The speed and error rate of DNA synthesis is influenced by the three-dimensional structure of the DNA. Using “third-generation” genome-wide DNA sequencing data, a team of researchers from Penn State and the Czech Academy of Sciences showed that sequences with the potential to form unusual DNA conformations, which are frequently associated with cancer and neurological […]Continue Reading ...
Carnegie Mellon University researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment of genetic conditions. Their findings are published in Communications Chemistry, a new Nature journal. The work was […]Continue Reading ...
About 1.5 billion years ago, tiny visitors came to live inside the cells that later evolved into all plant and animal life — including humans. Those visitors were mitochondria, small organelles whose prominent role is producing 90 percent of the chemical energy cells need to survive. Evolutionarily speaking, humans, animals and plants are thus a […]Continue Reading ...
Epigenetic changes often play an important role in cancer, because they cause the genetic material to be read incorrectly at certain locations. Genes that are especially critical are those that control the growth and death of cells. Scientists at Helmholtz Zentrum München have now discovered new details about the UHRF1 protein. UHRF1 catalyses particular steps […]Continue Reading ...
In this Friday, April 27, 2018 file photo, Joseph James DeAngelo, 72, who authorities suspect is the “Golden State Killer” responsible for at least a dozen murders and 50 rapes in the 1970s and 80s, is accompanied by Sacramento County Public Defender Diane Howard, right, during his arraignment in Sacramento County Superior Court in Sacramento, […]Continue Reading ...
O’Keefe’s HYPER-melt device (injected with dye for easier viewing) will help clinicians detect cancer and precancerous materials by separating blood samples into ever smaller portions for easier analysis. Credit: Johns Hopkins University As anyone who has played “Where’s Waldo” knows, searching for a single item in a landscape filled with a mélange of characters and […]Continue Reading ...
Researchers from City of Hope, a world-renowned comprehensive cancer center and independent biomedical research institution, have developed a synthetic DNA molecule that is programmed to jump-start the immune system to eradicate genetically distinct types of prostate cancer. Their novel two-step strategy eliminates STAT3, a master key that enables tumors to become resistant to existing therapies, […]Continue Reading ...
According to a latest report over 60 percent of the Americans’ ancestry can be traced through existing DNA databases. This includes even persons who have never submitted their DNA for evaluation say researchers because enough individuals have already submitted their genetic information. The latest study revealing this was published in the journal Science. Image Credit: […]Continue Reading ...
Researchers at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have established the trigger for catastrophic events that occur within the chromosomes of cancer cells. Novikov Aleksey | Shutterstock They found that failure of DNA repair systems promotes fragmentation and disrupted assembly of chromosomes. However, the researchers say these DNA repair defects could potentially be […]Continue Reading ...
Scientists are making strides in developing liquid biopsies for brain tumors by detecting tumor DNA in the fluid from around the brain and spine. Liquid biopsies are fluid samples from patients, for example from the blood or urine, which provide a less invasive way to monitor disease compared to tumor biopsies. A less intrusive test […]Continue Reading ...
It’s been a biological conundrum for years. How does a stem cell early in development manage to make so many different tissue types using the same genetic ingredients? Researchers have known that transcription factors — proteins that stimulate the expression of particular genes — are a key component of this transition. But in many cases, […]Continue Reading ...
Scientists at Nottingham University have decoded the longest continuous DNA sequence to date, measuring around 10,000 times longer than normal sequencing reads and twice as long as the previous record holder. Image Credit: fotohunter / Shutterstock In normal sequencing, DNA is divided into fragments and subsequently reassembled as the sequence is being read. The research […]Continue Reading ...
Credit: CC0 Public Domain Together with researchers from the University of Nantes and the University of Reims Champagne-Ardenne in France, experts from the National Research Nuclear University MEPhI have recently developed a quantum dot-based microarray that enables the screening of effective inhibitors (substances used for decreasing activity) of enzymes that repair DNA damage in cancer […]Continue Reading ...
Oct 19 2018 Mouse study implicates epigenetic changes in paternal sperm DNA A father’s exposure to nicotine may cause cognitive deficits in his children and even grandchildren, according to a study in mice publishing on October 16 in the open-access journal PLOS Biology by Pradeep Bhide of Florida State University in Tallahassee and colleagues. The […]Continue Reading ...
With the help of a new rendition of CRISPR-Cas9 gene editing technology, scientists at Stanford have shown that it’s possible to shuttle pieces of DNA around in the nucleus, affecting gene expression and cell behavior. The study, led by Stanley Qi, PhD, hinges on a reengineered version of CRISPR called “CRISPR-genome organization” or CRISPR-GO, which […]Continue Reading ...
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