August 13, 2018 A research team at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and Harvard Medical School reports a new kind of genome analysis that could identify large fractions of the population who have a much higher risk of developing serious common diseases, including coronary artery disease, breast cancer, or […]Continue Reading ...
July 31, 2018 A team led by scientists from the Johns Hopkins Bloomberg School of Public Health has sequenced and annotated the first complete mitochondrial genome of Anopheles funestus, one of the main vectors of malaria in sub-Saharan Africa. This milestone, published in June in Scientific Reports, offers a glimpse inside this insect’s genetic diversity, […]Continue Reading ...
July 10, 2018 Using genome editing to inactivate a protein called PCSK9 effectively reduces cholesterol levels in rhesus macaques, a species of monkey, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. This is the first demonstration of a clinically relevant reduction of gene expression in a large animal model […]Continue Reading ...
June 27, 2018 UPMC and the University of Pittsburgh today announced the launch of an advanced genome sequencing center to support clinical diagnostics and research initiatives in precision medicine and immunotherapy. The UPMC Genome Center, established with funding from the recently announced UPMC Immune Transplant and Therapy Center (ITTC) and the Institute for Precision Medicine […]Continue Reading ...
June 21, 2018 An interview with Dr. Jinghui Zhang, PhD, conducted by Kate Anderton, BSc What is the history of genomics research at St. Jude Children’s Research Hospital? In 2007, before the advent of next generation sequencing, St. Jude used microarrays to characterize gene expression and copy number variation and Sanger Sequencing to identify sequence […]Continue Reading ...
May 26, 2018 Scientists have created a new way of speeding up the genome evolution of baker’s yeast Saccharomyces cerevisiae, the same yeast people use for bread and beer production, to develop a synthetic yeast strain that can be transformed on demand for use in various industrial applications. A research team led by Prof. DAI […]Continue Reading ...
May 15, 2018 Genetic research aimed at improving healthcare will be the focus of the University of Queensland’s new Genome Innovation Hub. UQ Deputy Vice-Chancellor (Research) Professor Robyn Ward said the $6.6 million Hub was a collaborative research center that would develop projects between leading UQ scientists, industry, government bodies and international academics. “It […]Continue Reading ...
By Sally Robertson, BScApril 24, 2018 Researchers have used a sophisticated gene-editing technology to create a new type of embryonic stem cell and an atlas of the human genome. The data sheds light on the role of our genes in health and disease. Credit: vchal/Shutterstock.com The study, which was conducted by scientists from the Hebrew […]Continue Reading ...
July 13, 2018 In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations — larger-scale rearrangements of DNA that can encompass large chunks of chromosomes — disturb carefully balanced mechanisms that have evolved to regulate cell growth. Genes that are normally silent are massively activated and mutant proteins are formed. These […]Continue Reading ...
Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa. This is the first time researchers have successfully applied CRISPR technology to a type of inherited disease known as a dominant disorder. This same tool […]Continue Reading ...
June 21, 2018 The cell has its own paramedic team and emergency room to aid and repair damaged DNA, a new USC Dornsife study reveals. The findings are timely, as scientists are delving into the potential of genome editing with the DNA-cutting enzyme, CRISPR-Cas9, to treat diseases or to advance scientific knowledge about humans, plants, […]Continue Reading ...
Credit: CC0 Public Domain Once upon a time in Europe, pregnant women avoided rabbits to prevent their babies from being born with a “harelip.” But, that apparently isn’t the only misconception about the condition now known as cleft lip. In the May 1 issue of Cell Reports, UConn Health researchers report the popular modern belief […]Continue Reading ...
By Sally Robertson, BScMay 23, 2018 Researchers from the University of Barcelona, August Pi i Sunyer Biomedical Research Institute and Hospital Clínic Barcelona have created a high-resolution map of the entire epigenome of chronic lymphocytic leukemia, the most common form of leukemia. Image Credit: Kateryna Kon/Shutterstock.com Comparing the map with one of healthy cells flagged […]Continue Reading ...
May 8, 2018 Not all of your genome needs to be active at any given time. Some regions are prone to hopping around the genome in problematic ways if left unchecked; others code for genes that need to be turned off in certain cells or at certain times. One way that cells keep these genetic […]Continue Reading ...
April 11, 2018 Researchers at the University of Michigan Life Sciences Institute and the Howard Hughes Medical Institute have determined how satellite DNA, considered to be “junk DNA,” plays a crucial role in holding the genome together. Their findings, published recently in the journal eLife, indicate that this genetic “junk” performs the vital function of […]Continue Reading ...
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