The NLRP3 inflammasome (green) is expressed by immune cells (red) in the brains of people with Parkinson’s disease. Credit: University of Queensland A promising new therapy to stop Parkinson’s disease in its tracks has been developed at The University of Queensland. UQ Faculty of Medicine researcher Associate Professor Trent Woodruff said the team found that […]Continue Reading ...
Genetic mutations affecting a single gene play an outsized role in Parkinson’s disease. The mutations are generally responsible for the mass die-off of a set of dopamine-secreting, or dopaminergic, nerve cells in the brain involved in physical movement. The pathogenic variants of the gene, LRRK2, share a common tendency: They cause the protein it encodes to […]Continue Reading ...
Aggregated alpha-synuclein in the neurons of the appendix. Credit: Viviane Labrie | Van Andel Research Institute Scientists have found a new clue that Parkinson’s disease may get its start not in the brain but in the gut—maybe in the appendix. People who had their appendix removed early in life had a lower risk of getting […]Continue Reading ...
Genetic mutations affecting a single gene play an outsized role in Parkinson’s disease. They are generally responsible for the mass die-off of a set of dopamine-secreting (or dopaminergic) nerve cells in the brain involved in, among other things, physical movement. The pathogenic genetic variants of the gene, which goes by the acronym LRRK2 (pronounced “lurk 2”), […]Continue Reading ...
(HealthDay)—A new gene therapy might help improve motor symptoms in people with Parkinson’s disease who aren’t responding to other therapies, an early study has found. “This is not a cure of Parkinson’s disease,” said James Beck, chief scientific officer of the Parkinson’s Foundation. “This is a potentially good treatment for symptom control. It provides an […]Continue Reading ...
WEDNESDAY, Oct. 31, 2018 — Long belittled as inconsequential, the appendix is hardly the rock star of body organs. But its reputation may get a boost from new research that suggests that removing it may lower the risk for Parkinson’s disease. The finding follows an analysis that examined how appendix removal surgery (appendectomy) affected Parkinson’s […]Continue Reading ...
Oct 30 2018 A surge in Parkinson’s diagnoses is expected for people over the age of 60. Parkinson’s UK’s latest figures show that there are currently more than 77,000 people in the UK with Parkinson’s between the ages of 60 and 79. This is projected to increase by 20 percent by the year 2025 to […]Continue Reading ...
A defining feature of Parkinson’s disease is the clumps of alpha-synuclein protein that accumulate in the brain’s motor control area, destroying dopamine-producing neurons. Natural processes can’t clear these clusters, known as Lewy bodies, and no one has demonstrated how to stop the build up as well as breakdown of the clumps — until perhaps now. […]Continue Reading ...
In the wake of media and public reports about increased mortality linked to a new drug for treating Parkinson’s disease psychosis (PDP)—a symptom of the progressive nervous system disorder in which patients experience hallucinations and delusions—researchers at University of California San Diego School of Medicine conducted a retrospective study of qualifying patients in the UC […]Continue Reading ...
A high-tech form of brain surgery that replaces scalpels with sound waves improved quality of life for people with Parkinson’s disease that has resisted other forms of treatment, a new study has found. Further, the University of Virginia School of Medicine researchers conclude their study offers “comprehensive evidence of safety” in terms of the approach’s […]Continue Reading ...
Researchers at the Faculty of Medicine, University of Helsinki, make an unexpected and vital contribution to an international collaborative effort in Parkinson’s disease research. An international team of scientists led by the University of Dundee, UK have verified that a molecular pathway that has been studied for years under laboratory conditions, is also disrupted in […]Continue Reading ...
The vermiform appendix or appendix as we commonly know it, is a vestigial organ of the body which does not come into notice unless it is inflamed (such as in appendicitis). In cases of appendicitis, the finger like part of the gut at the base of the caecum is surgically removed. Now researchers have come […]Continue Reading ...
Jordi Pujols, Salvador Ventura and Samuel Peña at the UAB. Credit: Universitat Autònoma de Barcelona The small SynuClean-D molecule interrupts the formation of the alpha-synuclein amyloid fibres responsible for the onset of Parkinson’s disease, and reverts the neurodegeneration caused by the disease. The study, headed by Universitat Autònoma de Barcelona researchers, was published in PNAS. […]Continue Reading ...
A joint research group centered around Professor Hideyuki Okano and Associate Professor Jun Kohyama, Department of Physiology of the Keio University School of Medicine, together with a research group of Eisai Co., Ltd. has identified a compound that has the potential to be a treatment for Parkinson’s disease by using dopaminergic neurons differentiated from induced […]Continue Reading ...
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