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Antibiotic levels in water and potential risk of drug-resistant bugs

Antibiotic levels in water and potential risk of drug-resistant bugs

A JRC report brings together data on antibiotic levels in water, showing that small concentrations have found their way into a range of Europe’s waterbodies.

Because of the threat of new drug-resistant bugs evolving when these antibiotics come into contact with bacteria present in the water, scientists are gathering evidence to better understand the potential risk.

Their data confirms that the levels of antibiotic residues in drinking water are minute and do not represent a risk to human health.

However, antibiotic residues can be found at higher levels in waste water, surface waters, agricultural runoff and water used for aquaculture (farms of fish, muscles, seaweed and other marine species).

The report is part of JRC efforts dedicated to investigating the implications of antibiotics in water.

Scientists aim to determine the minimum concentration of antibiotics that could cause resistance in bacteria, so that future limits can be based on risk assessments that take into account this potential.

The report also highlights that the development and spread of antimicrobial resistance (AMR) (the phenomenon of bacteria resisting the effects of antibiotics) can be constrained if measures are taken to improve the effectiveness of wastewater treatment processes and to control the use of antibiotics in medicine and animal husbandry.

Where do antibiotics end up after they’ve done their job?

Antibiotics are prescribed for a vast range of bacterial infections in humans and have saved the lives of millions since their discovery.

They are also given to animals as part of veterinary treatment, including to control infections in farm livestock.

Resistant bacteria regularly evolve in places where antibiotics are commonly used – such as in hospitals where the MRSA ‘superbug’ (resistant to a wide range of antibiotics) is often found.

On top of this, antibiotics don’t simply disappear after they’ve done their job of fighting off a bug.

They are excreted from the body and so there’s also a risk of similar bugs proliferating in water in treatment plants, in manure and slurry, and in the environment if the concentration of antibiotics is high enough to select for their survival.

The prevalence of antibiotic use has led to growing concern over the spread of AMR. In Europe, about 25000 people die of infections from antimicrobial-resistant bacteria every year.

It’s also estimated that AMR costs the EU €1.5 bn per year in healthcare costs and productivity losses.

Which antibiotics? How are they monitored?

Looking at data on 45 antibiotics from 13 countries worldwide, the report’s authors found sulfamethoxazole, trimethoprim and ciprofloxacin to be the three most frequently found in the water that flows out of waste water treatment plants.

Most of the data came from Europe (79.2%) and, for the antibiotics detected, the concentrations ranged up to 1 µg/L (one millionth of a gram per litre).

These medicines are all commonly prescribed for urinary tract infections, while ciprofloxacin is also prescribed for ear and chest infections.

Similar concentrations of antibiotics were also reported in surface waters, despite the fact that a reduction in their levels might reasonably have been expected due to the dilution of these substances as effluents run into rivers and lakes.

Ciprofloxacin is included alongside amoxicillin, erythromycin, azithromycin and clarithromycin on the Watch List monitoring program under the EU’s Water Framework Directive, which gathers data on substances that may pose a risk at EU level.

The analytical methods used have to be able to detect concentrations as low as between 0.019 and 0.089 µg/L, corresponding to concentrations considered not to have direct effects on aquatic organisms such as algae, crustacean and fish.

Antibiotics in fish farms?

The report notes that therehasso far beenlittle research into the use and effects of antibiotics in the aquaculturesector.

In Europe,the use of antibiotics inallanimalfarming activities, including aquaculture,isregulatedby specific legislation.

Aquaculture products(as well as any products from the animal farming systems)must not contain pharmacologically active substances abovean established Maximum Residue Limit.

Efficient monitoring at EU levelreliesonsurveillance programmesimplementedin the EU Member States, andrelevant dataaremadeavailableto the Commission.

Aquaculture is the fastest growing food-producing sector and it is estimated to account for approximately half of the total food supply coming from fish.

While it is necessary to prevent bacterial diseases in aquaculture products, the use of vaccines could lessen the need for chemicals and antibiotics in this sector, on condition that vaccines against the most relevant diseases are registered and accessible in all EU member states.

Background

In June 2017 the Commission adopted the EU One Health Action Plan against AMR. The key objectives of this new plan include:

1. Making the EU a best practice region

2. Boosting research, development and innovation

3. Shaping the global agenda

The Commission has also adopted the first deliverables of the plan, for example the EU Guidelines on the prudent use of antimicrobials in human health.

The guidelines aim to reduce inappropriate use and promote prudent use of antimicrobials in people. They target all actors who are responsible for or play a role in antimicrobial use.

The Commission also recently adopted a Strategic Approach to Pharmaceuticals in the Environment – a set of actions addressing the multifaceted challenges that the release of pharmaceuticals poses to the environment.

Source:

https://ec.europa.eu/jrc/en/news/antibiotics-water-and-risk-drug-resistant-bacteria

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