Credit: CC0 Public Domain Mayo Clinic researchers and their collaborators have shown that when senescent cells—also known as “zombie cells”—are removed from fat tissue in obese mice, severity of diabetes and a range of its causes or consequences decline or disappear. The findings appear in Aging Cell. Inflammation and dysfunction of fat tissue cause some […]Continue Reading ...
Credit: CC0 Public Domain Aging affects every living organism, but the molecular processes that contribute to aging remain a subject of debate. While many things contribute to the aging process, one common theme in animal aging is inflammation—and this may be amplified by a class of selfish genetic elements. The human genome is littered with […]Continue Reading ...
Credit: CC0 Public Domain Red blood cells are the most plentiful cell type in our blood and play a vital role transporting oxygen around our body and waste carbon dioxide to the lungs. Injuries that cause significant blood loss prod the body to secrete a one-two punch of signals – stress steroids and erythropoietin (EPO) […]Continue Reading ...
Credit: McGill University According to the World Health Organization, approximately 180,000 deaths every year are caused by burns, with the majority occurring in low- and middle-income countries. Upon arriving at the emergency room with a burn, the patient undergoes a clinical inspection to assess both the severity of the lesion in relation to the affected […]Continue Reading ...
Credit: CC0 Public Domain Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory. The study, published in the journal Science Signaling, paves the way for characterizing and testing new drugs. The biosensors are based on the action of […]Continue Reading ...
Cannabinoid receptors in humans respond to compounds found in cannabis. Credit: @tsarcyanide/MIPT A Chinese research team joined forces with Russian and U.S. biologists to obtain the crystal structure of the human type 2 cannabinoid receptor. Their findings could lead to drugs against inflammatory, neurodegenerative, and other diseases. The authors of the paper, published in Cell, […]Continue Reading ...
Visualization on sample whole-slide images of the lung cancer histologic patterns identified by pathologists compared to those detected by a new machine learning model developed by researchers at Dartmouth’s Norris Cotton Cancer Center. The team rendered the image by overlaying color-coded dots on patches based on decisions generated by their computer model. A subjective qualitative […]Continue Reading ...
Colony of stem cells genetically modified with a double fail-safe mechanism to control the formation of tumors and the differentiation into non-desirable cell types. Cells are stained for the stem cell markers SOX2 (green) and TRA-1-60-R (red). A nuclear marker is shown in blue. Credit: Diabetes Research Institute, University of Miami Miller School of Medicine […]Continue Reading ...
Robotic body surrogates can help people with profound motor deficits interact with the world. Here, Henry Evans, a California man who helped Georgia Tech researchers with improvements to a web-based interface, uses the robot to shave himself. Credit: Henry Clever/Phillip Grice An interface system that uses augmented reality technology could help individuals with profound motor […]Continue Reading ...
Steroids act on adipocyte glucocorticoid receptors (GRs) :Activation of adipocyte GRs restricted healthy adipose expansion, causing insulin resistance, liver steatosis, and eventually diabetes. Credit: Osaka University Steroids are used for treating various diseases such as allergic disorders, but they occasionally cause adverse effects, such as steroid diabetes and other metabolic disturbances. Since steroids act throughout […]Continue Reading ...
Credit: CC0 Public Domain A global team of scientists have mapped the developmental pathway of a newborn’s life for the first time. The research, published in Nature Communications, could transform our understanding of health and disease in babies. Co-led by the MRC Unit The Gambia at the London School of Hygiene & Tropical Medicine, the […]Continue Reading ...
Mitochondria in hematopoetic stem cells, visualized with a green fluorescent dye. Credit: N. Vannini, Ludwig Institute for Cancer Research Stem cell-based therapies are becoming increasingly common, especially in the treatment of blood cancers like lymphoma and leukemia. In these cases, the patient’s cancerous blood stem cells are removed and replaced with new, healthy ones. However, […]Continue Reading ...
Credit: CC0 Public Domain In 1906, English statistician Francis Galton happened to visit a livestock fair where fairgoers were invited to guess the dressed weight of an ox scheduled for imminent slaughter. Some 800 attendees took part and afterwards Galton got hold of the contest data. This episode, which Galton reported in Nature, has become […]Continue Reading ...
Some important conditions are treated by misoprostol, including bleeding, inflammation, pain, and labor. Illustrated here is misoprostol in the binding site of the hormone prostaglandin E2 receptor 3. Credit: Yekaterina Kadyshevskaya, USC Bridge Institute Postpartum hemorrhaging is the world’s leading cause of death for women during and after childbirth, and the third-leading cause in the […]Continue Reading ...
Credit: Yale University In a lab dish, Yale researchers modeled two brain structures and their interactions to shed light on the origins of neuropsychiatric diseases. In-Hyun Park, associate professor of genetics, and his team created an organoid of the thalamus, a major hub that integrates sensory information and relays it to different areas of the […]Continue Reading ...
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