An antibody that binds simultaneously to two distinct regions of the HER2 receptor to block the growth of cancer cells has shown promising signs of anti-tumor activity in a number of cancers including those of the gullet (esophagus), stomach and bowel. Results from the phase I clinical trial of the drug, called ZW25, had been […]Continue Reading ...
When mental illness hijacks Margaret Rodgers’ mind, she acts out. Rodgers, 35, lives with depression and bipolar disorder. When left unchecked, the conditions drive the Alabama woman to excessive spending, crying and mania. Last autumn, Rodgers felt her mind unraveling. Living in Birmingham, she was uninsured, unable to afford treatment and in the throes of […]Continue Reading ...
The HER2 gene is a well-known driver of breast cancer, where changes in this gene are found in about 1-in-5 cases of the disease. HER2 also contributes to about 3 percent of lung cancers, representing about 6,500 patients per year. But while drugs like trastuzumab and lapatinib have proven effective in silencing the action of […]Continue Reading ...
Janet Winston had a rash that wouldn’t go away. The English professor from Eureka, Calif., always had been sensitive to ingredients in skin creams and cosmetics. This time, however, the antifungal cream she was prescribed to treat her persistent rash seemed to make things worse. Was she allergic to that, too? Winston, 56, who works […]Continue Reading ...
Last year, during her first year of medical school at Stanford, Claire Rhee underwent knee surgery. The months of recovery that followed helped her see from a new perspective: how difficult life as a medical student can be when you are not able-bodied. That spring, Rhee and her roommate, Maïté Van Hentenryck, also a first-year […]Continue Reading ...
WEDNESDAY, Sept. 26, 2018 (American Heart Association) — The day after Maggie Maine was born, doctors told her parents there was a 70 percent chance she’d never walk, talk or be able to feed or bathe herself. An MRI had found severe defects in both her heart and her brain. Relying on their faith, Jeff […]Continue Reading ...
Arna Shefrin was on a flight to San Francisco when she became struck by a paralyzing pain in her hip, the first sign of the bizarre illness that would plague her for the next year. In a matter of months, she would become bedridden, tormented by unrelenting pain and by an irritating rash that covered […]Continue Reading ...
Kira Hinslea wanted to play outside, but she knew she couldn’t until her mom checked an air-quality app on her phone. “Is it OK?” the 6-year-old eagerly asked her mother, Shirley Hinslea, one day late last month. Hinslea gave Kira the green light, and the child beamed with excitement. “Yes! Yes! Yes!” she yelled, sprinting […]Continue Reading ...
Cimone Stills, 15, has a medical condition that has caused her to have multiple seizures a day for most of her life. Specifically, she has treatment-resistant generalized epilepsy because of a genetic variation. Like many patients with such a serious illness, it affects her daily life and as a result, she was diagnosed with clinical […]Continue Reading ...
I intended to write one news article about FAST, the science exploration program created by a team of Stanford science graduate students that has touched the lives of scores of East San Jose youth. Simple, short and straightforward. But as I started talking and exchanging emails with the program’s founders, its current leaders and with […]Continue Reading ...
Elizabeth Jameson creates art from the one thing she cannot stand to look at — the MRIs of her brain. In 1991, Jameson was diagnosed with multiple sclerosis after losing the ability to speak during an otherwise unremarkable trip to the park with her two sons. Since then, she’s had many MRIs. To Jameson, these images […]Continue Reading ...
Toy initially studied epidemiology, the branch of medicine focused on the prevalence and distribution of disease. But one of her professors got her hooked on mathematical modeling. She earned a PhD in public health at Erasmus University Medical Center in Rotterdam and became a decision scientist. “A decision scientist helps to pick up loose ends […]Continue Reading ...
Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers who had not previously been treated with a HER2-targeted therapeutic, according to data from a phase I clinical trial presented at the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival, held Sept. 30-Oct. 3. Among 11 […]Continue Reading ...
“Since 2015, we have performed two smaller studies at Uppsala University Hospital with more than 20 patients showing very promising results. If we can demonstrate that the method works in larger scale, we believe it can quickly become a new “gold” standard worldwide. This would mean that difficult and stressful biopsies can be avoided for […]Continue Reading ...
A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target. A research team led by Karolina Palucka, M.D., Ph.D., a professor at The Jackson Laboratory (JAX), has collaborated with researchers at The Baylor Institute for Immunology […]Continue Reading ...
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