Scientists at Washington University School of Medicine in St. Louis now have used the gene-editing technology CRISPR to engineer human T cells that can attack human T cell cancers. They also engineered the T cells to eliminate a potentially dangerous side effect called graft-versus-host disease, where the therapeutic T cells that kill the cancer also […]Continue Reading ...
Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. “There is a need for new methods of treatment for high-risk patients, and that’s where […]Continue Reading ...
Dr Laura Eadie at work in the SAHMRI Leukaemia Research Laboratory. Credit: SAHMRI Adelaide scientists have devised a way to enhance the effectiveness of a patient’s leukaemia treatment by using a combination of drugs. Chronic myeloid leukaemia (CML) is a cancer of the blood and, while current treatments are effective in the majority of patients, […]Continue Reading ...
The project will support the development of the vaccine to protect animals against cancerous cells that are currently untreatable, and could easily translate to vaccines for humans’ use of spontaneously occurring cancers. Credit: Michigan State University Michigan State University scientists are engineering a virus-like particle, known as Qβ, that will generate anti-cancer immune responses in […]Continue Reading ...
Image shows the DNMT3A-DNA complex. A research team led by Jikui Song cracked the crystal structure for DNMT3A-DNA complex. The structure reveals that DNMT3A molecules attack two substrate sites adjacent to each other on the same DNA molecule. DNMT3L (green) is a regulatory protein of DNMT3A. Bp (base pairs) is a unit of length, with […]Continue Reading ...
Three-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by Tom Misteli, Ph.D., and Karen Meaburn, Ph.D. at the NIH IRP. Breast cancer spreads to other organs in the body according to certain specific patterns. This has been shown […]Continue Reading ...
Results from a retrospective study of 1,629 patients with non-Hodgkin lymphoma (NHL) showed that survival at 4 years following allogeneic hematopoietic cell transplantation (HCT) for patients age 65 years and older is comparable to patients age 55 to 64 years. The study demonstrates that age alone should not be a determinant when considering HCT for […]Continue Reading ...
Results of the phase II OPTIMA clinical trial indicate that patients with head and neck cancers associated with the human papillomavirus (HPV), including those with advanced nodal disease, can receive substantially lower radiation doses safely and effectively if they respond to induction chemotherapy initially. Patients who responded well to induction chemotherapy and subsequently received the […]Continue Reading ...
Pathology image, left, and corresponding terahertz image, right, of excised tissue from mouse breast tumor. Credit: University of Arkansas Engineering researchers at the University of Arkansas have moved closer to developing an alternative method of detecting and possibly treating breast cancer. The researchers, led by Magda El-Shenawee, professor of electrical engineering, work with pulsed, terahertz […]Continue Reading ...
Cancer — Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0 First-degree relatives affected by colorectal cancer comprise a patient’s elevated risk of developing bowel cancer. The same holds true for people who have large numbers of genetic risk markers in their genome. Both factors are usually used alternatively, not combined, to predict risk. Scientists […]Continue Reading ...
Every kind of cancer can spread to the spine, yet two physician-scientists who treat these patients describe a paucity of guidance for effectively providing care and minimizing pain. To resolve the confusion and address the continually changing landscape of spine oncology, a recent Michigan Medicine-led publication details a guide to explain the management of spinal […]Continue Reading ...
Credit: Yale University Yale School of Public Health researchers have developed a new method to predict likely resistance paths to cancer therapeutics, and a methodology to apply it to one of the most frequent cancer-causing genes. That gene, KRAS, is mutated in approximately 20 percent of all human cancers and has a major presence in […]Continue Reading ...
Killer T cells surround a cancer cell. Credit: NIH New research could help to safely adapt a new immunotherapy—currently only effective in blood cancers—for the treatment of solid cancers, such as notoriously hard-to-treat brain tumours. The study, led by Dr. Misty Jenkins from the Walter and Eliza Hall Institute of Medical Research, explains the crucial […]Continue Reading ...
Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. Credit: Nephron/Wikipedia Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer – triple-negative breast cancer – to thrive. Hormone therapy for […]Continue Reading ...
The CD19 molecule on a leukemia cell is like a tiny radio broadcasting to the world, “I’m leukemia. Come and get me.” Credit: Kevin Craft Leukemia is a deadly cancer in which rogue white blood cells roam the bloodstream, slowly killing the body that gave them life. But this insidious killer has an Achilles’ heel. […]Continue Reading ...
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