Researchers have developed a novel CAR-T cell therapy that can reduce B cell numbers known to cause the inflammatory responses in lupus. Alpha Tauri 3D Graphics | Shutterstock Lupus is a difficult condition to treat. It is an autoimmune condition that leads to kidney failure and other complications of different organs that can be fatal […]Continue Reading ...
Signaling properties and activity of CAR T cells are conditioned by the length of the CAR intracellular domain The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient’s own immune system to target cancer cells. One […]Continue Reading ...
When the FDA announced in 2017 that it was approving an immunotherapy treatment for children with certain relapsed blood cancers, doctors and patients were pretty excited. That treatment, tisagenlecleucel (brand name Kymriah), involves engineering the patient’s own immune cells to make biological chimeras, called CAR-T cells, that recognize and attack cancer. But on the heels […]Continue Reading ...
Physician-scientists from Children’s Hospital of Philadelphia (CHOP) presented updated efficacy and safety data on Kymriah(R)* (tisagenlecleucel, formerly CTL019) –the first-ever U.S. Food and Drug Administration (FDA) approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers at the 60th American Society of Hematology (ASH) annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell […]Continue Reading ...
CAR T Cell Therapy is revolutionizing the field of hematologic malignancies and has the potential to achieve cure for a number of dreadful diseases. The recent approvals of the first CAR T Cell treatments in Europe provide a great opportunity to fight hematologic malignancies, but also poses serious challenges given the peculiar nature of the […]Continue Reading ...
Cancer remains the second-leading cause of death in the United States. This year, an estimated 1.7 million new cases will be diagnosed, with nearly 610,000 people expected to die from the disease, according to the National Cancer Institute. Fortunately, several recent cancer treatments show considerable promise. Among them is Chimeric Antigen Receptor (CAR) T cell […]Continue Reading ...
Credit: CC0 Public Domain Today, a new blood cancer treatment was approved for use on the NHS in England. And in early September, NHS England announced another, similar treatment will be available to some children and young people with a different type of blood cancer. As with any new drug approval, these announcements are great […]Continue Reading ...
Researchers at the University of Pennsylvania have made a new discovery about a rare mechanism that triggers the relapse of acute lymphoblastic leukemia (ALL) after CAR T cell therapy. Image Credit: Juan Gaertner / Shutterstock The study, which was recently published in the journal Nature Medicine, has explained how a single leukemic cell became resistant […]Continue Reading ...
Recent FDA approval of CAR T cells for the treatment of leukemia and lymphoma has resulted in rapid growth in research on the therapeutic uses of such cells. The new AMSBIO experimental cell lines provide you with the power to screen antibodies and ligands against your target, enhancing your search for new CAR T therapies. […]Continue Reading ...
For this fall’s issue of Stanford Medicine magazine, which focused on all things digital, I wrote a story featuring the work of Pablo Paredes, PhD, instructor of radiology and of psychiatry and behavioral sciences at Stanford. Paredes aims to enhance people’s mental well-being and reduce stress — his strategy harnesses a suite of technologies, all comforting […]Continue Reading ...
In a new study, Indiana University scientists found toxic flame retardants in newly manufactured children’s car seats, sparking concerns about children’s health. Of the 18 children’s car seats tested, 15 contained new or traditional hazardous flame retardant chemicals. “New replacement flame retardants, often marketed as safer alternatives, are lurking in children’s products without rigorous safety […]Continue Reading ...
Mayo Clinic researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy (CAR-T cell therapy) in treating cancer. They are presenting results of their preclinical research at the 2018 annual meeting of the American Society of Hematology in San Diego. Reducing toxicity in CAR-T cell therapy “While CAR-T cell […]Continue Reading ...
Women with HER2-positive breast cancer that has spread to the brain need more treatment options, and City of Hope and Mustang Bio Inc. are meeting that challenge. A new City of Hope chimeric antigen receptor (CAR) T cell trial – the first to focus on HER2-positive breast cancer patients with brain metastases – is now […]Continue Reading ...
Kidney disease often lacks symptoms until it is at an advanced stage. Credit: Kristoffer Lindskov Hansen, Michael Bachmann Nielsen and Caroline Ewertsen, licensed under CC BY 4.0 Recent advances in kidney research have yielded dramatic headlines touting scientists’ ability to grow kidneys in the lab. But some experts worry that hype about tissue engineering is […]Continue Reading ...
Loyola University Chicago and Loyola Medicine have announced plans to become the first Chicago center to produce cancer-fighting CAR-T cells to treat leukemia and lymphoma. CAR-T cell therapy has been shown to be remarkably effective in treating cancer patients who have failed standard treatments, but it is expensive and can cause severe side effects. Loyola […]Continue Reading ...
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