A certain type of DNA marker predicts poor outcomes in multiple myeloma, researchers at Winship Cancer Institute, Emory University have found. The marker is a kind of rearrangement of chromosomes that is rarely tested for, but may indicate resistance to immunomodulatory drugs such as lenalidomide, which have become standard therapies in multiple myeloma. The results […]Continue Reading ...
What if doctors had a remote control that they could use to steer a patient’s own cells to a wound to speed up the healing process? Although such a device is still far from reality, researchers reporting in the ACS journal Nano Letters have taken an important first step: They used near-infrared light and an […]Continue Reading ...
A new study from BC Children’s Hospital, the University of British Columbia (UBC) and an international team of researchers published in the New England Journal of Medicine is the first to identify a rarely-seen type of DNA mutation as the cause of an inherited metabolic disorder. Inherited metabolic disorders — where the body can’t break […]Continue Reading ...
Scientists in Cambridge and London have developed a catalog of DNA mutation ‘fingerprints’ that could help doctors pinpoint the environmental culprit responsible for a patient’s tumor – including showing some of the fingerprints left in lung tumors by specific chemicals found in tobacco smoke. Our DNA, the human genome, comprises of a string of molecules […]Continue Reading ...
Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway. Described in Nature, this approach to programmable gene editing overcomes prior inefficiencies in gene correction. “It’s like hitting the reset button,” said Scot A. Wolfe, […]Continue Reading ...
Almost one percent of all American babies are born with malformed hearts. Heart abnormalities are at once the most common and most deadly type of birth defect in the U.S. Malformations in the structures of the right side of the heart have been linked to mutations in the master regulator gene Nkx2-5. Researchers at the […]Continue Reading ...
Diseases affecting mitochondria, the powerhouses of our cells, are often caused by mutations in the mitochondrial DNA. Symptoms of such mitochondrial diseases in mice can be ameliorated by increasing their levels of mitochondrial DNA, according to a study by researchers at Karolinska Institutet. The study is published in Science Advances and can, according to the […]Continue Reading ...
An experimental combination drug therapy attacking the DNA integrity of cancer cells is showing promise for a possible new cancer therapy in the future. Scientists at the University of Alberta used two drugs together to enhance DNA damage to human breast cancer cells in mice and reduce their capacity to repair themselves. By doing so, […]Continue Reading ...
Every living organism on Earth has a genome, the complete set of DNA containing all of the information needed to develop and maintain the organism. Humans inherit three billion long strings of DNA called chromosomes from each parent, so your genome can help identify your personal ancestry. But genomes can also identify the movement of […]Continue Reading ...
Researchers have discovered that the spatial organization of the genome can be altered using small molecule compounds which are considered as promising anti-cancer drugs. This work opens up the prospect of developing a new class of anticancer epigenetic drugs that alter the 3D genome. The results were published in Nature Communications. The properties of a […]Continue Reading ...
Scientists have discovered that the cause of cancer is “written” within the DNA of tumors, a finding that could help doctors to pinpoint the triggers underlying the development of individual tumors. ImageFlow | Shutterstock Previously, the roots of many cancer have been unclear, with doctors unable to attribute the disease to any particular culprit among […]Continue Reading ...
Thus, the prospects for early pancreatic cancer detection are of enormous importance. Innovation Fund Denmark has just granted 13.1 million kroner for new and promising pancreatic cancer diagnostic technologies. Associate professor Birgitte Regenberg, University of Copenhagen’s Department of Biology heads the project. She and her research group have developed an extremely sensitive diagnostic method using […]Continue Reading ...
Researchers at Karolinska Institutet present a publicly available resource that can accelerate the use of so-called FISH techniques for studying how the genome is spatially organized in the cell nucleus. The new platform, which enables more cost-effective analyses for both research and diagnostic labs, is described in the scientific journal Nature Communications. DNA fluorescence in […]Continue Reading ...
A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA. RNA polymerase II (RNAPII)–the enzyme that produces RNA from a DNA template–can become stuck due to […]Continue Reading ...
Mar 25 2019 Genetic mutations that drive the development of a common type of childhood leukemia can be traced back to errors by the immune system during the production of antibodies. Dr. Christopher Kirkham, joint first author on the paper The discovery by scientists at the University of Leeds could lead to new ways to […]Continue Reading ...
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