Dr Alan Yu and Associate Professor Seth Masters. Credit: Walter and Eliza Hall Institute of Medical Research Australian researchers have uncovered clues in the immune system that reveal how the balance of ‘good’ gut bacteria is maintained. The information could help in the prevention and treatment of inflammatory bowel disease (IBD). The study, published in […]Continue Reading ...
The DNA receptor (green) is bound to DNA (blue) inside immune cells (macrophages) (cell membrane colored pink) during infection. Credit: the Rathinam Lab Inflammation is one strategy your body uses to fight infection, but if it gets out of control it can kill instead of heal. In the Sept. 18 issue of Immunity, UConn Health […]Continue Reading ...
Researcher Gillian Dunphy in the lab at Lancaster University. Credit: Lancaster University Our immune system is working every day to protect us from bacteria, viruses, and parasites, but it can also detect when our own cells are damaged. Research led by Lancaster University has now discovered how skin cells alert the immune system, when their […]Continue Reading ...
BAFF increased the IL-6-producing effector B cells but suppressed the IL-10-producing regulatory B cells. Furthermore, effector B cells play a pathogenic role in scleroderma while regulatory B cells play a protective role. Credit: Kanazawa University Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in […]Continue Reading ...
Researchers Matthew Drake, M.D. (left), and lab manager Emily Blum use a confocal microscope to generate three-dimensional imagery of airway nerves. Their research demonstrated that inflammatory cells can alter nerve structure in the lungs to cause asthma. Credit: Kristyna Wentz-Graff/OHSU A new study implicates remodeling of nerves in the airways as a key contributor to […]Continue Reading ...
Fig. 1. The role of miRNAs in IBD. miR-29 loaded on a supercarbonate apatite prevents the development of inflammation by suppressing the production of inflammatory cytokines (IL-6, TGF-β, and IL-23) secreted from dendritic cells and by suppressing the differentiation of naive T cells to Th17 cells. Credit: Osaka University Inflammatory bowel disease (IBD), such as […]Continue Reading ...
Top: CCL17-producing neurons (green) and microglia (red) in the hippocampus. Bottom: Reconstruction of an individual microglia cell from wild-type or CCL17-knockout mice. Credit: Lorenz Fülle/Uni Bonn The chemotactic protein CCL17 attracts immune cells to where they are needed. Doctors have long known that a high level of CCL17 in the body indicates an allergic reaction. […]Continue Reading ...
As mammals age, immune cells in the brain known as microglia become chronically inflamed. In this state, they produce chemicals known to impair cognitive and motor function. That’s one explanation for why memory fades and other brain functions decline during old age. But, according to a new study from the University of Illinois, there may […]Continue Reading ...
Nancy Lainez (left) and Djurdjica Coss. Credit: I. Pittalwala, UC Riverside. Whether we like it or not, everyone accumulates fat. For women, it usually accumulates around the hips, resulting in a pear-shaped look. In men, fat tends to build up around the abdomen, creating an apple shape. As it turns out, it’s healthier to be […]Continue Reading ...
Two variants of an autoimmune disease that affects thousands but is hard to diagnose are relatively common among black Africans, research shows. The findings, relating to systemic lupus erythematosus, or SLE, could improve diagnosis and treatment of the condition. They could enable better management of the disease in patients of African descent, particularly in southern […]Continue Reading ...
Compared with 2D monolayers the use of 3D cell cultures, like those described in the current review, more faithfully recapitulate some of the subtle interactions between pathogens and hosts within the living body. Credit: Jennifer Barrila, Cheryl Nickerson and Michael Northrop and licensed by ASU through Shutterfly. The inset looking into the intestine is from […]Continue Reading ...
The research suggests when individuals with specific variations in certain genes are exposed to traffic pollution, they display more intense asthma symptoms than people that lack those same gene variations. Credit: NIEHS Asthma patients, with a specific genetic profile, exhibit more intense symptoms following exposure to traffic pollution, according to researchers at the National Institutes […]Continue Reading ...
Macrophages are not just the vacuum cleaners of the immune system. They also support other cells. These long-lived macrophages in the intestines of mice (in green) make contact with the nerve cells of the gastrointestinal tract (in red). The macrophages provide growth factors for the nerve cells. The nerve cells die off without the macrophages. […]Continue Reading ...
Artistic rendering of the surface of a human dendritic cell illustrating sheet-like processes that fold back onto the membrane surface. Credit: National Institutes of Health (NIH) Inflammatory bowel disease (IBD), which afflicts millions of people worldwide, arises when the immune system mounts an overly aggressive response against microorganisms, dietary substances, or cells of the gut. […]Continue Reading ...
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