The series of molecular steps linking inflammation and cancer, as shown in in the gastric epithelial cells. Inflammatory molecules IL-1α/β, lead to enhancement of MIR135B. This is turn activates FOXN3 and RECK genes, that lead to tumour like properties in cells. Credit: Kanazawa University Severe inflammation in tissues is often associated with the occurrence of […]Continue Reading ...
A new model by Rice University researchers details a direct connection between gene expression and metabolism and how cancer cells take advantage of it to adapt to hostile environments, a process known as metabolic plasticity. Credit: Dongya Jia/Rice University When metastatic cancer cells need to avoid a threat, they simply reprogram themselves. Rice University scientists […]Continue Reading ...
Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left – diagnostic of a LMP tumour). Epithelium in a frond-like architecture is seen at the top of image. Credit: Nephron /Wikipedia. CC BY-SA 3.0 Research on a bacterial […]Continue Reading ...
An illustration of chromatin contacts in the cell nucleus that activate transcription. Credit: Giovanni Ciriello (UNIL) Inside cells DNA is tightly wrapped around proteins and packed in a complex, 3-D structure called chromatin. Chromatin not only protects genetic material from damage, but also organizes the entire genome by regulating the expression of genes in three […]Continue Reading ...
Arnoldo Frigessi is the main person behind the new idea of making tens of thousands of virtual copies of the individual cancer patient and then testing all the treatments in a simulation model to find the most optimal treatment. Credit: Ola Sæther In ten years, computers will be able to propose the most suitable cancer […]Continue Reading ...
Health policy played a surprisingly robust role in President Donald Trump’s 2019 State of the Union address. The president laid out an ambitious set of health goals in his speech Tuesday to Congress and the nation, including reining in drug prices, ending the transmission of HIV in the U.S. during the next decade and dedicating […]Continue Reading ...
Herman Sintim, the Drug Discovery Professor of Chemistry in Purdue University’s Department of Chemistry, is leading a team of researchers developing a series of drug compounds that have shown promise in treating acute myeloid leukemia, most notably in cases where patients have a recurrence of the fairly rare but aggressive blood cancer that is one […]Continue Reading ...
When Antonina Mitrofanova learned she couldn’t become an oncologist, she changed majors to computer science. Now, a pioneer in the emerging field of biomedical informatics she is fighting cancer with big data. Credit: Nick Romanenko A Rutgers study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for […]Continue Reading ...
(HealthDay)—Neoadjuvant administration of programmed cell death protein 1 (PD-1) blockade seems to enhance local and systemic antitumor immune response in glioblastoma, according to a study published online Feb. 11 in Nature Medicine. Timothy F. Cloughesy, M.D., from the University of California in Los Angeles, and colleagues examined immune responses and survival after neoadjuvant and/or adjuvant […]Continue Reading ...
President Donald Trump announced Tuesday during his State of the Union address that he was asking Congress to allocate $500 million over the next 10 years for pediatric cancer research. Organizations such as the American Cancer Society viewed the investment as a positive step. “Any increase in current funding levels is a good thing,” said Keysha […]Continue Reading ...
Credit: CC0 Public Domain MIT cancer biologists have discovered a new mechanism that lung tumors exploit to promote their own survival: These tumors alter bacterial populations within the lung, provoking the immune system to create an inflammatory environment that in turn helps the tumor cells to thrive. In mice that were genetically programmed to develop […]Continue Reading ...
It was not the centerpiece, but health was a persistent theme in President Donald Trump’s State of the Union address at the Capitol on Tuesday night. Although the administration has focused more on issues of trade, taxes and immigration, the president laid out a series of health-related goals, including some that even Democrats indicated could […]Continue Reading ...
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