Healthy white blood cells, called “T-cells,” play a crucial role in how the body fights follicular lymphoma. That’s according to the results of a study led by Mayo Clinic hematologists Zhi Zhang Yang, M.D., and Stephen Ansell, M.D., Ph.D., that was published in Cell Reports. T-cells are a key part of the immune system and […]Continue Reading ...
Researchers have been advancing methods to generate insulin-producing beta cells from pluripotent stem cells (PSC) for the clinical treatment of type 1 diabetes (T1D). However, transplantation of these immature cells into patients poses substantial risks, namely the development of tumors (teratomas) and the growth of these stem cells into unwanted cell types. Pluripotent stem cells […]Continue Reading ...
CRCHUM researchers are exploring a potential therapeutic approach Researchers at the University of Montreal Hospital Research Centre (CRCHUM) have shown that immunotherapy treatments against cancer could reduce the amount of virus that persists in people on triple therapy. In a study published in the journal Nature Communications, they show, in the cells of people living […]Continue Reading ...
FAU researchers have now discovered that so-called TRM cells (shown in yellow) presumably cause flare-ups in chronic inflammatory diseases such as Morbus Crohn or ulcerative colitis. Credit: Universitätsklinikum Erlangen/Sebastian Zundler Patients affected by the chronic inflammatory bowel diseases morbus Crohn and ulcerative colitis often suffer from flare-ups, which damage intestinal tissue. Despite advances in treating […]Continue Reading ...
Specialized lung cells appear in the developing fetus much earlier than scientists previously thought. A new animal study reports how cells that become alveoli, the tiny compartments in which gas exchange occurs in the lung, begin their specialized roles very early in prenatal life. The researchers say that investigating the fetal signaling pathways active in […]Continue Reading ...
Cancer: The word alone evokes dread, anxiety, and fear. Accordingly, many women living with the disease and undergoing treatment experience chronic stress and depression. Scientists have demonstrated, in studies with rodents and humans, that stress can exacerbate cancer’s progression, but it wasn’t clear how. A new study, published in The Journal of Clinical Investigation, establishes […]Continue Reading ...
Scanning electromicrograph of an HIV-infected T cell. Credit: NIAID Researchers can now quickly and accurately count a hidden, inactive form of the human immunodeficiency virus (HIV) that lurks in patients’ cells. This version of HIV embeds into cells’ genomes and can persist despite otherwise successful therapies—thwarting attempts to cure the infection. Using a new genetic […]Continue Reading ...
Human beings are not the only ones who suffer from stress – even microorganisms can be affected. Now, researchers from Chalmers University of Technology, Sweden, have devised a new method to study how single biological cells react to stressful situations. Understanding these responses could help develop more effective drugs for serious diseases. As well as […]Continue Reading ...
The University of Minnesota Medical School continues its legacy of advancing cell replacement therapies with a scientific breakthrough that highlights the promise of cell therapies for muscular dystrophy. The research published in Proceedings of the National Academy of Sciences of the United States of America (PNAS) allows authors Tania Incitti, Ph.D., Post-Doctoral Associate, and Rita […]Continue Reading ...
Sponsored Content by AlveoleFeb 18 2019 News-Medical speaks to Marie-Charlotte Manus from Alvéole, to find out about a new technology called PRIMO that improves the physiological relevance of cells in culture by giving researchers the ability to customize the cellular microenvironment. What is the cellular microenvironment and how does it influence cellular mechanisms? The cellular […]Continue Reading ...
The series of molecular steps linking inflammation and cancer, as shown in in the gastric epithelial cells. Inflammatory molecules IL-1α/β, lead to enhancement of MIR135B. This is turn activates FOXN3 and RECK genes, that lead to tumour like properties in cells. Credit: Kanazawa University Severe inflammation in tissues is often associated with the occurrence of […]Continue Reading ...
UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally “invisible” to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants. Because these “universal” stem cells can be manufactured more efficiently than stem cells tailor-made for […]Continue Reading ...
Cleveland Clinic researchers publish findings in Nature Ecology and Evolution Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression. While mutations in cancer cells significantly affect drug sensitivity, it is increasingly recognized that ecological […]Continue Reading ...
A new model by Rice University researchers details a direct connection between gene expression and metabolism and how cancer cells take advantage of it to adapt to hostile environments, a process known as metabolic plasticity. Credit: Dongya Jia/Rice University When metastatic cancer cells need to avoid a threat, they simply reprogram themselves. Rice University scientists […]Continue Reading ...
Scanning electron micrograph of human T lymphocyte or T cell. Credit: NIAID/NIH In rheumatoid arthritis, immune cells called helper T cells behave differently from their counterparts in healthy cells and in other autoimmune diseases. Stanford scientists have learned why. Stanford University School of Medicine investigators succeeded in countering inflammation and tissue damage caused by rheumatoid […]Continue Reading ...
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