Postoperative liver dysfunction (failure) is the most serious complication that can occur following liver resection (full or partial hepatectomy) to remove liver tumors. Hitherto, the only tests available for preoperative risk stratification are both time-consuming and expensive. A MedUni Vienna research group has now shown that a particular microRNA signature has the potential to serve […]Continue Reading ...
Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers. The study was posted in March on Gastroenterology, the online journal of the American Gastroenterological Association. Print publication is scheduled for July. While therapies have been available to treat […]Continue Reading ...
Even as overall cancer incidence and mortality decrease in the United States, the number of people diagnosed with liver cancer is on the rise. Current therapies for liver cancer are largely ineffective, resulting in poor outcomes, but new preclinical data from University of California San Diego School of Medicine offers proof-of-principle for a combination immunotherapy […]Continue Reading ...
Studies could speed the development of new treatments for liver disease Novel therapies based on a process known as RNA interference (RNAi) hold great promise for treating a variety of diseases by blocking specific genes in a patient’s cells. Many of the earliest RNAi treatments have focused on diseases of the liver, because RNA-carrying particles […]Continue Reading ...
One in four people in Western and Asian societies develop a build-up of fat in the liver as a result of an unhealthy diet. This disease – referred to as non-alcoholic fatty liver disease (NAFLD) – causes no symptoms initially but can develop into end-stage liver cirrhosis with limited treatment options. A discovery, published today […]Continue Reading ...
Credit: CC0 Public Domain A randomized clinical study of adolescent boys with nonalcoholic fatty liver disease (NAFLD) found that a diet low in free sugars (those sugars added to foods and beverages and occurring naturally in fruit juices) resulted in significant improvement in NAFLD compared to a usual diet. The study was conducted at Emory […]Continue Reading ...
More than 10 percent of patients waiting for a liver transplant die each year. This observational study looked at trends in the transplantation of livers from older donors (70 and older) and outcomes in recipients of these older livers from 2003 to 2016. There was a decrease in the use of liver grafts from older […]Continue Reading ...
A new study has uncovered that the standard method for ranking patients on the waitlist for lifesaving liver transplantation may not prioritize some of the sickest candidates for the top of the list. “Ultimately, we hope this information will help clinicians recognize that certain patients with a high risk of mortality may not be captured […]Continue Reading ...
Close up of two red AIDS awareness ribbons pinned to white fabric. Credit: NIAID The first large-scale clinical trial to study liver transplantation between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Liver Study will determine the safety of this practice by evaluating liver recipients for […]Continue Reading ...
The liver is the only organ in the body that can regenerate. But some patients who undergo a liver resection, a surgery that removes a diseased portion of the organ, end up needing a transplant because the renewal process doesn’t work. A new Michigan State University study, published in the journal Blood, shows that the […]Continue Reading ...
A nationwide consortium of researchers has identified the first genetic defect linked to biliary atresia, a mysterious liver disease that is the leading cause for liver transplantation in children. The results were published in the journal Hepatology. The causes of biliary atresia were unknown, so this is a major advance that will move the field […]Continue Reading ...
Crigler-Najjar syndrome affects about one in a million people at birth. Because of a defective gene, these individuals lack an essential enzyme in their liver to eliminate bilirubin, a toxic bile pigment that accumulates in all body tissues causing jaundice and potentially leading to irreversible and lethal neurological damage. Researchers from the EU-funded CURECN project […]Continue Reading ...
UNIST Professor Hyug Moo Kwon (standing) and Jun Ho Lee, lead paper author. Credit: Ulsan National Institute of Science and Technology Analysing the levels of a protein called TonEBP could provide valuable insight into the likelihood of recurrence of hepatocellular carcinoma, an aggressive cancer of the liver, following its surgical removal. Drugs that target TonEBP […]Continue Reading ...
The first large-scale clinical trial to study liver transplantation between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Liver Study will determine the safety of this practice by evaluating liver recipients for potential transplant-related and HIV-related complications following surgery. The study is sponsored by the National […]Continue Reading ...
“The best diet, to make it very simple, is to shop the outside aisles in supermarkets,” said Dr. Joel Lavine, chief of gastroenterology at Morgan Stanley Children’s Hospital.Continue Reading ...
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