Researchers pinpoint how brain activity changes in mouse models of Parkinson’s disease, hinting at what may drive symptoms in humans The tell-tale tremors of Parkinson’s disease emerge from abnormal activity in a brain region crucial for voluntary movement. Using a mouse model of the disease, researchers at the Okinawa Institute of Science and Technology Graduate […]Continue Reading ...
Patients with Parkinson’s disease are known to have abnormal brain waves especially beta waves in their subthalamaic nucleus (STN) region of the brain. Until now there have been no studies that connect these abnormal beta waves or “β-band oscillation” and the movement difficulties typically seen with Parkinson’s disease. Authors write, “Previous studies demonstrated that l-DOPA […]Continue Reading ...
The federal Food and Drug Administration has approved a new, scalpel-free treatment for tremor in patients with medication-resistant Parkinson’s disease. The procedure, called focused ultrasound, allows doctors to perform brain surgery without cutting into the skull. It was shown safe and effective for reducing medication-resistant Parkinson’s tremor in clinical trials led by neurosurgeon Jeff Elias, […]Continue Reading ...
Scientists have taken a key step towards improving an emerging class of treatments for Parkinson’s disease. The advance could markedly improve a next generation of therapies for the condition, which affects around one in 350 people in the UK. It could aid development of the promising treatment—known as cell replacement therapy—which was first used in […]Continue Reading ...
Researchers at the University of Barcelona have found that defects in brain glial cells called astrocytes are linked to the accumulation of alpha-synuclein; a toxic protein that is thought to contribute to Parkinson’s disease. Antiv | Shutterstock The astrocytes, which were derived from patients with Parkinson’s, had a genetic mutation that affects cell clean-up capabilities. […]Continue Reading ...
An interview with Kristen Sowalsky, DC, Ph.D., from APDM Wearable Technologies at SfN 2018, discussing the Opal wearable sensor and its impact on Parkinson’s disease research. What does APDM stand for, and where did the journey start for the company? APDM began in 2007 when Dr. James McNames, Professor and Chair of Electrical and Computer […]Continue Reading ...
Scientists working to treat debilitating diseases often are split into two categories: those who see patients, and those who don’t. But graduate student Johanna O’Day has the best of both worlds — and she’s making it her mission to bridge the gap for others too. By day, O’Day works in two labs at Stanford, one […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia The human brain is rich in lipids. Investigators studying Parkinson’s disease (PD) have become increasingly interested in lipids since both molecular and genetic studies have pointed to the disruption of the balance of the brain’s […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Researchers from the University of Barcelona have shown that defective versions of human brain cells called astrocytes are linked to the buildup of a toxic protein that is the hallmark of Parkinson’s disease. The studied […]Continue Reading ...
A team of scientists led by Prof. Antonella Consiglio from the IDIBELL and the University of Barcelona (UB), and Prof. Angel Raya from the Center of Regenerative Medicine of Barcelona (CMR[B]/IDIBELL) have discovered that defective versions of human brain cells called astrocytes are linked to the buildup of a toxic protein that is one the […]Continue Reading ...
A Michigan State University researcher has received a $2.8 million federal grant to develop a gene therapy that could reduce and possibly eliminate a frustrating side effect of a drug commonly prescribed to Parkinson’s patients. The research could mean a significant advance for the up to 90 percent of patients who develop dyskinesia, a drug-induced […]Continue Reading ...
Sponsored Content by AbcamJan 10 2019 An interview with Dr. Nicole Polinski from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and Dr. Elnaz Atabakhsh from Abcam, discussing the importance of developing biomarkers for Parkinson’s and the partnership between MJFF and Abcam. Which biomarkers are currently used for Parkinson’s disease and why are additional […]Continue Reading ...
Mr Jonathan Bernardini and Associate Professor Grant Dewson. Credit: The Walter and Eliza Hall Institute Australian researchers have discovered how a protein linked to Parkinson’s disease may protect cells such as neurons in the brain. The study revealed how a protein called Parkin—which is lost in certain forms of Parkinson’s disease – ‘buys time’ for […]Continue Reading ...
Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Combining low doses of a toxic herbicide with sugar-binding proteins called lectins may trigger Parkinsonism—symptoms typical of Parkinson’s disease like body tremors and slowing of body motions—after the toxin travels from the stomach to the […]Continue Reading ...
Shutterstock”> Experimental cancer drug shows promise for Parkinson’s. Credit: Shutterstock The study, funded by Parkinson’s UK, suggests that the drug, tasquinimod, which is not yet on the market, works by controlling genes that may cause Parkinson’s. This happens when the drug interacts with a protein inside brain cells. The team at the Oxford Parkinson’s Disease […]Continue Reading ...
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