Inflammatory bowel disease (IBD), an umbrella term for a number of gut disorders—including ulcerative colitis and Crohn’s disease—remains a clinical challenge. Current treatments don’t work for all patients, and many stop working over time. But despite their different responses to treatment, all IBD patients share a commonality: intestinal inflammation. Better understanding what drives gut inflammation […]Continue Reading ...
Credit: CC0 Public Domain Sometimes, the immune system mistakenly attacks the body’s healthy tissue by responding to infections that do not exist. This causes chronic inflammation and leads to diseases including lupus (SLE), and this is what happens when the body activates the STING protein. Now, researchers from Aarhus University have discovered that a new […]Continue Reading ...
Credit: CC0 Public Domain Chronic rhinosinusitis is distinct from your average case of seasonal allergies. It causes the sinuses to become inflamed and swollen for months to years at a time, leading to difficulty breathing and other symptoms that make patients feel miserable. In some people, this condition also produces tissue outgrowths known as nasal […]Continue Reading ...
Credit: CC0 Public Domain Inflammatory bowel disease (IBD) is a set of painful conditions that can cause severe diarrhea and fatigue. Treatments can include medications and surgery. But now researchers report that a simple dietary intervention could mitigate colonic inflammation and improve gut health. In this case, a strawberry—or rather, less than a cupful of […]Continue Reading ...
Inflammation is part of the body’s natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer’s disease and other conditions. Inflammasomes—protein-based molecular machines—trigger inflammation in response to different signals generated by cell stress, tissue injury or infectious organisms. In a study published online July 25 in the journal Nature, University of […]Continue Reading ...
A small pilot clinical trial published in The FASEB Journal shows that targeted nutrient therapy can improve lung function in obese individuals with asthma without requiring weight loss. Specifically, the study demonstrated that eating two CHORI-Bars (patent-pending supplement bars designed to fill nutritional gaps in poor diets) daily for eight weeks improved lung function in […]Continue Reading ...
Bowel of a patient with Ulcerative Colitis, a chronic inflammatory bowel disease. In green: macrophage marker, in red: activated p38 protein, in blue: nucleus. Credit: Catrin Youssif, IRB Barcelona. Scientists headed by ICREA researcher Angel R. Nebreda at the Institute for Research in Biomedicine (IRB Barcelona) report a new mechanism that contributes to the development […]Continue Reading ...
Brain scans showing white matter damage. Credit: Gottesman lab Researchers at Johns Hopkins have added to evidence that rising and chronic inflammation as measured by a biomarker in the blood in middle and late age are linked to visible structural changes in the brains of people with poor cognition and dementia. The authors say results […]Continue Reading ...
A model of several TLR4 receptors within the mammalian plasma membrane. Credit: A*STAR Bioinformatics Institute Toll-like receptor 4 (TLR4) is a protein that plays a vital role in the body’s immune response by sensing the presence of infection. It has long been thought to also sense particular types of fats, which suggested a mechanism linking […]Continue Reading ...
New research reveals how the body clock controls inflammation. Pictured left to right: Dr Richard Carroll, Dr Annie Curtis, Mariana Cervantes and George Timmons at RCSI (Royal College of Surgeons in Ireland). Credit: Patrick Bolger Researchers at RCSI and Trinity College Dublin have revealed insights into how the body clock controls the inflammatory response, which […]Continue Reading ...
The team of researchers from the Marshall University School of Pharmacy and Marshall University Joan C. Edwards School of Medicine who identified inflammatory biomarkers in T cells includes (front row, from left) Jun Fan, Ph.D.; Donald A. Primerano, Ph.D.; (back row, from left) Bryanna Roar, third-year Pharm.D. student; Jeremy McAleer, Ph.D.; James Denvir, Ph.D. Credit: […]Continue Reading ...
(HealthDay)—Atopic dermatitis (AD) dramatically impacts the quality of life of patients, according to a study published online July 16 in the Annals of Allergy, Asthma & Immunology. Jonathan I. Silverberg, M.D., Ph.D., from Northwestern University in Chicago, and colleagues assessed the patient-burden of AD among 602 U.S. patients. The researchers found that adults with AD […]Continue Reading ...
Lawrence Steinman and his team have found that nicotine-mimicking molecules might work as anti-inflammatory drugs for conditions like gout and rheumatoid arthritis. Credit: Norbert von der Groeben Stanford researchers discovered that a receptor that binds to nicotine and to clusters of beta-amyloid molecules is found on certain types of immune cells that can act as […]Continue Reading ...
Dr. Clint Allred (second from left) and colleagues in the laboratory. Credit: Texas A&M College of Agriculture and Life Sciences A recent study in a preclinical model of inflammatory bowel disease shows dietary exposure to bisphenol-A, or BPA, found in polycarbonate plastics and epoxy resins, can increase mortality and worsen its symptoms. Dr. Clint Allred, […]Continue Reading ...
Laurie Harrington. Credit: UAB In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. These cells could become potential therapeutic targets to ameliorate or cure Crohn’s disease and ulcerative colitis. Furthermore, if this subset of […]Continue Reading ...
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