving benefits
April 18, 2019 - Researchers identify cause of inherited metabolic disorder
April 18, 2019 - Single strip of white paint not sufficient to protect people who ride bikes
April 18, 2019 - Partner status influences link between sexual problems and self-efficacy in breast cancer survivors
April 18, 2019 - Colorectal Neoplasia Risk Up for Hodgkin Lymphoma Survivors
April 18, 2019 - Rigid spine muscular dystrophy – Genetics Home Reference
April 18, 2019 - Simple bile acid blood test could tell risk of stillbirth
April 18, 2019 - Center for Experimental Therapeutics aims to enable all steps of drug development | News Center
April 18, 2019 - Falling for telephone scams could be an early sign of dementia
High-Tech Capsule Could One Day Replace Insulin Injections

High-Tech Capsule Could One Day Replace Insulin Injections

image_pdfDownload PDFimage_print

THURSDAY, Feb. 7, 2019 — For people with type 2 diabetes, could the days of having to jab themselves with a needle whenever they need insulin be over?

It’s now a distinct possibility, say researchers who have developed a capsule that can deliver insulin once it reaches the stomach. The new device has only been tested in animals so far, and such findings don’t always pan out in humans, but the scientists say the results look promising.

“If you try to deliver insulin orally, the acid and enzymes [in the digestive system] break up the proteins,” explained senior study author Dr. Giovanni Traverso. He’s from Brigham and Women’s Hospital in Boston and the department of mechanical engineering at MIT in Cambridge, Mass.

That’s why insulin — a hormone that helps regulate blood sugar — has to be delivered by injection. But Traverso said that people with type 2 diabetes often delay beginning treatment with insulin because of the discomfort and stigma attached to insulin injections.

“People would prefer the oral route over injections,” he said.

To try to meet this challenge, the researchers developed a capsule that contains a small needle that’s made of compressed insulin. The capsule is about the size of a blueberry.

When the device reaches the stomach, the capsule reorients itself and injects the insulin into the lining of the stomach.

Lead author Alex Abramson, a Ph.D. student in the department of chemical engineering at MIT, said, “The system had to be self-orienting. The stomach is a large space and there’s no guarantee where it will land.”

So, the researchers borrowed “technology” from the leopard tortoise, found in Africa. The animal’s shell has a high, steep dome. This allows it to right itself if it rolls onto its back.

The researchers also had to make sure the capsule had a chance to right itself before the injection occurred. To accomplish this, they loaded the insulin needle onto a compressed spring that’s held in place by a sugar disk. The sugar disk takes 5.5 minutes to dissolve, according to Abramson.

Once it dissolves, the insulin needle is injected into the stomach lining. There are no pain receptors in the stomach, so the injection shouldn’t hurt, the researchers noted.

After the capsule has delivered its contents, the remains pass harmlessly through the digestive system.

Tests in pigs have shown the device is able to successfully deliver insulin in the same quantities that people with type 2 diabetes would typically take.

The researchers also looked at the stomach tissue where the insulin was injected and saw no signs of damage or abnormalities. They also didn’t see any changes in the way the pigs ate or in their stool patterns.

Traverso said the researchers will continue the animal experiments and are hoping to test the insulin capsule in humans in approximately three years. In addition to insulin, he said that the capsule system could likely be used to deliver drugs for other diseases.

Endocrinologist Dr. Minisha Sood is from Lenox Hill Hospital in New York City, and was not part of the study. “This technology is something I never imagined would be possible. Thus far, it’s only been tested in animals, but it’s a proof-of-concept study that is promising, and I’m looking forward to seeing how this pans out in human trials,” she said.

“Making oral insulin available will dramatically improve the options for people with diabetes — it would be life-changing,” Sood explained. Currently, she added, people with diabetes who need to be on insulin often have a delay of seven to 10 years before they begin insulin therapy. Having to inject insulin is one of the main reasons for this delay, she said.

The capsule system was developed by a team of researchers from MIT, Brigham and Women’s Hospital, and insulin manufacturer Novo Nordisk.

The study was published Feb. 7 in the journal Science.

More information

Learn more by watching this video from the researchers on the insulin pill.

© 2019 HealthDay. All rights reserved.

Posted: February 2019

Tagged with:

About author

Related Articles