Oct 12 2018 AMSBIO has added an important new product to its immunotherapy range – a PD-L2 / TCR activator – CHO Recombinant Cell Line. PD-L2 is one of the key players in immune checkpoint therapy, which is the focus of the 2018 Nobel Prize for Physiology & Medicine . This work pioneered by Professor […]Continue Reading ...
In multiple sclerosis, a defective response of the body’s own immune system leads to brain tissue damage. Gastrointestinal microbiota could play a far greater role in the pathogenesis of the disease than previously assumed, researchers at the University of Zurich have now found. Multiple sclerosis is an autoimmune disease in which the body’s own immune […]Continue Reading ...
While chemotherapy destroys cancerous cells along with normal cells, often with toxic and debilitating effects on a patients’ body, immunotherapy unleashes the body’s immune system to target tumour cells A revolutionary cancer treatment pioneered by the winners of the 2018 Nobel Prize for Medicine has been hailed as the future of fighting the disease—and it […]Continue Reading ...
Scientists at Scripps Research have discovered the role of an immune system double agent. This molecule, called USP18, can help curtail immune responses, but it can also open the door to bacterial infections, such as harmful listeria and staph infections. “I call the molecule a ‘wolf in sheep’s clothing,’ ” says Namir Shaabani, PhD, a […]Continue Reading ...
Australian researchers have uncovered clues in the immune system that reveal how the balance of ‘good’ gut bacteria is maintained. This information could help in the prevention and treatment of inflammatory bowel disease (IBD). The study, published in the journal Nature Communications, showed that the increased presence of a protein responsible for sensing infection – […]Continue Reading ...
Research conducted by teams of British scientists has found that yellow deposits (known as drusen) found at the back of the eye in AMD patients contain protein covered waste products that attract and activate faulty immune cells leading to low grade but chronic inflammation and ultimately sight-threatening retinal damage. Jessica L. Teeling, Professor of Experimental Neuro-immunology […]Continue Reading ...
Training the body’s immune cells to seek out and fight cancer is a promising new approach in the fight against the disease. That’s because immune cells are already generally equipped to distinguish between healthy and infected or diseased cells. But in many cases, the cancers themselves have evolved ways to either dampen or evade the […]Continue Reading ...
Killer T cells surround a cancer cell. Credit: NIH Scientists at the VIB-UGent Center for Medical Biotechnology have taken important steps toward the development of cancer-targeting immunotherapy. The research team developed a treatment in mice that destroys part of the tumor and stimulates the immune system to attack persistent surviving cancer cells. In addition, the […]Continue Reading ...
A research team led by Peter Sloot, professor of Complex Adaptive Systems at the UvA, has managed to pinpoint the mechanisms behind the immune response triggered in patients undergoing open heart surgery. The team’s research reveals that by administering supplementary enzymes, so-called alkaline phosphates, to patients undergoing cardiac surgery, the latter can regain control over […]Continue Reading ...
A type of ‘supercharged’ immune cell could be mass-produced to help fight cancer. The researchers behind the early-stage finding, from Imperial College London, say the development could mark the next generation of cutting-edge immunotherapy treatments, called CAR-T therapies. These personalized treatments involve reprogramming immune cells to kill cancer. NHS England announced on Friday it would […]Continue Reading ...
Researcher Gillian Dunphy in the lab at Lancaster University. Credit: Lancaster University Our immune system is working every day to protect us from bacteria, viruses, and parasites, but it can also detect when our own cells are damaged. Research led by Lancaster University has now discovered how skin cells alert the immune system, when their […]Continue Reading ...
Physicians who specialize in a devastating and aggressive immune disorder called hemophagocytic lymphohistiocytosis (HLH) report in a new study that extra care should be taken to ensure an HLH diagnosis doesn’t obscure possible underlying cancers. Because HLH is dangerously aggressive in its progression and attack on vital organs–often causing death–doctors frequently pursue immediate treatment for […]Continue Reading ...
HIV infecting a human cell. Credit: NIH Immune activation and inflammation persist in the majority of treated HIV-infected individuals and is associated with excess risk of mortality and morbidity. A new study by Boston University School of Medicine (BUSM) researchers suggests that use of HIV RNA expression inhibitors as adjunct therapy might diminish atypical inflammation […]Continue Reading ...
Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells. Credit: Eindhoven University of Technology Plasmacytoid dendritic cells (pDCs) are a rare type of immune cells that secrete large quantities of type 1 interferon (I-IFN), a key driver of immunity to infectious invaders and cancer. However, the mechanisms that control […]Continue Reading ...
Researchers at the University of Maryland School of Medicine (UMSOM) have made a surprising discovery: during fetal development, a particular immune cell seems to play a key role in determining the male or female characteristics of the brain. “This a totally new discovery,” says Margaret McCarthy, professor and chairman of the UMSOM Department of Pharmacology. […]Continue Reading ...
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