Breaking News
April 22, 2019 - The U.S government may account for up to $37.8 billion due to opioid epidemic
April 22, 2019 - Improving ACA’s Insurance Coverage Provisions will lead to better care for patients
April 22, 2019 - Study identifies possible therapeutic effects of curcumin on stomach cancer
April 22, 2019 - Hyaline fibromatosis syndrome – Genetics Home Reference
April 22, 2019 - Scientists use CRISPR for possible ‘bubble boy’ therapy
April 22, 2019 - Hematologist (and a mom, singer, actress and much more) stands up for diversity
April 22, 2019 - Novel AI voice tool can help diagnose PTSD
April 22, 2019 - Overlooked part of cell’s internal machinery may hold key to treating acute myeloid leukemia
April 22, 2019 - MIT scientists reverse some behavioral symptoms of rare neurodevelopmental disorder
April 22, 2019 - Scientists find new therapy target for drug-induced liver failure
April 22, 2019 - Opioid dose variability could lead to increased risk of overdose, study suggests
April 22, 2019 - Newly developed model predicts salmonella outbreaks several months in advance
April 22, 2019 - Deep-learning model better predicts survival outcomes for lung cancer
April 22, 2019 - One in Three U.S. Adults Aged 35 to 44 May Have Drinking Problem
April 22, 2019 - Why the measles virus is so contagious
April 22, 2019 - Magnet ‘Zap’ to the Brain Might Jumpstart Aging Memory
April 22, 2019 - Immune response to gut microbes may be early indicator of type 1 diabetes
April 22, 2019 - Destination Limbo: Health Suffers Among Asylum Seekers In Crowded Border Shelter
April 22, 2019 - Research shows how dopamine contributes to sex differences in worms
April 22, 2019 - Marijuana users weigh less compared to non-users
April 22, 2019 - Research uncovers critical RNA processing aberrations in ALS and FTD
April 22, 2019 - Many cancer patients use marijuana and prescription opioids, study reveals
April 22, 2019 - Frailty may up fracture risk in patients with type 2 diabetes
April 22, 2019 - Study provides new insight into how obesity, insulin resistance can affect cognition
April 22, 2019 - Study seeks to better understand the genetic causes for hypospadias
April 22, 2019 - FDA grants approval of first generic naloxone nasal spray to treat opioid overdose
April 22, 2019 - FDA authorizes marketing of first medical device to treat ADHD
April 22, 2019 - Vanderbilt researchers to develop and test ‘safe harbor’ standards of care
April 22, 2019 - You’re probably brushing your teeth wrong – here are four tips for better dental health
April 22, 2019 - Pharmacy closures contribute to medication non-adherence among heart patients
April 22, 2019 - Using Edge AI technology to observe behavior of cattle
April 22, 2019 - Bacteria play a role in the development of stomach ulcers in pigs
April 22, 2019 - Hand Hygiene Compliance Poor in Task Transitions
April 22, 2019 - smoking could harm your baby
April 22, 2019 - Scientists identify rare, paradoxical response to antiretroviral therapy
April 21, 2019 - More TV, Tablets, More Attention Issues at Age 5
April 21, 2019 - Drug reduces risk of kidney failure in people with diabetes, study finds
April 21, 2019 - New research identifies novel link between antibiotic resistance and climate change
April 21, 2019 - Simple intervention can provide lasting protection for teens against junk food marketing
April 21, 2019 - The protein p38-gamma identified as a new therapeutic target in liver cancer
April 21, 2019 - Novel system enables researchers to study bacteria within mini-tissues in a dish
April 21, 2019 - Discovery of oral cancer biomarkers could save thousands of lives
April 21, 2019 - Geneva Exhibition committee gives gold medals to two medications developed by Kazan
April 21, 2019 - Scientists aim to minimize or eliminate hair loss during cancer treatment
April 21, 2019 - WiFi interacts with signaling pathways in the human brain
April 21, 2019 - Stroke Hospitalizations Down in Black, White Medicare Enrollees
April 21, 2019 - First common risk genes discovered for autism
April 21, 2019 - Researchers map auditory sensory system of the mouse brain
April 21, 2019 - Scientists Bring Pig’s Brain, Dead 4 Hours, Back to ‘Cellular Activity’
April 21, 2019 - Virtual reality a promising tool for reducing fears and phobia in autism
April 21, 2019 - New analysis lists out opportunities for U.S. medical schools to advance population health
April 21, 2019 - More sleep may help teens with ADHD focus and organize
April 21, 2019 - Breakthrough antibody treatment suppresses HIV without antivirals
April 21, 2019 - AveXis Data Reinforce Effectiveness of Zolgensma in Treating Spinal Muscular Atrophy (SMA) Type 1
April 21, 2019 - Is your hand pain arthritis, carpal tunnel or something else?
April 21, 2019 - Measles outbreaks may become more frequent if vaccination rates continue to decline
April 21, 2019 - Researchers succeed in accelerating process of creating 3D images
April 21, 2019 - Tiny worm mimics key genetic risk for Alzheimer’s
April 21, 2019 - Angry dreams explained by brain waves
April 20, 2019 - Parenteral Antimicrobial Tx at Home Burdens Children’s Caregivers
April 20, 2019 - Diabetes treatment may keep dementia, Alzheimer’s at bay
April 20, 2019 - New bandage-like biosensor collects and analyzes sweat
April 20, 2019 - A comprehensive, centralized database of bovine milk compounds
April 20, 2019 - Two new epigenetic regulators maintain self-renewal of embryonic stem cells
April 20, 2019 - New Evidence That Veggies Beat Steak for Heart Health
April 20, 2019 - Study reveals genes associated with heavy drinking and alcoholism
April 20, 2019 - Texas A&M AgriLife becomes the newest member of NutriRECS international consortium
April 20, 2019 - In most states, insurance won’t cover addiction treatments
April 20, 2019 - Computer-based memory games may be beneficial for individuals with fragile X syndrome
April 20, 2019 - Timing of food intake influences molecular clock in the liver of mice
April 20, 2019 - Precise decoding of breast cancer cells paves way for new treatment option
April 20, 2019 - Scientists use 3D imaging to help model complex processes performed by placenta
April 20, 2019 - MediciNova Announces Plans to Move Forward with a Phase 3 Trial of MN-166 (ibudilast) in ALS
April 20, 2019 - Genetic variants that protect against obesity could aid new weight loss medicines
April 20, 2019 - New technology developed for microscopic imaging in living organisms
April 20, 2019 - when quitting cigarettes, consider using more nicotine, not less
April 20, 2019 - Key proteins can block Listeria without triggering the death of host cells
April 20, 2019 - Researchers create a working model of cerebral tract to study brain function
April 20, 2019 - New study shows that microbes can help break toxic chemical in dust
April 20, 2019 - Scientists use NIR light and injected DNA nanodevice to guide stem cells to injury

Guidelines on the use of genetic testing in psychiatry

image_pdfDownload PDFimage_print

An expert committee of psychiatrists and geneticists has issued revised guidelines for the use of genetic testing in psychiatric care. The new guidelines, which represent the first complete revision since 2014, address several controversial questions, including the use of genetic testing to guide treatment decisions (pharmacogenetics), diagnosis of mental disorders with powerful new molecular genetic technologies, and the special ethical challenges posed by genetic testing in psychiatric patients. The guidelines are written especially for non-specialist health care providers who may find the growing menu of clinical genetic tests confusing and difficult to evaluate, while facing a spike in genetic testing requests by patients and their families.

The committee, an official body within the International Society of Psychiatric Genetics (ISPG), issued its first guidelines in 2013. Co-chaired by genetics researcher and psychiatrist Dr. Francis J. McMahon and medical geneticist Dr. Franziska Degenhardt, the committee includes over 50 international experts from the fields of precision medicine, pharmacogenomics, psychiatry, neurodevelopment, and medical genetics. Contributors reviewed the most up-to-date scientific evidence and debated a number of controversial points for months in an attempt to reach consensus on key issues.

Dr. Thomas G. Schulze, professor of psychiatry at the University of Munich and President of the ISPG called the statement a demonstration of ISPG’s “commitment to provide meaningful guidance to health care providers who urgently need it to treat their patients in the best possible ways.” He also cautioned that while “psychiatric genetics has made major progress over the last decade and we can start using the knowledge gained for the benefit of our patients, we should not succumb to overly optimistic claims. That’s the main message of this statement.”

The current guidelines are the first to be issued since the advent of widespread chromosomal testing for autism and other neurodevelopment disorders. The guidelines also address emerging issues raised by growing interest in direct-to-consumer tests, which do not require a doctor’s order, and by aggressive marketing of commercial genetic testing panels that purport to help doctors select safer and more effective medicines for psychiatric patients.

For the first time, the committee failed to reach consensus on some key questions. Although genetic testing for small chromosomal deletions and duplications—known as copy number variants or CNVs—is now widely used in children with autism and other neurodevelopmental disorders, committee members could not agree on CNV testing in most adults with mental illness. Some have argued that identification of particular CNVs in adults with major mental illnesses such as schizophrenia may help patients and their families better understand and accept a psychiatric diagnosis. If such a CNV is found in a family, those who carry it face a substantially greater risk of both mental illness and, in some cases, medical problems. On the other hand, these CNVs are very uncommon in adults with mental illness and do not as yet change the way psychiatrists treat patients.

The committee also failed to reach consensus on the widespread use of genetic tests designed to help doctors choose the safest and most effective medications for treating mental illnesses. Such tests have been aggressively marketed to both doctors and patients in recent years, even though evidence in support of better treatment outcomes has been inconclusive. The committee did agree that some specific pharmacogenetic tests should be used when doctors are considering prescribing drugs such as carbamazepine, since those tests have been proven to identify people at substantially increased risk for rare but serious side effects.

“The fact that the committee could not reach consensus on every aspect,” noted Schulze, “speaks to the complexity of the issues.”

Not everything was controversial. The committee recommended that genome-wide testing should be accompanied by professional counseling and a warning that unexpected findings may arise with implications for long-term health (such as cancer). Committee members also agreed that direct-to-consumer testing provided no health benefits to psychiatric patients, that genetic test results must be safeguarded against unauthorized disclosure, that there was a need for more genetic education of mental health professionals and the general public, and that more research was needed to identify relevant genes and clarify the proper role of genetic testing in psychiatric care.

The guidelines are posted on the ISPG website at: https://ispg.net/genetic-testing-statement/


Concerns surround use of direct-to-consumer genetic testing



Provided by
The International Society of Psychiatric Genetics

Citation:
Guidelines on the use of genetic testing in psychiatry (2019, March 11)
retrieved 22 March 2019
from https://medicalxpress.com/news/2019-03-guidelines-genetic-psychiatry.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Tagged with:

About author

Related Articles