What makes one person different from one another, and how did these differences evolve? A study by University at Buffalo biologists is illuminating one aspect of this complicated question. The research examines hot spots of genetic variation within the human genome, examining the sections of our DNA that are most likely to differ significantly from […]Continue Reading ...
Mar 19 2019 Australian researchers have used current hepatitis B virus (HBV) genome sequences to deduce ancient human population movements into Australia, adding weight to the theory that the mainland Aboriginal population separated from other early humans at least 59 thousand years ago and possibly entered the country near the Tiwi Islands. The discovery was […]Continue Reading ...
Human chromosomes during metaphase. Credit: Steffen Dietzel/Wikipedia When researchers say they have sequenced the human genome, there is a caveat to this statement: a lot of the human genome is sequenced and assembled, but there are regions that are full of repetitive elements, making them difficult to map. One piece that is notoriously difficult to […]Continue Reading ...
Knowledge from gypsy moth genome could aid fight against deforestation, give insights into immunity The European gypsy moth (EGM) is perhaps the country’s most famous invasive insect – a nonnative species accidentally introduced to North America in the 1860s when a few escaped from a breeding experiment in suburban Boston. The caterpillars have been slowly […]Continue Reading ...
Jan 11 2019 Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications. The work appears January 10 in the journal […]Continue Reading ...
Given this morning’s reports of infants possibly born in China whose genomes were edited by CRISPR-based technology, the American Society of Human Genetics (ASHG) reaffirms the cautious but proactive approach recommended in its 2017 position statement on human germline genome editing, published in The American Journal of Human Genetics. Along with 10 other global organizations […]Continue Reading ...
Credit: CC0 Public Domain Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease. Properly producing and managing this large amount of data is both challenging and necessary for the progress of […]Continue Reading ...
The speed and error rate of DNA synthesis is influenced by the three-dimensional structure of the DNA. Using “third-generation” genome-wide DNA sequencing data, a team of researchers from Penn State and the Czech Academy of Sciences showed that sequences with the potential to form unusual DNA conformations, which are frequently associated with cancer and neurological […]Continue Reading ...
Scientists have shown that different segments of a virus genome can exist in distinct cells but work together to cause an infection. The findings, published in the open-access journal eLife, upturn a fundamental model in virology that a virus genome enters and replicates within a single cell and then moves on to replicate in another. […]Continue Reading ...
A helicase, Pfh1, can thanks to several different mechanisms protect the genome from DNA obstacles and damages associated with cancer. This is shown in a new doctoral thesis at Umeå University, Sweden. Approximately one per cent of each organism’s genome encodes helicases. Helicases are mostly known as motor enzymes that can unwrap double-stranded DNA by […]Continue Reading ...
Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in the air we breathe and the food we eat. Genome instability can lead to genetic disorders, chronic diseases and a predisposition to cancer. A new Tel […]Continue Reading ...
The New York Genome Center (NYGC) has received approval from the New York State Department of Health to offer whole genome and RNA transcriptome sequencing in its Clinical Laboratory Evaluation Program (CLEP)-certified laboratory. This is the first approval by New York State for a whole genome sequencing test for oncology, and currently NYGC’s Clinical Lab […]Continue Reading ...
For the past 17 years, most scientists around the globe have been using the nucleic acid sequence, or genome, an assembly of DNA information, from primarily a single individual as a kind of “baseline” reference and human species representation for comparing genetic variety among groups of people. Known as the GRCh38 reference genome, it is […]Continue Reading ...
With a genome that’s regularly broken into 225,000 pieces and reassembled, a pond protist may be the perfect creature to teach us how genomic stability—often lost in cancer—is maintained.Continue Reading ...
Studying the three-dimensional structure of DNA and its dynamics is revealing a lot of information about gene expression, expanding our knowledge of how cells, tissues and organs actually work in health and disease. Properly producing and managing this large amount of data is both challenging and necessary for the progress of this field. In a […]Continue Reading ...
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