Hongbo Chi, PhD, led the group that showed disrupting either mTORC1 or metabolic activity blocked Th1-like features in Th17 cells in the laboratory as well as neuroinflammation in models. Credit: St. Jude Children’s Research Hospital St. Jude Children’s Research Hospital scientists have discovered a subset of helper T cells that may help to redefine understanding […]Continue Reading ...
A study published in the British Journal of Dermatology indicates that an investigational nonsteroidal topical cream (PAC-14028) may be effective for treating atopic dermatitis, one of the most common inflammatory skin diseases. The trial involved a cream that blocks the transient receptor potential vanilloid subfamily, member 1, an ion channel involved in the perception of […]Continue Reading ...
(HealthDay)—Holiday get-togethers can be risky for people with food allergies. About 15 million people in the United States have one or more food allergies. “It’s unfortunate that there’s been such an uptick in food allergy diagnoses, but the good thing is people are talking about it and there’s not as much stigma as there was […]Continue Reading ...
Christian Bertrand/Shutterstock”> Flea, the bass player with the Red Hot Chili Peppers, suffered from chronic fatigue syndrome. Credit: Christian Bertrand/Shutterstock Chronic fatigue syndrome (CFS) affects up to 24m people, globally, but little is known about its causes. Our latest study unravels some of this mystery. The results suggest that an overactive immune system may trigger […]Continue Reading ...
Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAID Researchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to […]Continue Reading ...
Researchers from Penn and Technical University of Dresden found that the protein Del-1 takes on different functions depending on the cell that secretes it. When secreted by the immune system’s macrophages, it acts as a bridge between those cells and neutrophils to help clear inflammation. Credit: University of Pennsylvania Health conditions that involve inflammation run […]Continue Reading ...
Oregon State University researchers have discovered two key factors behind the intestinal inflammation that plagues people suffering from a disorder that affects their immune system. The findings, published in Clinical Immunology, are important because common variable immunodeficiency, known as CVID, afflicts hundreds of thousands of people worldwide. A significant proportion of them will have potentially […]Continue Reading ...
OIST scientists have discovered that JunB promotes immunosuppressive functions of effector regulatory T cells in colon and lungs. FOXp3, found by a group so scientists in the US in 2001, is a transcription factor responsible for hereditary immune diseases in humans. Credit: OIST Our immune systems defend our bodies against dangerous invaders and help clean […]Continue Reading ...
Credit: CC0 Public Domain For the first time, researchers have identified that an immune cell subset called gamma delta T cells that may be causing and/or perpetuating the systemic inflammation found in normal aging in the general geriatric population and in HIV-infected people who are responding well to drugs (anti-retrovirals). Even with effective viral control, […]Continue Reading ...
Professor Julian Crane, from the Department of Medicine at the University of Otago, Wellington Giving a probiotic supplement to pregnant mothers and their infants significantly reduces the chances of a child developing eczema for the first 11 years of their life, researchers have shown. The probiotic Lactobacillus rhamnosus (HN001) given to mothers at a late […]Continue Reading ...
Credit: University of Rhode Island A number of patients who suffer from asthma are bringing their condition under control, increasing their lung function and decreasing the frequency of asthma attacks—all without going to the doctor’s office. The patients involved in a URI College of Nursing professor’s study are benefitting from an emerging trend among nurses […]Continue Reading ...
A protein generated as part of our body’s immune response to intestinal worms could slow the progression of emphysema, according to a Rutgers study. The study appears in the journal Cell Reports. Past studies have shown that harmful inflammation associated with activated immune cells can contribute to the development of emphysema, a chronic lung disease […]Continue Reading ...
Lack of Foxp1 leads to inflammation of the large intestine (colitis). (Left) In healthy conditions, iTreg cells (blue) with sufficient Foxp1 keep a check over other immune cells (T-cells, orange, green and purple) in the large intestine. (Right) If Foxp1 is absent, iTreg cells are dramatically reduced and therefore can’t control the activity of other […]Continue Reading ...
(HealthDay)—The U.S. Food and Drug Administration on Monday approved Gamifant (emapalumab-lzsg) for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in pediatric (as young as newborn) and adult patients who have refractory, recurrent, or progressive disease or intolerance with conventional HLH treatment. Gamifant is the first drug to be approved specifically for HLH. The drug’s efficacy […]Continue Reading ...
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