Credit: CC0 Public Domain What treatments are available for patients with the rare inflammatory disease known as urticarial vasculitis? How effective are these treatments? Researchers from Charité – Universitätsmedizin Berlin embarked on a systematic review and meta-analysis to address these questions. Recently published in the Journal of Allergy and Clinical Immunology, the results of this […]Continue Reading ...
(HealthDay)—Loss to follow-up is common with inflammatory bowel disease (IBD), and both low C-reactive protein levels and long travel time to the hospital are predictors of follow-up loss, according to a study published in the Journal of Gastroenterology and Hepatology. Dae Hyung Woo, from the Yeungnam University College of Medicine in South Korea, and colleagues […]Continue Reading ...
Credit: Marek Skupinski Children who develop inflammatory bowel disease (ulcerative colitis or Crohn’s disease) have an increased risk of death, both in childhood and later in life, a study from Karolinska Institutet published in the journal Gastroenterology reports. It is therefore important that patients who are diagnosed as children are carefully monitored, argue the researchers […]Continue Reading ...
Credit : Susanna M. Hamilton, Broad Communications A study of gut microbes from more than 400 children points to how the microbiome behaves in this inflammatory bowel disease. The gastrointestinal tract hosts a complicated set of relationships involving a variety of host cells (e.g., epithelial cells, immune cells) and the array of microbes that make […]Continue Reading ...
High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia Crohn’s disease is a lifelong condition characterized by a fluctuating course of gastro-intestinal inflammation with repeated flares and remissions. Any part of the alimentary tract from the mouth to the anus can be affected resulting in diverse symptoms including abdominal pain, watery […]Continue Reading ...
Inflammatory bowel disease (IBD), an umbrella term for a number of gut disorders—including ulcerative colitis and Crohn’s disease—remains a clinical challenge. Current treatments don’t work for all patients, and many stop working over time. But despite their different responses to treatment, all IBD patients share a commonality: intestinal inflammation. Better understanding what drives gut inflammation […]Continue Reading ...
A model of several TLR4 receptors within the mammalian plasma membrane. Credit: A*STAR Bioinformatics Institute Toll-like receptor 4 (TLR4) is a protein that plays a vital role in the body’s immune response by sensing the presence of infection. It has long been thought to also sense particular types of fats, which suggested a mechanism linking […]Continue Reading ...
New research reveals how the body clock controls inflammation. Pictured left to right: Dr Richard Carroll, Dr Annie Curtis, Mariana Cervantes and George Timmons at RCSI (Royal College of Surgeons in Ireland). Credit: Patrick Bolger Researchers at RCSI and Trinity College Dublin have revealed insights into how the body clock controls the inflammatory response, which […]Continue Reading ...
High magnification micrograph of Crohn’s disease. Biopsy of esophagus. H&E stain. Credit: Nephron/Wikipedia In the first study of its kind, cannabis oil has been shown to significantly improve the symptoms of Crohn’s disease and the quality of life of sufferers but, contrary to previous medical thinking, has no effect on gut inflammation. In a randomised, […]Continue Reading ...
Kidney infection with the fungal pathogen Candida albicans causes tissue damage. In wild-type mice, DNGR-1 expressed on dendritic cells detects this injury, and this triggers a reduction in the production of Mip-2, a chemokine that attracts neutrophils. Mice lacking DNGR-1 do not recognize the tissue injury and therefore do not reduce Mip-2 production. The resulting […]Continue Reading ...
Credit: CC0 Public Domain Increased physical activity is now being emphasized as a treatment option for the gastric intestinal disease known as IBS. Research at Sahlgrenska Academy, Sweden, indicates improvements in both intestinal function and self-esteem of patients who exercise more. “Increased physical activity is associated with an improvement in gastrointestinal symptoms and, in the […]Continue Reading ...
Credit: Mary Ann Liebert, Inc., publishers Researchers have performed a comprehensive review of the current state and future potential of using biologic medications to treat asthma in children. They evaluated a broad scope of approved biologics, the available information for each, and whether predictive or monitoring biomarkers are available for each biologic drug, presenting that […]Continue Reading ...
Credit: CC0 Public Domain Sometimes, the immune system mistakenly attacks the body’s healthy tissue by responding to infections that do not exist. This causes chronic inflammation and leads to diseases including lupus (SLE), and this is what happens when the body activates the STING protein. Now, researchers from Aarhus University have discovered that a new […]Continue Reading ...
Credit: CC0 Public Domain Chronic rhinosinusitis is distinct from your average case of seasonal allergies. It causes the sinuses to become inflamed and swollen for months to years at a time, leading to difficulty breathing and other symptoms that make patients feel miserable. In some people, this condition also produces tissue outgrowths known as nasal […]Continue Reading ...
Credit: CC0 Public Domain Inflammatory bowel disease (IBD) is a set of painful conditions that can cause severe diarrhea and fatigue. Treatments can include medications and surgery. But now researchers report that a simple dietary intervention could mitigate colonic inflammation and improve gut health. In this case, a strawberry—or rather, less than a cupful of […]Continue Reading ...
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